Smo (smoothened, frizzled class receptor) - Rat Genome Database

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Gene: Smo (smoothened, frizzled class receptor) Mus musculus
Analyze
Symbol: Smo
Name: smoothened, frizzled class receptor
RGD ID: 735969
MGI Page MGI
Description: Enables oxysterol binding activity; protein kinase A catalytic subunit binding activity; and protein sequestering activity. Involved in several processes, including regionalization; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including nervous system development; positive regulation of cell population proliferation; and regionalization. Located in several cellular components, including centriole; ciliary membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; genitourinary system; and skeleton. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bent body; bnb; E130215L21Rik; Smoh; smoothened; smoothened homolog; smoothened homolog (Drosophila)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm4066  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,735,480 - 29,761,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,735,502 - 29,761,364 (+)EnsemblGRCm39 Ensembl
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBIMGSCv36mm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
captopril  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
Cyclopamine  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
folic acid  (EXP)
gemcitabine  (ISO)
gentamycin  (ISO)
glucose  (EXP)
goralatide  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
itraconazole  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
menadione  (ISO)
methotrexate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (ISO)
sonidegib  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
theaflavin  (EXP)
titanium dioxide  (EXP)
valproic acid  (ISO)
vismodegib  (EXP,ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-tubulin acetylation  (IMP)
anterior/posterior pattern specification  (IMP)
apoptotic process  (IMP)
astrocyte activation  (IMP)
atrial septum morphogenesis  (IGI)
axon extension involved in axon guidance  (ISO)
cell development  (IMP)
cell fate specification  (IMP)
cell population proliferation  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to cholesterol  (IEP)
central nervous system development  (IBA,IGI)
central nervous system neuron differentiation  (IMP)
cerebellar cortex morphogenesis  (IMP)
cerebral cortex development  (IMP)
commissural neuron axon guidance  (IBA,ISO)
contact inhibition  (ISO,ISS)
dentate gyrus development  (IMP)
determination of left/right asymmetry in lateral mesoderm  (IMP)
determination of left/right symmetry  (IMP)
developmental growth  (IMP)
digestive tract development  (IMP)
dopaminergic neuron differentiation  (IMP)
dorsal/ventral neural tube patterning  (IMP)
dorsal/ventral pattern formation  (IMP)
embryonic organ development  (IGI)
epithelial cell differentiation  (IMP)
epithelial cell proliferation  (IMP)
epithelial-mesenchymal cell signaling  (IMP)
facial nerve development  (ISO)
forebrain morphogenesis  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IDA)
hair follicle development  (IMP)
hair follicle morphogenesis  (IMP)
heart looping  (IMP)
heart morphogenesis  (IGI)
homeostasis of number of cells within a tissue  (IDA)
in utero embryonic development  (IMP)
left/right axis specification  (IMP)
mammary gland epithelial cell differentiation  (IMP)
mesenchymal to epithelial transition  (ISO)
mesenchymal to epithelial transition involved in metanephric renal vesicle formation  (IMP)
midgut development  (IMP)
multicellular organism growth  (IGI,IMP)
myoblast migration  (IGI)
negative regulation of apoptotic process  (IMP)
negative regulation of cellular process  (ISO)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of epithelial cell differentiation  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of hair follicle development  (IMP)
negative regulation of hepatocyte proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein phosphorylation  (IDA)
negative regulation of transcription by RNA polymerase II  (IMP)
neural crest cell migration  (IGI)
neuroblast proliferation  (IGI)
neuron projection regeneration  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
ossification  (IMP)
osteoblast differentiation  (IMP,ISO)
pancreas morphogenesis  (IMP)
pattern specification process  (IBA,IMP)
positive regulation of autophagy  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of gene expression  (IMP,ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of multicellular organism growth  (IMP)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (IGI)
positive regulation of organ growth  (IMP)
