PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html ).
Term: endocrine gland cancer pathway
Accession: PW:0000700
browse the term
Definition: A general term grouping neoplastic pathways of the adrenal gland, ovaries and pancreas, pituitary and thyroid.
Synonyms: related_synonym: endocrine gland neoplasm pathway
Symbol
Object Name
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Actl6a
actin-like 6A
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chr 2:115,492,374...115,508,401
Ensembl chr 2:115,492,285...115,508,401
G
Akt1
AKT serine/threonine kinase 1
IEA
KEGG
rno:05212
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Akt2
AKT serine/threonine kinase 2
ISO IEA
KEGG RGD
PMID:19506583
rno:05212, RGD:5490965
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
G
Akt3
AKT serine/threonine kinase 3
IEA
KEGG
rno:05212
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
G
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor 6
IEA
KEGG
rno:05212
NCBI chr X:135,145,447...135,264,636
Ensembl chr X:135,146,786...135,275,304
G
Arid1a
AT-rich interaction domain 1A
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
G
Arid1b
AT-rich interaction domain 1B
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493
G
Bad
BCL2-associated agonist of cell death
IEA
KEGG
rno:05212
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bcl2l1
Bcl2-like 1
IEA
KEGG
rno:05212
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
G
Boc
BOC cell adhesion associated, oncogene regulated
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr11:56,122,697...56,198,060
Ensembl chr11:56,122,750...56,198,059
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05212
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
G
Brca2
BRCA2, DNA repair associated
IEA
KEGG
rno:05212
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
G
Casp9
caspase 9
IEA
KEGG
rno:05212
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccnd1
cyclin D1
IEA
KEGG
rno:05212
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cdc42
cell division cycle 42
IEA
KEGG
rno:05212
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
G
Cdk4
cyclin-dependent kinase 4
IEA
KEGG
rno:05212
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Cdk6
cyclin-dependent kinase 6
IEA
KEGG
rno:05212
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
IEA ISO
KEGG RGD
PMID:18772397
rno:05212, RGD:5490966
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
G
Chuk
component of inhibitor of nuclear factor kappa B kinase complex
IEA
KEGG
rno:05212
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
G
E2f1
E2F transcription factor 1
IEA
KEGG
rno:05212
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
E2f3
E2F transcription factor 3
IEA
KEGG
rno:05212
NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
G
Egf
epidermal growth factor
ISO IEA
KEGG RGD
PMID:19506583
rno:05212, RGD:5490965
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
ISO IEA
KEGG RGD
PMID:19506583
rno:05212, RGD:5490965
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Erbb2
erb-b2 receptor tyrosine kinase 2
IEA
KEGG
rno:05212
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Gli1
GLI family zinc finger 1
ISO
RGD
PMID:21186299 PMID:18772397
RGD:5491005 , RGD:5490966
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
G
Gli3
GLI family zinc finger 3
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
IEA
KEGG
rno:05212
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
IEA
KEGG
rno:05212
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
G
Ilk
integrin-linked kinase
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
G
Itga11
integrin subunit alpha 11
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
G
Itga4
integrin subunit alpha 4
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
G
Itga9
integrin subunit alpha 9
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
G
Jak1
Janus kinase 1
IEA
KEGG
rno:05212
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
G
Kras
KRAS proto-oncogene, GTPase
ISO IEA
KEGG RGD
PMID:19506583 PMID:18772397
rno:05212, RGD:5490965 , RGD:5490966
NCBI chr 4:178,185,418...178,218,484
G
Lrp2
LDL receptor related protein 2
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:05212
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:05212
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk10
mitogen activated protein kinase 10
IEA
KEGG
rno:05212
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
G
Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:05212
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
IEA
KEGG
rno:05212
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
IEA
KEGG
rno:05212
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Met
MET proto-oncogene, receptor tyrosine kinase
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Nfkb1
nuclear factor kappa B subunit 1
IEA
KEGG
rno:05212
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Pbrm1
polybromo 1
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
G
Pgf
placental growth factor
IEA
KEGG
rno:05212
NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
IEA
KEGG
rno:05212
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
IEA
KEGG
rno:05212
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
IEA
KEGG
rno:05212
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
IEA
KEGG
rno:05212
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
IEA
KEGG
rno:05212
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
G
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
IEA
KEGG
rno:05212
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
G
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
IEA
KEGG
rno:05212
NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
G
Pld1
phospholipase D1
IEA
KEGG
rno:05212
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
G
Pten
phosphatase and tensin homolog
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
G
Rac1
Rac family small GTPase 1
IEA
KEGG
rno:05212
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
G
Rac2
Rac family small GTPase 2
IEA
KEGG
rno:05212
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
G
Rad51
