RPS6KB1 (ribosomal protein S6 kinase B1) - Rat Genome Database
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Gene: RPS6KB1 (ribosomal protein S6 kinase B1) Homo sapiens
Analyze
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
RGD ID: 731644
HGNC Page HGNC
Description: Exhibits protein serine/threonine/tyrosine kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; TOR signaling; and negative regulation of insulin receptor signaling pathway. Localizes to mitochondrion and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 70 kDa ribosomal protein S6 kinase 1; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; P70S6K1; PS6K; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; s6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; STK14A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100287072   LOC100996361  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,893,046 - 59,950,574 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,970,482 - 58,027,935 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371757,970,407 - 58,027,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-gambogic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
14,15-EET  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-bromopyruvic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrolein  (EXP)
actinomycin D  (EXP,ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha,alpha-trehalose  (ISO)
alpha-(methylamino)isobutyric acid  (EXP)
alternariol  (ISO)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
ANTIMYCIN  (EXP)
apigenin  (EXP)
arachidonic acid  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (EXP)
aucubin  (EXP)
avobenzone  (EXP)
azathioprine  (EXP,ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
BAPTA  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzofurans  (EXP)
beta-D-glucosamine  (EXP)
beta-thujaplicin  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
BMS-754807  (EXP)
bortezomib  (EXP)
bromobenzene  (ISO)
bucladesine  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin a  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbachol  (EXP)
carbon disulfide  (ISO)
celastrol  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysophanol  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
Corynoxine B  (EXP)
crocidolite asbestos  (EXP)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
dactolisib  (EXP)
daunorubicin  (EXP,ISO)
Deguelin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP)
Dictamnine  (EXP)
dieckol  (EXP)
dihydrolipoic acid  (ISO)
dimercaprol  (EXP)
dioscin  (EXP)
dioxygen  (EXP)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
enzacamene  (EXP)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
everolimus  (EXP,ISO)
fasudil hydrochloride  (EXP)
fingolimod hydrochloride  (EXP)
flavanones  (EXP)
flavokawain B  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
formaldehyde  (EXP)
frenolicin B  (EXP)
Fusaric acid  (ISO)
galangin  (EXP)
gefitinib  (EXP)
genistein  (ISO)
gingerol  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycerol 2-phosphate  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hexadecanoic acid  (EXP)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
IC-87114  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
KN-93  (ISO)
L-ascorbic acid 2-phosphate  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lonidamine  (EXP)
LY294002  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
metoprolol  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
ML-7  (ISO)
morin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (ISO)
naringin  (ISO)
neomycin  (ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
Nodularin  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oligopeptide  (EXP)
orotic acid  (EXP)
ouabain  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
paraquat  (EXP)
Parthenin  (EXP)
PD173074  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP)
pioglitazone  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
prazosin  (ISO)
progesterone  (ISO)
propranolol  (ISO)
puerarin  (EXP,ISO)
pyrvinium  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rottlerin  (ISO)
rucaparib  (EXP)
Salidroside  (ISO)
SB 203580  (ISO)
SB 415286  (EXP)
serpentine asbestos  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Sodium salicylate  (ISO)
sorafenib  (EXP)
stilbenoid  (EXP)
