Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6) - Rat Genome Database

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Gene: Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6) Rattus norvegicus
Analyze
Symbol: Arhgef6
Name: Rac/Cdc42 guanine nucleotide exchange factor 6 (Ensembl:Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6)
RGD ID: 1359674
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 46. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; rho guanine nucleotide exchange factor 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,344,314 - 137,461,067 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,901,995 - 141,018,759 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X138,471,394 - 138,588,158 (-)NCBIRnor_WKY
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,946,362 - 142,068,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X142,019,794 - 142,141,990 (-)NCBI
CeleraX143,180,944 - 143,297,823 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Kutsche K, etal., Nat Genet. 2000 Oct;26(2):247-50.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16641100   PMID:18325335   PMID:19261846   PMID:22554054   PMID:23793062   PMID:25450678  


Genomics

Comparative Map Data
Arhgef6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,344,314 - 137,461,067 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,901,995 - 141,018,759 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X138,471,394 - 138,588,158 (-)NCBIRnor_WKY
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,946,362 - 142,068,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X142,019,794 - 142,141,990 (-)NCBI
CeleraX143,180,944 - 143,297,823 (-)NCBICelera
Cytogenetic MapXq37NCBI
ARHGEF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,665,550 - 136,780,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX136,665,547 - 136,780,932 (-)EnsemblGRCh38hg38GRCh38
GRCh37X135,747,709 - 135,863,091 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,575,375 - 135,691,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X135,473,232 - 135,589,023NCBI
CeleraX136,111,384 - 136,227,182 (-)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX125,018,703 - 125,134,374 (-)NCBIHuRef
CHM1_1X135,659,375 - 135,775,269 (-)NCBICHM1_1
T2T-CHM13v2.0X134,974,276 - 135,089,655 (-)NCBIT2T-CHM13v2.0
Arhgef6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,276,845 - 56,384,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,276,845 - 56,384,089 (-)EnsemblGRCm39 Ensembl
GRCm38X57,231,485 - 57,338,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,231,485 - 57,338,729 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X54,484,662 - 54,591,906 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,578,271 - 53,685,513 (-)NCBIMGSCv36mm8
CeleraX43,709,095 - 43,814,976 (-)NCBICelera
Cytogenetic MapXA6NCBI
Arhgef6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,360,072 - 8,459,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,360,027 - 8,459,309 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X136,060,652 - 136,176,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,058,879 - 136,176,110 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X125,794,158 - 125,909,809 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARHGEF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X107,031,586 - 107,133,402 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,034,118 - 107,133,082 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,853,143 - 92,954,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X109,011,566 - 109,112,628 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX109,011,570 - 109,112,366 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X106,152,309 - 106,253,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,343,657 - 108,445,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,985,467 - 108,087,145 (-)NCBIUU_Cfam_GSD_1.0
Arhgef6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X105,016,252 - 105,126,029 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,488,532 - 10,598,493 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651310,488,525 - 10,598,366 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,796,485 - 111,917,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,796,485 - 111,917,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,658,249 - 127,763,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,672,701 - 111,793,597 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,672,713 - 111,792,856 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606549,359,175 - 49,486,195 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,319,793 - 10,465,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,320,388 - 10,464,081 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef6
273 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000001158
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
DXRat141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,183,402 - 135,183,610 (+)MAPPERmRatBN7.2
Rnor_6.0X159,760,012 - 159,760,219NCBIRnor6.0
Rnor_5.0X154,385,788 - 154,385,995UniSTSRnor5.0
RGSC_v3.4X141,982,743 - 141,982,950RGDRGSC3.4
RGSC_v3.4X141,982,744 - 141,982,951UniSTSRGSC3.4
RGSC_v3.1X142,056,176 - 142,056,383RGD
CeleraX143,216,854 - 143,217,061UniSTS
SHRSP x BN MapX44.63UniSTS
SHRSP x BN MapX44.63RGD
Cytogenetic MapXq36UniSTS
RH144315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,186,611 - 135,186,721 (+)MAPPERmRatBN7.2
Rnor_6.0X159,763,221 - 159,763,330NCBIRnor6.0
Rnor_5.0X154,388,997 - 154,389,106UniSTSRnor5.0
RGSC_v3.4X141,985,953 - 141,986,062UniSTSRGSC3.4
CeleraX143,220,057 - 143,220,166UniSTS
RH 3.4 MapX958.1UniSTS
Cytogenetic MapXq36UniSTS
px-17e5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,154,816 - 135,154,940 (+)MAPPERmRatBN7.2
