Ralb (RAS like proto-oncogene B) - Rat Genome Database

Name: Ralb
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ralb (RAS like proto-oncogene B) Rattus norvegicus

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Symbol:

Ralb

Name:

RAS like proto-oncogene B

RGD ID:

619852

Description:

Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of exocyst assembly and regulation of exocyst localization. Predicted to be located in midbody. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dRalb; GTP binding protein; GTP binding protein); RALB Ras like proto-oncogene B; ras-related protein Ral-B; v-ral simian leukemia viral oncogene homolog B; v-ral simian leukemia viral oncogene homolog B (ras related); v-ral simian leukemia viral oncogene homolog B (ras related, GTP binding protein)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RALB (RAS like proto-oncogene B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ralb (v-ral simian leukemia viral oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ralb (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RALB (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RALB (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ralb (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RALB (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RALB (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ralb (RAS like proto-oncogene B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RALB (RAS like proto-oncogene B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ralb (v-ral simian leukemia viral oncogene B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ralba (v-ral simian leukemia viral oncogene homolog Ba (ras related))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ral-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rala	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,140,834 - 33,176,997 (-)	NCBI		GRCr8
mRatBN7.2	13	30,588,036 - 30,624,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	30,588,033 - 30,624,202 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	33,170,277 - 33,206,411 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,458,108 - 34,494,251 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	31,732,301 - 31,768,394 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	35,494,716 - 35,531,503 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	35,494,721 - 35,511,020 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	40,612,013 - 40,646,132 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	32,229,646 - 32,238,410 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	32,232,469 - 32,241,225 (-)	NCBI
Celera	13	30,485,122 - 30,521,405 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pancreatic adenocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

aconitine (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

ampicillin (EXP)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

captan (ISO)

chlordecone (ISO)

chloropicrin (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

fenthion (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (ISO)

haloperidol (EXP)

isoflurane (ISO)

ivermectin (ISO)

methimazole (EXP)

metronidazole (EXP)

microcystin-LR (ISO)

N-nitrosodimethylamine (EXP)

neomycin (EXP)

nickel sulfate (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenol red (ISO)

PhIP (EXP)

propiconazole (EXP)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vancomycin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

cell division (IEA)

cellular response to exogenous dsRNA (IEA,ISO)

cellular response to starvation (IEA,ISO)

positive regulation of autophagosome assembly (IEA,ISO)

positive regulation of epidermal growth factor receptor signaling pathway (IEA,ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of protein serine/threonine kinase activity (ISO)

Ras protein signal transduction (IBA)

receptor internalization (IEA,ISO)

regulation of exocyst assembly (IDA)

regulation of exocyst localization (IDA)

signal transduction (IEA)

Cellular Component

cytosol (TAS)

midbody (IEA,ISO,ISS)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

ATPase binding (IEA,ISO)

G protein activity (IEA)

GDP binding (IBA,IEA,ISO)

GTP binding (IBA,IEA,ISO,ISS,NAS)

GTPase activity (IBA,ISO,ISS)

protein binding (ISO)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ceramide signaling pathway (IEA)

pancreatic cancer pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.	Lim KH, etal., Curr Biol. 2006 Dec 19;16(24):2385-94. doi: 10.1016/j.cub.2006.10.023.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	RalB mobilizes the exocyst to drive cell migration.	Rosse C, etal., Mol Cell Biol. 2006 Jan;26(2):727-34.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins.	Wildey GM, etal., Biochem Biophys Res Commun 1993 Jul 15;194(1):552-9.

Additional References at PubMed

PMID:15489334	PMID:16330713	PMID:17202486	PMID:17875936	PMID:18756269	PMID:19166349	PMID:22393054	PMID:22871113	PMID:23376485	PMID:23533145	PMID:24056301

Genomics

Comparative Map Data

Ralb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,140,834 - 33,176,997 (-)	NCBI		GRCr8
mRatBN7.2	13	30,588,036 - 30,624,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	30,588,033 - 30,624,202 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	33,170,277 - 33,206,411 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,458,108 - 34,494,251 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	31,732,301 - 31,768,394 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	35,494,716 - 35,531,503 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	35,494,721 - 35,511,020 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	40,612,013 - 40,646,132 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	32,229,646 - 32,238,410 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	32,232,469 - 32,241,225 (-)	NCBI
Celera	13	30,485,122 - 30,521,405 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

