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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-nonylphenol
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Accession:CHEBI:34440 term browser browse the term
Definition:A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Synonyms:related_synonym: 4-n-Nonylphenol;   Formula=C15H24O;   InChI=1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3;   InChIKey=IGFHQQFPSIBGKE-UHFFFAOYSA-N;   SMILES=CCCCCCCCCc1ccc(O)cc1;   p-Nonylphenol;   p-n-Nonylphenol;   para Nonyl phenol
 xref: CAS:104-40-5;   HMDB:HMDB0038982;   KEGG:C14550;   LINCS:LSM-19987
 xref_mesh: MESH:C041594
 xref: PMID:18506497;   PMID:21823570;   PMID:22133150;   PMID:24805085;   PPDB:1543;   Reaxys:2047450


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4-nonylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) decreases expression
multiple interactions		 EXP 4-nonylphenol results in decreased expression of ABCG2 protein
fulvestrant affects the reaction [4-nonylphenol results in decreased expression of ABCG2 protein]		 CTD PMID:27036933 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 multiple interactions ISO ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]] CTD PMID:28703301 NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 multiple interactions
affects response to substance		 ISO [ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein] CTD PMID:28703301 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO 4-nonylphenol results in increased expression of ADIPOQ protein CTD PMID:24388992 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of AFAP1L2 mRNA CTD PMID:23626723 NCBI chr10:114,280,725...114,405,175
Ensembl chr10:114,294,824...114,404,756 		JBrowse link
G AFP alpha fetoprotein affects binding ISO 4-nonylphenol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AHR aryl hydrocarbon receptor affects activity
affects binding
increases activity		 ISO
EXP		 4-nonylphenol affects the activity of AHR protein
4-nonylphenol binds to AHR protein
4-nonylphenol results in increased activity of AHR protein		 CTD PMID:18294747 PMID:20436506 PMID:28728110 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
decreases expression		 ISO 4-nonylphenol results in decreased phosphorylation of AKT1 protein
[bisphenol A co-treated with 4-nonylphenol] results in increased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased expression of AKT1 mRNA]		 CTD PMID:26804764 PMID:30228064 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 increases expression ISO 4-nonylphenol results in increased expression of AKT2 mRNA CTD PMID:30228064 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G AMH anti-Mullerian hormone decreases expression ISO 4-nonylphenol analog results in decreased expression of AMH mRNA CTD PMID:27086933 NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 affects expression
increases expression		 ISO 4-nonylphenol affects the expression of APAF1 mRNA
4-nonylphenol results in increased expression of APAF1 protein		 CTD PMID:26804764 PMID:27109770 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433 		JBrowse link
G AR androgen receptor affects activity
multiple interactions
decreases expression		 ISO
EXP		 4-nonylphenol affects the activity of AR protein
4-nonylphenol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
4-nonylphenol analog results in decreased expression of AR mRNA		 CTD PMID:16169144 PMID:18294747 PMID:27086933 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATG12 autophagy related 12 increases expression ISO 4-nonylphenol results in increased expression of ATG12 mRNA CTD PMID:28041982 PMID:30228064 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837 		JBrowse link
G ATG3 autophagy related 3 increases expression ISO 4-nonylphenol results in increased expression of ATG3 mRNA CTD PMID:28041982 NCBI chr 3:112,532,510...112,561,962
Ensembl chr 3:112,532,510...112,562,046 		JBrowse link
G ATG5 autophagy related 5 increases expression ISO 4-nonylphenol results in increased expression of ATG5 mRNA CTD PMID:28041982 PMID:30228064 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G ATG7 autophagy related 7 increases expression ISO 4-nonylphenol results in increased expression of ATG7 mRNA CTD PMID:28041982 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of B3GNT3 mRNA CTD PMID:23626723 NCBI chr19:17,794,791...17,813,576
Ensembl chr19:17,794,828...17,813,576 		JBrowse link
G B4GALT1 beta-1,4-galactosyltransferase 1 increases expression EXP 4-nonylphenol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,100,493...33,167,336 		JBrowse link
