Smo (smoothened, frizzled class receptor) - Rat Genome Database
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Gene: Smo (smoothened, frizzled class receptor) Mus musculus
Symbol: Smo
Name: smoothened, frizzled class receptor
RGD ID: 735969
Description: Predicted to have patched binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Localizes to 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Predicted to colocalize with Golgi apparatus and caveola. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bent body; bnb; E130215L21Rik; Smoh; smoothened; smoothened homolog
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4066  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39629,735,496 - 29,761,365 (+)NCBIGRCm39mm39
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBImm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
calciol  (EXP)
captopril  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
Cyclopamine  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
folic acid  (EXP)
gemcitabine  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
menadione  (ISO)
methotrexate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (ISO)
sonidegib  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
theaflavin  (EXP)
titanium dioxide  (EXP)
valproic acid  (ISO)
vismodegib  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IMP)
astrocyte activation  (IMP)
atrial septum morphogenesis  (IGI)
axon extension involved in axon guidance  (ISO)
cell development  (IMP)
cell fate specification  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to cholesterol  (IEP)
central nervous system development  (IBA,IGI)
central nervous system neuron differentiation  (IMP)
cerebellar cortex morphogenesis  (IMP)
cerebral cortex development  (IMP)
commissural neuron axon guidance  (IBA,ISO)
contact inhibition  (ISO)
dentate gyrus development  (IMP)
determination of left/right asymmetry in lateral mesoderm  (IMP)
determination of left/right symmetry  (IMP)
developmental growth  (IMP)
digestive tract development  (IMP)
dorsal/ventral neural tube patterning  (IMP)
dorsal/ventral pattern formation  (IMP)
embryonic organ development  (IGI)
epithelial-mesenchymal cell signaling  (IMP)
facial nerve development  (ISO)
forebrain morphogenesis  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
hair follicle morphogenesis  (IMP)
heart looping  (IMP)
heart morphogenesis  (IGI)
homeostasis of number of cells within a tissue  (IDA)
in utero embryonic development  (IMP)
left/right axis specification  (IMP)
mammary gland epithelial cell differentiation  (IMP)
mesenchymal to epithelial transition involved in metanephric renal vesicle formation  (IMP)
midgut development  (IMP)
multicellular organism development  (IEA)
multicellular organism growth  (IGI,IMP)
myoblast migration  (IGI)
negative regulation of apoptotic process  (IMP)
negative regulation of DNA binding  (IGI,IMP)
negative regulation of epithelial cell differentiation  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of hair follicle development  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of transcription, DNA-templated  (IMP)
neural crest cell migration  (IGI)
neuron projection regeneration  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
ossification  (IMP)
osteoblast differentiation  (IMP)
osteoblast proliferation  (ISO)
pancreas morphogenesis  (IMP)
pattern specification process  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of gene expression  (IMP,ISO)
positive regulation of hh target transcription factor activity  (IMP)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of multicellular organism growth  (IMP)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (IGI)
positive regulation of organ growth  (IMP)
positive regulation of protein import into nucleus  (IGI)
positive regulation of smoothened signaling pathway  (IBA,IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of transcription, DNA-templated  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
protein localization to nucleus  (IMP)
protein stabilization  (IDA)
regulation of gene expression  (IGI)
regulation of heart morphogenesis  (IMP)
regulation of stem cell population maintenance  (IMP)
response to organic substance  (ISO)
response to wounding  (ISO)
signal transduction  (IEA)
skeletal muscle fiber development  (IMP)
smooth muscle tissue development  (ISO)
smoothened signaling pathway  (IBA,IGI,IMP,ISO)
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation  (IMP)
smoothened signaling pathway involved in ventral spinal cord patterning  (IMP)
somite development  (IMP)
spermatogenesis  (ISO)
thalamus development  (IMP)
type B pancreatic cell development  (IMP)
vasculogenesis  (IMP)
ventral midline determination  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IEA)
abnormal ameloblast morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal cardiac neural crest cell migration  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral aqueduct morphology  (IAGP)
abnormal chorioallantoic fusion  (IEA)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo size  (IEA)
abnormal embryo turning  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal enamel organ morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal ethmoid bone morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal floor plate morphology  (IAGP)
abnormal forebrain development  (IEA)
abnormal heart looping  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inner dental epithelium morphology  (IAGP)
abnormal intestinal enteroendocrine cell morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal smooth muscle morphology  (IAGP)
abnormal intestine development  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal lens development  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal neural crest cell apoptosis  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor cell number  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal optic stalk morphology  (IAGP)
abnormal optic vesicle formation  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal outer dental epithelium morphology  (IAGP)
abnormal pericardium morphology  (IEA)
abnormal rhombomere morphology  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skin morphology  (IEA)
abnormal sphenoid bone morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal stellate reticulum morphology  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporomandibular joint morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal thyroid cartilage morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal visceral yolk sac morphology  (IEA)
abnormal vitelline vasculature morphology  (IAGP)
absent enamel cord  (IAGP)
absent gonial bone  (IAGP)
absent incus  (IAGP)
absent lacrimal bone  (IAGP)
absent lower incisors  (IAGP)
absent malleus  (IAGP)
absent middle ear ossicles  (IAGP)
absent neuronal precursor cells  (IAGP)
absent orbitosphenoid bone  (IAGP)
absent palatine bone  (IAGP)
absent presphenoid bone  (IAGP)
absent pterygoid process  (IAGP)
absent Reichert cartilage  (IAGP)
absent stapes  (IAGP)
absent styloid process  (IAGP)
absent Tomes' process  (IAGP)
absent tongue  (IAGP)
absent tympanic ring  (IAGP)
absent vitelline blood vessels  (IAGP)
absent vomer bone  (IAGP)
anophthalmia  (IAGP)
astrocytosis  (IAGP)
atrial septal defect  (IAGP)
blood vessel atresia  (IAGP)
broad limb buds  (IAGP)
decreased brain size  (IAGP)
decreased cardiac neural crest cell number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased heart rate  (IEA)
decreased length of long bones  (IAGP)
decreased motor neuron number  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged tectum  (IAGP)
exencephaly  (IAGP)
forebrain hypoplasia  (IAGP)
fused first pharyngeal arch  (IAGP)
fused molars  (IAGP)
hemorrhage  (IAGP)
holoprosencephaly  (IAGP)
impaired cardiac neural crest cell differentiation  (IAGP)
incomplete embryo turning  (IAGP)
increased forebrain size  (IAGP)
increased heart rate variability  (IEA)
increased spinal cord size  (IAGP)
Meckel's cartilage hypoplasia  (IAGP)
nasal bone hypoplasia  (IAGP)
nasal septum hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pericardial edema  (IAGP)
perinatal lethality  (IAGP)
persistent truncus arteriosis  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prolonged PR interval  (IEA)
pulmonary artery hypoplasia  (IAGP)
right aortic arch  (IAGP)
short fibula  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short Meckel's cartilage  (IAGP)
short scapula  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small alisphenoid bone  (IAGP)
small cerebellum  (IAGP)
small mandibular condyloid process  (IAGP)
small temporal bone squamous part  (IAGP)
small zygomatic bone  (IAGP)
thin external granule cell layer  (IAGP)
transposition of great arteries  (IAGP)
ventricular septal defect  (IAGP)

References - curated
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Additional References at PubMed
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PMID:24617895   PMID:24697898   PMID:24771701   PMID:24797473   PMID:24813615   PMID:24948802   PMID:24952464   PMID:24952961   PMID:25140582   PMID:25176648   PMID:25268479   PMID:25314078  
PMID:25355313   PMID:25362352   PMID:25422376   PMID:25446516   PMID:25451166   PMID:25516975   PMID:25535338   PMID:25609427   PMID:25626636   PMID:25644602   PMID:25760946   PMID:25848030  
PMID:25936505   PMID:25995356   PMID:26015562   PMID:26057579   PMID:26100903   PMID:26141957   PMID:26238476   PMID:26290370   PMID:26297872   PMID:26345456   PMID:26373671   PMID:26373672  
PMID:26416758   PMID:26436454   PMID:26439398   PMID:26457609   PMID:26496610   PMID:26530396   PMID:26645982   PMID:26658258   PMID:26697723   PMID:26702830   PMID:26769565   PMID:26837596  
PMID:26901434   PMID:26912893   PMID:26931153   PMID:26932670   PMID:26996322   PMID:27002170   PMID:27018594   PMID:27113760   PMID:27162362   PMID:27185526   PMID:27214567   PMID:27320915  
