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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-Nitrobenzanthrone
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Accession:CHEBI:181932 term browser browse the term
Synonyms:exact_synonym: 3-nitrobenzo[b]phenalen-7-one
 related_synonym: Formula=C17H9NO3;   InChI=1S/C17H9NO3/c19-17-12-5-2-1-4-10(12)11-8-9-15(18(20)21)13-6-3-7-14(17)16(11)13/h1-9H;   InChIKey=QAJOWHGESRCVLY-UHFFFAOYSA-N;   SMILES=O=C1C=2C3=C(C=4C1=CC=CC4)C=CC([N+]([O-])=O)=C3C=CC2
 xref: CAS:17117-34-9;   Chemspider:2103821;   KEGG:C20824
 xref_mesh: MESH:C117220


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3-Nitrobenzanthrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3bp ABI family member 3 binding protein increases expression ISO 3-nitrobenzanthrone results in increased expression of ABI3BP mRNA CTD PMID:34036453 NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ADAMTS1 mRNA CTD PMID:34036453 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Adgra2 adhesion G protein-coupled receptor A2 increases expression ISO 3-nitrobenzanthrone results in increased expression of ADGRA2 mRNA CTD PMID:34036453 NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483 		JBrowse link
G Adm2 adrenomedullin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ADM2 mRNA CTD PMID:34036453 NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-nitrobenzanthrone binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases reduction		 ISO [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases reduction		 ISO [AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction
multiple interactions		 ISO AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone
[AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone		 CTD PMID:30406992 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 3-nitrobenzanthrone results in increased expression of and results in increased phosphorylation of AKT1 protein; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein] CTD PMID:34036453 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ang angiogenin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ANG mRNA CTD PMID:34036453 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Apoe apolipoprotein E increases expression ISO 3-nitrobenzanthrone results in increased expression of APOE mRNA CTD PMID:34036453 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ARAP2 mRNA CTD PMID:34036453 NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154 		JBrowse link
G Areg amphiregulin increases expression ISO 3-nitrobenzanthrone results in increased expression of AREG mRNA CTD PMID:34036453 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of BICC1 mRNA CTD PMID:34036453 NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of BMP4 mRNA CTD PMID:34036453 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 3-nitrobenzanthrone results in increased expression of BMPER mRNA CTD PMID:34036453 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256 		JBrowse link
G Bnc2 basonuclin zinc finger protein 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of BNC2 mRNA CTD PMID:34036453 NCBI chr 5:98,679,071...99,016,044
Ensembl chr 5:98,687,410...99,079,426 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of BTG1 mRNA CTD PMID:34036453 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Cav1 caveolin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of CAV1 mRNA CTD PMID:34036453 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CCBE1 mRNA CTD PMID:34036453 NCBI chr18:59,579,851...59,823,977
Ensembl chr18:59,580,768...59,824,400 		JBrowse link
G Cd24 CD24 molecule increases expression ISO 3-nitrobenzanthrone results in increased expression of CD24 mRNA CTD PMID:34036453 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd34 CD34 molecule affects expression ISO 3-nitrobenzanthrone affects the expression of CD34 mRNA CTD PMID:34036453 NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CDH1 mRNA; 3-nitrobenzanthrone results in decreased expression of CDH1 protein CTD PMID:34036453 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk14 cyclin-dependent kinase 14 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CDK14 mRNA CTD PMID:34036453 NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3-nitrobenzanthrone results in increased expression of CDKN1A protein CTD PMID:25230394 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chrdl1 chordin-like 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CHRDL1 mRNA CTD PMID:34036453 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921 		JBrowse link
G Cldn3 claudin 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CLDN3 mRNA CTD PMID:34036453 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO 3-nitrobenzanthrone results in decreased expression of COL18A1 mRNA CTD PMID:34036453 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO 3-nitrobenzanthrone results in increased expression of COL5A2 mRNA CTD PMID:34036453 NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO 3-nitrobenzanthrone affects the expression of COL6A1 mRNA CTD PMID:34036453 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CTNNB1 mRNA CTD PMID:34036453 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO 3-nitrobenzanthrone results in increased expression of CXCL14 mRNA CTD PMID:19879285 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CXCR4 mRNA CTD PMID:34036453 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO CYP1A1 protein affects the reaction [3-nitrobenzanthrone results in increased abundance of Reactive Oxygen Species]