RAD51 recombinase
IEA
KEGG
rno:05212
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05212
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Rala
RAS like proto-oncogene A
IEA
KEGG
rno:05212
NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063
G
Ralb
RAS like proto-oncogene B
IEA
KEGG
rno:05212
NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
G
Ralbp1
ralA binding protein 1
IEA
KEGG
rno:05212
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
G
Ralgds
ral guanine nucleotide dissociation stimulator
IEA
KEGG
rno:05212
NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
G
Rb1
RB transcriptional corepressor 1
IEA
KEGG
rno:05212
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Rela
RELA proto-oncogene, NF-kB subunit
IEA
KEGG
rno:05212
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Shh
sonic hedgehog signaling molecule
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
G
Smad2
SMAD family member 2
IEA
KEGG
rno:05212
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
G
Smad3
SMAD family member 3
ISO IEA
KEGG RGD
PMID:18772397
rno:05212, RGD:5490966
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
G
Smad4
SMAD family member 4
ISO IEA
KEGG RGD
PMID:18772397 PMID:19506583
rno:05212, RGD:5490966 , RGD:5490965
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
G
Smarca4
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975
G
Stat1
signal transducer and activator of transcription 1
IEA
KEGG
rno:05212
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Stat3
signal transducer and activator of transcription 3
IEA
KEGG
rno:05212
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Tcf7l2
transcription factor 7 like 2
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967
G
Tgfa
transforming growth factor alpha
ISO IEA
KEGG RGD
PMID:19506583
rno:05212, RGD:5490965
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
G
Tgfb1
transforming growth factor, beta 1
IEA
KEGG
rno:05212
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tgfb2
transforming growth factor, beta 2
IEA
KEGG
rno:05212
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
G
Tgfb3
transforming growth factor, beta 3
IEA
KEGG
rno:05212
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
G
Tgfbr1
transforming growth factor, beta receptor 1
IEA
KEGG
rno:05212
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
G
Tgfbr2
transforming growth factor, beta receptor 2
ISO IEA
KEGG RGD
PMID:18772397 PMID:19506583
rno:05212, RGD:5490966 , RGD:5490965
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
G
Tp53
tumor protein p53
ISO IEA
DNA:mutations:exon
KEGG RGD
PMID:18772397
rno:05212, RGD:5490966
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Vegfa
vascular endothelial growth factor A
IEA
KEGG
rno:05212
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Vegfb
vascular endothelial growth factor B
IEA
KEGG
rno:05212
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
G
Vegfc
vascular endothelial growth factor C
IEA
KEGG
rno:05212
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
G
Vegfd
vascular endothelial growth factor D
IEA
KEGG
rno:05212
NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295
G
Wnt9a
Wnt family member 9A
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133
Symbol
Object Name
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05216
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
G
Ccdc6
coiled-coil domain containing 6
IEA
KEGG
rno:05216
NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
G
Ccnd1
cyclin D1
IEA
KEGG
rno:05216
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cdh1
cadherin 1
IEA
KEGG
rno:05216
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Ctnnb1
catenin beta 1
IEA
KEGG
rno:05216
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Hras
HRas proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Kras
KRAS proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 4:178,185,418...178,218,484
G
Lef1
lymphoid enhancer binding factor 1
IEA
KEGG
rno:05216
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:05216
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Map2k2
mitogen activated protein kinase kinase 2
IEA
KEGG
rno:05216
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:05216
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:05216
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Myc
MYC proto-oncogene, bHLH transcription factor
IEA
KEGG
rno:05216
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Ncoa4
nuclear receptor coactivator 4
IEA
KEGG
rno:05216
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
G
Nras
NRAS proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
IEA
KEGG
rno:05216
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
G
Pax8
paired box 8
IEA
KEGG
rno:05216
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
G
Pparg
peroxisome proliferator-activated receptor gamma
IEA
KEGG
rno:05216
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ret
ret proto-oncogene
IEA
KEGG
rno:05216
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
G
Rxra
retinoid X receptor alpha
IEA
KEGG
rno:05216
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
Rxrb
retinoid X receptor beta
IEA
KEGG
rno:05216
NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
G
Rxrg
retinoid X receptor gamma
IEA
KEGG
rno:05216
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
G
Tcf3
transcription factor 3
IEA
KEGG
rno:05216
NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
G
Tcf7
transcription factor 7
IEA
KEGG
rno:05216
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
G
Tcf7l2
transcription factor 7 like 2
IEA
KEGG
rno:05216
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967
G
Tfg
trafficking from ER to golgi regulator
IEA
KEGG
rno:05216
NCBI chr11:43,885,542...43,911,976
Ensembl chr11:43,885,661...43,911,976
G
Tp53
tumor protein p53
IEA
KEGG
rno:05216
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Tpm3
tropomyosin 3
IEA
KEGG
rno:05216
NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
G
Tpr
translocated promoter region, nuclear basket protein
IEA
KEGG
rno:05216
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all