succimer  (ISO)
sulfates  (EXP)
sunitinib  (EXP)
superoxide  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
Tautomycin  (ISO)
Temsirolimus  (EXP,ISO)
teriflunomide  (EXP)
testosterone  (EXP,ISO)
thioacetamide  (ISO)
Thiorphan  (EXP)
torin 1  (EXP,ISO)
trametinib  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
ursolic acid  (EXP)
usnic acid  (EXP)
valproic acid  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zotarolimus  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEA,ISO)
apoptotic process  (IEA)
behavioral fear response  (IEA,ISO)
cell migration  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (IBA,ISO)
cellular response to interferon-gamma  (IEA,ISO)
cellular response to organic cyclic compound  (ISO)
G1/S transition of mitotic cell cycle  (IMP)
germ cell development  (IEA,ISO)
long-chain fatty acid import into cell  (ISO,ISS)
long-term memory  (IEA,ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IMP,ISO)
peptidyl-serine phosphorylation  (IBA,IMP,ISO)
phosphatidylinositol-mediated signaling  (TAS)
positive regulation of mitotic cell cycle  (IMP)
positive regulation of skeletal muscle tissue growth  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of translation  (IMP)
positive regulation of translational initiation  (IMP)
protein kinase B signaling  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
regulation of glucose import  (IEA,ISO)
response to amino acid  (ISO)
response to drug  (IEA,ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to glucagon  (IEA,ISO)
response to glucocorticoid  (ISO)
response to glucose  (IEA,ISO)
response to heat  (IEA,ISO)
response to insulin  (ISO)
response to leucine  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to nutrient  (IEA,ISO)
response to nutrient levels  (IDA)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to testosterone  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to tumor necrosis factor  (IEA,ISO)
response to wounding  (IEA,ISO)
signal transduction  (TAS)
skeletal muscle atrophy  (IEA,ISO)
skeletal muscle contraction  (IEA,ISO)
TOR signaling  (IBA,IDA,IMP)

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (IBA,IDA)
cytosol  (ISO,TAS)
mitochondrial outer membrane  (IEA)
mitochondrion  (IDA,ISO)
neuron projection  (IEA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
synapse  (IEA,ISO)

References

Additional References at PubMed
PMID:1922062   PMID:8871403   PMID:9271440   PMID:9427642   PMID:9445476   PMID:9465032   PMID:9653190   PMID:9804755   PMID:10089566   PMID:10197603   PMID:10200280   PMID:10567431  
PMID:10601311   PMID:10807185   PMID:10971657   PMID:10973943   PMID:11013237   PMID:11171059   PMID:11279232   PMID:11297520   PMID:11331760   PMID:11438723   PMID:11500364   PMID:11516946  
PMID:11733037   PMID:11774034   PMID:11853558   PMID:11914378   PMID:12014987   PMID:12019261   PMID:12023960   PMID:12052877   PMID:12054624   PMID:12150925   PMID:12150926   PMID:12477932  
PMID:12529391   PMID:12586835   PMID:12604610   PMID:12668683   PMID:12718876   PMID:12733712   PMID:12747804   PMID:12759354   PMID:12801526   PMID:12867426   PMID:12869548   PMID:14673156  
PMID:14679009   PMID:14702039   PMID:14709557   PMID:15024086   PMID:15028555   PMID:15066126   PMID:15071500   PMID:15149849   PMID:15158097   PMID:15203190   PMID:15236312   PMID:15249583  
PMID:15304500   PMID:15314020   PMID:15319361   PMID:15341740   PMID:15342556   PMID:15474452   PMID:15533996   PMID:15589845   PMID:15623621   PMID:15659381   PMID:15696579   PMID:15723049  
PMID:15760907   PMID:15790787   PMID:15809305   PMID:15812314   PMID:15843522   PMID:15854902   PMID:15896331   PMID:15899889   PMID:15905173   PMID:15953364   PMID:16049009   PMID:16109716  
PMID:16183647   PMID:16262259   PMID:16286006   PMID:16364302   PMID:16407298   PMID:16434552   PMID:16469801   PMID:16640565   PMID:16715128   PMID:16763566   PMID:16810323   PMID:16818690  
PMID:16826166   PMID:16837165   PMID:16839745   PMID:16883576   PMID:16895915   PMID:16899564   PMID:16914728   PMID:16922504   PMID:16931574   PMID:16962100   PMID:16964243   PMID:17043309  
PMID:17045920   PMID:17052453   PMID:17053147   PMID:17081983   PMID:17255101   PMID:17310252   PMID:17336708   PMID:17386266   PMID:17427199   PMID:17512525   PMID:17569770   PMID:17599906  