RALB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	120,240,070 - 120,294,710 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	120,240,064 - 120,294,710 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	121,010,428 - 121,052,286 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	120,726,884 - 120,768,756 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	120,726,643 - 120,768,515	NCBI
Celera	2	114,337,260 - 114,379,139 (+)	NCBI		Celera
Cytogenetic Map	2	q14.2	ENTREZGENE
HuRef	2	113,334,200 - 113,376,091 (+)	NCBI		HuRef
CHM1_1	2	121,014,820 - 121,056,700 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	120,674,829 - 120,729,465 (+)	NCBI		T2T-CHM13v2.0

Ralb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	119,398,035 - 119,432,512 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	119,398,035 - 119,432,524 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	119,470,305 - 119,504,782 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	119,470,305 - 119,504,794 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	121,366,882 - 121,401,359 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	121,297,855 - 121,332,174 (-)	NCBI		MGSCv36	mm8
Celera	1	122,129,019 - 122,163,492 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.29	NCBI

Ralb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	9,531,538 - 9,574,766 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	9,533,081 - 9,574,464 (-)	NCBI	ChiLan1.0	ChiLan1.0

RALB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	22,254,513 - 22,296,579 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	22,269,488 - 22,311,548 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	7,185,192 - 7,227,220 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	120,760,879 - 120,802,697 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	120,748,123 - 120,802,698 (+)	Ensembl	panpan1.1		panPan2

RALB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	29,820,006 - 29,868,345 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	29,768,359 - 29,868,335 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	30,077,023 - 30,124,832 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	31,195,778 - 31,243,919 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	31,195,778 - 31,243,835 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	29,882,347 - 29,930,196 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	30,051,930 - 30,099,493 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	31,237,496 - 31,285,578 (-)	NCBI		UU_Cfam_GSD_1.0

Ralb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	91,338,266 - 91,379,916 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	50,236,409 - 50,279,583 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	50,237,804 - 50,279,483 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RALB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	31,064,355 - 31,122,621 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	31,064,341 - 31,118,437 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	36,646,622 - 36,696,923 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RALB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	9,999,828 - 10,041,158 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	9,999,904 - 10,016,473 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	12,647,588 - 12,689,047 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ralb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	24,803,311 - 24,821,038 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	24,804,794 - 24,841,744 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ralb
189 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	228
Count of miRNA genes:	151
Interacting mature miRNAs:	173
Transcripts:	ENSRNOT00000003413
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34266636	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	11766535	32331607	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	30395351	41184251	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	11766535	32331607	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	5994668	34535351	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	42356786	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat

Markers in Region

RH128968

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	30,588,081 - 30,588,238 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	35,494,765 - 35,494,921	NCBI	Rnor6.0
Rnor_5.0	13	40,612,057 - 40,612,213	UniSTS	Rnor5.0
RGSC_v3.4	13	32,229,690 - 32,229,846	UniSTS	RGSC3.4
Celera	13	30,485,166 - 30,485,322	UniSTS
Cytogenetic Map	13	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC072505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L19699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003413 ⟹ ENSRNOP00000003413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	30,588,039 - 30,624,202 (-)	Ensembl
Rnor_6.0 Ensembl	13	35,494,721 - 35,511,020 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096405 ⟹ ENSRNOP00000087562

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	30,588,033 - 30,624,034 (-)	Ensembl

RefSeq Acc Id:

NM_053821 ⟹ NP_446273

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,140,836 - 33,176,997 (-)	NCBI
mRatBN7.2	13	30,588,038 - 30,624,199 (-)	NCBI
Rnor_6.0	13	35,494,721 - 35,531,485 (-)	NCBI
Rnor_5.0	13	40,612,013 - 40,646,132 (-)	NCBI
RGSC_v3.4	13	32,229,646 - 32,238,410 (-)	RGD
Celera	13	30,485,122 - 30,521,405 (-)	RGD

