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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionEXP 6480464CTDCarboplatin results in increased expression of CASP9 protein

PMID:18483861
Casp9decreases expressionISORGD:691476480464CTDCarboplatin results in decreased expression of CASP9 mRNA

PMID:15576332 PMID:17404015
Casp9increases activityISORGD:691476480464CTDCarboplatin results in increased activity of CASP9 protein

PMID:15996812
Casp9multiple interactionsISORGD:618676480464CTDAcetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein] Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]

PMID:18483861
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