PMID:17604271   PMID:17616691   PMID:17622239   PMID:17693255   PMID:17908691   PMID:17936702   PMID:18025271   PMID:18279656   PMID:18423201   PMID:18451027   PMID:18461003   PMID:18498745  
PMID:18505677   PMID:18550814   PMID:18565837   PMID:18652687   PMID:18660489   PMID:18813808   PMID:18829578   PMID:18952604   PMID:19065636   PMID:19085255   PMID:19112174   PMID:19168580  
PMID:19171678   PMID:19240722   PMID:19266162   PMID:19285034   PMID:19322201   PMID:19402821   PMID:19553685   PMID:19730801   PMID:19801633   PMID:19815051   PMID:19864428   PMID:19881535  
PMID:19889638   PMID:19913121   PMID:19914247   PMID:19936974   PMID:19953087   PMID:19961954   PMID:19995915   PMID:20137651   PMID:20157535   PMID:20173664   PMID:20187284   PMID:20190034  
PMID:20374740   PMID:20410302   PMID:20423989   PMID:20433920   PMID:20459645   PMID:20599538   PMID:20599721   PMID:20617335   PMID:20628086   PMID:20657550   PMID:20731018   PMID:20819778  
PMID:20932932   PMID:20953835   PMID:20961652   PMID:21035469   PMID:21048031   PMID:21067588   PMID:21071439   PMID:21075311   PMID:21093473   PMID:21184268   PMID:21224254   PMID:21228102  
PMID:21258406   PMID:21289241   PMID:21292829   PMID:21297943   PMID:21390332   PMID:21397856   PMID:21424608   PMID:21440577   PMID:21444676   PMID:21460630   PMID:21467264   PMID:21536668  
PMID:21541441   PMID:21561857   PMID:21602892   PMID:21609291   PMID:21710263   PMID:21757621   PMID:21795849   PMID:21832049   PMID:21833088   PMID:21873635   PMID:21900206   PMID:21981924  
PMID:21986499   PMID:21988832   PMID:22017876   PMID:22110663   PMID:22113269   PMID:22248270   PMID:22286763   PMID:22348058   PMID:22391570   PMID:22439934   PMID:22442669   PMID:22457523  
PMID:22493283   PMID:22544753   PMID:22574368   PMID:22645648   PMID:22684641   PMID:22705322   PMID:22795649   PMID:22797923   PMID:22871496   PMID:22939624   PMID:22977662   PMID:23044732  
PMID:23045529   PMID:23128233   PMID:23184942   PMID:23251661   PMID:23273915   PMID:23276696   PMID:23330000   PMID:23376066   PMID:23393338   PMID:23443539   PMID:23632629   PMID:23639457  
PMID:23731517   PMID:23739915   PMID:23816567   PMID:23886172   PMID:23938603   PMID:24023352   PMID:24030155   PMID:24058693   PMID:24067973   PMID:24089522   PMID:24157791   PMID:24239466  
PMID:24247430   PMID:24277938   PMID:24280132   PMID:24287118   PMID:24332215   PMID:24337579   PMID:24396066   PMID:24440085   PMID:24447434   PMID:24456794   PMID:24469069   PMID:24501087  
PMID:24582588   PMID:24606695   PMID:24648513   PMID:24652283   PMID:24661902   PMID:24675012   PMID:24706758   PMID:24729449   PMID:24859886   PMID:24860943   PMID:24875531   PMID:24887566  
PMID:24901052   PMID:24936148   PMID:25061101   PMID:25118997   PMID:25134527   PMID:25165983   PMID:25220053   PMID:25241761   PMID:25273559   PMID:25311616   PMID:25356520   PMID:25379021  
PMID:25600244   PMID:25635535   PMID:25659153   PMID:25738361   PMID:25762619   PMID:25784113   PMID:25846498   PMID:26080838   PMID:26143260   PMID:26169935   PMID:26172298   PMID:26235873  
PMID:26238185   PMID:26362858   PMID:26427479   PMID:26468204   PMID:26496226   PMID:26496610   PMID:26506538   PMID:26514620   PMID:26582459   PMID:26626074   PMID:26818518   PMID:27053111  
PMID:27109477   PMID:27151441   PMID:27167192   PMID:27174914   PMID:27235588   PMID:27294524   PMID:27325676   PMID:27342859   PMID:27385002   PMID:27445438   PMID:27460085   PMID:27492635  
PMID:27493124   PMID:27503909   PMID:27595116   PMID:27634387   PMID:27663511   PMID:27729611   PMID:27742835   PMID:27765914   PMID:27780861   PMID:27846372   PMID:27863387   PMID:27900644  
PMID:27965359   PMID:27993682   PMID:28079472   PMID:28138309   PMID:28178239   PMID:28192480   PMID:28270148   PMID:28276898   PMID:28319113   PMID:28376174   PMID:28514442   PMID:28611215  
PMID:28716898   PMID:28718761   PMID:28792981   PMID:28877935   PMID:28986522   PMID:29117863   PMID:29270715   PMID:29305864   PMID:29335436   PMID:29403037   PMID:29483509   PMID:29507620  
PMID:29509190   PMID:29750193   PMID:29862445   PMID:30003927   PMID:30143258   PMID:30560585   PMID:30575818   PMID:30612880   PMID:30712414   PMID:30833605   PMID:30857853   PMID:31147451  
PMID:31541523   PMID:31757663   PMID:31957828   PMID:31959810   PMID:31997546   PMID:32020217   PMID:32054043   PMID:32098126   PMID:32295907   PMID:32814053   PMID:33189822  


Genomics

Comparative Map Data
