Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10289
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Casp3
Name:	caspase 3

Acc ID:	CHEBI:31355
Term:	carboplatin
Definition:	A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID:	MESH:D016190

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Casp3	increases expression	EXP		6480464	CTD	Carboplatin results in increased expression of CASP3 protein	PMID:18483861 PMID:20368269
Casp3	multiple interactions	EXP		6480464	CTD	Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]	PMID:20368269
Casp3	increases activity	ISO	RGD:731002	6480464	CTD	Carboplatin results in increased activity of CASP3 protein	PMID:22302033
Casp3	increases expression	ISO	RGD:2275	6480464	CTD	Carboplatin results in increased expression of CASP3 protein	PMID:20368269
Casp3	increases expression	ISO	RGD:731002	6480464	CTD	Carboplatin results in increased expression of CASP3 mRNA	PMID:15576332
Casp3	multiple interactions	ISO	RGD:2275	6480464	CTD	Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein] Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]	PMID:18483861 PMID:20368269
Casp3	multiple interactions	ISO	RGD:731002	6480464	CTD	2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein] Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]	PMID:16275998 PMID:22302033

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