CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)

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Gene: CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit) Homo sapiens

Analyze

Symbol:

CHRNA4

Name:

cholinergic receptor nicotinic alpha 4 subunit

RGD ID:

10356

HGNC Page

HGNC

Description:

Enables acetylcholine receptor activity and acetylcholine-gated cation-selective channel activity. Involved in several processes, including behavioral response to nicotine; membrane depolarization; and response to hypoxia. Part of acetylcholine-gated channel complex. Implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Biomarker of Alzheimer's disease and Lewy body dementia.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

acetylcholine receptor, nicotinic, alpha 4 (neuronal); BFNC; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; EBN; EBN1; FLJ95812; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,343,223 - 63,361,349 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	63,343,223 - 63,378,401 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	61,974,575 - 61,992,701 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,445,109 - 61,463,192 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	20	61,446,464 - 61,463,192	NCBI
Celera	20	58,652,104 - 58,670,128 (-)	NCBI
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	58,700,254 - 58,717,202 (-)	NCBI		HuRef
CHM1_1	20	61,875,694 - 61,893,903 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,149,372 - 65,167,972 (-)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (IEP)

amyotrophic lateral sclerosis (IAGP)

attention deficit hyperactivity disorder (EXP)

autistic disorder (EXP)

autosomal dominant nocturnal frontal lobe epilepsy (IAGP)

autosomal dominant nocturnal frontal lobe epilepsy 1 (IAGP)

autosomal recessive dyskeratosis congenita 5 (IAGP)

congestive heart failure (ISO)

developmental and epileptic encephalopathy (IAGP)

developmental and epileptic encephalopathy 33 (IAGP)

Developmental Disabilities (EXP)

dystonia (EXP)

early infantile epileptic encephalopathy (IAGP)

frontal lobe epilepsy (EXP)

frontotemporal dementia (IAGP)

genetic disease (IAGP)

Inflammation (EXP)

intellectual disability (IAGP)

Lewy body dementia (IEP)

nervous system disease (EXP)

neuronal ceroid lipofuscinosis (IAGP)

nicotine dependence (EXP,IAGP)

sleep disorder (EXP)

Tobacco Use Disorder (IAGP)

visual epilepsy (EXP,IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-lobeline (EXP)

(S)-anabasine (ISO)

(S)-nicotine (EXP,ISO)

1,1-dichloroethene (ISO)

1,1-dimethyl-4-phenylpiperazinium iodide (EXP,ISO)

1,2-dichloroethane (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

13-desmethylspirolide C (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP)

2,2',4,4'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

4-nonylphenol (EXP)

4-octylphenol (EXP)

5-fluorouracil (EXP)

6-propyl-2-thiouracil (ISO)

acetamiprid (ISO)

acetylcholine (EXP,ISO)

acrylamide (ISO)

alcuronium (EXP)

aldicarb (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

aluminium hydroxide (EXP)

Amaranth (ISO)

ammonium chloride (ISO)

Antimony trioxide (EXP)

aristolochic acid (EXP)

arsane (EXP)

arsenic atom (EXP)

arsenite(3-) (ISO)

atracurium (EXP)

atropine (EXP,ISO)

azoxystrobin (EXP)

barium(0) (ISO)

bendiocarb (ISO)

bentonite (EXP)

benzene (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Brilliant Blue (ISO)

butan-1-ol (EXP)

calcium atom (ISO)

calcium(0) (ISO)

carbachol (EXP,ISO)

carbamazepine (EXP)

carbaryl (ISO)

carbon nanotube (ISO)

chloroethene (ISO)

choline (EXP,ISO)

cisatracurium (EXP)

Citreoviridin (ISO)

clothianidin (EXP)

cocaine (ISO)

Cuprizon (ISO)

cytisine (EXP,ISO)

decabromodiphenyl ether (EXP)

decamethonium (EXP)

deguelin (EXP)