RPS6KB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,893,046 - 59,950,574 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,970,482 - 58,027,935 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371757,970,407 - 58,027,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
Rps6kb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,389,695 - 86,435,711 (-)NCBIGRCm39mm39
GRCm381186,498,869 - 86,544,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,498,871 - 86,544,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,312,511 - 86,358,309 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,330,178 - 86,360,969 (-)NCBImm8
Celera1196,115,093 - 96,160,675 (-)NCBICelera
Cytogenetic Map11CNCBI
Rps6kb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21071,323,777 - 71,367,908 (-)NCBI
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Celera1070,248,523 - 70,289,589 (-)NCBICelera
Cytogenetic Map10q26NCBI
Rps6kb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554513,181,085 - 3,225,610 (-)NCBIChiLan1.0ChiLan1.0
RPS6KB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11758,798,930 - 58,856,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBIMhudiblu_PPA_v0panPan3
RPS6KB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl934,387,091 - 34,425,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1934,387,084 - 34,590,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rps6kb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364903,441,046 - 3,492,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,111,653 - 36,160,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11633,498,098 - 33,556,553 (-)NCBI
ChlSab1.1 Ensembl1633,497,392 - 33,556,453 (-)Ensembl
Rps6kb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248711,667,292 - 1,705,550 (+)NCBI

Position Markers
D17S1604  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,977,507 - 57,977,629UniSTSGRCh37
Build 361755,332,289 - 55,332,411RGDNCBI36
Celera1754,441,013 - 54,441,139RGD
Cytogenetic Map17qUniSTS
Cytogenetic Map17q23.1UniSTS
HuRef1753,350,038 - 53,350,164UniSTS
Marshfield Genetic Map1781.46UniSTS
Marshfield Genetic Map1781.46RGD
Genethon Genetic Map1782.9UniSTS
TNG Radiation Hybrid Map1726134.0UniSTS
Stanford-G3 RH Map172529.0UniSTS
Whitehead-YAC Contig Map17 UniSTS
GeneMap99-G3 RH Map173030.0UniSTS
D17S1994  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371758,024,375 - 58,024,724UniSTSGRCh37
Build 361755,379,157 - 55,379,506RGDNCBI36
Celera1754,487,890 - 54,488,239RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,396,837 - 53,397,186UniSTS
GeneMap99-G3 RH Map173024.0UniSTS
G42204  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,976,138 - 57,976,237UniSTSGRCh37
Build 361755,330,920 - 55,331,019RGDNCBI36
Celera1754,439,644 - 54,439,743RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,348,669 - 53,348,768UniSTS
RH69849  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371758,027,450 - 58,027,690UniSTSGRCh37
Build 361755,382,232 - 55,382,472RGDNCBI36
Celera1754,490,964 - 54,491,204RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,399,911 - 53,400,151UniSTS
GeneMap99-GB4 RH Map17372.64UniSTS
WI-17810  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,974,125 - 57,974,260UniSTSGRCh37
Build 361755,328,907 - 55,329,042RGDNCBI36
Celera1754,437,631 - 54,437,766RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,346,656 - 53,346,791UniSTS
GeneMap99-GB4 RH Map17375.6UniSTS
Whitehead-RH Map17432.5UniSTS
NCBI RH Map17665.5UniSTS
D17S1554  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371758,024,064 - 58,024,238UniSTSGRCh37
Build 361755,378,846 - 55,379,020RGDNCBI36
Cytogenetic Map17q23.1UniSTS
Whitehead-YAC Contig Map17 UniSTS
MARC_10535-10536:1000147856:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371720,640,792 - 20,641,161UniSTSGRCh37
GRCh371758,024,500 - 58,024,870UniSTSGRCh37
Build 361720,581,384 - 20,581,753RGDNCBI36
Celera1721,900,584 - 21,900,953RGD
Celera1754,488,015 - 54,488,385UniSTS
HuRef1753,396,962 - 53,397,332UniSTS
HuRef1719,843,681 - 19,844,050UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR128-1hsa-miR-128-3pOncomiRDBexternal_infoNANA22442669
MIR145hsa-miR-145-5pOncomiRDBexternal_infoNANA21917858

Predicted Target Of
Summary Value
Count of predictions:3525
Count of miRNA genes:1231
Interacting mature miRNAs:1533
Transcripts:ENST00000225577, ENST00000393021, ENST00000406116, ENST00000443572, ENST00000472940, ENST00000475155, ENST00000477179, ENST00000489824, ENST00000587061, ENST00000587622, ENST00000590928, ENST00000592726
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1750 1333 1199 218 1007 115 3698 1327 1626 201 1073 1485 120 1 1098 2306 5 2
Low 689 1646 527 406 932 350 659 870 2108 218 387 128 55 106 482 1
Below cutoff 12 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001272042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001272043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001272044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001272060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_161462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA424792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC245929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI806441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG614269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP359158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ719717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA444907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB050838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS498704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000225577   ⟹   ENSP00000225577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,121 - 59,950,574 (+)Ensembl
RefSeq Acc Id: ENST00000393021   ⟹   ENSP00000376744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,046 - 59,950,421 (+)Ensembl
RefSeq Acc Id: ENST00000406116   ⟹   ENSP00000384335
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,145 - 59,948,188 (+)Ensembl
RefSeq Acc Id: ENST00000443572   ⟹   ENSP00000441993
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,130 - 59,947,137 (+)Ensembl
RefSeq Acc Id: ENST00000472940   ⟹   ENSP00000468058
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,086 - 59,947,461 (+)Ensembl
RefSeq Acc Id: ENST00000475155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,945,191 - 59,946,941 (+)Ensembl
RefSeq Acc Id: ENST00000477179
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,126 - 59,913,805 (+)Ensembl
RefSeq Acc Id: ENST00000489824   ⟹   ENSP00000466562
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,893,138 - 59,931,692 (+)Ensembl
RefSeq Acc Id: ENST00000587061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,947,578 - 59,950,420 (+)Ensembl
RefSeq Acc Id: ENST00000587622
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,931,320 - 59,934,522 (+)Ensembl
RefSeq Acc Id: ENST00000590928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,934,145 - 59,935,037 (+)Ensembl
RefSeq Acc Id: ENST00000592726   ⟹   ENSP00000464805
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,906,988 - 59,914,668 (+)Ensembl
RefSeq Acc Id: NM_001272042   ⟹   NP_001258971
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
GRCh371757,970,407 - 58,027,787 (+)NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBI
CHM1_11758,034,428 - 58,091,804 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001272043   ⟹   NP_001258972
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,420 (+)NCBI
GRCh371757,970,407 - 58,027,787 (+)NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBI
CHM1_11758,034,428 - 58,091,804 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001272044   ⟹   NP_001258973
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
GRCh371757,970,407 - 58,027,787 (+)NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBI
CHM1_11758,034,428 - 58,091,804 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001272060   ⟹   NP_001258989
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
GRCh371757,970,407 - 58,027,787 (+)NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBI
CHM1_11758,034,428 - 58,091,804 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001369669   ⟹   NP_001356598
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369670   ⟹   NP_001356599
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369671   ⟹   NP_001356600
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369672   ⟹   NP_001356601
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369673   ⟹   NP_001356602
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369674   ⟹   NP_001356603
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369675   ⟹   NP_001356604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369676   ⟹   NP_001356605
