Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDCarboplatin results in increased expression of CASP3 protein

PMID:18483861 PMID:20368269
Casp3multiple interactionsEXP 6480464CTDPravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]

PMID:20368269
Casp3increases activityISORGD:7310026480464CTDCarboplatin results in increased activity of CASP3 protein

PMID:22302033
Casp3increases expressionISORGD:22756480464CTDCarboplatin results in increased expression of CASP3 protein

PMID:20368269
Casp3increases expressionISORGD:7310026480464CTDCarboplatin results in increased expression of CASP3 mRNA

PMID:15576332
Casp3multiple interactionsISORGD:22756480464CTDAcetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein] Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]

PMID:18483861 PMID:20368269
Casp3multiple interactionsISORGD:7310026480464CTD2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein] Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]

PMID:16275998 PMID:22302033
Go Back to source page   Continue to Ontology report