G BAD BCL2 associated agonist of cell death increases expression ISO 4-nonylphenol results in increased expression of BAD mRNA; 4-nonylphenol results in increased expression of BAD protein CTD PMID:26804764 PMID:27087316 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO
EXP		 3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]
4-nonylphenol results in decreased expression of BAX mRNA; 4-nonylphenol results in decreased expression of BAX protein
4-nonylphenol results in increased expression of BAX mRNA; 4-nonylphenol results in increased expression of BAX protein		 CTD PMID:15461258 PMID:26804032 PMID:26804764 PMID:27087316 PMID:27109770 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
decreases expression
multiple interactions		 EXP
ISO		 4-nonylphenol results in increased expression of BCL2 mRNA
4-nonylphenol results in decreased expression of BCL2 mRNA; 4-nonylphenol results in decreased expression of BCL2 protein
[bisphenol A co-treated with 4-nonylphenol] results in decreased expression of BCL2 mRNA		 CTD PMID:15461258 PMID:26804764 PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression ISO 4-nonylphenol results in decreased expression of BCL2L1 mRNA; 4-nonylphenol results in decreased expression of BCL2L1 protein CTD PMID:27087316 PMID:27109770 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BCL2L11 BCL2 like 11 increases expression ISO 4-nonylphenol results in increased expression of BCL2L11 protein CTD PMID:26804764 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
4-nonylphenol results in increased expression of BECN1 mRNA; 4-nonylphenol results in increased expression of BECN1 protein		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions ISO 4-nonylphenol results in increased cleavage of and results in increased activity of BID protein CTD PMID:22056370 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BTC betacellulin multiple interactions ISO [ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; [RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein] CTD PMID:28703301 NCBI chr 4:74,744,759...74,794,523
Ensembl chr 4:74,744,759...74,794,523 		JBrowse link
G CASP1 caspase 1 increases expression
decreases expression		 ISO 4-nonylphenol results in increased expression of CASP1 mRNA
4-nonylphenol results in decreased expression of CASP1 mRNA		 CTD PMID:27087316 PMID:27109770 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP2 caspase 2 increases expression ISO 4-nonylphenol results in increased expression of CASP2 mRNA CTD PMID:27087316 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CASP3 caspase 3 increases cleavage
multiple interactions
affects expression
increases expression		 ISO 4-nonylphenol results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 4-nonylphenol results in decreased expression of and results in increased phosphorylation of CASP3 protein; [bisphenol A co-treated with 4-nonylphenol] results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased expression of CASP3 protein modified form]
4-nonylphenol affects the expression of CASP3 mRNA
4-nonylphenol results in increased expression of and results in increased activity of CASP3 protein; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of and results in increased activity of CASP3 protein		 CTD PMID:22056370 PMID:26804764 PMID:27109770 PMID:29029336 PMID:30228064 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP4 caspase 4 increases expression ISO 4-nonylphenol results in increased expression of CASP4 mRNA CTD PMID:27087316 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP6 caspase 6 decreases expression ISO 4-nonylphenol results in decreased expression of CASP6 mRNA CTD PMID:27109770 NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583 		JBrowse link
G CASP7 caspase 7 decreases expression ISO 4-nonylphenol results in decreased expression of CASP7 mRNA CTD PMID:27109770 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 increases cleavage
decreases expression
increases expression
multiple interactions		 ISO 4-nonylphenol results in increased cleavage of CASP8 protein
4-nonylphenol results in decreased expression of CASP8 mRNA
4-nonylphenol results in increased expression of CASP8 mRNA
4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA]; bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA]		 CTD PMID:22056370 PMID:27087316 PMID:30228064 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases cleavage
increases expression
decreases expression		 ISO 4-nonylphenol results in increased cleavage of CASP9 protein
4-nonylphenol results in increased expression of CASP9 mRNA