3-nitrobenzanthrone results in increased expression of CYP1A1 mRNA		 CTD PMID:17477947 PMID:25230394 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of CYP1B1 mRNA CTD PMID:34036453 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 affects expression ISO 3-nitrobenzanthrone affects the expression of DDR2 mRNA CTD PMID:34036453 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of DSC2 mRNA CTD PMID:34036453 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392 		JBrowse link
G Ecm1 extracellular matrix protein 1 affects expression ISO 3-nitrobenzanthrone affects the expression of ECM1 mRNA CTD PMID:34036453 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO 3-nitrobenzanthrone results in decreased expression of EPCAM mRNA CTD PMID:34036453 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Eps8l1 EPS8-like 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of EPS8L1 mRNA CTD PMID:34036453 NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ERBB2 mRNA CTD PMID:34036453 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ereg epiregulin increases expression
multiple interactions		 ISO 3-nitrobenzanthrone results in increased expression of EREG mRNA; 3-nitrobenzanthrone results in increased expression of EREG protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]		 CTD PMID:34036453 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Etv4 ETS variant transcription factor 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of ETV4 mRNA CTD PMID:34036453 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974 		JBrowse link
G F11r F11 receptor decreases expression ISO 3-nitrobenzanthrone results in decreased expression of F11R mRNA CTD PMID:34036453 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402 		JBrowse link
G Fbln1 fibulin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FBLN1 mRNA CTD PMID:34036453 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fbln5 fibulin 5 increases expression ISO 3-nitrobenzanthrone results in increased expression of FBLN5 mRNA CTD PMID:34036453 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755 		JBrowse link
G Fgf18 fibroblast growth factor 18 affects expression ISO 3-nitrobenzanthrone affects the expression of FGF18 mRNA CTD PMID:34036453 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of FGF2 mRNA CTD PMID:34036453 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FGF9 mRNA CTD PMID:34036453 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of FGFR2 mRNA CTD PMID:34036453 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FLT4 mRNA CTD PMID:34036453 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Foxo4 forkhead box O4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FOXO4 mRNA CTD PMID:34036453 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Fst follistatin increases expression ISO 3-nitrobenzanthrone results in increased expression of FST mRNA CTD PMID:34036453 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Gdf6 growth differentiation factor 6 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of GDF6 mRNA CTD PMID:34036453 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 3-nitrobenzanthrone results in increased expression of GREM1 mRNA CTD PMID:34036453 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of HIPK2 mRNA CTD PMID:34036453 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Hoxb3 homeo box B3 increases expression ISO 3-nitrobenzanthrone results in increased expression of HOXB3 mRNA CTD PMID:34036453 NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene CTD PMID:17483118 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ID2 mRNA CTD PMID:34036453 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of IGFBP4 mRNA CTD PMID:34036453 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Il15 interleukin 15 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IL15 mRNA CTD PMID:34036453 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IL18 mRNA CTD PMID:34036453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta affects expression ISO 3-nitrobenzanthrone affects the expression of IL1B mRNA CTD PMID:34036453 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion		 ISO 3-nitrobenzanthrone results in increased expression of IL6 mRNA
IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
3-nitrobenzanthrone results in increased secretion of IL6 protein		 CTD PMID:34036453 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO 3-nitrobenzanthrone results in increased expression of INHBA mRNA CTD PMID:34036453 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Irf6 interferon regulatory factor 6 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IRF6 mRNA CTD PMID:34036453 NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386 		JBrowse link
G Isl1 ISL LIM homeobox 1 affects expression ISO 3-nitrobenzanthrone affects the expression of ISL1 mRNA CTD PMID:34036453 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Itga1 integrin subunit alpha 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ITGA1 mRNA CTD PMID:34036453 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of ITGB1BP1 mRNA CTD PMID:34036453 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Itgb3 integrin subunit beta 3 affects expression ISO 3-nitrobenzanthrone affects the expression of ITGB3 mRNA CTD PMID:34036453 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itm2a integral membrane protein 2A affects expression ISO 3-nitrobenzanthrone affects the expression of ITM2A mRNA CTD PMID:34036453 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Jam2 junctional adhesion molecule 2 affects expression ISO 3-nitrobenzanthrone affects the expression of JAM2 mRNA CTD PMID:34036453 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063 		JBrowse link
G Jcad junctional cadherin 5 associated increases expression ISO 3-nitrobenzanthrone results in increased expression of JCAD mRNA CTD PMID:34036453 NCBI chr17:53,089,382...53,130,996