Sequence:

show sequence

CAGCGGGAACGCGCTCCGGGGGGTGGGGACGCGCGAGCTCACGACTGCTCAATGACAAATCGAC
TGGGGACAGCTGGGGTCCGGCCCCAGGACGGGGCGGGGCGCGCGTGAGAGCCGCGAGTCTGGTT
GTGCACATAGCCAGAGCGGCGGTGGGACGGCTCCCTCAGCTCCTCATCTGGGCCATCTGTCCGT
GTGTCGCTGCCTCAGACCAGCAGGATGGCTGCCAACAAAGGCAAGAGCCAGGGCTCCCTGGTCC
TTCACAAGGTCATCATGGTCGGCAGTGGGGGAGTCGGCAAGTCAGCCCTGACGCTCCAGTTCAT
GTATGACGAGTTTGTAGAAGACTATGAGCCCACCAAAGCCGACAGTTACAGAAAGAAGGTGGTT
CTCGACGGAGAAGAGGTTCAGATAGACATCCTGGACACAGCCGGCCAGGAGGACTATGCGGCCA
TCCGTGACAACTACTTCCGAAGCGGAGAAGGCTTTCTGCTGGTGTTCTCCATCACGGAGCACGA
GTCTTTCACCGCCACAGCTGAGTTCAGGGAACAGATCCTCCGAGTCAAGGCCGAGGAGGACAAA
ATCCCTCTGCTGGTCGTGGGCAACAAGTCTGACCTGGAGGAGCGGAGGCAGGTGCCCGTGGAGG
AGGCCCGAGGCAAAGCGGAAGAGTGGGGTGTGCAGTATGTGGAGACATCCGCAAAGACCCGAGC
CAACGTGGACAAGGTGTTCTTTGATCTGATGAGAGAAATCCGGGCAAAAAAGATGTCGGAAAAC
AAGGACAAGAACGGCAGGAAAAGCGGCAAGAGCAAGAAGAGTTTCAAAGAGCGGTGCTGCTTGC
TGTGAGTGGGCCGCGGACAGAGCGAGCGGAGAAGGCCACATTGCAGCGCGCCGAGCCCAGGTGG
CCTCCCCCTGGCTCCCCACTCTCCGCAGCTGTATTCACTATCACTTCTTGAGATGGGACAGATA
CCTGTGCACCAGTGGCTGGCAGGAGAAAGACGCCTTCGTCTGTGCGTCTGTGCGATGCATCTGC
TAACGTTGCCAGGAGCTTTGAGAGTCTGCCCCCTCCCACCCTCCCTGAACCGTGACTGTCACCA
GCTCTAGGGTCAGGAATCTGAGTTGTGTTGACAAGAAAGAGGATTGCCACGGCGGCTTGTCCCC
CCCTGTTCTAGGACATGGTCATCTTTTGTTGGAAAATCAAAATGCTTCACATTAGCAGGGCGTG
CTGGTGCACCCCTGTAGTCCCAGAACTCTAGAAGGTAAGGCAGGGAGGGTAGCCTGAGCCCAAG
GCCAGCCTGGGCTACCTAGCAAGACCCTGTCTCTAAAAGGAAAAAGAACTAACATCTTATTTTC
TTAGATTTAAAAAGAGGGTCTCTGGCAAGACCCCTCGTTAGTTCTTATCAGTTTAGAAGTAGAC
AGGGGGCGGAAAACCTAAGCTCAGGTAATACTGAAAAAGCCAAAACAATTTGTTTTTTTTTTTT
TTCTGTTTTAAAAGATAAACTTCTGTGACTTGGAAGCAGAATTAGAAAGATGAACTTCACTTGG
TCCAGATAGGCTGAACCAAGCCTCCTGGCGTTTGTAGAGAAAGTGGGACGCTGTTCCCTTCATA
CTTAAATGCCAGCCAGGTGCTGGCTGTGGGCTTCCCTCCCTAACACCCTTACTTAGTAGTGAGG
AAACTTTGTGTGGGGGAGATGTAGGCCTGTGCCCCAGAACAAGCTTTCTTTTTTCTGACTGGAT
CATCTCACCTTTTCTGGTTCCCTCCCACTCCAGCCATAGGCCTGTTCTTTTTCTTCCTTTCTGA
AAAATGTGACCAGTTCAAATTATGTCCCAGGACACGGGCCAGCGCCAGCTACCTCTGCAGACTC
TACAAGCGGAAGAGGGGAAGGCTCAGAAGGGAGGGCCATCTCCTGTAGCTCCCGGCAGTTGGTT
CTGGTGACACTGACATGAACCAGGTTCCAGAGGCTCACACCCACTCTCTGTTAAGCCTCCTCTC
GGGGAAGGGGACTCTGGGACTGGGGGCTGCCACTGAGCACACACACTCCTCCCATTTTCCAGAA
GTGAACATTTCACGTTTTGGTGCCGAATGTGAATCTGGGTGGGAAGAGCGGGAGCCCTTCTAAT
GGATGTTTTTTTTAACAGAGGTTATGGAATCCAAGGTCTGATCCCTGGAAACTTGTGTCACTTC
CAAAGAATCATGGGCTTTTTCGAATTAAAAAAAATTACACTTTTAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090267 ⟹ XP_038946195