4-nonylphenol results in decreased expression of CASP9 mRNA		 CTD PMID:22056370 PMID:27087316 PMID:27109770 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase decreases expression ISO 4-nonylphenol results in decreased expression of CAT mRNA CTD PMID:27087316 PMID:27109770 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCBE1 collagen and calcium binding EGF domains 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CCBE1 mRNA CTD PMID:23626723 NCBI chr18:59,430,939...59,697,721
Ensembl chr18:59,430,939...59,697,662 		JBrowse link
G CCN5 cellular communication network factor 5 increases expression
multiple interactions		 EXP 4-nonylphenol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr20:44,714,861...44,727,811
Ensembl chr20:44,714,844...44,728,509 		JBrowse link
G CCNA2 cyclin A2 decreases expression ISO 4-nonylphenol results in decreased expression of CCNA2 protein CTD PMID:26804764 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 increases expression ISO 4-nonylphenol results in increased expression of CCNB1 protein CTD PMID:26804764 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 decreases expression
increases expression		 ISO
EXP		 4-nonylphenol results in decreased expression of CCND1 protein
4-nonylphenol results in increased expression of CCND1 mRNA; 4-nonylphenol results in increased expression of CCND1 protein		 CTD PMID:26804032 PMID:26804764 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 decreases expression EXP 4-nonylphenol results in decreased expression of CCNE1 mRNA CTD PMID:26804032 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
decreases expression		 ISO
EXP		 4-nonylphenol results in increased expression of CDKN1A protein
4-nonylphenol results in decreased expression of CDKN1A protein		 CTD PMID:26804032 PMID:26804764 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
decreases expression		 ISO
EXP		 4-nonylphenol results in increased expression of CDKN1B protein
4-nonylphenol results in decreased expression of CDKN1B mRNA		 CTD PMID:26804032 PMID:26804764 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C increases expression EXP 4-nonylphenol results in increased expression of CDKN1C protein CTD PMID:26027920 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775 		JBrowse link
G CHEK1 checkpoint kinase 1 increases phosphorylation EXP 4-nonylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 increases phosphorylation EXP 4-nonylphenol results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013 		JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr15:78,624,111...78,661,641
Ensembl chr15:78,624,111...78,727,754 		JBrowse link
G COL14A1 collagen type XIV alpha 1 chain multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of COL14A1 mRNA CTD PMID:23626723 NCBI chr 8:120,124,454...120,373,573
Ensembl chr 8:120,059,780...120,373,573 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein] CTD PMID:23626723 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CSF1R mRNA CTD PMID:23626723 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372 		JBrowse link
G CSF2 colony stimulating factor 2 increases secretion EXP 4-nonylphenol results in increased secretion of CSF2 protein CTD PMID:20194071 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTSD cathepsin D increases expression EXP 4-nonylphenol results in increased expression of CTSD protein CTD PMID:26804032 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA CTD PMID:29029336 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions
decreases expression		 ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA
4-nonylphenol results in decreased expression of CYP17A1 mRNA		 CTD PMID:29029336 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression
multiple interactions		 ISO 4-nonylphenol results in decreased expression of CYP19A1 mRNA; 4-nonylphenol results in decreased expression of CYP19A1 protein
[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 protein		 CTD PMID:29029336 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression ISO 4-nonylphenol results in decreased expression of CYP1B1 mRNA CTD PMID:27087316 PMID:27109770 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression
multiple interactions		 EXP
ISO		 4-nonylphenol results in increased expression of CYP2B6 mRNA
4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]
4-nonylphenol results in increased expression of CYP2B10 mRNA
4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]		 CTD PMID:17483497 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G DIO2 iodothyronine deiodinase 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] CTD PMID:23626723 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] CTD PMID:23626723 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G DNMT3L DNA methyltransferase 3 like multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] CTD PMID:23626723 NCBI chr21:44,246,339...44,261,897
