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Gene: CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit) Homo sapiens
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Symbol: CHRNA4
Name: cholinergic receptor nicotinic alpha 4 subunit
Description: Exhibits acetylcholine receptor activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity. Involved in several processes, including DNA repair; behavioral response to nicotine; and response to hypoxia. Localizes to acetylcholine-gated channel complex. Implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Biomarker of Alzheimer's disease and Lewy body dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetylcholine receptor, nicotinic, alpha 4 (neuronal); BFNC; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; EBN; EBN1; FLJ95812; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
Orthologs:
Mus musculus (house mouse) : Chrna4 (cholinergic receptor, nicotinic, alpha polypeptide 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)
Canis lupus familiaris (dog) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)
Sus scrofa (pig) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2063,343,223 - 63,378,401 (-)EnsemblGRCh38hg38GRCh38
GRCh382063,343,223 - 63,375,471 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372061,974,662 - 62,009,487 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,445,109 - 61,463,192 (-)NCBINCBI36hg18NCBI36
Build 342061,446,464 - 61,463,192NCBI
Celera2058,652,104 - 58,670,128 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2058,700,254 - 58,717,202 (-)NCBIHuRef
CHM1_12061,875,694 - 61,893,903 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CHRNA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10356
Created: 2000-05-25
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.