Desformylflustrabromine (EXP)

diazinon (ISO)

dichlorine (ISO)

dichloroacetic acid (ISO)

dichlorvos (EXP)

dieldrin (ISO)

diethyl maleate (EXP)

diethylstilbestrol (EXP)

dihydro-beta-erythroidine (EXP,ISO)

dioxygen (ISO)

dopamine (ISO)

elemental selenium (EXP)

epibatidine (EXP,ISO)

EPTC (ISO)

ethanol (ISO)

fenoxycarb (ISO)

fulvestrant (EXP)

galanthamine (EXP)

galanthamine Trifluoroacetic acid (EXP)

genistein (ISO)

hexachlorophene (ISO)

Hexamethonium (EXP,ISO)

imidacloprid (EXP,ISO)

indigo carmine (ISO)

magnesium dihydroxide (EXP)

Mecamylamine (EXP,ISO)

mercury dichloride (ISO)

methoxychlor (ISO)

methyllycaconitine (EXP,ISO)

Mivacurium (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nicotine (EXP,ISO)

nitrofen (ISO)

NS-398 (ISO)

ozone (ISO)

pancuronium (EXP)

paracetamol (ISO)

paraoxon (ISO)

phenobarbital (ISO)

physostigmine (EXP)

picoxystrobin (EXP)

potassium dichromate (ISO)

progesterone (EXP)

propoxur (ISO)

pyrazines (EXP)

pyridines (EXP)

pyrimidifen (EXP)

resveratrol (EXP)

rivastigmine (EXP)

rocuronium (EXP)

rotenone (EXP)

scopolamine (EXP)

selenium atom (EXP)

silicon dioxide (ISO)

sodium fluoride (ISO)

streptozocin (ISO)

succinylcholine (EXP)

Sunset Yellow FCF (ISO)

T-2 toxin (ISO)

tacrine (EXP,ISO)

tamoxifen (EXP)

tartrazine (ISO)

tetrachloroethene (EXP,ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thifluzamide (EXP)

toluene (EXP,ISO)

triphenyl phosphate (EXP)

Triptolide (ISO)

triptonide (ISO)

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (EXP,ISO)

tubocurarine (EXP,ISO)

tunicamycin (EXP)

urethane (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

varenicline (EXP,ISO)

vecuronium bromide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (ISO)

action potential (ISS)

B cell activation (ISO,ISS)

behavioral response to nicotine (IMP,ISO)

calcium ion transport (ISO,ISS)

chemical synaptic transmission (IBA,IEA,NAS)

cognition (IMP)

DNA repair (IMP)

excitatory postsynaptic potential (IEA)

exploration behavior (ISO)

inhibitory postsynaptic potential (ISO,ISS)

ion transmembrane transport (IBA,IEA)

ion transport (IEA,NAS)

locomotory behavior (ISO)

membrane depolarization (IDA,ISO,ISS)

nervous system process (IBA,IMP,ISO)

neuronal action potential (ISO)

regulation of acetylcholine-gated cation channel activity (ISO)

regulation of dopamine secretion (ISO,ISS)

regulation of membrane potential (IBA,ISO,ISS)

regulation of postsynaptic membrane potential (IEA)

regulation of synaptic vesicle exocytosis (ISO)

respiratory gaseous exchange by respiratory system (ISO)

response to acetylcholine (ISO)

response to hypoxia (IDA)

response to nicotine (IBA,IDA,ISO)

response to oxidative stress (IMP)

sensory perception of pain (ISO,ISS)

signal transduction (IBA,IDA)

synaptic transmission, cholinergic (IBA,ISO,ISS)

Cellular Component

acetylcholine-gated channel complex (IDA,IPI,ISO)

anchoring junction (IEA)

cellular anatomical entity (IEA)

cholinergic synapse (ISO)

dendrite (ISO,ISS)

dopaminergic synapse (ISO)

external side of plasma membrane (ISS)

integral component of membrane (IEA,NAS)

integral component of plasma membrane (IBA)

integral component of postsynaptic specialization membrane (ISO)

integral component of presynaptic membrane (ISO)

membrane (IEA,ISO,ISS)

neuron projection (IBA)

neuronal cell body (ISO,ISS)

plasma membrane (IEA,ISS,TAS)

postsynaptic membrane (IEA)

protein-containing complex (ISO)

synapse (IBA,IEA)