Ensembl chr21:44,246,339...44,262,216 		JBrowse link
G EBF2 EBF transcription factor 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of EBF2 mRNA CTD PMID:23626723 NCBI chr 8:25,841,725...26,045,413
Ensembl chr 8:25,841,725...26,045,413 		JBrowse link
G EEIG1 estrogen-induced osteoclastogenesis regulator 1 increases expression EXP 4-nonylphenol results in increased expression of EEIG1 mRNA CTD PMID:14605097 NCBI chr 9:127,940,582...127,980,989
Ensembl chr 9:127,940,582...127,980,989 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO 4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases expression EXP 4-nonylphenol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
increases activity
affects localization
affects binding		 EXP
ISO		 4-nonylphenol binds to and results in increased activity of ESR1 protein; 4-nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]
4-nonylphenol results in decreased expression of ESR1 mRNA
4-nonylphenol results in increased activity of ESR1 protein; 4-nonylphenol results in increased activity of ESR1 protein mutant form
4-nonylphenol affects the localization of ESR1 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]
4-nonylphenol binds to ESR1 protein
4-nonylphenol results in decreased expression of ESR1 mRNA; 4-nonylphenol results in decreased expression of ESR1 protein
4-nonylphenol analog results in decreased expression of ESR1 mRNA; 4-nonylphenol analog results in decreased expression of ESR1 protein		 CTD PMID:11518614 PMID:11530281 PMID:12127041 PMID:12598185 PMID:16393665 More... NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 affects localization
multiple interactions
affects binding
decreases expression		 ISO
EXP		 4-nonylphenol affects the localization of ESR2 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
4-nonylphenol binds to and results in increased activity of ESR2 protein; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA
4-nonylphenol binds to ESR2 protein
4-nonylphenol analog results in decreased expression of ESR2 mRNA; 4-nonylphenol analog results in decreased expression of ESR2 protein		 CTD PMID:11518614 PMID:12224631 PMID:19913605 PMID:20950447 PMID:21783566 More... NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FAM153A family with sequence similarity 153 member A multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of FAM153A mRNA CTD PMID:23626723 NCBI chr 5:177,694,247...177,783,425
Ensembl chr 5:177,707,981...177,784,435 		JBrowse link
G FAS Fas cell surface death receptor increases expression ISO 4-nonylphenol results in increased expression of FAS mRNA; 4-nonylphenol results in increased expression of FAS protein CTD PMID:27087316 PMID:27109770 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand increases expression ISO 4-nonylphenol results in increased expression of FASLG mRNA; 4-nonylphenol results in increased expression of FASLG protein CTD PMID:27087316 PMID:27109770 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FASN fatty acid synthase increases expression ISO 4-nonylphenol results in increased expression of FASN mRNA CTD PMID:24388992 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FCGR3A Fc gamma receptor IIIa multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of FCGR3A mRNA CTD PMID:23626723 NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP 4-nonylphenol results in increased expression of FOS mRNA; 4-nonylphenol results in increased expression of FOS protein CTD PMID:24308608 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression
multiple interactions		 ISO 4-nonylphenol results in decreased expression of FSHB protein
[4-nonylphenol results in increased susceptibility to bisphenol A] which results in increased secretion of FSHB protein		 CTD PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G GCNT4 glucosaminyl (N-acetyl) transferase 4 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of GCNT4 mRNA CTD PMID:23626723 NCBI chr 5:75,016,969...75,054,060
Ensembl chr 5:75,025,346...75,052,558 		JBrowse link
G GH1 growth hormone 1 increases secretion
increases expression
multiple interactions		 ISO 4-nonylphenol results in increased secretion of GH1 protein
4-nonylphenol results in increased expression of GH1 mRNA; 4-nonylphenol results in increased expression of GH1 protein