positive regulation of protein import into nucleus  (IGI)
positive regulation of smoothened signaling pathway  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
protein import into nucleus  (IGI)
protein localization to nucleus  (IMP)
protein stabilization  (IDA)
regulation of gene expression  (IGI)
regulation of heart morphogenesis  (IMP)
regulation of somatic stem cell population maintenance  (IMP)
response to inositol  (IDA)
signal transduction  (IEA)
skeletal muscle fiber development  (IMP)
smooth muscle tissue development  (IEA)
smoothened signaling pathway  (IBA,IDA,IGI,IMP,ISO)
somite development  (IMP)
spermatogenesis  (ISO)
spinal cord dorsal/ventral patterning  (IMP)
thalamus development  (IMP)
type B pancreatic cell development  (IMP)
vasculogenesis  (IMP)
ventral midline determination  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ameloblast morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal cardiac neural crest cell migration  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal enamel organ morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal ethmoid bone morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal floor plate morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inner dental epithelium morphology  (IAGP)
abnormal intestinal enteroendocrine cell morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal smooth muscle morphology  (IAGP)
abnormal intestine development  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal lens development  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal neural crest cell apoptosis  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor cell number  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal optic stalk morphology  (IAGP)
abnormal optic vesicle formation  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal outer dental epithelium morphology  (IAGP)
abnormal pericardium morphology  (IEA)
abnormal rhombomere morphology  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skin morphology  (IEA)
abnormal sphenoid bone morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal stellate reticulum morphology  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporomandibular joint morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal thyroid cartilage morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent enamel cord  (IAGP)
absent gonial bone  (IAGP)
absent incus  (IAGP)
absent lacrimal bone  (IAGP)
absent lower incisors  (IAGP)
absent malleus  (IAGP)
absent middle ear ossicles  (IAGP)
absent neuronal precursor cells  (IAGP)
absent orbitosphenoid bone  (IAGP)
absent palatine bone  (IAGP)
absent presphenoid bone  (IAGP)
absent pterygoid process  (IAGP)
absent Reichert cartilage  (IAGP)
absent stapes  (IAGP)
absent styloid process  (IAGP)
absent Tomes' process  (IAGP)
absent tongue  (IAGP)
absent tympanic ring  (IAGP)
absent vitelline blood vessels  (IAGP)
absent vomer bone  (IAGP)
anophthalmia  (IAGP)
astrocytosis  (IAGP)
atrial septal defect  (IAGP)
blood vessel atresia  (IAGP)
broad limb buds  (IAGP)
decreased brain size  (IAGP)
decreased cardiac neural crest cell number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased heart rate  (IEA)
decreased length of long bones  (IAGP)
decreased motor neuron number  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged cerebral aqueduct  (IAGP)
enlarged tectum  (IAGP)
exencephaly  (IAGP)
forebrain hypoplasia  (IAGP)
fused first pharyngeal arch  (IAGP)
fused molars  (IAGP)
hemorrhage  (IAGP)
holoprosencephaly  (IAGP)
impaired cardiac neural crest cell differentiation  (IAGP)
incomplete embryo turning  (IAGP)
increased forebrain size  (IAGP)
increased heart rate variability  (IEA)
increased spinal cord size  (IAGP)
Meckel's cartilage hypoplasia  (IAGP)
nasal bone hypoplasia  (IAGP)
nasal septum hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pericardial edema  (IAGP)
perinatal lethality  (IAGP)
persistent truncus arteriosus  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prolonged RR interval  (IEA)
pulmonary artery hypoplasia  (IAGP)
right aortic arch  (IAGP)
short fibula  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short Meckel's cartilage  (IAGP)
short scapula  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small alisphenoid bone  (IAGP)
small cerebellum  (IAGP)
small mandibular condyloid process  (IAGP)
small temporal bone squamous part  (IAGP)
small zygomatic bone  (IAGP)
thin external granule cell layer  (IAGP)
transposition of great arteries  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling. Arimura S, etal., Gastroenterology. 2009 Aug;137(2):629-38. doi: 10.1053/j.gastro.2009.04.059. Epub 2009 May 7.
2. Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis. Banerjee SB, etal., Eur J Neurosci. 2005 Oct;22(7):1570-80.
3. Smoothened agonist augments proliferation and survival of neural cells. Bragina O, etal., Neurosci Lett. 2010 Sep 27;482(2):81-5. doi: 10.1016/j.neulet.2010.06.068. Epub 2010 Jul 1.
4. Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions. Cai D, etal., J Cell Physiol. 2019 Jul;234(7):10827-10834. doi: 10.1002/jcp.27908. Epub 2018 Dec 7.
5. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
6. Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis. Ding YL, etal., Asian Pac J Cancer Prev. 2012;13(8):4001-5. doi: 10.7314/apjcp.2012.13.8.4001.
7. Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. Gao J, etal., Gene Ther. 2006 Nov;13(22):1587-94. Epub 2006 Jul 6.
8. Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease. Gibson MK, etal., Ann Surg. 2013 Jul;258(1):82-8. doi: 10.1097/SLA.0b013e318270500d.
9. Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model. He H, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Oct;30(5):659-65. doi: 10.1007/s11596-010-0560-z. Epub 2010 Nov 10.
10. Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Hu Q, etal., Front Cell Neurosci. 2017 Jan 18;10:306. doi: 10.3389/fncel.2016.00306. eCollection 2016.
11. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Huang SS, etal., Exp Neurol. 2013 Sep;247:680-8. doi: 10.1016/j.expneurol.2013.03.004. Epub 2013 Mar 13.
12. Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Hwang RF, etal., Mol Cancer Res. 2012 Sep;10(9):1147-57. doi: 10.1158/1541-7786.MCR-12-0022. Epub 2012 Aug 2.
13. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
14. Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis. Li R, etal., J Inflamm (Lond). 2015 Mar 28;12:24. doi: 10.1186/s12950-015-0072-5. eCollection 2015.
15. Prognostic value of hedgehog signal component expressions in hepatoblastoma patients. Li YC, etal., Eur J Med Res. 2010 Nov 25;15(11):468-74. doi: 10.1186/2047-783x-15-11-468.
16. Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models. Ma H, etal., Med Sci Monit. 2017 Mar 28;23:1493-1500. doi: 10.12659/msm.903012.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
21. Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers. Niyaz M, etal., J Cell Biochem. 2019 Feb 19. doi: 10.1002/jcb.28477.
22. PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts. Ohki K, etal., Int J Oral Maxillofac Surg. 2004 Sep;33(6):584-92.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Olive KP, etal., Science. 2009 Jun 12;324(5933):1457-61. Epub 2009 May 21.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling. Pratap A, etal., J Drug Target. 2012 Nov;20(9):770-82. doi: 10.3109/1061186X.2012.719900. Epub 2012 Sep 20.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Rohner A, etal., Mol Cancer Ther. 2012 Jan;11(1):57-65. doi: 10.1158/1535-7163.MCT-11-0691. Epub 2011 Nov 14.
32. [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. Rong ZX, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1728-31.
33. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Sicklick JK, etal., Carcinogenesis. 2006 Apr;27(4):748-57. doi: 10.1093/carcin/bgi292. Epub 2005 Dec 8.
34. SMO mutations confer poor prognosis in malignant pleural mesothelioma. Signorelli D, etal., Transl Lung Cancer Res. 2020 Oct;9(5):1940-1951. doi: 10.21037/tlcr-19-425.
35. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Stone DM, etal., Nature 1996 Nov 14;384(6605):129-34.
36. Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. Tojo M, etal., Pathol Int. 1999 Aug;49(8):687-94.
37. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
38. Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. Wang H, etal., Asian Pac J Cancer Prev. 2012;13(5):2319-24. doi: 10.7314/apjcp.2012.13.5.2319.
39. Sonic hedgehog expression in a rat model of chronic pancreatitis. Wang LW, etal., World J Gastroenterol. 2014 Apr 28;20(16):4712-7. doi: 10.3748/wjg.v20.i16.4712.
40. Association between donor and recipient smoothened gene polymorphisms and the risk of hepatocellular carcinoma recurrence following orthotopic liver transplantation in a Han Chinese population. Wang P, etal., Tumour Biol. 2015 Sep;36(10):7807-15. doi: 10.1007/s13277-015-3370-x. Epub 2015 May 6.
41. Expression of sonic hedgehog signaling pathways in a rat model of chronic pancreatitis. Wei-Guo H, etal., Saudi Med J. 2010 Jan;31(1):14-7.
42. Neuroprotective effect of up-regulated Sonic hedgehog in retinal ganglion cells following chronic ocular hypertension. Wu J, etal., Invest Ophthalmol Vis Sci. 2010 Jan 13.
43. Activating Smoothened mutations in sporadic basal-cell carcinoma. Xie J, etal., Nature 1998 Jan 1;391(6662):90-2.
44. Expression and regulation of hedgehog signaling pathway in pancreatic cancer. Yang Y, etal., Langenbecks Arch Surg. 2009 Apr 25.
45. Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis. Yoshizaki A, etal., World J Gastroenterol. 2006 Sep 21;12(35):5687-91. doi: 10.3748/wjg.v12.i35.5687.
46. Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke. Zhang L, etal., Stroke. 2013 Jul;44(7):1965-72. doi: 10.1161/STROKEAHA.111.000831. Epub 2013 May 21.
47. SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. Zhang Y, etal., J Exp Clin Cancer Res. 2013 Feb 5;32:7. doi: 10.1186/1756-9966-32-7.
48. Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis. Zhao L, etal., Toxicol Lett. 2014 Mar 3;225(2):318-24. doi: 10.1016/j.toxlet.2013.12.022. Epub 2014 Jan 2.
49. FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. Zhou S, etal., PLoS Genet. 2015 Jun 19;11(6):e1005214. doi: 10.1371/journal.pgen.1005214. eCollection 2015 Jun.
Additional References at PubMed
PMID:9196051   PMID:9636176   PMID:9655803   PMID:9768360   PMID:9799615   PMID:10064544   PMID:10208865   PMID:10349636   PMID:10385121   PMID:10482238   PMID:10512189   PMID:10922068  
PMID:10981962   PMID:11042159   PMID:11076861   PMID:11165486   PMID:11217851   PMID:11311154   PMID:11440720   PMID:11517919   PMID:11748145   PMID:11807029   PMID:12372258   PMID:12372301  
PMID:12403705   PMID:12421714   PMID:12435628   PMID:12477932   PMID:12679031   PMID:12971894   PMID:14531791   PMID:14595839   PMID:14633591   PMID:14691545   PMID:14973295   PMID:14973297  
PMID:14980515   PMID:15005800   PMID:15042696   PMID:15107405   PMID:15199404   PMID:15217369   PMID:15294868   PMID:15306695   PMID:15371303   PMID:15661904   PMID:15668330   PMID:15755804  
PMID:15782199   PMID:15906375   PMID:16061793   PMID:16136078   PMID:16141072   PMID:16141073   PMID:16168717   PMID:16221724   PMID:16229832   PMID:16357211   PMID:16364285   PMID:16396903  
PMID:16459297   PMID:16518394   PMID:16543460   PMID:16571625   PMID:16571630   PMID:16598417   PMID:16602821   PMID:16687132   PMID:16766711   PMID:16854976   PMID:16885213   PMID:16888132  
PMID:16905129   PMID:16908539   PMID:16935278   PMID:16945339   PMID:16958114   PMID:17043310   PMID:17191253   PMID:17199044   PMID:17344228   PMID:17435610   PMID:17504941   PMID:17537964  
PMID:17560974   PMID:17641202   PMID:17881491   PMID:17881493   PMID:17960137   PMID:18083924   PMID:18160632   PMID:18272593   PMID:18287559   PMID:18297065   PMID:18324732   PMID:18327258  
PMID:18328428   PMID:18353302   PMID:18359851   PMID:18417110   PMID:18429041   PMID:18434416   PMID:18441277   PMID:18480159   PMID:18488998   PMID:18497258   PMID:18515092   PMID:18568073  