Molecular Function

acetylcholine binding (IC,ISO)

acetylcholine receptor activity (IDA,ISO)

acetylcholine-gated cation-selective channel activity (IBA,IDA,IEA,ISO,TAS)

excitatory extracellular ligand-gated ion channel activity (IBA)

extracellular ligand-gated ion channel activity (IEA)

heterocyclic compound binding (ISO)

ion channel activity (IEA)

ligand-gated ion channel activity (TAS)

neurotransmitter receptor activity (IBA)

protein binding (IPI,ISO)

protein-containing complex binding (ISO)

quaternary ammonium group binding (ISO)

transmembrane signaling receptor activity (IEA)

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (TAS)

alfentanil pharmacodynamics pathway (EXP)

bupivacaine pharmacodynamics pathway (EXP)

buprenorphine pharmacodynamics pathway (EXP)

chloroprocaine pharmacodynamics pathway (EXP)

citalopram pharmacodynamics pathway (EXP)

cocaine pharmacodynamics pathway (EXP)

codeine and morphine pharmacodynamics pathway (EXP)

desipramine pharmacodynamics pathway (EXP)

diphenoxylate pharmacodynamics pathway (EXP)

escitalopram pharmacodynamics pathway (EXP)

ethylmorphine pharmacodynamics pathway (EXP)

fentanyl pharmacodynamics pathway (EXP)

fluoxetine pharmacodynamics pathway (EXP)

heroin pharmacodynamics pathway (EXP)

hydrocodone pharmacodynamics pathway (EXP)

hydromorphone pharmacodynamics pathway (EXP)

imipramine pharmacodynamics pathway (EXP)

levacetylmethadol pharmacodynamics pathway (EXP)

levobupivacaine phgarmacodynamics pathway (EXP)

levorphanol pharmacodynamics pathway (EXP)

lidocaine pharmacodynamics pathway (EXP)

mepivacaine pharmacodynamics pathway (EXP)

methadone pharmacodynamics pathway (EXP)

nalbuphine pharmacodynamics pathway (EXP)

naloxone pharmacodynamics pathway (EXP)

naltrexone pharmacodynamics pathway (EXP)

nicotine pharmacodynamics pathway (EXP)

nicotine pharmacokinetics pathway (EXP)

oxybuprocaine pharmacodynamics pathway (EXP)

oxycodone pharmacodynamics pathway (EXP)

oxymorphone pharmacodynamics pathway (EXP)

pentazocine pharmacodynamics pathway (EXP)

prilocaine pharmacodynamics pathway (EXP)

procaine pharmacodynamics pathway (EXP)

remifentanil pharmacodynamics pathway (EXP)

ropivacaine pharmacodynamics pathway (EXP)

tramadol pharmacodynamics pathway (EXP)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Amyotrophic lateral sclerosis (IAGP)

Anxiety (IAGP)

Attention deficit hyperactivity disorder (IAGP)

Autosomal dominant inheritance (IAGP)

Bilateral tonic-clonic seizure (IAGP)

Childhood onset (IAGP)

Cognitive impairment (IAGP)

Confusional arousal (IAGP)

Depression (IAGP)

EEG with focal spikes (IAGP)

Focal hyperkinetic seizure (IAGP)

Focal-onset seizure (IAGP)

Frontotemporal dementia (IAGP)

Hyperventilation (IAGP)

Incomplete penetrance (IAGP)

Increased theta frequency activity in EEG (IAGP)

Intellectual disability (IAGP)

Intellectual disability, mild (IAGP)

Motor stereotypy (IAGP)

Nocturnal seizures (IAGP)

