CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: oxoicosatetraenoic acid
Accession: CHEBI:61704
browse the term
Definition: Any C20 polyunsaturated fatty acid having four double bonds and at least one oxo group.
Synonyms: related_synonym: keto-ETE; keto-ETEs; ketoeicosatetraenoic acid; ketoeicosatetraenoic acids; oxo-ETE; oxo-ETEs; oxoETE; oxoETEs; oxoeicosatetraenoic acid; oxoeicosatetraenoic acids; oxoicosatetraenoic acids
cyclic_relationship: is_conjugate_acid_of CHEBI:131859
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Hmox1
heme oxygenase 1
increases expression
ISO
15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of HMOX1 protein
CTD
PMID:25450232
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions decreases activity
ISO
[15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein
CTD
PMID:25450232
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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Il1b
interleukin 1 beta
multiple interactions
ISO
15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:25450232
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
multiple interactions
ISO
15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:25450232
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
[15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein
CTD
PMID:25450232
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of NQO1 protein
CTD
PMID:25450232
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO
15-keto-5,8,11,13-eicosatetraenoic acid results in decreased expression of TNF mRNA 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:25450232
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Csf2
colony stimulating factor 2
increases secretion
ISO
5-oxo-6,8,11,14-eicosatetraenoic acid results in increased secretion of CSF2 protein
CTD
PMID:15136573
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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