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Gene: ADAM10 (ADAM metallopeptidase domain 10) Homo sapiens
Symbol: ADAM10
Name: ADAM metallopeptidase domain 10
Description: Exhibits metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Involved in several processes, including membrane protein ectodomain proteolysis; pore complex assembly; and positive regulation of T cell chemotaxis. Localizes to several cellular components, including perinuclear endoplasmic reticulum; pore complex; and tetraspanin-enriched microdomain. Implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; AD10; AD18; ADAM 10; CD156c; CDw156; disintegrin and metalloproteinase domain-containing protein 10; HsT18717; kuz; kuzbanian protein homolog; MADM; mammalian disintegrin-metalloprotease; RAK
Mus musculus (house mouse) : Adam10 (a disintegrin and metallopeptidase domain 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adam10 (ADAM metallopeptidase domain 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam10 (ADAM metallopeptidase domain 10)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM10 (ADAM metallopeptidase domain 10)
Canis lupus familiaris (dog) : ADAM10 (ADAM metallopeptidase domain 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam10 (ADAM metallopeptidase domain 10)
Sus scrofa (pig) : ADAM10 (ADAM metallopeptidase domain 10)
Chlorocebus sabaeus (African green monkey) : ADAM10 (ADAM metallopeptidase domain 10)
Heterocephalus glaber (naked mole-rat) : Adam10 (ADAM metallopeptidase domain 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1558,588,809 - 58,749,791 (-)EnsemblGRCh38hg38GRCh38
GRCh381558,588,809 - 58,749,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371558,887,403 - 59,042,177 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,675,802 - 56,829,469 (-)NCBINCBI36hg18NCBI36
Build 341556,676,368 - 56,829,469NCBI
Celera1535,776,749 - 35,930,110 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1535,711,409 - 35,864,717 (-)NCBIHuRef
CHM1_11559,005,400 - 59,160,121 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ADAM10
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735847
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.