Ensembl chr17:53,089,382...53,130,967 		JBrowse link
G Krt7 keratin 7 affects expression ISO 3-nitrobenzanthrone affects the expression of KRT7 mRNA CTD PMID:34036453 NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052 		JBrowse link
G Lad1 ladinin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of LAD1 mRNA CTD PMID:34036453 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967 		JBrowse link
G Llgl2 LLGL scribble cell polarity complex component 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of LLGL2 mRNA CTD PMID:34036453 NCBI chr10:101,050,978...101,086,527
Ensembl chr10:101,051,408...101,086,525 		JBrowse link
G Lum lumican decreases expression ISO 3-nitrobenzanthrone results in decreased expression of LUM mRNA CTD PMID:34036453 NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO 3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:34036453 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO 3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]		 CTD PMID:34036453 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO 3-nitrobenzanthrone results in increased expression of MET mRNA; 3-nitrobenzanthrone results in increased expression of MET protein CTD PMID:34036453 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of MMP2 mRNA CTD PMID:34036453 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Myo1d myosin ID affects expression ISO 3-nitrobenzanthrone affects the expression of MYO1D mRNA CTD PMID:34036453 NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349 		JBrowse link
G Myo5c myosin VC decreases expression ISO 3-nitrobenzanthrone results in decreased expression of MYO5C mRNA CTD PMID:34036453 NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases activity		 ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone
NAT1 protein results in increased activity of 3-nitrobenzanthrone		 CTD PMID:15805261 PMID:20545351 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases activity
increases response to substance		 ISO [NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]
NAT2 protein results in increased activity of 3-nitrobenzanthrone
NAT2 protein results in increased susceptibility to 3-nitrobenzanthrone		 CTD PMID:15805261 PMID:17483118 PMID:20545351 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of NDRG1 mRNA CTD PMID:34036453 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nf1 neurofibromin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of NF1 mRNA CTD PMID:34036453 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects metabolic processing
affects response to substance
multiple interactions		 ISO NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone
NFE2L2 protein affects the susceptibility to 3-nitrobenzanthrone
[NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone] which affects the abundance of 3-aminobenzanthrone		 CTD PMID:31746589 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
increases metabolic processing
affects binding
multiple interactions
increases reduction		 ISO 3-nitrobenzanthrone results in increased expression of NQO1 mRNA
NQO1 protein results in increased activity of 3-nitrobenzanthrone
NQO1 protein results in increased metabolism of 3-nitrobenzanthrone
3-nitrobenzanthrone binds to NQO1 protein
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone		 CTD PMID:15805261 PMID:20545351 PMID:25230394 PMID:28922594 PMID:30406992 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of NR4A1 mRNA CTD PMID:34036453 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nrp1 neuropilin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of NRP1 mRNA CTD PMID:34036453 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 affects expression ISO 3-nitrobenzanthrone affects the expression of NRP2 mRNA CTD PMID:34036453 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 3-nitrobenzanthrone results in decreased expression of OAS1 mRNA CTD PMID:34036453 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Pdpn podoplanin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PDPN mRNA CTD PMID:34036453 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Pkn1 protein kinase N1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PKN1 mRNA CTD PMID:34036453 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Plxnd1 plexin D1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PLXND1 mRNA CTD PMID:34036453 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PMP22 mRNA CTD PMID:34036453 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [POR protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; POR protein results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppfibp2 PPFIA binding protein 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PPFIBP2 mRNA CTD PMID:34036453 NCBI chr 1:161,504,774...161,687,339
Ensembl chr 1:161,504,890...161,655,212 		JBrowse link
G Ppl periplakin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PPL mRNA CTD PMID:34036453 NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575 		JBrowse link
G Ptx3 pentraxin 3 increases expression ISO 3-nitrobenzanthrone results in increased expression of PTX3 mRNA CTD PMID:34036453 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PYCARD mRNA CTD PMID:34036453 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Ramp2 receptor activity modifying protein 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of RAMP2 mRNA CTD PMID:34036453 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of HLA-DPB1 mRNA CTD PMID:34036453 NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618 		JBrowse link
G Sema3e semaphorin 3E decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SEMA3E mRNA CTD PMID:34036453 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of SFRP1 mRNA CTD PMID:34036453 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Slc37a1 solute carrier family 37 member 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SLC37A1 mRNA CTD PMID:34036453 NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892 		JBrowse link
G Slit2 slit guidance ligand 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of SLIT2 mRNA CTD PMID:34036453 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of SNAI2 mRNA; 3-nitrobenzanthrone results in increased expression of SNAI2 protein CTD PMID:34036453 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO 3-nitrobenzanthrone results in increased expression of SNAI3 mRNA CTD PMID:34036453 NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression
multiple interactions		 ISO 3-nitrobenzanthrone results in increased expression of SOX9 mRNA; 3-nitrobenzanthrone results in increased expression of SOX9 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]		 CTD PMID:34036453 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SPINT1 mRNA CTD PMID:34036453 NCBI chr 3:106,231,082...106,244,121
Ensembl chr 3:106,231,444...106,244,119 		JBrowse link
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SPOCK3 mRNA CTD PMID:34036453 NCBI chr16:26,382,895...26,815,943
Ensembl chr16:26,383,383...26,815,205 		JBrowse link
G Srf serum response factor increases expression ISO 3-nitrobenzanthrone results in increased expression of SRF mRNA CTD PMID:34036453 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Srgn serglycin increases expression ISO 3-nitrobenzanthrone results in increased expression of SRGN mRNA CTD PMID:34036453 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of STAT1 mRNA CTD PMID:34036453 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO 3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]		 CTD PMID:34036453 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sulf1 sulfatase 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SULF1 mRNA CTD PMID:34036453 NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases response to substance
increases activity		 ISO [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene
SULT1A1 protein results in increased susceptibility to 3-nitrobenzanthrone
SULT1A1 protein results in increased activity of 3-nitrobenzanthrone		 CTD PMID:15805261 PMID:17483118 PMID:20545351 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SYNE1 mRNA CTD PMID:34036453 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322 		JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TCF4 mRNA CTD PMID:34036453 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of THBS1 mRNA CTD PMID:34036453 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of THBS2 mRNA CTD PMID:34036453 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 affects expression ISO 3-nitrobenzanthrone affects the expression of TIMP4 mRNA CTD PMID:34036453 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Tjp3 tight junction protein 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TJP3 mRNA CTD PMID:34036453 NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279 		JBrowse link
G Tnc tenascin C increases expression ISO 3-nitrobenzanthrone results in increased expression of TNC mRNA CTD PMID:34036453 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TNFSF12 mRNA CTD PMID:34036453 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213 		JBrowse link
G Tns1 tensin 1 affects expression ISO 3-nitrobenzanthrone affects the expression of TNS1 mRNA CTD PMID:34036453 NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225 		JBrowse link
G Tom1l1 target of myb1 like 1 membrane trafficking protein decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TOM1L1 mRNA CTD PMID:34036453 NCBI chr10:75,464,577...75,508,304
Ensembl chr10:75,464,577...75,508,250 		JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
increases mutagenesis		 ISO 3-nitrobenzanthrone results in decreased expression of TP53 mRNA; 3-nitrobenzanthrone results in decreased expression of TP53 protein
3-nitrobenzanthrone results in increased expression of TRP53 protein
3-nitrobenzanthrone results in increased mutagenesis of TP53 gene		 CTD PMID:18765419 PMID:25230394 PMID:34036453 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
affects expression		 ISO 3-nitrobenzanthrone results in increased expression of TWIST1 protein
3-nitrobenzanthrone affects the expression of TWIST1 mRNA		 CTD PMID:34036453 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Twist2 twist family bHLH transcription factor 2 multiple interactions
increases expression		 ISO EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein]
3-nitrobenzanthrone results in increased expression of TWIST2 mRNA; 3-nitrobenzanthrone results in increased expression of TWIST2 protein		 CTD PMID:34036453 NCBI chr 9:92,374,740...92,419,222
Ensembl chr 9:92,374,574...92,419,222 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of VAMP8 mRNA CTD PMID:34036453 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of ZEB1 mRNA CTD PMID:34036453 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ZEB2 mRNA CTD PMID:34036453 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        xenobiotic 18774
          phenanthrenes 303
            3-Nitrobenzanthrone 135
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                carbocyclic compound 18620
                                  carbopolycyclic compound 17191
                                    carbotricyclic compound 1561
                                      phenanthrenes 303
                                        3-Nitrobenzanthrone 135
paths to the root