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]		 CTD PMID:19145065 PMID:19463694 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 increases expression EXP 4-nonylphenol results in increased expression of GPER1 mRNA CTD PMID:29783106 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815 		JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression ISO 4-nonylphenol results in decreased expression of GPX1 mRNA CTD PMID:27109770 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G H2AX H2A.X variant histone increases phosphorylation EXP 4-nonylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HAS2 hyaluronan synthase 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of HAS2 mRNA CTD PMID:23626723 NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440 		JBrowse link
G HBEGF heparin binding EGF like growth factor increases secretion
multiple interactions		 ISO 4-nonylphenol results in increased secretion of HBEGF protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]		 CTD PMID:28703301 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603 		JBrowse link
G HOXA1 homeobox A1 multiple interactions ISO 4-nonylphenol inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] CTD PMID:23696197 NCBI chr 7:27,092,993...27,096,000
Ensembl chr 7:27,092,993...27,096,000 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity EXP 4-nonylphenol results in decreased activity of HSD11B1 protein CTD PMID:16184081 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity EXP 4-nonylphenol results in decreased activity of HSD11B2 protein CTD PMID:16184081 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO 4-nonylphenol results in decreased expression of HSD3B1 mRNA CTD PMID:29029336 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G IFNG interferon gamma affects secretion
decreases expression		 EXP
ISO		 4-nonylphenol affects the secretion of IFNG protein
4-nonylphenol results in decreased expression of IFNG mRNA		 CTD PMID:20194071 PMID:27109770 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 increases secretion EXP 4-nonylphenol results in increased secretion of IL10 protein CTD PMID:20194071 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta affects secretion
affects expression		 EXP
ISO		 4-nonylphenol affects the secretion of IL1B protein
4-nonylphenol affects the expression of IL1B mRNA		 CTD PMID:20194071 PMID:27109770 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL4 interleukin 4 affects secretion EXP 4-nonylphenol affects the secretion of IL4 protein CTD PMID:20194071 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IYD iodotyrosine deiodinase multiple interactions EXP 4-nonylphenol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 6:150,369,012...150,405,969
Ensembl chr 6:150,368,892...150,405,969 		JBrowse link
G KCNB2 potassium voltage-gated channel subfamily B member 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of KCNB2 mRNA CTD PMID:23626723 NCBI chr 8:72,537,225...72,938,349
Ensembl chr 8:72,537,225...72,938,349 		JBrowse link
G KCNV1 potassium voltage-gated channel modifier subfamily V member 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KCNV1 mRNA CTD PMID:23626723 NCBI chr 8:109,963,636...109,975,771
Ensembl chr 8:109,963,636...109,975,771 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KLK6 mRNA CTD PMID:23626723 NCBI chr19:50,958,631...50,969,591
Ensembl chr19:50,958,631...50,969,673 		JBrowse link
G LAMP3 lysosomal associated membrane protein 3 decreases expression EXP 4-nonylphenol results in decreased expression of LAMP3 mRNA CTD PMID:20678512 NCBI chr 3:183,122,215...183,163,813
Ensembl chr 3:183,122,215...183,163,839 		JBrowse link
G LEP leptin increases expression ISO 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions
affects expression
decreases expression
increases secretion		 ISO 4-nonylphenol inhibits the reaction [bisphenol A results in increased secretion of LHB protein]; 4-nonylphenol results in decreased expression of and results in decreased secretion of LHB protein; bisphenol A inhibits the reaction [4-nonylphenol results in increased secretion of LHB protein]
4-nonylphenol affects the expression of LHB protein
4-nonylphenol results in decreased expression of LHB protein		 CTD PMID:15888928 PMID:17033158 PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G LPAR3 lysophosphatidic acid receptor 3 increases expression ISO 4-nonylphenol results in increased expression of LPAR3 mRNA CTD PMID:24460192 NCBI chr 1:84,811,602...84,893,206
Ensembl chr 1:84,811,602...84,893,206 		JBrowse link
G LPL lipoprotein lipase increases expression ISO 4-nonylphenol results in increased expression of LPL mRNA CTD PMID:24388992 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G LTF lactotransferrin multiple interactions EXP [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA CTD PMID:21783566 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234 		JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression ISO 4-nonylphenol results in increased expression of MAP1LC3A mRNA CTD PMID:30228064 NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO 4-nonylphenol results in increased phosphorylation of MAPK1 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK1 protein]
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]		 CTD PMID:17174995 PMID:19463694 PMID:20870566 PMID:20950447 PMID:28849599 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO 4-nonylphenol results in increased phosphorylation of MAPK3 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK3 protein]
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]		 CTD PMID:19463694 PMID:20870566 PMID:20950447 PMID:28849599 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK8 protein CTD PMID:27086933 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK9 protein CTD PMID:27086933 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 4-nonylphenol results in decreased expression of MCL1 protein CTD PMID:26804764 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
increases phosphorylation		 ISO 4-nonylphenol results in decreased phosphorylation of MTOR protein
4-nonylphenol inhibits the reaction [bisphenol A results in decreased expression of MTOR mRNA]; 4-nonylphenol inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NAALAD2 mRNA CTD PMID:23626723 NCBI chr11:90,131,699...90,192,894
Ensembl chr11:90,131,515...90,192,894 		JBrowse link
G NID1 nidogen 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NID1 mRNA CTD PMID:23626723 NCBI chr 1:235,975,830...236,065,090
Ensembl chr 1:235,975,830...236,065,109 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 affects binding
multiple interactions
increases activity		 EXP
ISO		 4-nonylphenol binds to NR1I2 protein
4-nonylphenol binds to and results in increased activity of NR1I2 protein
4-nonylphenol results in increased activity of NR1I2 protein
4-nonylphenol promotes the reaction [NR1I2 protein results in increased expression of CYP3A23-3A1 mRNA]		 CTD PMID:15792627 PMID:17483497 PMID:20869355 PMID:25680588 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity
multiple interactions
affects localization
increases response to substance		 EXP
ISO		 4-nonylphenol results in increased activity of NR1I3 protein; 4-nonylphenol results in increased activity of NR1I3 protein alternative form
1,5-benzothiazepine analog inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; 4-nonylphenol binds to and results in increased activity of NR1I3 protein; 4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form; 4-nonylphenol inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; PK 11195 results in decreased susceptibility to [4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form]
4-nonylphenol affects the localization of NR1I3 protein
4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]
NR1I3 protein results in increased susceptibility to 4-nonylphenol		 CTD PMID:17483497 PMID:20869355 PMID:21227907 PMID:21315811 PMID:28927721 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G OR10H1 olfactory receptor family 10 subfamily H member 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of OR10H1 mRNA CTD PMID:23626723 NCBI chr19:15,804,549...15,815,664
Ensembl chr19:15,804,549...15,815,664 		JBrowse link
G OR2T10 olfactory receptor family 2 subfamily T member 10 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of OR2T10 mRNA CTD PMID:23626723 NCBI chr 1:248,590,487...248,597,700
Ensembl chr 1:248,590,487...248,597,700 		JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta multiple interactions
decreases activity		 ISO 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]
4-nonylphenol results in decreased activity of P4HB protein		 CTD PMID:16617682 NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856 		JBrowse link
G PCNA proliferating cell nuclear antigen increases expression
decreases expression
affects expression		 EXP
ISO		 4-nonylphenol results in increased expression of PCNA mRNA
4-nonylphenol results in increased expression of PCNA protein
4-nonylphenol results in decreased expression of PCNA mRNA; 4-nonylphenol results in decreased expression of PCNA protein
4-nonylphenol affects the expression of PCNA mRNA		 CTD PMID:15461258 PMID:18839522 PMID:27087316 PMID:27109770 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PDZK1 PDZ domain containing 1 increases expression EXP 4-nonylphenol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:16393665 NCBI chr 1:145,670,852...145,707,400
Ensembl chr 1:145,670,852...145,708,148 		JBrowse link
G PGR progesterone receptor increases expression
decreases expression		 EXP
ISO		 4-nonylphenol results in increased expression of PGR mRNA
4-nonylphenol analog results in decreased expression of PGR mRNA		 CTD PMID:16393665 PMID:17033158 PMID:27086933 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases expression		 ISO 4-nonylphenol promotes the reaction [bisphenol A results in increased expression of PIK3CG mRNA]; bisphenol A promotes the reaction [4-nonylphenol results in increased expression of PIK3CG mRNA] CTD PMID:30228064 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G POU5F1 POU class 5 homeobox 1 increases expression ISO 4-nonylphenol results in increased expression of POU5F1 mRNA CTD PMID:20615461 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO 4-nonylphenol results in increased expression of PPARG mRNA CTD PMID:24388992 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPFIA4 PTPRF interacting protein alpha 4 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 NCBI chr 1:203,026,491...203,078,736
Ensembl chr 1:203,026,491...203,078,740 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein] CTD PMID:28041982 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [4-nonylphenol results in increased susceptibility to bisphenol A] which results in decreased expression of PRKAA2 mRNA; [bisphenol A co-treated with 4-nonylphenol] results in decreased expression of PRKAA2 mRNA CTD PMID:30228064 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335 		JBrowse link
G PRL prolactin increases expression
multiple interactions
increases secretion		 ISO 4-nonylphenol results in increased expression of PRL mRNA
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]
4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]		 CTD PMID:17174995 PMID:19463694 PMID:20950447 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PTEN phosphatase and tensin homolog increases expression
multiple interactions
decreases phosphorylation		 ISO 4-nonylphenol results in increased expression of PTEN mRNA
4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein]		 CTD PMID:30228064 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G RHBDF2 rhomboid 5 homolog 2 affects response to substance
multiple interactions		 ISO RHBDF2 protein affects the susceptibility to 4-nonylphenol
[RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein		 CTD PMID:28703301 NCBI chr17:76,470,893...76,501,427
Ensembl chr17:76,470,891...76,501,790 		JBrowse link
G ROPN1B rhophilin associated tail protein 1B multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of ROPN1B mRNA CTD PMID:23626723 NCBI chr 3:125,969,178...125,983,454
Ensembl chr 3:125,969,160...125,983,454 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:26804764 PMID:28041982 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G RXRA retinoid X receptor alpha decreases expression ISO 4-nonylphenol results in decreased expression of RXRA mRNA CTD PMID:16013040 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G S100G S100 calcium binding protein G increases expression ISO 4-nonylphenol results in increased expression of S100G mRNA; 4-nonylphenol results in increased expression of S100G protein CTD PMID:17365578 NCBI chr  X:16,650,158...16,654,670
Ensembl chr  X:16,650,158...16,654,670 		JBrowse link
G SBSPON somatomedin B and thrombospondin type 1 domain containing multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA CTD PMID:23626723 NCBI chr 8:73,064,543...73,093,172
Ensembl chr 8:73,064,543...73,124,088 		JBrowse link
G SDR16C5 short chain dehydrogenase/reductase family 16C member 5 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SDR16C5 mRNA CTD PMID:23626723 NCBI chr 8:56,300,005...56,320,175
Ensembl chr 8:56,300,005...56,320,776 		JBrowse link
G SERF1A small EDRK-rich factor 1A multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SERF1A mRNA CTD PMID:23626723 NCBI chr 5:70,900,669...70,918,530
Ensembl chr 5:70,025,251...70,043,113
Ensembl chr 5:70,025,251...70,043,113 		JBrowse link
G SHBG sex hormone binding globulin affects binding EXP 4-nonylphenol binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G SKIL SKI like proto-oncogene increases expression EXP 4-nonylphenol results in increased expression of SKIL protein CTD PMID:24308608 NCBI chr 3:170,357,715...170,396,849
Ensembl chr 3:170,357,342...170,396,835 		JBrowse link
G SLC7A7 solute carrier family 7 member 7 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SLC7A7 mRNA CTD PMID:23626723 NCBI chr14:22,773,222...22,819,791
Ensembl chr14:22,773,222...22,829,820 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions
decreases phosphorylation		 EXP fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SOD1 superoxide dismutase 1 decreases expression ISO 4-nonylphenol results in decreased expression of SOD1 mRNA CTD PMID:27087316 PMID:27109770 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO 4-nonylphenol results in increased expression of SREBF1 mRNA CTD PMID:24388992 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of STAR mRNA CTD PMID:29029336 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases metabolic processing EXP SULT1A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 increases metabolic processing EXP SULT1A3 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310 		JBrowse link
G SULT1B1 sulfotransferase family 1B member 1 increases metabolic processing EXP SULT1B1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr 4:69,721,167...69,760,620
Ensembl chr 4:69,721,167...69,787,961 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 multiple interactions EXP 4-nonylphenol inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 increases metabolic processing EXP SULT2A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G TF transferrin increases expression ISO 4-nonylphenol analog results in increased expression of TRF mRNA CTD PMID:27086933 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TFF1 trefoil factor 1 increases expression EXP 4-nonylphenol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TGFA transforming growth factor alpha multiple interactions
increases secretion		 ISO ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of TGFA protein] CTD PMID:28703301 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein] CTD PMID:31077750 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G TNF tumor necrosis factor affects secretion
increases expression
decreases expression		 EXP
ISO		 4-nonylphenol affects the secretion of TNF protein
4-nonylphenol results in increased expression of TNF mRNA; 4-nonylphenol results in increased expression of TNF protein
4-nonylphenol results in decreased expression of TNF protein		 CTD PMID:20194071 PMID:27109770 PMID:28490175 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 increases expression
increases phosphorylation		 ISO
EXP		 4-nonylphenol results in increased expression of TP53 mRNA; 4-nonylphenol results in increased expression of TP53 protein
4-nonylphenol results in increased phosphorylation of TP53 protein		 CTD PMID:27087316 PMID:27109770 PMID:32466334 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRMT9B tRNA methyltransferase 9B (putative) multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of TRMT9B mRNA CTD PMID:23626723 NCBI chr 8:12,945,673...13,029,777
Ensembl chr 8:12,945,642...13,031,503 		JBrowse link
G TSC2 TSC complex subunit 2 decreases phosphorylation
multiple interactions		 ISO 4-nonylphenol results in decreased phosphorylation of TSC2 protein
dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of TSC2 protein]		 CTD PMID:26804764 PMID:28041982 NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491 		JBrowse link
G TTR transthyretin multiple interactions EXP 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:31077750 NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833 		JBrowse link
G VIPR1 vasoactive intestinal peptide receptor 1 multiple interactions EXP [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of VIPR1 mRNA CTD PMID:23626723 NCBI chr 3:42,489,299...42,537,568
Ensembl chr 3:42,489,299...42,537,573 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26502
    role 26316
      chemical role 24355
        environmental contaminant 20994
          4-nonylphenol 158
Path 2
Term Annotations click to browse term
  CHEBI ontology 26502
    subatomic particle 26470
      composite particle 26478
        hadron 26478
          baryon 26478
            nucleon 26470
              atomic nucleus 26478
                atom 26478
                  main group element atom 26206
                    p-block element atom 26206
                      carbon group element atom 25649
                        carbon atom 25611
                          organic molecular entity 25611
                            organic molecule 25362
                              organic cyclic compound 24410
                                organic aromatic compound 24005
                                  phenols 21216
                                    4-nonylphenol 158
paths to the root