PMID:18590716   PMID:18614579   PMID:18617531   PMID:18725519   PMID:18728187   PMID:18772113   PMID:18827223   PMID:18832070   PMID:18927434   PMID:19116665   PMID:19124651   PMID:19136624  
PMID:19169242   PMID:19196978   PMID:19218434   PMID:19223390   PMID:19246386   PMID:19286674   PMID:19304890   PMID:19357274   PMID:19365551   PMID:19366682   PMID:19369393   PMID:19474320  
PMID:19484749   PMID:19497283   PMID:19497284   PMID:19521566   PMID:19549984   PMID:19574535   PMID:19619492   PMID:19654211   PMID:19666503   PMID:19684112   PMID:19774071   PMID:19809516  
PMID:19815519   PMID:19839776   PMID:19850026   PMID:19854269   PMID:19861162   PMID:19906862   PMID:19906863   PMID:19914374   PMID:19946319   PMID:19948480   PMID:19952108   PMID:19955443  
PMID:19996169   PMID:20081193   PMID:20130264   PMID:20159447   PMID:20185768   PMID:20185815   PMID:20188061   PMID:20212115   PMID:20339091   PMID:20375059   PMID:20386748   PMID:20400693  
PMID:20542037   PMID:20558667   PMID:20654717   PMID:20943901   PMID:20971735   PMID:21177415   PMID:21209331   PMID:21276786   PMID:21307272   PMID:21312341   PMID:21339645   PMID:21447550  
PMID:21552265   PMID:21606373   PMID:21618536   PMID:21659505   PMID:21677750   PMID:21695114   PMID:21731673   PMID:21791285   PMID:21831920   PMID:21859383   PMID:21873635   PMID:21931618  
PMID:21976698   PMID:21983857   PMID:22007132   PMID:22016185   PMID:22051878   PMID:22064698   PMID:22076636   PMID:22144466   PMID:22179047   PMID:22186138   PMID:22232070   PMID:22275805  
PMID:22340494   PMID:22402139   PMID:22402963   PMID:22517907   PMID:22522309   PMID:22595669   PMID:22661232   PMID:22689656   PMID:22698544   PMID:22840514   PMID:22841315   PMID:22864913  
PMID:22869526   PMID:22884371   PMID:22885334   PMID:22889265   PMID:22898775   PMID:22912492   PMID:22912493   PMID:22981989   PMID:22983747   PMID:22986504   PMID:22987639   PMID:22987640  
PMID:22992748   PMID:23026747   PMID:23152377   PMID:23166838   PMID:23177959   PMID:23201023   PMID:23201751   PMID:23236128   PMID:23288923   PMID:23300826   PMID:23332756   PMID:23343527  
PMID:23482494   PMID:23563311   PMID:23614009   PMID:23618354   PMID:23643936   PMID:23645682   PMID:23671675   PMID:23680462   PMID:23762363   PMID:23830865   PMID:23831757   PMID:23872235  
PMID:23873040   PMID:23877428   PMID:23954590   PMID:24000064   PMID:24016759   PMID:24076664   PMID:24130328   PMID:24171105   PMID:24174682   PMID:24229643   PMID:24244405   PMID:24302887  
PMID:24311692   PMID:24347536   PMID:24548465   PMID:24553180   PMID:24617895   PMID:24697898   PMID:24771701   PMID:24797473   PMID:24813615   PMID:24948802   PMID:24952464   PMID:24952961  
PMID:25140582   PMID:25176648   PMID:25268479   PMID:25314078   PMID:25355313   PMID:25362352   PMID:25422376   PMID:25446516   PMID:25451166   PMID:25458012   PMID:25516975   PMID:25535338  
PMID:25609427   PMID:25626636   PMID:25644602   PMID:25760946   PMID:25848030   PMID:25936505   PMID:25986147   PMID:25995356   PMID:26015562   PMID:26057579   PMID:26100903   PMID:26141957  
PMID:26238476   PMID:26290370   PMID:26297872   PMID:26345456   PMID:26373671   PMID:26373672   PMID:26416758   PMID:26436454   PMID:26439398   PMID:26457609   PMID:26496610   PMID:26530396  
PMID:26645982   PMID:26658258   PMID:26697723   PMID:26702830   PMID:26769565   PMID:26837596   PMID:26901434   PMID:26912893   PMID:26931153   PMID:26932670   PMID:26996322   PMID:27002170  
PMID:27018594   PMID:27113760   PMID:27162362   PMID:27185526   PMID:27214567   PMID:27320915   PMID:27414798   PMID:27414999   PMID:27490099   PMID:27552050   PMID:27626380   PMID:27633013  
PMID:27633995   PMID:27705744   PMID:27720610   PMID:27727273   PMID:27793670   PMID:27807033   PMID:27815529   PMID:28112475   PMID:28131983   PMID:28154160   PMID:28167794   PMID:28195124  