Paroxysmal dystonia (IAGP)

Psychotic mentation (IAGP)

Seizure (IAGP)

Somnambulism (IAGP)

Suicidal ideation (IAGP)

Urinary incontinence (IAGP)

References

References - curated


1.	Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2.	Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
3.	Bordia T, etal., J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. doi: 10.1124/jpet.112.194852. Epub 2012 May 1.
4.	GOA_HUMAN data from the GO Consortium
5.	Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
6.	Matsushima N, etal., Epilepsy Res 2002 Feb;48(3):181-6.
7.	Mouse Genome Database (MGD)
8.	OMIM Disease Annotation Pipeline
9.	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	RGD automated import pipeline for gene-chemical interactions
12.	RGD automated import pipeline for human HPO-to-gene-to-disease annotations
13.	Teaktong T, etal., J Neurol Sci 2004 Oct 15;225(1-2):39-49.
14.	Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.

Additional References at PubMed

PMID:1492743	PMID:1505988	PMID:2351675	PMID:7550350	PMID:7647781	PMID:7721089	PMID:7806245	PMID:8833159	PMID:8889548	PMID:8906617	PMID:8987816	PMID:9009220
PMID:10563623	PMID:11261808	PMID:11342559	PMID:11352901	PMID:11409698	PMID:11771745	PMID:11780052	PMID:12121305	PMID:12185808	PMID:12189247	PMID:12202488	PMID:12214130
PMID:12477932	PMID:12556914	PMID:12565129	PMID:12663058	PMID:12681012	PMID:12781587	PMID:12782394	PMID:12887442	PMID:12887446	PMID:14623738	PMID:15046869	PMID:15154117
PMID:15717291	PMID:15790597	PMID:15902904	PMID:15944128	PMID:16023355	PMID:16091357	PMID:16174636	PMID:16183856	PMID:16205844	PMID:16238698	PMID:16332175	PMID:16344560
PMID:16407231	PMID:16456787	PMID:16608406	PMID:16636791	PMID:16825297	PMID:16869227	PMID:17226798	PMID:17373692	PMID:17385675	PMID:17488453	PMID:17504247	PMID:17559419
PMID:17590520	PMID:17613539	PMID:17768273	PMID:17948872	PMID:17955458	PMID:17977823	PMID:17981562	PMID:18042647	PMID:18043764	PMID:18226955	PMID:18298895	PMID:18534558
PMID:18691652	PMID:18762859	PMID:18821565	PMID:18937294	PMID:18991851	PMID:19016604	PMID:19020039	PMID:19058789	PMID:19058950	PMID:19059502	PMID:19063970	PMID:19101612
PMID:19156168	PMID:19259974	PMID:19290018	PMID:19300482	PMID:19336370	PMID:19352218	PMID:19429020	PMID:19482438	PMID:19484724	PMID:19498063	PMID:19506906	PMID:19577488
PMID:19620239	PMID:19628475	PMID:19693267	PMID:19803686	PMID:19874574	PMID:19896235	PMID:20189461	PMID:20201926	PMID:20231857	PMID:20301348	PMID:20331911	PMID:20438829
PMID:20493238	PMID:20584212	PMID:20634891	PMID:20649589	PMID:20734064	PMID:20736995	PMID:20881005	PMID:20943775	PMID:21130611	PMID:21203548	PMID:21252231	PMID:21321393
PMID:21343288	PMID:21396349	PMID:21432576	PMID:21445957	PMID:21451042	PMID:21500914	PMID:21593077	PMID:21683344	PMID:21740768	PMID:21753767	PMID:21757735	PMID:21821135
PMID:21873635	PMID:21900206	PMID:22008229	PMID:22103306	PMID:22118295	PMID:22119468	PMID:22253823	PMID:22359659	PMID:22373960	PMID:22553201	PMID:22722381	PMID:22760121
PMID:22873564	PMID:22947540	PMID:23000369	PMID:23037950	PMID:23240931	PMID:23349463	PMID:23350800	PMID:23429692	PMID:23437071	PMID:23553665	PMID:23720086	PMID:23731290
PMID:23734673	PMID:23843950	PMID:24327142	PMID:24385388	PMID:24428733	PMID:24498031	PMID:24850280	PMID:24982426	PMID:25282705	PMID:25639542	PMID:25729002	PMID:25869137
PMID:25934188	PMID:26125703	PMID:26440539	PMID:26598620	PMID:26612384	PMID:26644472	PMID:26684647	PMID:26801076	PMID:26858154	PMID:26952864	PMID:26982087	PMID:27054571
PMID:27109789	PMID:27123786	PMID:27277673	PMID:27344019	PMID:27445102	PMID:27565302	PMID:27645992	PMID:27698419	PMID:27721068	PMID:27895161	PMID:28446611	PMID:28469204
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PMID:32814053	PMID:33657187	PMID:33961781

