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Gene: RPS6KB1 (ribosomal protein S6 kinase B1) Homo sapiens
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
Description: Exhibits protein serine/threonine/tyrosine kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; TOR signaling; and negative regulation of insulin receptor signaling pathway. Localizes to the mitochondrion and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 70 kDa ribosomal protein S6 kinase 1; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; P70S6K1; PS6K; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; s6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; STK14A
Mus musculus (house mouse) : Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6kb1 (ribosomal protein S6 kinase B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6kb1 (ribosomal protein S6 kinase B1)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KB1 (ribosomal protein S6 kinase B1)
Canis lupus familiaris (dog) : RPS6KB1 (ribosomal protein S6 kinase B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6kb1 (ribosomal protein S6 kinase B1)
Sus scrofa (pig) : RPS6KB1 (ribosomal protein S6 kinase B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381759,893,046 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,970,407 - 58,027,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RPS6KB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731644
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.