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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552436
Species: Mus musculus
RGD Object: Gene
Symbol: Pdcd1lg2
Name: programmed cell death 1 ligand 2
Acc ID: CHEBI:31355
Term: carboplatin
Definition: A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Chemical ID: MESH:D016190
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdcd1lg2multiple interactionsEXP 6480464CTDSTAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]

PMID:21765211
Pdcd1lg2decreases expressionISORGD:13149986480464CTDCarboplatin results in decreased expression of PDCD1LG2

PMID:21765211
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.