PMID:28286175   PMID:28344083   PMID:28380258   PMID:28556366   PMID:28564646   PMID:28591579   PMID:28688895   PMID:28715412   PMID:28793255   PMID:28797033   PMID:28805814   PMID:28817564  
PMID:28885142   PMID:28917838   PMID:28941984   PMID:29031500   PMID:29038301   PMID:29078327   PMID:29088375   PMID:29133390   PMID:29166577   PMID:29229834   PMID:29230039   PMID:29244023  
PMID:29365079   PMID:29487109   PMID:29532549   PMID:29571613   PMID:29632244   PMID:29739868   PMID:29789719   PMID:29792854   PMID:29899403   PMID:29945868   PMID:30058223   PMID:30144507  
PMID:30148884   PMID:30206138   PMID:30291164   PMID:30315164   PMID:30352686   PMID:30352852   PMID:30355159   PMID:30361701   PMID:30366594   PMID:30456390   PMID:30458056   PMID:30470823  
PMID:30478225   PMID:30630826   PMID:30653268   PMID:30679745   PMID:30702346   PMID:30814516   PMID:30983567   PMID:31036156   PMID:31071314   PMID:31072004   PMID:31120883   PMID:31167144  
PMID:31194676   PMID:31226309   PMID:31263273   PMID:31269445   PMID:31301300   PMID:31373354   PMID:31382618   PMID:31488567   PMID:31604927   PMID:31605511   PMID:31608494   PMID:31638600  
PMID:31845891   PMID:31873117   PMID:31964774   PMID:32129762   PMID:32151560   PMID:32234482   PMID:32241942   PMID:32325033   PMID:32350360   PMID:32435793   PMID:32561646   PMID:32679029  
PMID:32702291   PMID:32910808   PMID:32938678   PMID:32966817   PMID:33063110   PMID:33328171   PMID:33328632   PMID:33826897   PMID:33886552   PMID:34062094   PMID:34093381   PMID:34132778  
PMID:34161280   PMID:34161574   PMID:34339499   PMID:34433966   PMID:34482626   PMID:34486668   PMID:34552196   PMID:34568800   PMID:34600946   PMID:34984806   PMID:35048440   PMID:35112129  
PMID:35353806   PMID:35421372   PMID:35472633   PMID:35589396   PMID:35835905   PMID:35905011   PMID:36218069   PMID:36459481   PMID:36543133   PMID:36577057   PMID:36821837   PMID:36920550  
PMID:37029430   PMID:37300483   PMID:37810243   PMID:37845394   PMID:38051593   PMID:38117649   PMID:38355793   PMID:38771121  


Genomics

Comparative Map Data
Smo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,735,480 - 29,761,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,735,502 - 29,761,364 (+)EnsemblGRCm39 Ensembl
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBIMGSCv36mm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
SMO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,188,633 - 129,213,545 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,188,633 - 129,213,545 (+)EnsemblGRCh38hg38GRCh38
GRCh377128,828,474 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,615,949 - 128,640,622 (+)NCBINCBI36Build 36hg18NCBI36
Build 347128,422,663 - 128,447,334NCBI
Celera7123,625,432 - 123,650,109 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7123,189,938 - 123,214,626 (+)NCBIHuRef
CHM1_17128,762,307 - 128,786,971 (+)NCBICHM1_1
T2T-CHM13v2.07130,501,540 - 130,526,468 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,212,668 - 128,237,345 (+)NCBI
Smo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,311,084 - 59,341,280 (+)NCBIGRCr8
mRatBN7.2458,343,626 - 58,373,823 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,343,529 - 58,373,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,327,690 - 63,351,689 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,243,861 - 59,267,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,645,743 - 57,669,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,019,941 - 57,041,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,019,941 - 57,042,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,787,102 - 56,809,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,623,494 - 56,645,571 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,898,313 - 56,920,866 (+)NCBI
Celera453,450,322 - 53,474,674 (+)NCBICelera
Cytogenetic Map4q22NCBI