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369677   ⟹   NP_001356606
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369678   ⟹   NP_001356607
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_001369679   ⟹   NP_001356608
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NM_003161   ⟹   NP_003152
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
GRCh371757,970,407 - 58,027,787 (+)NCBI
Build 361755,325,225 - 55,382,569 (+)NCBI Archive
HuRef1753,342,941 - 53,400,248 (+)NCBI
CHM1_11758,034,428 - 58,091,804 (+)NCBI
Sequence:
RefSeq Acc Id: NR_161455
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161456
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161457
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161458
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161459
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161460
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161461
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: NR_161462
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,950,574 (+)NCBI
RefSeq Acc Id: XM_011525102   ⟹   XP_011523404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,136 - 59,940,938 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958051
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,136 - 59,950,422 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258971 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258972 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258973 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258989 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356598 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356599 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356600 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356601 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356602 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356603 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356604 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356605 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356606 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356607 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356608 (Get FASTA)   NCBI Sequence Viewer  
  NP_003152 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36410 (Get FASTA)   NCBI Sequence Viewer  
  AAH36033 (Get FASTA)   NCBI Sequence Viewer  
  AAH53365 (Get FASTA)   NCBI Sequence Viewer  
  BAG35726 (Get FASTA)   NCBI Sequence Viewer  
  BAG56781 (Get FASTA)   NCBI Sequence Viewer  
  BAG59646 (Get FASTA)   NCBI Sequence Viewer  
  BAG61973 (Get FASTA)   NCBI Sequence Viewer  
  CAM82744 (Get FASTA)   NCBI Sequence Viewer  
  CDL93497 (Get FASTA)   NCBI Sequence Viewer  
  EAW94382 (Get FASTA)   NCBI Sequence Viewer  
  EAW94383 (Get FASTA)   NCBI Sequence Viewer  
  EAW94384 (Get FASTA)   NCBI Sequence Viewer  
  P23443 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_003152   ⟸   NM_003161
- Peptide Label: isoform a
- UniProtKB: P23443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258973   ⟸   NM_001272044
- Peptide Label: isoform d
- UniProtKB: P23443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258989   ⟸   NM_001272060
- Peptide Label: isoform e
- UniProtKB: P23443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258972   ⟸   NM_001272043
- Peptide Label: isoform c
- UniProtKB: P23443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258971   ⟸   NM_001272042
- Peptide Label: isoform b
- UniProtKB: P23443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011523404   ⟸   XM_011525102
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001356599   ⟸   NM_001369670
- Peptide Label: isoform g
RefSeq Acc Id: NP_001356602   ⟸   NM_001369673
- Peptide Label: isoform j
RefSeq Acc Id: NP_001356601   ⟸   NM_001369672
- Peptide Label: isoform i
RefSeq Acc Id: NP_001356608   ⟸   NM_001369679
- Peptide Label: isoform l
RefSeq Acc Id: NP_001356606   ⟸   NM_001369677
- Peptide Label: isoform l
RefSeq Acc Id: NP_001356607   ⟸   NM_001369678
- Peptide Label: isoform l
RefSeq Acc Id: NP_001356605   ⟸   NM_001369676
- Peptide Label: isoform l
RefSeq Acc Id: NP_001356603   ⟸   NM_001369674
- Peptide Label: isoform k
RefSeq Acc Id: NP_001356604   ⟸   NM_001369675
- Peptide Label: isoform k
RefSeq Acc Id: NP_001356598   ⟸   NM_001369669