PMID:27414798   PMID:27414999   PMID:27490099   PMID:27552050   PMID:27626380   PMID:27633013   PMID:27633995   PMID:27705744   PMID:27720610   PMID:27727273   PMID:27793670   PMID:27815529  
PMID:28112475   PMID:28154160   PMID:28167794   PMID:28195124   PMID:28286175   PMID:28344083   PMID:28350784   PMID:28556366   PMID:28564646   PMID:28591579   PMID:28688895   PMID:28715412  
PMID:28793255   PMID:28797033   PMID:28805814   PMID:28817564   PMID:28885142   PMID:28917838   PMID:28941984   PMID:29031500   PMID:29078327   PMID:29088375   PMID:29133390   PMID:29166577  
PMID:29229834   PMID:29230039   PMID:29244023   PMID:29365079   PMID:29487109   PMID:29532549   PMID:29571613   PMID:29632244   PMID:29739868   PMID:29789719   PMID:29792854   PMID:29899403  
PMID:29945868   PMID:30058223   PMID:30144507   PMID:30148884   PMID:30206138   PMID:30291164   PMID:30315164   PMID:30352686   PMID:30352852   PMID:30361701   PMID:30366594   PMID:30456390  
PMID:30478225   PMID:30630826   PMID:30653268   PMID:30679745   PMID:30814516   PMID:30983567   PMID:31036156   PMID:31071314   PMID:31072004   PMID:31120883   PMID:31167144   PMID:31194676  
PMID:31226309   PMID:31263273   PMID:31269445   PMID:31301300   PMID:31373354   PMID:31382618   PMID:31604927   PMID:31605511   PMID:31608494   PMID:31845891   PMID:31873117   PMID:31964774  
PMID:32129762   PMID:32151560   PMID:32234482   PMID:32241942   PMID:32325033   PMID:32350360   PMID:32561646   PMID:32702291  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39629,735,496 - 29,761,365 (+)NCBIGRCm39mm39
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBImm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7129,188,633 - 129,213,545 (+)EnsemblGRCh38hg38GRCh38
GRCh387129,188,633 - 129,213,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,828,713 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh377128,828,474 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,615,949 - 128,640,622 (+)NCBINCBI36hg18NCBI36
Build 347128,422,663 - 128,447,334NCBI
Celera7123,625,432 - 123,650,109 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7123,189,938 - 123,214,626 (+)NCBIHuRef
CHM1_17128,762,307 - 128,786,971 (+)NCBICHM1_1
CRA_TCAGchr7v27128,212,668 - 128,237,345 (+)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2458,344,101 - 58,372,828 (+)NCBI
Rnor_6.0 Ensembl457,019,941 - 57,042,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0457,019,941 - 57,041,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0456,787,102 - 56,809,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,623,494 - 56,645,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,898,313 - 56,920,866 (+)NCBI
Celera453,450,322 - 53,474,674 (+)NCBICelera
Cytogenetic Map4q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554799,964,170 - 9,993,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,963,377 - 9,991,670 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17133,668,523 - 133,693,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,668,304 - 133,693,048 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07121,143,968 - 121,168,873 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1 Ensembl147,518,856 - 7,528,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1147,518,871 - 7,527,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
SpeTri2.0NW_0049365795,893,064 - 5,917,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1819,450,734 - 19,479,374 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,450,730 - 19,478,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,520,306 - 20,548,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12197,788,955 - 97,814,549 (+)NCBI
ChlSab1.1 Ensembl2197,788,624 - 97,814,709 (+)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247837,012,385 - 7,039,302 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,056 - 85,024,255UniSTSGRCm38
GRCm38629,761,063 - 29,761,263UniSTSGRCm38
MGSCv371385,163,661 - 85,163,860UniSTSGRCm37
MGSCv37629,711,063 - 29,711,263UniSTSGRCm37
Celera1387,255,683 - 87,255,882UniSTS
Celera629,772,308 - 29,772,508UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,059 - 85,024,232UniSTSGRCm38
GRCm38629,761,086 - 29,761,260UniSTSGRCm38
MGSCv371385,163,664 - 85,163,837UniSTSGRCm37
MGSCv37629,711,086 - 29,711,260UniSTSGRCm37
Celera1387,255,686 - 87,255,859UniSTS
Celera629,772,331 - 29,772,505UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,577 - 85,024,929UniSTSGRCm38
GRCm38629,760,451 - 29,760,803UniSTSGRCm38
MGSCv371385,164,182 - 85,164,534UniSTSGRCm37
MGSCv37629,710,451 - 29,710,803UniSTSGRCm37
Celera1387,256,198 - 87,256,550UniSTS
Celera629,771,690 - 29,772,042UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,751,222 - 29,751,334UniSTSGRCm38
MGSCv37629,701,222 - 29,701,334UniSTSGRCm37
Celera629,762,432 - 29,762,568UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map67.0UniSTS
Whitehead Genetic66.6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,760,336 - 29,761,067UniSTSGRCm38
MGSCv37629,710,336 - 29,711,067UniSTSGRCm37
Celera629,771,575 - 29,772,312UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map67.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A3.3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144496Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144496Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144496Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633535476335Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920738249326Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751334Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345314181Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707543297169Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797246118070Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122246751334Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122246751334Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61770000053500000Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61773466351734784Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1773466351734784Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61773466351734784Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61963941153639411Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61963941153639411Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61963941153639411Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62007289554072895Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62380000057800000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2831405962314181Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir125b-2mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Mir326mmu-miR-326-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Mir125b-1mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Mir324mmu-miR-324-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:293
Interacting mature miRNAs:347
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_176996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF089721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW555326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB659739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB665395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ947565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA749812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN665198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ883552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY442313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001812   ⟹   ENSMUSP00000001812
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl629,735,694 - 29,761,365 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201515
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl629,735,503 - 29,738,004 (+)Ensembl
RefSeq Acc Id: NM_176996   ⟹   NP_795970
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39629,735,496 - 29,761,365 (+)NCBI
GRCm38629,735,497 - 29,761,366 (+)ENTREZGENE
MGSCv37629,685,497 - 29,711,366 (+)RGD
Celera629,744,569 - 29,772,611 (+)RGD
RefSeq Acc Id: XM_006505106   ⟹   XP_006505169
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39629,752,541 - 29,761,359 (+)NCBI
GRCm38629,751,222 - 29,761,360 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_795970   ⟸   NM_176996
- Peptide Label: precursor
- UniProtKB: P56726 (UniProtKB/Swiss-Prot),   Q4VBD5 (UniProtKB/TrEMBL),   Q8BJN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505169   ⟸   XM_006505106
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000001812   ⟸   ENSMUST00000001812
Protein Domains
Frizzled   FZ   G_PROTEIN_RECEP_F2_4

RGD ID:6838882
Promoter ID:MM_KWN:45387
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   ES_Cell,   Kidney,   Lung,   MEF_B4
Mouse AssemblyChrPosition (strand)Source
MGSCv36629,685,446 - 29,686,347 (+)MPROMDB
RGD ID:6889200
Promoter ID:EPDNEW_M8051
Type:initiation region
Description:Mus musculus smoothened, frizzled class receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M8052  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38629,735,524 - 29,735,584EPDNEW
RGD ID:6889202
Promoter ID:EPDNEW_M8052
Type:initiation region
Description:Mus musculus smoothened, frizzled class receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M8051  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38629,735,644 - 29,735,704EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108075 AgrOrtholog
Ensembl Genes ENSMUSG00000001761 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000001812 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001812 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMO_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319757 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11309:SF35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smo PhenoGen
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMO_MOUSE UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-30 Smo  smoothened, frizzled class receptor    smoothened homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED