Slc31a2 (solute carrier family 31, member 2) - Rat Genome Database
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Gene: Slc31a2 (solute carrier family 31, member 2) Mus musculus
Analyze
Symbol: Slc31a2
Name: solute carrier family 31, member 2
RGD ID: 1317462
MGI Page MGI
Description: Involved in cellular copper ion homeostasis and regulation of copper ion transmembrane transport. Localizes to late endosome; membrane; and recycling endosome. Is expressed in brain; retina nuclear layer; and urinary system. Orthologous to human SLC31A2 (solute carrier family 31 member 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI604396; copper transporter 2; Ctr; CTR2; MGC117640; probable low affinity copper uptake protein 2; solute carrier family 31 (copper transporters), member 2; solute carrier family 31 member 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,198,630 - 62,216,649 (+)NCBIGRCm39mm39
GRCm38462,280,393 - 62,298,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,262,562 - 62,298,411 (+)EnsemblGRCm38mm10GRCm38
MGSCv37461,947,479 - 61,959,445 (+)NCBIGRCm37mm9NCBIm37
MGSCv36461,772,806 - 61,784,772 (+)NCBImm8
Celera460,958,637 - 60,970,603 (+)NCBICelera
Cytogenetic Map4B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
bathocuproine disulfonic acid  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboplatin  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
lipopolysaccharide  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mirex  (ISO)
perfluorononanoic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrathiomolybdate(2-)  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9831461   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15226823   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:19521566   PMID:20930109   PMID:21677750   PMID:21873635   PMID:21947380   PMID:24167251   PMID:24522273   PMID:26342034   PMID:28507097  


Genomics

Comparative Map Data
Slc31a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,198,630 - 62,216,649 (+)NCBIGRCm39mm39
GRCm38462,280,393 - 62,298,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,262,562 - 62,298,411 (+)EnsemblGRCm38mm10GRCm38
MGSCv37461,947,479 - 61,959,445 (+)NCBIGRCm37mm9NCBIm37
MGSCv36461,772,806 - 61,784,772 (+)NCBImm8
Celera460,958,637 - 60,970,603 (+)NCBICelera
Cytogenetic Map4B3NCBI
SLC31A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9113,150,976 - 113,164,140 (+)EnsemblGRCh38hg38GRCh38
GRCh389113,150,976 - 113,164,140 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379115,913,287 - 115,926,420 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh379115,913,238 - 115,926,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369114,953,059 - 114,966,243 (+)NCBINCBI36hg18NCBI36
Build 349112,992,850 - 113,005,958NCBI
Celera986,561,147 - 86,574,330 (+)NCBI
Cytogenetic Map9q32ENTREZGENE
HuRef985,520,955 - 85,534,138 (+)NCBIHuRef
CHM1_19116,059,787 - 116,072,968 (+)NCBICHM1_1
Slc31a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2575,738,008 - 75,748,542 (+)NCBI
Rnor_6.0 Ensembl578,120,607 - 78,131,114 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0578,120,606 - 78,131,111 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0582,242,372 - 82,252,910 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,281,958 - 79,292,436 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1579,293,234 - 79,296,349 (+)NCBI
Celera574,680,083 - 74,690,581 (+)NCBICelera
Cytogenetic Map5q24NCBI
Slc31a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,332,749 - 14,343,700 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541914,332,749 - 14,343,363 (-)NCBIChiLan1.0ChiLan1.0
SLC31A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19112,622,147 - 112,644,611 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,622,147 - 112,635,294 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0984,249,284 - 84,271,596 (+)NCBIMhudiblu_PPA_v0panPan3
SLC31A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1167,526,465 - 67,529,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11167,522,316 - 67,531,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc31a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936559421,236 - 434,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC31A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,794,913 - 253,805,282 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,795,005 - 253,805,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,589,392 - 284,599,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC31A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,406,173 - 26,419,782 (-)NCBI
ChlSab1.1 Ensembl1226,406,011 - 26,419,634 (-)Ensembl
Slc31a2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476021,945,493 - 21,955,303 (-)NCBI

Position Markers
AI604396  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38462,297,461 - 62,297,596UniSTSGRCm38
MGSCv37461,958,495 - 61,958,630UniSTSGRCm37
Celera460,969,653 - 60,969,788UniSTS
Cytogenetic Map4B3UniSTS
Whitehead/MRC_RH4978.86UniSTS
Slc31a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B3UniSTS
cM Map433.07UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763365441Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261689063979Mouse
1357645Lvrq9_mliver weight QTL 9 (mouse)Not determined41789261689063979Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261689063979Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261689063979Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663365441Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108500000Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283180920Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105299798Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105944663Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44636529480365441Mouse
12879977Bod2_mbone length and organs 2 (mouse)44636529480365441Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123233418Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44668558980685589Mouse
11532688Mh_mmodifier of hemostasis (mouse)44838653882386538Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000077000000Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45018202584182171Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45018202584182171Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588592400Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993875068Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124161387Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103400000Mouse
13524838Hbasrq1a_mhabituation of the acoustic startle response QTL 1a (mouse)45455335288553352Mouse
13524841Hbasrq1_mhabituation of the acoustic startle response QTL 1 (mouse)45455335288553352Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000129100000Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094900000Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45912901493129014Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46022704094227187Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46022704094227187Mouse
1357443Lhyp_mlung hyperpermeability (mouse)Not determined46049801266846581Mouse
25394561Skmw53_mskeletal muscle weight 53, TA (mouse)46222005669919794Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:930
Count of miRNA genes:417
Interacting mature miRNAs:490
Transcripts:ENSMUST00000084530, ENSMUST00000107467, ENSMUST00000107468
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000084530   ⟹   ENSMUSP00000081578
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl462,286,449 - 62,298,411 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107467   ⟹   ENSMUSP00000103091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl462,291,547 - 62,297,477 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107468   ⟹   ENSMUSP00000103092
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl462,262,562 - 62,297,355 (+)Ensembl
RefSeq Acc Id: NM_001290518   ⟹   NP_001277447
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,209,784 - 62,216,649 (+)NCBI
GRCm38462,291,547 - 62,298,412 (+)NCBI
Celera460,958,627 - 60,970,604 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025286   ⟹   NP_079562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,204,666 - 62,216,649 (+)NCBI
GRCm38462,286,429 - 62,298,412 (+)NCBI
MGSCv37461,947,479 - 61,959,445 (+)RGD
Celera460,958,627 - 60,970,604 (+)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006537712   ⟹   XP_006537775
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,198,630 - 62,216,648 (+)NCBI
GRCm38462,280,393 - 62,298,411 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079562   ⟸   NM_025286
- Peptide Label: isoform 1
- UniProtKB: Q9CPU9 (UniProtKB/Swiss-Prot),   Q4KL43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006537775   ⟸   XM_006537712
- Peptide Label: isoform X1
- UniProtKB: Q9D524 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277447   ⟸   NM_001290518
- Peptide Label: isoform 2
- UniProtKB: Q9CPU9 (UniProtKB/Swiss-Prot),   Q9D524 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000081578   ⟸   ENSMUST00000084530
RefSeq Acc Id: ENSMUSP00000103092   ⟸   ENSMUST00000107468
RefSeq Acc Id: ENSMUSP00000103091   ⟸   ENSMUST00000107467

Promoters
RGD ID:6836403
Promoter ID:MM_KWN:37943
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_025286,   UC008TEF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36461,947,306 - 61,947,806 (+)MPROMDB
RGD ID:6836405
Promoter ID:MM_KWN:37944
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Spleen
Transcripts:UC008TEG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36461,951,901 - 61,952,822 (+)MPROMDB
RGD ID:6883588
Promoter ID:EPDNEW_M5245
Type:initiation region
Name:Slc31a2_1
Description:Mus musculus solute carrier family 31, member 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38462,286,476 - 62,286,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333844 AgrOrtholog
Ensembl Genes ENSMUSG00000066152 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000081578 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103091 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000103092 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000084530 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107467 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000107468 ENTREZGENE, UniProtKB/TrEMBL
InterPro Cop_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333844 ENTREZGENE
NCBI Gene 20530 ENTREZGENE
PANTHER PTHR12483 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ctr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc31a2 PhenoGen
UniProt COPT2_MOUSE UniProtKB/Swiss-Prot
  Q3U9W6_MOUSE UniProtKB/TrEMBL
  Q4KL43 ENTREZGENE, UniProtKB/TrEMBL
  Q9CPU9 ENTREZGENE
  Q9D524 ENTREZGENE, UniProtKB/TrEMBL