- Peptide Label: isoform f
RefSeq Acc Id: NP_001356600   ⟸   NM_001369671
- Peptide Label: isoform h
RefSeq Acc Id: ENSP00000441993   ⟸   ENST00000443572
RefSeq Acc Id: ENSP00000384335   ⟸   ENST00000406116
RefSeq Acc Id: ENSP00000376744   ⟸   ENST00000393021
RefSeq Acc Id: ENSP00000468058   ⟸   ENST00000472940
RefSeq Acc Id: ENSP00000464805   ⟸   ENST00000592726
RefSeq Acc Id: ENSP00000466562   ⟸   ENST00000489824
RefSeq Acc Id: ENSP00000225577   ⟸   ENST00000225577
Promoters
RGD ID:6794665
Promoter ID:HG_KWN:26731
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000376094,   NM_016261,   OTTHUMT00000319324,   OTTHUMT00000319326,   OTTHUMT00000319327,   OTTHUMT00000319328,   UC002IXX.1,   UC010DDG.1,   UC010DDH.1,   UC010DDI.1,   UC010DDJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361755,324,921 - 55,325,862 (-)MPROMDB
RGD ID:7235867
Promoter ID:EPDNEW_H23680
Type:initiation region
Name:RPS6KB1_1
Description:ribosomal protein S6 kinase B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,893,121 - 59,893,181EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q22-23.2(chr17:56623275-60285107)x1 copy number loss See cases [RCV000511292] Chr17:56623275..60285107 [GRCh37]
Chr17:17q22-23.2
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q22-23.1(chr17:57582867-58080569)x3 copy number gain not provided [RCV000752157] Chr17:57582867..58080569 [GRCh37]
Chr17:17q22-23.1
benign
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2
pathogenic
NM_003161.4(RPS6KB1):c.135G>A (p.Glu45=) single nucleotide variant not provided [RCV000962529] Chr17:59893319 [GRCh38]
Chr17:57970680 [GRCh37]
Chr17:17q23.1
benign
NM_003161.4(RPS6KB1):c.141+8C>G single nucleotide variant not provided [RCV000896413] Chr17:59893333 [GRCh38]
Chr17:57970694 [GRCh37]
Chr17:17q23.1
likely benign
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2
pathogenic
NM_003161.4(RPS6KB1):c.313-8T>A single nucleotide variant not provided [RCV000958727] Chr17:59914627 [GRCh38]
Chr17:57991988 [GRCh37]
Chr17:17q23.1
benign
GRCh37/hg19 17q23.1(chr17:57931020-57986918)x1 copy number loss not provided [RCV001006909] Chr17:57931020..57986918 [GRCh37]
Chr17:17q23.1
uncertain significance
GRCh37/hg19 17q23.1(chr17:57616400-57986918)x1 copy number loss not provided [RCV001006908] Chr17:57616400..57986918 [GRCh37]
Chr17:17q23.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10436 AgrOrtholog
COSMIC RPS6KB1 COSMIC
Ensembl Genes ENSG00000108443 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000225577 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376744 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000384335 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000441993 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000464805 UniProtKB/TrEMBL
  ENSP00000466562 UniProtKB/TrEMBL
  ENSP00000468058 UniProtKB/TrEMBL
Ensembl Transcript ENST00000225577 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393021 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000406116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000443572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000472940 UniProtKB/TrEMBL
  ENST00000489824 UniProtKB/TrEMBL
  ENST00000592726 UniProtKB/TrEMBL
GTEx ENSG00000108443 GTEx
HGNC ID HGNC:10436 ENTREZGENE
Human Proteome Map RPS6KB1 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S6_kinase UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:6198 UniProtKB/Swiss-Prot
NCBI Gene 6198 ENTREZGENE
OMIM 608938 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PharmGKB PA34851 PharmGKB
PIRSF Ribsml_S6_kin_1 UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt K7EIM2_HUMAN UniProtKB/TrEMBL
  K7EMM2_HUMAN UniProtKB/TrEMBL
  K7ER06_HUMAN UniProtKB/TrEMBL
  KS6B1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G0X7_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R779 UniProtKB/Swiss-Prot
  B4DLT4 UniProtKB/Swiss-Prot
  B4DTG1 UniProtKB/Swiss-Prot
  E7ESB8 UniProtKB/Swiss-Prot
  F6UYM1 UniProtKB/Swiss-Prot
  Q7Z721 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 RPS6KB1  ribosomal protein S6 kinase B1    ribosomal protein S6 kinase, 70kDa, polypeptide 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 RPS6KB1  ribosomal protein S6 kinase, 70kDa, polypeptide 1  RPS6KB1  ribosomal protein S6 kinase, 70kDa, polypeptide 1  Symbol and/or name change 5135510 APPROVED