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,140,834 - 33,176,722 (-)	NCBI
mRatBN7.2	13	30,588,036 - 30,624,034 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446273	(Get FASTA)	NCBI Sequence Viewer
	XP_038946195	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42004	(Get FASTA)	NCBI Sequence Viewer
	AAH72505	(Get FASTA)	NCBI Sequence Viewer
	EDL87913	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003413.6
	ENSRNOP00000087562.1
	ENSRNOP00055018279
	ENSRNOP00060006858
	ENSRNOP00065011543
GenBank Protein	P36860	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446273 ⟸ NM_053821

- UniProtKB:

P36860 (UniProtKB/Swiss-Prot), A6K7W8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQI
DILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGN
KSDLEERRQVPVEEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKS
GKSKKSFKERCCLL

hide sequence

Ensembl Acc Id:

ENSRNOP00000003413 ⟸ ENSRNOT00000003413

RefSeq Acc Id:	XP_038946195 ⟸ XM_039090267
- Peptide Label:	isoform X1
- UniProtKB:	P36860 (UniProtKB/Swiss-Prot), A6K7W8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087562 ⟸ ENSRNOT00000096405

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P36860-F1-model_v2	AlphaFold	P36860	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619852	AgrOrtholog
BioCyc Gene	G2FUF-18523	BioCyc
Ensembl Genes	ENSRNOG00000002440	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013141	UniProtKB/Swiss-Prot
	ENSRNOG00060005469	UniProtKB/Swiss-Prot
	ENSRNOG00065009578	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003413.7	UniProtKB/TrEMBL
	ENSRNOT00000096405.1	UniProtKB/Swiss-Prot
	ENSRNOT00055022511	UniProtKB/Swiss-Prot
	ENSRNOT00060009099	UniProtKB/Swiss-Prot
	ENSRNOT00065015348	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTPase_Ras-type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116546	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	116546	ENTREZGENE
PANTHER	PTHR24070	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24070:SF199	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ralb	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002440	RatGTEx
	ENSRNOG00055013141	RatGTEx
	ENSRNOG00060005469	RatGTEx
	ENSRNOG00065009578	RatGTEx
SMART	RAB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RHO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6K7W8	ENTREZGENE, UniProtKB/TrEMBL
	F1LQ62_RAT	UniProtKB/TrEMBL
	P36860	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-24	Ralb	RAS like proto-oncogene B	Ralb	RALB Ras like proto-oncogene B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-05-20	Ralb	RALB Ras like proto-oncogene B	Ralb	v-ral simian leukemia viral oncogene homolog B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-07-23	Ralb	v-ral simian leukemia viral oncogene homolog B	Ralb	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Ralb	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	Ralb	v-ral simian leukemia viral oncogene homolog B (ras related)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-22	Ralb	v-ral simian leukemia viral oncogene homolog B (ras related)	Ralb	v-ral simian leukemia viral oncogene homolog B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Ralb	v-ral simian leukemia viral oncogene homolog B			Symbol and Name updated	629477	APPROVED
2003-03-12	Ralb	v-ral simian leukemia viral oncogene homolog B	dRalb	v-ral simian leukemia viral oncogene homolog B (ras related)	Data merged from RGD:628783	628472	PROVISIONAL
2003-02-27	dRalb	v-ral simian leukemia viral oncogene homolog B (ras related)			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Ralb	v-ral simian leukemia viral oncogene homolog B (ras related)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_transcript	2.3 kb transcript is detected	633818

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)