Rnor_6.0X159,731,400 - 159,731,523NCBIRnor6.0
Rnor_5.0X154,357,999 - 154,358,122UniSTSRnor5.0
RGSC_v3.4X141,954,095 - 141,954,218UniSTSRGSC3.4
CeleraX143,188,244 - 143,188,367UniSTS
Cytogenetic MapXq36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 16 19 8 11 2 25 11 8
Low 1 11 41 41 41 74 33 16
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001158   ⟹   ENSRNOP00000001158
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)Ensembl
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096866   ⟹   ENSRNOP00000096317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,786 - 135,197,390 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103631   ⟹   ENSRNOP00000084113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,789 - 135,275,304 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111102   ⟹   ENSRNOP00000088717
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115452   ⟹   ENSRNOP00000083356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,786 - 135,197,390 (-)Ensembl
RefSeq Acc Id: NM_001005565   ⟹   NP_001005565
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,147,481 - 135,264,206 (-)NCBI
Rnor_6.0X159,724,065 - 159,840,804 (-)NCBI
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBI
RGSC_v3.4X141,946,362 - 142,068,557 (-)RGD
CeleraX143,180,944 - 143,297,823 (-)RGD
Sequence:
RefSeq Acc Id: XM_008773651   ⟹   XP_008771873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,343 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773652   ⟹   XP_008771874
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773653   ⟹   XP_008771875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773654   ⟹   XP_008771876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,147,481 - 135,252,810 (-)NCBI
Rnor_6.0X159,724,065 - 159,829,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602114   ⟹   XP_017457603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,147,481 - 135,253,556 (-)NCBI
Rnor_6.0X159,724,065 - 159,830,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099906   ⟹   XP_038955834
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099907   ⟹   XP_038955835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099908   ⟹   XP_038955836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099909   ⟹   XP_038955837
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,147,481 - 135,225,668 (-)NCBI
RefSeq Acc Id: XM_039099910   ⟹   XP_038955838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,147,481 - 135,252,810 (-)NCBI
RefSeq Acc Id: XM_039099911   ⟹   XP_038955839
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X135,145,447 - 135,197,425 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001005565   ⟸   NM_001005565
- Sequence:
RefSeq Acc Id: XP_008771874   ⟸   XM_008773652
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008771873   ⟸   XM_008773651
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771875   ⟸   XM_008773653
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008771876   ⟸   XM_008773654
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017457603   ⟸   XM_017602114
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000001158   ⟸   ENSRNOT00000001158
RefSeq Acc Id: XP_038955836   ⟸   XM_039099908
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038955835   ⟸   XM_039099907
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038955834   ⟸   XM_039099906
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955839   ⟸   XM_039099911
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038955838   ⟸   XM_039099910
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038955837   ⟸   XM_039099909
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000084113   ⟸   ENSRNOT00000103631
RefSeq Acc Id: ENSRNOP00000088717   ⟸   ENSRNOT00000111102
RefSeq Acc Id: ENSRNOP00000096317   ⟸   ENSRNOT00000096866
RefSeq Acc Id: ENSRNOP00000083356   ⟸   ENSRNOT00000115452
Protein Domains
Calponin-homology (CH)   DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XXR3-F1-model_v2 AlphaFold Q5XXR3 1-772 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359674 AgrOrtholog
BioCyc Gene G2FUF-906 BioCyc
Ensembl Genes ENSRNOG00000000869 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001158 ENTREZGENE
  ENSRNOP00000001158.7 UniProtKB/TrEMBL
  ENSRNOP00000083356.1 UniProtKB/TrEMBL
  ENSRNOP00000084113 ENTREZGENE
  ENSRNOP00000084113.1 UniProtKB/TrEMBL
  ENSRNOP00000088717 ENTREZGENE
  ENSRNOP00000088717.1 UniProtKB/TrEMBL
  ENSRNOP00000096317 ENTREZGENE
  ENSRNOP00000096317.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001158 ENTREZGENE
  ENSRNOT00000001158.8 UniProtKB/TrEMBL
  ENSRNOT00000096866 ENTREZGENE
  ENSRNOT00000096866.1 UniProtKB/TrEMBL
  ENSRNOT00000103631 ENTREZGENE
  ENSRNOT00000103631.1 UniProtKB/TrEMBL
  ENSRNOT00000111102 ENTREZGENE
  ENSRNOT00000111102.1 UniProtKB/TrEMBL
  ENSRNOT00000115452.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AlphaPIX_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GEF_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_Cool_Pix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363509 UniProtKB/Swiss-Prot
NCBI Gene 363509 ENTREZGENE
Pfam betaPIX_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef6 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZX43_RAT UniProtKB/TrEMBL
  A0A8I6APF5_RAT UniProtKB/TrEMBL
  A0A8I6G8W1_RAT UniProtKB/TrEMBL
  A0A8I6GGI3_RAT UniProtKB/TrEMBL
  ARHG6_RAT UniProtKB/Swiss-Prot
  D3ZWQ8_RAT UniProtKB/TrEMBL
  Q5XXR3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor 6  Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  arhgef6  rac/cdc42 guanine nucleotide exchange factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 arhgef6  rac/cdc42 guanine nucleotide exchange factor 6      Symbol and Name status set to provisional 70820 PROVISIONAL