Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carboplatin
go back to main search page
Accession:CHEBI:31355 term browser browse the term
Definition:A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Synonyms:exact_synonym: (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
 related_synonym: Formula=C6H12N2O4Pt;   Formula=C6H6O4Pt.2H3N;   InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2;   InChIKey=OLESAACUTLOWQZ-UHFFFAOYSA-L;   Paraplatin;   SMILES=[H][N]([H])([H])[Pt]1(OC(=O)C2(CCC2)C(=O)O1)[N]([H])([H])[H];   carboplatine;   carboplatino;   carboplatinum;   cbdca;   cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II);   cis-diammine(1,1-cyclobutanedicarboxylato)platinum;   cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)
 alt_id: CHEBI:76407
 xref: CAS:41575-94-4;   DrugBank:DB00958;   Gmelin:1044703;   Gmelin:51428;   HMDB:HMDB0015093;   KEGG:D01363;   LINCS:LSM-4265
 xref_mesh: MESH:D016190
 xref: PDBeChem:QPT;   PMID:11666286;   PMID:14568240;   PMID:15896850;   PMID:16411667;   PMID:17180231;   PMID:17497898;   PMID:17655933;   PMID:18336396;   PMID:1855275;   PMID:19774597;   PMID:21629880;   PMID:22525758;   PMID:23143236;   PMID:23275170;   PMID:23396873;   PMID:24121332;   PMID:25195879;   PMID:25195881;   PMID:26000441;   PMID:26239545;   PMID:26327386;   PMID:26893290;   PMID:28511060;   PMID:29632935;   PMID:31567140;   PMID:31930743;   PMID:32072678;   PMID:32487607;   PMID:32579504;   PMID:33052033;   PMID:33324858;   PMID:33542435;   PMID:33716231;   PMID:33807309;   PMID:33814494;   PMID:33829940;   PMID:33885718;   PMID:9654475;   Patent:DE2329485;   Reaxys:11327310;   Reaxys:11335262;   Reaxys:15523471;   Wikipedia:Carboplatin


show annotations for term's descendants           Sort by:
carboplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases expression ISO Carboplatin results in decreased expression of ABCB1 mRNA; Carboplatin results in decreased expression of ABCB1 protein CTD PMID:27692344 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases expression ISO Carboplatin results in decreased expression of ABCB4 mRNA CTD PMID:18172885 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases expression ISO Carboplatin results in decreased expression of ABCC1 mRNA; Carboplatin results in decreased expression of ABCC1 protein CTD PMID:27692344 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases expression ISO Carboplatin results in decreased expression of ABCC2 mRNA; Carboplatin results in decreased expression of ABCC2 protein CTD PMID:27692344 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases expression ISO Carboplatin results in decreased expression of ABCG2 mRNA; Carboplatin results in decreased expression of ABCG2 protein CTD PMID:27692344 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acvr1c activin A receptor, type IC increases response to substance ISO ACVR1C results in increased susceptibility to Carboplatin CTD PMID:21224400 NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907 		JBrowse link
G Ahr aryl-hydrocarbon receptor decreases expression ISO Carboplatin results in decreased expression of AHR mRNA CTD PMID:36536508 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO Carboplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]; Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]] CTD PMID:18483861 PMID:33190582 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid decreases expression ISO Carboplatin results in decreased expression of ALAS2 mRNA CTD PMID:21296123 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects response to substance ISO ALDH1A1 protein affects the susceptibility to Carboplatin CTD PMID:18854779 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Carboplatin CTD PMID:18854779 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
G Anxa4 annexin A4 decreases response to substance
multiple interactions
affects localization		 ISO ANXA4 protein results in decreased susceptibility to Carboplatin
ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]
Carboplatin affects the localization of ANXA4 protein		 CTD PMID:24150977 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566 		JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 increases response to substance ISO ARFGEF1 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr 1:10,207,732...10,303,306
Ensembl chr 1:10,207,796...10,302,895 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide decreases expression ISO Carboplatin results in decreased expression of ATP1A1 mRNA CTD PMID:18172885 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide affects localization
multiple interactions		 ISO Carboplatin affects the localization of ATP7A protein
[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]		 CTD PMID:24038379 PMID:24150977 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions ISO ATP7B protein binds to and results in increased metabolism of Carboplatin CTD PMID:23751120 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
increases expression		 ISO Carboplatin results in decreased expression of BAX mRNA
[Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; Carboplatin results in increased cleavage of and results in increased expression of BAX protein
Carboplatin results in increased expression of BAX mRNA; Carboplatin results in increased expression of BAX protein		 CTD PMID:15131059 PMID:15576332 PMID:33002289 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Carboplatin results in decreased expression of BCL2 mRNA; Carboplatin results in decreased expression of BCL2 protein CTD PMID:9664115 PMID:15576332 PMID:15996812 PMID:17404015 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions		 EXP
ISO		 Carboplatin results in decreased expression of BCL2L1 protein
Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]		 CTD PMID:18483861 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l12 BCL2 like 12 increases expression ISO Carboplatin results in increased expression of BCL2L12 mRNA CTD PMID:15576332 NCBI chr 7:44,640,646...44,647,011
Ensembl chr 7:44,640,646...44,648,136 		JBrowse link
G Becn1 beclin 1, autophagy related decreases expression
multiple interactions		 ISO Carboplatin results in decreased expression of BECN1 protein
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]		 CTD PMID:27692344 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases response to substance ISO BIRC2 protein results in decreased susceptibility to Carboplatin CTD PMID:10815900 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Blmh bleomycin hydrolase decreases expression ISO Carboplatin results in decreased expression of BLMH mRNA CTD PMID:18172885 NCBI chr11:76,836,482...76,878,215
Ensembl chr11:76,815,635...76,878,205 		JBrowse link
G Brca1 breast cancer 1, early onset decreases activity ISO Carboplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta affects response to substance ISO CAMKK2 protein affects the susceptibility to Carboplatin CTD PMID:28634229 NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472 		JBrowse link
G Canx calnexin decreases expression ISO Carboplatin results in decreased expression of CANX mRNA CTD PMID:18172885 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500 		JBrowse link
G Casp2 caspase 2 decreases expression ISO Carboplatin results in decreased expression of CASP2 mRNA CTD PMID:18172885 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 protein; Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]
Carboplatin results in increased expression of CASP3 mRNA; Carboplatin results in increased expression of CASP3 protein
[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein; Carboplatin promotes the reaction [[Pulsatilla saponin A co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pulsatilla saponin A promotes the reaction [[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]		 CTD PMID:15576332 PMID:16275998 PMID:18483861 PMID:20368269 PMID:22302033 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Carboplatin results in increased activity of CASP7 protein
palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]		 CTD PMID:22302033 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
decreases expression		 ISO
EXP		 Carboplatin results in increased activity of CASP9 protein
Carboplatin results in increased expression of CASP9 protein
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]
Carboplatin results in decreased expression of CASP9 mRNA		 CTD PMID:15576332 PMID:15996812 PMID:17404015 PMID:18483861 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression		 ISO Carboplatin results in decreased activity of CAT protein
Carboplatin results in decreased expression of and results in decreased activity of CAT protein
Carboplatin results in decreased expression of CAT protein		 CTD PMID:11124453 PMID:15109710 PMID:15225673 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]] CTD PMID:33190582 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd274 CD274 antigen decreases expression ISO Carboplatin results in decreased expression of CD274; Carboplatin results in decreased expression of CD274 protein CTD PMID:21765211 PMID:27692344 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd44 CD44 antigen decreases expression ISO Carboplatin results in decreased expression of CD44 mRNA CTD PMID:18172885 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Carboplatin results in decreased expression of CDC25B mRNA CTD PMID:21296123 NCBI chr 2:131,028,356...131,040,431
Ensembl chr 2:131,028,869...131,040,417 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Carboplatin results in decreased expression of CDC42 mRNA CTD PMID:18172885 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Carboplatin results in increased expression of CDKN1A protein
Carboplatin results in increased expression of CDKN1A mRNA		 CTD PMID:9664115 PMID:18172885 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Carboplatin results in increased expression of CITED2 mRNA CTD PMID:18172885 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422 		JBrowse link
G Clu clusterin decreases expression ISO Carboplatin results in decreased expression of CLU mRNA CTD PMID:18172885 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases response to substance ISO COPS5 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr 1:10,094,825...10,108,384
Ensembl chr 1:10,094,826...10,108,393 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] CTD PMID:18483861 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Dct dopachrome tautomerase decreases response to substance ISO DCT protein results in decreased susceptibility to Carboplatin CTD PMID:15897911 NCBI chr14:118,250,202...118,289,658
Ensembl chr14:118,250,202...118,289,656 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carboplatin results in increased expression of DDIT3 mRNA CTD PMID:18172885 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin] CTD PMID:16685392 NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha affects phosphorylation ISO Carboplatin affects the phosphorylation of EIF2S1 protein CTD PMID:29053414 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO [Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein CTD PMID:12695858 NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557 		JBrowse link
G Epo erythropoietin increases expression ISO Carboplatin results in increased expression of EPO protein CTD PMID:17891399 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] CTD PMID:16446318 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Carboplatin results in increased expression of FAS mRNA CTD PMID:15576332 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fshb follicle stimulating hormone beta increases expression ISO Carboplatin results in increased expression of FSHB protein CTD PMID:8776818 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gsr glutathione reductase decreases activity ISO Carboplatin results in decreased activity of GSR protein CTD PMID:11124453 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects response to substance ISO GSTP1 gene affects the susceptibility to Carboplatin CTD PMID:12360105 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
increases phosphorylation		 ISO Carboplatin results in increased expression of H2AX protein
palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; phellopterin promotes the reaction [[Carboplatin results in increased phosphorylation of H2AX protein] which results in increased susceptibility to Carboplatin]; phellopterin promotes the reaction [Carboplatin results in increased phosphorylation of H2AX protein]		 CTD PMID:22302033 PMID:37708916 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hax1 HCLS1 associated X-1 multiple interactions ISO Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] CTD PMID:18483861 NCBI chr 3:89,902,753...89,906,023
Ensembl chr 3:89,902,753...89,906,087 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain decreases expression ISO Carboplatin results in decreased expression of HBB mRNA CTD PMID:21296123
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
decreases response to substance
increases expression		 EXP
ISO		 HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]
Carboplatin results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Carboplatin
Carboplatin results in increased expression of HMOX1 mRNA		 CTD PMID:18172885 PMID:20368269 PMID:21198546 PMID:26260164 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO Carboplatin results in decreased expression of HSD17B4 mRNA CTD PMID:18172885 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336 		JBrowse link
G Hspa1a heat shock protein 1A increases expression ISO Carboplatin results in increased expression of HSPA1A mRNA CTD PMID:18172885 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO Carboplatin results in increased expression of HSPA1B mRNA CTD PMID:18172885 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa5 heat shock protein 5 decreases expression ISO Carboplatin results in decreased expression of HSPA5 mRNA CTD PMID:18172885 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspb1 heat shock protein 1 increases expression ISO Carboplatin results in increased expression of HSPB1 mRNA CTD PMID:18172885 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor decreases expression ISO Carboplatin results in decreased expression of IGF2R mRNA CTD PMID:18172885 NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551 		JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Carboplatin CTD PMID:7834629 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases response to substance ISO IL6R protein results in decreased susceptibility to Carboplatin CTD PMID:7834629 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Jun jun proto-oncogene decreases expression ISO Carboplatin results in decreased expression of JUN mRNA CTD PMID:18172885 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Carboplatin results in decreased expression of MAP3K1 mRNA CTD PMID:18172885 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527 		JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 decreases expression ISO Carboplatin results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr15:102,406,079...102,425,311
Ensembl chr15:102,406,081...102,425,499 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 decreases expression ISO Carboplatin results in decreased expression of MAPK14 mRNA CTD PMID:18172885 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 decreases expression ISO Carboplatin results in decreased expression of MAPK6 mRNA CTD PMID:18172885 NCBI chr 9:75,294,064...75,317,303
Ensembl chr 9:75,276,344...75,317,287 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Carboplatin results in decreased expression of MGMT mRNA CTD PMID:18172885 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA CTD PMID:27692344 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir495 microRNA 495 multiple interactions ISO [MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin CTD PMID:24038379 NCBI chr12:109,685,188...109,685,250
Ensembl chr12:109,685,188...109,685,250 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions EXP Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]] CTD PMID:33190582 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein CTD PMID:18852009 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Carboplatin results in decreased expression of MSH2 mRNA CTD PMID:18172885 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Carboplatin results in decreased expression of MT1A mRNA CTD PMID:18172885 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Myc myelocytomatosis oncogene increases response to substance ISO MYC protein results in increased susceptibility to Carboplatin CTD PMID:21324178 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nanog Nanog homeobox increases expression ISO Carboplatin results in increased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Nbas neuroblastoma amplified sequence affects response to substance ISO NBAS intron polymorphism affects the susceptibility to Carboplatin CTD PMID:21844884 NCBI chr12:13,319,102...13,687,381
Ensembl chr12:13,319,134...13,633,812 		JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression ISO Carboplatin results in decreased expression of NCKAP1 mRNA CTD PMID:18172885 NCBI chr 2:80,330,856...80,411,526
Ensembl chr 2:80,330,856...80,411,724 		JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 multiple interactions
increases activity		 EXP
ISO		 HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4] CTD PMID:21198546 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
decreases expression		 ISO Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]
Carboplatin results in decreased expression of NFKB1 mRNA		 CTD PMID:12675310 PMID:18172885 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation
multiple interactions		 ISO Carboplatin results in decreased phosphorylation of NFKBIA protein
NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]		 CTD PMID:12675310 PMID:15120608 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nodal nodal growth differentiation factor increases response to substance ISO NODAL results in increased susceptibility to Carboplatin CTD PMID:21224400 NCBI chr10:61,253,751...61,261,117
Ensembl chr10:61,253,751...61,261,117 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Carboplatin results in increased expression of NQO1 mRNA CTD PMID:18172885 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nras neuroblastoma ras oncogene decreases expression ISO Carboplatin results in decreased expression of NRAS mRNA CTD PMID:18172885 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to Carboplatin CTD PMID:26378035 NCBI chr19:12,085,964...12,093,192
Ensembl chr19:12,085,080...12,093,261 		JBrowse link
G Osm oncostatin M increases expression ISO Carboplatin results in increased expression of OSM mRNA CTD PMID:36536508 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Carboplatin results in increased cleavage of PARP1 protein CTD PMID:15996812 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator decreases expression ISO Carboplatin results in decreased expression of PAWR mRNA CTD PMID:18172885 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]
Carboplatin results in increased expression of PCNA mRNA		 CTD PMID:16685392 PMID:18172885 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 decreases expression
multiple interactions		 ISO
EXP		 Carboplatin results in decreased expression of PDCD1LG2
STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]		 CTD PMID:21765211 NCBI chr19:29,388,319...29,450,327
Ensembl chr19:29,388,319...29,448,561 		JBrowse link
G Pdia4 protein disulfide isomerase associated 4 decreases expression ISO Carboplatin results in decreased expression of PDIA4 mRNA CTD PMID:18172885 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364 		JBrowse link
G Pdia6 protein disulfide isomerase associated 6 decreases expression ISO Carboplatin results in decreased expression of PDIA6 mRNA CTD PMID:18172885 NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Carboplatin results in increased expression of PMAIP1 protein CTD PMID:20802529 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Prkd2 protein kinase D2 affects response to substance ISO PRKD2 protein affects the susceptibility to Carboplatin CTD PMID:37951334 NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389 		JBrowse link
G Psmb2 proteasome (prosome, macropain) subunit, beta type 2 increases expression ISO Carboplatin results in increased expression of PSMB2 mRNA CTD PMID:18172885 NCBI chr 4:126,571,460...126,603,503
Ensembl chr 4:126,571,423...126,603,507 		JBrowse link
G Psmb4 proteasome (prosome, macropain) subunit, beta type 4 decreases expression ISO Carboplatin results in decreased expression of PSMB4 mRNA CTD PMID:18172885 NCBI chr 3:94,791,635...94,794,269
Ensembl chr 3:94,791,404...94,794,272 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases response to substance
multiple interactions		 ISO PTGS2 protein results in decreased susceptibility to Carboplatin
wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]		 CTD PMID:18089846 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rab10 RAB10, member RAS oncogene family decreases expression ISO Carboplatin results in decreased expression of RAB10 mRNA CTD PMID:18172885 NCBI chr12:3,297,428...3,359,969
Ensembl chr12:3,297,428...3,359,969 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Carboplatin CTD PMID:16061639 NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Carboplatin results in decreased localization of and results in decreased activity of RELA protein; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:12675310 PMID:15120608 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression ISO Carboplatin results in decreased expression of SCD2 mRNA CTD PMID:18172885 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Sik1 salt inducible kinase 1 increases response to substance ISO SIK1 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778 		JBrowse link
G Slc31a1 solute carrier family 31, member 1 decreases response to substance
increases response to substance
increases uptake
increases import
multiple interactions		 EXP
ISO		 SLC31A1 gene mutant form results in decreased susceptibility to Carboplatin
SLC31A1 protein results in increased susceptibility to Carboplatin
SLC31A1 protein results in increased uptake of Carboplatin
SLC31A1 protein results in increased import of Carboplatin
[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin		 CTD PMID:15634647 PMID:16847145 PMID:19509135 PMID:22914438 PMID:23123662 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006 		JBrowse link
G Slc31a2 solute carrier family 31, member 2 decreases uptake EXP SLC31A2 protein results in decreased uptake of Carboplatin CTD PMID:19509135 NCBI chr 4:62,198,630...62,216,649
Ensembl chr 4:62,180,799...62,216,648 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO Carboplatin results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
decreases expression		 ISO Carboplatin results in decreased expression of and results in decreased activity of SOD1 protein
Carboplatin results in decreased expression of SOD1 protein		 CTD PMID:15109710 PMID:15225673 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
decreases expression		 ISO Carboplatin results in increased expression of and results in increased activity of SOD2 protein
Carboplatin results in decreased expression of SOD2 protein		 CTD PMID:15109710 PMID:15225673 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 increases expression ISO Carboplatin results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions EXP STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2] CTD PMID:21765211 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Stk39 serine/threonine kinase 39 decreases expression ISO Carboplatin results in decreased expression of STK39 mRNA CTD PMID:18172885 NCBI chr 2:68,040,789...68,302,381
Ensembl chr 2:68,040,789...68,302,612 		JBrowse link
G Stx2 syntaxin 2 increases response to substance ISO STX2 protein results in increased susceptibility to Carboplatin CTD PMID:24039787 NCBI chr 5:129,061,621...129,085,664
Ensembl chr 5:129,061,621...129,085,638 		JBrowse link
G Tfap2a transcription factor AP-2, alpha increases response to substance ISO TFAP2A protein results in increased susceptibility to Carboplatin CTD PMID:16204029 NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein CTD PMID:18852009 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions ISO TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO Carboplatin results in increased expression of TP53 mRNA; Carboplatin results in increased expression of TP53 protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 protein		 CTD PMID:9664115 PMID:15131059 PMID:33002289 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tyms thymidylate synthase multiple interactions ISO PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin] CTD PMID:16685392 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases expression ISO Carboplatin results in decreased expression of UGT1A6 mRNA CTD PMID:18172885 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Vim vimentin decreases expression ISO Carboplatin results in decreased expression of VIM mRNA CTD PMID:18172885 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Xdh xanthine dehydrogenase affects activity ISO Carboplatin affects the activity of XDH protein CTD PMID:15225673 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C decreases response to substance EXP XPC results in decreased susceptibility to Carboplatin CTD PMID:19372135 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression ISO Carboplatin results in decreased expression of ZFP36L1 mRNA CTD PMID:18172885 NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        aetiopathogenetic role 21269
          genotoxin 19500
            mutagen 19404
              carboplatin 124
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            organic ion 10068
                              organic anion 3679
                                carboxylic acid anion 2517
                                  dicarboxylic acid anion 251
                                    dicarboxylic acid dianion 251
                                      cyclobutanedicarboxylate 124
                                        cyclobutane-1,1-dicarboxylate(2-) 124
                                          carboplatin 124
paths to the root