Genomics

Comparative Map Data

CHRNA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,343,223 - 63,361,349 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	63,343,223 - 63,378,401 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	61,974,575 - 61,992,701 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,445,109 - 61,463,192 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	20	61,446,464 - 61,463,192	NCBI
Celera	20	58,652,104 - 58,670,128 (-)	NCBI
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	58,700,254 - 58,717,202 (-)	NCBI		HuRef
CHM1_1	20	61,875,694 - 61,893,903 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,149,372 - 65,167,972 (-)	NCBI

Chrna4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	180,664,104 - 180,685,365 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	180,660,173 - 180,685,339 (-)	Ensembl
GRCm38	2	181,022,311 - 181,043,579 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	181,018,380 - 181,043,546 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	180,757,016 - 180,773,882 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	180,951,719 - 180,968,585 (-)	NCBI			mm8
Celera	2	185,108,778 - 185,125,645 (-)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	103.54	NCBI

Chrna4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	168,136,246 - 168,157,839 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	3	168,136,266 - 168,156,957 (-)	Ensembl
Rnor_6.0	3	176,533,182 - 176,547,965 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,527,516 - 176,548,208 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,243,234 - 180,258,017 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,171,214 - 170,185,998 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	170,077,249 - 170,092,033 (-)	NCBI
Celera	3	164,428,976 - 164,443,759 (+)	NCBI		Celera
RH 3.4 Map	3	1531.39	RGD
RH 3.4 Map	3	1564.7	RGD
Cytogenetic Map	3	q43	NCBI

Chrna4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	825,308 - 841,270 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955528	825,314 - 840,994 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	20	61,267,958 - 61,284,640 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	61,270,631 - 61,283,005 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	20	59,730,759 - 59,748,678 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CHRNA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	47,024,948 - 47,036,507 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	47,025,187 - 47,042,266 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	46,208,582 - 46,223,310 (-)	NCBI
ROS_Cfam_1.0	24	47,978,552 - 47,993,300 (-)	NCBI
ROS_Cfam_1.0 Ensembl	24	47,977,796 - 47,988,696 (-)	Ensembl
UMICH_Zoey_3.1	24	46,993,833 - 47,005,225 (-)	NCBI
UNSW_CanFamBas_1.0	24	47,118,082 - 47,132,739 (-)	NCBI
UU_Cfam_GSD_1.0	24	47,874,247 - 47,888,996 (-)	NCBI

Chrna4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	195,227,250 - 195,242,216 (-)	NCBI
SpeTri2.0	NW_004936514	10,680,893 - 10,695,859 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	62,420,546 - 62,436,165 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	62,424,672 - 62,436,646 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CHRNA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	851,790 - 862,685 (+)	NCBI	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666050	48,462,591 - 48,480,754 (+)	NCBI	Vero_WHO_p1.0

Chrna4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	29,026,908 - 29,044,464 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624741	29,024,668 - 29,039,684 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

D20S127E

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,976,386 - 61,976,515	UniSTS	GRCh37
Build 36	20	61,446,830 - 61,446,959	RGD	NCBI36
Celera	20	58,653,825 - 58,653,954	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,701,978 - 58,702,107	UniSTS
GeneMap99-G3 RH Map	20	2846.0	UniSTS

RH64135

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,976,381 - 61,976,493	UniSTS	GRCh37
Build 36	20	61,446,825 - 61,446,937	RGD	NCBI36
Celera	20	58,653,820 - 58,653,932	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,701,973 - 58,702,085	UniSTS

RH75305

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,975,789 - 61,975,968	UniSTS	GRCh37
Build 36	20	61,446,233 - 61,446,412	RGD	NCBI36
Celera	20	58,653,228 - 58,653,407	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,701,381 - 58,701,560	UniSTS

RH78607

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,974,825 - 61,974,966	UniSTS	GRCh37
Build 36	20	61,445,269 - 61,445,410	RGD	NCBI36
Celera	20	58,652,264 - 58,652,405	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,700,417 - 58,700,558	UniSTS

RH12050

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,975,502 - 61,975,626	UniSTS	GRCh37
Build 36	20	61,445,946 - 61,446,070	RGD	NCBI36
Celera	20	58,652,941 - 58,653,065	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,701,094 - 58,701,218	UniSTS

RH70691

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,976,688 - 61,976,843	UniSTS	GRCh37
Build 36	20	61,447,132 - 61,447,287	RGD	NCBI36
Celera	20	58,654,127 - 58,654,282	RGD
Cytogenetic Map	20	q13.2-q13.3	UniSTS
HuRef	20	58,702,280 - 58,702,435	UniSTS

CHRNA4_1625

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	20	61,976,384 - 61,977,245	UniSTS	GRCh37
Build 36	20	61,446,828 - 61,447,689	RGD	NCBI36
Celera	20	58,653,823 - 58,654,684	RGD
HuRef	20	58,701,976 - 58,702,837	UniSTS

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	3262
Count of miRNA genes:	1085
Interacting mature miRNAs:	1347
Transcripts:	ENST00000370263, ENST00000463705, ENST00000467563, ENST00000475033, ENST00000480012, ENST00000498043
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

High

Medium

216

206

295

Low

802

143

151

142

193

2712

124

480

425

Below cutoff

1994

2229

623

199

842

3482

1932

626

743

927

143

924

2376

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_011931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_000744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001256573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_046317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK296430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK314907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL121827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY786507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY816234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY857197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY857198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY857199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY878243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY878244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY956347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC096290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC096291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC096292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC096293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM710937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA530118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ093071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L35901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U62433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X87629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X89746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y08421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000370263 ⟹ ENSP00000359285

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,343,223 - 63,361,349 (-)	Ensembl

RefSeq Acc Id:

ENST00000463705

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,344,069 - 63,377,993 (-)	Ensembl

RefSeq Acc Id:

ENST00000467563

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,346,594 - 63,361,304 (-)	Ensembl

RefSeq Acc Id:

ENST00000475033

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,370,753 - 63,378,137 (-)	Ensembl

RefSeq Acc Id:

ENST00000480012

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,374,421 - 63,378,401 (-)	Ensembl

RefSeq Acc Id:

ENST00000498043 ⟹ ENSP00000429513

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,346,594 - 63,359,699 (-)	Ensembl

RefSeq Acc Id:

ENST00000615287 ⟹ ENSP00000483388

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,343,310 - 63,361,396 (-)	Ensembl

RefSeq Acc Id:

ENST00000626188

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,359,399 - 63,359,839 (-)	Ensembl

RefSeq Acc Id:

ENST00000627000 ⟹ ENSP00000486914

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,346,594 - 63,361,304 (-)	Ensembl

RefSeq Acc Id:

ENST00000627869

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,355,643 - 63,356,138 (-)	Ensembl

RefSeq Acc Id:

ENST00000628606

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	20	63,360,983 - 63,361,165 (-)	Ensembl

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB