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Gene: CHRNB4 (cholinergic receptor nicotinic beta 4 subunit) Homo sapiens
Symbol: CHRNB4
Name: cholinergic receptor nicotinic beta 4 subunit
Description: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetylcholine receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit
Mus musculus (house mouse) : Chrnb4 (cholinergic receptor, nicotinic, beta polypeptide 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Canis lupus familiaris (dog) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrnb4 (cholinergic receptor nicotinic beta 4 subunit)
Sus scrofa (pig) : CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381578,623,282 - 78,655,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371578,916,636 - 78,933,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,703,691 - 76,720,642 (-)NCBINCBI36hg18NCBI36
Build 341576,703,690 - 76,720,642NCBI
Celera1555,852,898 - 55,869,734 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1555,674,500 - 55,691,566 (-)NCBIHuRef
CHM1_11579,035,191 - 79,052,089 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CHRNB4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732764
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.