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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735684
Species: Mus musculus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31, member 1
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1decreases response to substanceEXP 6480464CTDSLC31A1 gene mutant form results in decreased susceptibility to Carboplatin

PMID:16847145
Slc31a1increases uptakeEXP 6480464CTDSLC31A1 protein results in increased uptake of Carboplatin

PMID:16847145 PMID:19509135
Slc31a1increases importISORGD:6200596480464CTDSLC31A1 protein results in increased import of Carboplatin

PMID:23123662
Slc31a1increases response to substanceISORGD:7356836480464CTDSLC31A1 protein results in increased susceptibility to Carboplatin

PMID:15634647
Slc31a1increases uptakeISORGD:7356836480464CTDSLC31A1 protein results in increased uptake of Carboplatin

PMID:15634647
Slc31a1multiple interactionsISORGD:7356836480464CTD[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin

PMID:22914438
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