Smo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,964,170 - 9,993,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,963,377 - 9,991,670 (+)NCBIChiLan1.0ChiLan1.0
SMO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,999,428 - 166,024,105 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1718,009,925 - 18,034,351 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07121,143,968 - 121,168,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,668,523 - 133,693,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,668,304 - 133,693,048 (+)Ensemblpanpan1.1panPan2
SMO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,518,871 - 7,527,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,518,856 - 7,528,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,206,323 - 7,229,356 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,284,734 - 7,307,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,284,738 - 7,307,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,489,837 - 7,512,985 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,231,685 - 7,254,904 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,376,821 - 7,399,952 (-)NCBIUU_Cfam_GSD_1.0
Smo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511825,760,467 - 25,784,726 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365795,892,542 - 5,917,281 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365795,893,064 - 5,917,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,450,743 - 19,478,898 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,450,730 - 19,478,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,520,306 - 20,548,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,788,955 - 97,814,549 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,788,624 - 97,814,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660425,588,304 - 5,614,118 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,011,899 - 7,039,921 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,012,385 - 7,039,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smo
681 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:293
Interacting mature miRNAs:347
Transcripts:ENSMUST00000001812
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
Smo  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,056 - 85,024,255UniSTSGRCm38
GRCm38629,761,063 - 29,761,263UniSTSGRCm38
MGSCv371385,163,661 - 85,163,860UniSTSGRCm37
MGSCv37629,711,063 - 29,711,263UniSTSGRCm37
Celera1387,255,683 - 87,255,882UniSTS
Celera629,772,308 - 29,772,508UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
AU041277  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,059 - 85,024,232UniSTSGRCm38
GRCm38629,761,086 - 29,761,260UniSTSGRCm38
MGSCv371385,163,664 - 85,163,837UniSTSGRCm37
MGSCv37629,711,086 - 29,711,260UniSTSGRCm37
Celera1387,255,686 - 87,255,859UniSTS
Celera629,772,331 - 29,772,505UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
UniSTS:237068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381385,024,577 - 85,024,929UniSTSGRCm38
GRCm38629,760,451 - 29,760,803UniSTSGRCm38
MGSCv371385,164,182 - 85,164,534UniSTSGRCm37
MGSCv37629,710,451 - 29,710,803UniSTSGRCm37
Celera1387,256,198 - 87,256,550UniSTS
Celera629,771,690 - 29,772,042UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map13C3UniSTS
D6Mit159  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,751,222 - 29,751,334UniSTSGRCm38
MGSCv37629,701,222 - 29,701,334UniSTSGRCm37
Celera629,762,432 - 29,762,568UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map67.0UniSTS
Whitehead Genetic66.6UniSTS
Smoh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38629,760,336 - 29,761,067UniSTSGRCm38
MGSCv37629,710,336 - 29,711,067UniSTSGRCm37
Celera629,771,575 - 29,772,312UniSTS
Cytogenetic Map6A3.3UniSTS
cM Map67.2UniSTS
Smo  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A3.3UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_176996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF089721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW555326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB659739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB665395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ947565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA749812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN665198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ883552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY442313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000001812   ⟹   ENSMUSP00000001812
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl629,735,693 - 29,761,364 (+)Ensembl
GRCm38.p6 Ensembl629,735,694 - 29,761,365 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl629,735,502 - 29,738,003 (+)Ensembl
GRCm38.p6 Ensembl629,735,503 - 29,738,004 (+)Ensembl
RefSeq Acc Id: NM_176996   ⟹   NP_795970
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39629,735,480 - 29,761,359 (+)NCBI
GRCm38629,735,497 - 29,761,366 (+)ENTREZGENE
MGSCv37629,685,497 - 29,711,366 (+)RGD
Celera629,744,569 - 29,772,611 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505106   ⟹   XP_006505169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39629,752,541 - 29,761,359 (+)NCBI
GRCm38629,751,222 - 29,761,360 (+)NCBI
Sequence:
RefSeq Acc Id: NP_795970   ⟸   NM_176996
- Peptide Label: precursor
- UniProtKB: P56726 (UniProtKB/Swiss-Prot),   Q4VBD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505169   ⟸   XM_006505106
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000001812   ⟸   ENSMUST00000001812
Protein Domains
Frizzled/Smoothened 7TM   FZ   G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56726-F1-model_v2 AlphaFold P56726 1-793 view protein structure

Promoters
RGD ID:6838882
Promoter ID:MM_KWN:45387
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   ES_Cell,   Kidney,   Lung,   MEF_B4
Transcripts:UC009BEE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36629,685,446 - 29,686,347 (+)MPROMDB
RGD ID:6889200
Promoter ID:EPDNEW_M8051
Type:initiation region
Name:Smo_1
Description:Mus musculus smoothened, frizzled class receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8052  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38629,735,524 - 29,735,584EPDNEW
RGD ID:6889202
Promoter ID:EPDNEW_M8052
Type:initiation region
Name:Smo_2
Description:Mus musculus smoothened, frizzled class receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8051  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38629,735,644 - 29,735,704EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108075 AgrOrtholog
Ensembl Genes ENSMUSG00000001761 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001812 ENTREZGENE
  ENSMUST00000001812.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMO_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMO_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319757 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108075 ENTREZGENE
NCBI Gene Smo ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11309:SF35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SMO RGD
PhenoGen Smo PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P56726 ENTREZGENE
  Q4VBD5 ENTREZGENE, UniProtKB/TrEMBL
  Q80VD0_MOUSE UniProtKB/TrEMBL
  Q8BJN8_MOUSE UniProtKB/TrEMBL
  Q8K2P8_MOUSE UniProtKB/TrEMBL
  SMO_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Smo  smoothened, frizzled class receptor  Smo  smoothened homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Smo  smoothened homolog (Drosophila)  Smo  smoothened, frizzled class receptor  Symbol and/or name change 5135510 APPROVED
2015-06-30 Smo  smoothened, frizzled class receptor    smoothened homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED