PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) - Rat Genome Database
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Gene: PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) Homo sapiens
Analyze
Symbol: PRKAA1
Name: protein kinase AMP-activated catalytic subunit alpha 1
RGD ID: 732865
HGNC Page HGNC
Description: Exhibits AMP-activated protein kinase activity. Involved in several processes, including CAMKK-AMPK signaling cascade; motor behavior; and neuron cellular homeostasis. Localizes to cytosol and nuclear speck. Implicated in Huntington's disease; breast cancer; and colon cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK subunit alpha-1; AMPKa1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; tau-protein kinase PRKAA1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl540,759,379 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh38540,759,379 - 40,798,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,759,481 - 40,798,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-nonylphenol  (ISO)
5-aminolevulinic acid  (ISO)
acadesine  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
afimoxifene  (EXP)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
amiodarone  (EXP)
amlexanox  (ISO)
ammonium chloride  (ISO)
ANTIMYCIN  (ISO)
apigenin  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
capsaicin  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
celecoxib  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cylindrospermopsin  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
Deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dioscin  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
econazole  (ISO)
enalapril  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (EXP)
histamine  (EXP)
hydrogen peroxide  (EXP)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
naproxen  (ISO)
nickel atom  (EXP)
nicotinamide  (EXP)
nitric oxide  (EXP)
Nonylphenol  (ISO)
O-palmitoylcarnitine  (EXP)
oleic acid  (EXP)
orlistat  (ISO)
orotic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
pentanal  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phorone  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
progesterone  (ISO)
pterostilbene  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 203580  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium azide  (ISO)
sodium dichromate  (ISO)
steviol  (ISO)
sumatriptan  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
theophylline  (EXP)
thioacetamide  (ISO)
thymoquinone  (EXP)
triacsin C  (ISO)
Tributyltin oxide  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
U0126  (ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (NAS)
bile acid and bile salt transport  (IEA,ISO)
bile acid signaling pathway  (IEA,ISO)
CAMKK-AMPK signaling cascade  (IC,IMP,TAS)
cell cycle arrest  (TAS)
cellular response to calcium ion  (ISO,ISS)
cellular response to drug  (IEA,ISO)
cellular response to ethanol  (IEA,ISO)
cellular response to glucose starvation  (ISO,ISS)
cellular response to glucose stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to nutrient levels  (ISO,ISS)
cellular response to organonitrogen compound  (IEA,ISO)
cellular response to oxidative stress  (ISO,ISS)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cholesterol biosynthetic process  (IEA)
cold acclimation  (IEA,ISO)
energy homeostasis  (ISO,ISS,TAS)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (ISO,ISS)
fatty acid oxidation  (IEA,ISO)
glucose homeostasis  (ISO,ISS)
glucose metabolic process  (IEA,ISO)
histone-serine phosphorylation  (IEA)
intracellular signal transduction  (IBA)
lipid biosynthetic process  (ISO,ISS)
macroautophagy  (TAS)
motor behavior  (IGI)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of gene expression  (ISO,ISS)
negative regulation of glucosylceramide biosynthetic process  (NAS)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of lipid catabolic process  (ISO,ISS)
negative regulation of TOR signaling  (ISO,ISS)
negative regulation of tubulin deacetylation  (ISO,ISS)
neuron cellular homeostasis  (IGI)
positive regulation of autophagy  (IDA,IMP,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular protein localization  (ISO,ISS)
positive regulation of cholesterol biosynthetic process  (NAS)
positive regulation of gene expression  (IDA,ISO)
positive regulation of glycolytic process  (ISO,ISS)
positive regulation of mitochondrial transcription  (IEA,ISO)
positive regulation of peptidyl-lysine acetylation  (ISO,ISS)
positive regulation of protein targeting to mitochondrion  (IEA,ISO)
positive regulation of skeletal muscle tissue development  (IEA,ISO)
protein phosphorylation  (IBA,IDA,IEA,ISO)
regulation of bile acid secretion  (IEA,ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of macroautophagy  (TAS)
regulation of microtubule cytoskeleton organization  (ISO,ISS)
regulation of peptidyl-serine phosphorylation  (IEA,ISO)
regulation of signal transduction by p53 class mediator  (TAS)
regulation of stress granule assembly  (IEA,ISO)
regulation of vesicle-mediated transport  (IEA,ISO)
response to 17alpha-ethynylestradiol  (IEA,ISO)
response to activity  (IEA,ISO)
response to caffeine  (IEA,ISO)
response to camptothecin  (IEA,ISO)
response to drug  (ISO)
response to gamma radiation  (ISO,ISS)
response to hydrogen peroxide  (ISO)
response to hypoxia  (NAS)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
signal transduction  (TAS)
Wnt signaling pathway  (IEA)

Cellular Component
apical plasma membrane  (IEA,ISO)
axon  (ISO,ISS)
cytoplasm  (IBA,IDA,ISO)
cytosol  (IDA,TAS)
dendrite  (ISO,ISS)
neuronal cell body  (ISO,ISS)
nuclear speck  (IDA)
nucleoplasm  (TAS)
nucleotide-activated protein kinase complex  (ISO,ISS,TAS)
nucleus  (IBA,ISO,ISS)
protein-containing complex  (ISO)

References

Additional References at PubMed
PMID:1322130   PMID:2900138   PMID:7907095   PMID:8094892   PMID:8163463   PMID:8621713   PMID:8626596   PMID:8663446   PMID:8910387   PMID:9091312   PMID:9224708   PMID:9710607  
PMID:9845345   PMID:9857077   PMID:10698692   PMID:10760274   PMID:10862786   PMID:11042152   PMID:11052978   PMID:11165240   PMID:11171059   PMID:11500364   PMID:11546797   PMID:11903059  
PMID:11913976   PMID:11971957   PMID:11997383   PMID:12091379   PMID:12194824   PMID:12368907   PMID:12391032   PMID:12477932   PMID:12788940   PMID:12791703   PMID:12847291   PMID:12853467  
PMID:12869384   PMID:12890675   PMID:14557259   PMID:14651849   PMID:14702039   PMID:14709557   PMID:14970221   PMID:14976552   PMID:14985344   PMID:14985505   PMID:15024086   PMID:15261145  
PMID:15485651   PMID:15489334   PMID:15866171   PMID:16054041   PMID:16054095   PMID:16306228   PMID:16344560   PMID:16405649   PMID:16466905   PMID:16806233   PMID:16912160   PMID:17028174  
PMID:17088252   PMID:17584647   PMID:18195011   PMID:18276112   PMID:18303014   PMID:18347656   PMID:18359290   PMID:18403135   PMID:18439900   PMID:18480843   PMID:18614941   PMID:18663353  
PMID:18674809   PMID:18801964   PMID:18836454   PMID:18950855   PMID:18976975   PMID:18996102   PMID:19020741   PMID:19049348   PMID:19050283   PMID:19138981   PMID:19197243   PMID:19211918  
PMID:19322201   PMID:19442239   PMID:19491292   PMID:19502591   PMID:19556893   PMID:19616115   PMID:19720090   PMID:19723093   PMID:19723094   PMID:19723101   PMID:19723105   PMID:19728147  
PMID:19887561   PMID:19913121   PMID:19914239   PMID:19923924   PMID:19948975   PMID:19966861   PMID:20080969   PMID:20103647   PMID:20167678   PMID:20217115   PMID:20368287   PMID:20368732  
PMID:20392842   PMID:20462511   PMID:20538596   PMID:20562859   PMID:20564492   PMID:20602615   PMID:20615388   PMID:20628086   PMID:20660302   PMID:20682687   PMID:20801214   PMID:20821366  
PMID:20861072   PMID:20876741   PMID:21048031   PMID:21072212   PMID:21079763   PMID:21088205   PMID:21209024   PMID:21232561   PMID:21344388   PMID:21416543   PMID:21432774   PMID:21460634  
PMID:21474997   PMID:21516116   PMID:21567395   PMID:21651489   PMID:21670147   PMID:21678424   PMID:21728993   PMID:21775054   PMID:21807092   PMID:21873635   PMID:21892142   PMID:21909354  
PMID:21988832   PMID:21994947   PMID:22007913   PMID:22012985   PMID:22021095   PMID:22037551   PMID:22065577   PMID:22065581   PMID:22212710   PMID:22363791   PMID:22378745   PMID:22406815  
PMID:22419736   PMID:22434430   PMID:22462548   PMID:22480519   PMID:22553202   PMID:22564965   PMID:22607554   PMID:22674476   PMID:22688514   PMID:22810586   PMID:22815988   PMID:22833096  
PMID:22869372   PMID:22897928   PMID:22935535   PMID:22939624   PMID:22939629   PMID:22988252   PMID:23000302   PMID:23022380   PMID:23171948   PMID:23221389   PMID:23228943   PMID:23291726  
PMID:23306156   PMID:23324179   PMID:23367447   PMID:23376776   PMID:23417417   PMID:23418352   PMID:23453806   PMID:23455922   PMID:23463002   PMID:23475945   PMID:23506848   PMID:23589839  
PMID:23592276   PMID:23602568   PMID:23625915   PMID:23648710   PMID:23671028   PMID:23677989   PMID:23685869   PMID:23712032   PMID:23716691   PMID:23723070   PMID:23728343   PMID:23778007  
PMID:23800577   PMID:23819460   PMID:23861218   PMID:23878245   PMID:23883584   PMID:23899558   PMID:23904275   PMID:23963659   PMID:23982477   PMID:24018441   PMID:24047437   PMID:24055274  
PMID:24072697   PMID:24080159   PMID:24095280   PMID:24104889   PMID:24166503   PMID:24186207   PMID:24190973   PMID:24371122   PMID:24395629   PMID:24414799   PMID:24419061   PMID:24441100  
PMID:24472739   PMID:24491542   PMID:24561578   PMID:24619908   PMID:24655923   PMID:24700636   PMID:24711643   PMID:24722188   PMID:24770722   PMID:24797263   PMID:24799027   PMID:24871657  
PMID:24916949   PMID:24925061   PMID:24955726   PMID:24988326   PMID:25017332   PMID:25024613   PMID:25025067   PMID:25047736   PMID:25122135   PMID:25151490   PMID:25225183   PMID:25256353  
PMID:25330949   PMID:25348630   PMID:25356873   PMID:25362209   PMID:25367309   PMID:25404641   PMID:25412657   PMID:25416956   PMID:25425646   PMID:25484082   PMID:25556665   PMID:25586669  
PMID:25595658   PMID:25632961   PMID:25651975   PMID:25656579   PMID:25659498   PMID:25679763   PMID:25686248   PMID:25687571   PMID:25703587   PMID:25727016   PMID:25751139   PMID:25751140  
PMID:25840010   PMID:25846811   PMID:25852190   PMID:25858560   PMID:25874865   PMID:25902870   PMID:25921289   PMID:25933205   PMID:25937278   PMID:25955819   PMID:25963833   PMID:25980607  
PMID:26001218   PMID:26029847   PMID:26041108   PMID:26058395   PMID:26103054   PMID:26121488   PMID:26124005   PMID:26129866   PMID:26143491   PMID:26186194   PMID:26196392   PMID:26198640  
PMID:26232429   PMID:26236947   PMID:26260992   PMID:26276392   PMID:26322680   PMID:26330165   PMID:26339598   PMID:26344197   PMID:26397839   PMID:26398719   PMID:26427441   PMID:26437602  
PMID:26439621   PMID:26447757   PMID:26456332   PMID:26479318   PMID:26485766   PMID:26486079   PMID:26496610   PMID:26520441   PMID:26544976   PMID:26549445   PMID:26549816   PMID:26616021  
PMID:26638075   PMID:26642043   PMID:26644014   PMID:26648451   PMID:26655341   PMID:26707164   PMID:26718214   PMID:26755628   PMID:26772531   PMID:26804175   PMID:26843621   PMID:26876938  
PMID:26999735   PMID:27001465   PMID:27021965   PMID:27041569   PMID:27060201   PMID:27072494   PMID:27103439   PMID:27103440   PMID:27107012   PMID:27121290   PMID:27150059   PMID:27251406  
PMID:27259535   PMID:27304906   PMID:27305174   PMID:27322180   PMID:27364911   PMID:27416781   PMID:27430620   PMID:27449087   PMID:27497953   PMID:27534430   PMID:27568570   PMID:27612659  
PMID:27657826   PMID:27661114   PMID:27687210   PMID:27689873   PMID:27726301   PMID:27751856   PMID:27758862   PMID:27794481   PMID:27797909   PMID:27813479   PMID:27840174   PMID:27840318  
PMID:27864418   PMID:27878239   PMID:27878249   PMID:27902686   PMID:27914812   PMID:27996156   PMID:28008135   PMID:28009297   PMID:28052040   PMID:28059666   PMID:28065882   PMID:28085543  
PMID:28103582   PMID:28147330   PMID:28186975   PMID:28234358   PMID:28258165   PMID:28259820   PMID:28298606   PMID:28319085   PMID:28330873   PMID:28336748   PMID:28386764   PMID:28438603  
PMID:28440461   PMID:28466106   PMID:28514442   PMID:28515276   PMID:28524645   PMID:28560405   PMID:28561066   PMID:28562331   PMID:28600513   PMID:28639909   PMID:28647373   PMID:28651973  
PMID:28665143   PMID:28675297   PMID:28743498   PMID:28791376   PMID:28847510   PMID:28876465   PMID:28919424   PMID:28923415   PMID:28978464   PMID:29024810   PMID:29039450   PMID:29048631  
PMID:29079190   PMID:29094484   PMID:29115402   PMID:29122080   PMID:29133590   PMID:29172540   PMID:29203239   PMID:29222348   PMID:29247651   PMID:29284117   PMID:29306791   PMID:29339542  
PMID:29343420   PMID:29413962   PMID:29448096   PMID:29484444   PMID:29504441   PMID:29526819   PMID:29540478   PMID:29566977   PMID:29620653   PMID:29654166   PMID:29702405   PMID:29725013  
PMID:29755474   PMID:29892012   PMID:29982462   PMID:30007356   PMID:30056112   PMID:30057310   PMID:30096433   PMID:30104247   PMID:30109811   PMID:30111748   PMID:30140075   PMID:30157903  
PMID:30206123   PMID:30230919   PMID:30232152   PMID:30253744   PMID:30270274   PMID:30334324   PMID:30340465   PMID:30347867   PMID:30373152   PMID:30405100   PMID:30413706   PMID:30424508  
PMID:30428154   PMID:30431068   PMID:30463013   PMID:30475873   PMID:30509973   PMID:30527811   PMID:30530493   PMID:30574617   PMID:30606143   PMID:30718913   PMID:30733294   PMID:30733434  
PMID:30737378   PMID:30818055   PMID:30856283   PMID:30881990   PMID:30993829   PMID:30997723   PMID:31042624   PMID:31053472   PMID:31060777   PMID:31091453   PMID:31115373   PMID:31144451  
PMID:31217475   PMID:31232032   PMID:31358902   PMID:31395901   PMID:31409640   PMID:31413360   PMID:31515488   PMID:31530214   PMID:31530934   PMID:31580256   PMID:31584290   PMID:31727877  
PMID:31841039   PMID:31900314   PMID:31980649   PMID:32029897   PMID:32098961   PMID:32132656   PMID:32193335   PMID:32382009   PMID:32417395   PMID:32457219   PMID:32588910   PMID:32603375  
PMID:32663610   PMID:32759774   PMID:33022274  


Genomics

Comparative Map Data
PRKAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl540,759,379 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh38540,759,379 - 40,798,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,759,481 - 40,798,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
Prkaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBImm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
Prkaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,240,298 - 54,275,978 (+)NCBI
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBICelera
Cytogenetic Map2q16NCBI
Prkaa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
PRKAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,627,844 - 74,666,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0panPan3
PRKAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,321 - 25,783,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBI
Prkaa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBI

Position Markers
STS-N23112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,798,990 - 40,799,152UniSTSGRCh37
Build 36540,834,747 - 40,834,909RGDNCBI36
Celera540,687,582 - 40,687,744RGD
Cytogenetic Map5p12UniSTS
HuRef540,750,877 - 40,751,039UniSTS
GeneMap99-GB4 RH Map5147.51UniSTS
SGC34175  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,759,515 - 40,759,640UniSTSGRCh37
Build 36540,795,272 - 40,795,397RGDNCBI36
Celera540,648,100 - 40,648,225RGD
Cytogenetic Map5p12UniSTS
HuRef540,711,338 - 40,711,463UniSTS
GeneMap99-GB4 RH Map5136.46UniSTS
Whitehead-RH Map5126.5UniSTS
NCBI RH Map5155.9UniSTS
RH18516  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,759,515 - 40,759,691UniSTSGRCh37
Build 36540,795,272 - 40,795,448RGDNCBI36
Celera540,648,100 - 40,648,276RGD
Cytogenetic Map5p12UniSTS
HuRef540,711,338 - 40,711,514UniSTS
GeneMap99-GB4 RH Map5147.72UniSTS
RH71041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,773,238 - 40,773,392UniSTSGRCh37
Build 36540,808,995 - 40,809,149RGDNCBI36
Celera540,661,830 - 40,661,984RGD
Cytogenetic Map5p12UniSTS
HuRef540,725,069 - 40,725,223UniSTS
GeneMap99-GB4 RH Map5147.72UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR652hsa-miR-652-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:2194
Count of miRNA genes:1055
Interacting mature miRNAs:1293
Transcripts:ENST00000296800, ENST00000354209, ENST00000397006, ENST00000397128, ENST00000505783, ENST00000506652, ENST00000509874, ENST00000511248, ENST00000513152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2423 2148 1670 608 1557 449 3992 1549 2084 362 1435 1609 175 1 1203 2434 5 2
Low 16 843 56 16 394 16 365 648 1650 57 25 4 1 354 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_206907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB022017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ049192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ716041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX494823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD512588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB236105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000296800   ⟹   ENSP00000296800
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,768,385 - 40,798,174 (-)Ensembl
RefSeq Acc Id: ENST00000354209   ⟹   ENSP00000346148
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,762,770 - 40,798,374 (-)Ensembl
RefSeq Acc Id: ENST00000397006
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,777,160 - 40,798,170 (-)Ensembl
RefSeq Acc Id: ENST00000397128   ⟹   ENSP00000380317
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,759,379 - 40,798,198 (-)Ensembl
RefSeq Acc Id: ENST00000505783
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,764,770 - 40,771,855 (-)Ensembl
RefSeq Acc Id: ENST00000506652
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,764,937 - 40,798,148 (-)Ensembl
RefSeq Acc Id: ENST00000509874
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,767,507 - 40,798,189 (-)Ensembl
RefSeq Acc Id: ENST00000511248
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,777,016 - 40,798,159 (-)Ensembl
RefSeq Acc Id: ENST00000513152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,764,242 - 40,764,788 (-)Ensembl
RefSeq Acc Id: NM_001355028   ⟹   NP_001341957
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,798,177 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355029   ⟹   NP_001341958
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,798,177 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355034   ⟹   NP_001341963
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,768,385 - 40,798,195 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355035   ⟹   NP_001341964
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,798,177 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355036   ⟹   NP_001341965
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,798,177 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001355037   ⟹   NP_001341966
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,798,177 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006251   ⟹   NP_006242
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,379 - 40,798,195 (-)NCBI
GRCh37540,759,481 - 40,798,297 (-)ENTREZGENE
Build 36540,795,238 - 40,834,054 (-)NCBI Archive
HuRef540,711,304 - 40,750,184 (-)ENTREZGENE
CHM1_1540,761,376 - 40,800,178 (-)NCBI
Sequence:
RefSeq Acc Id: NM_206907   ⟹   NP_996790
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,379 - 40,798,195 (-)NCBI
GRCh37540,759,481 - 40,798,297 (-)ENTREZGENE
Build 36540,795,238 - 40,834,054 (-)NCBI Archive
HuRef540,711,304 - 40,750,184 (-)ENTREZGENE
CHM1_1540,761,376 - 40,800,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009624   ⟹   XP_016865113
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,822 - 40,781,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009625   ⟹   XP_016865114
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,759,389 - 40,781,066 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006242   ⟸   NM_006251
- Peptide Label: isoform 1
- UniProtKB: Q13131 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_996790   ⟸   NM_206907
- Peptide Label: isoform 2
- UniProtKB: Q13131 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016865113   ⟸   XM_017009624
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016865114   ⟸   XM_017009625
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001341965   ⟸   NM_001355036
- Peptide Label: isoform 6
- Sequence:
RefSeq Acc Id: NP_001341958   ⟸   NM_001355029
- Peptide Label: isoform 4
- Sequence:
RefSeq Acc Id: NP_001341964   ⟸   NM_001355035
- Peptide Label: isoform 6
- Sequence:
RefSeq Acc Id: NP_001341966   ⟸   NM_001355037
- Peptide Label: isoform 6
- Sequence:
RefSeq Acc Id: NP_001341957   ⟸   NM_001355028
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001341963   ⟸   NM_001355034
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: ENSP00000296800   ⟸   ENST00000296800
RefSeq Acc Id: ENSP00000346148   ⟸   ENST00000354209
RefSeq Acc Id: ENSP00000380317   ⟸   ENST00000397128
Protein Domains
Protein kinase

Promoters
RGD ID:6869474
Promoter ID:EPDNEW_H7902
Type:initiation region
Name:PRKAA1_1
Description:protein kinase AMP-activated catalytic subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7903  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,798,177 - 40,798,237EPDNEW
RGD ID:6869476
Promoter ID:EPDNEW_H7903
Type:single initiation site
Name:PRKAA1_2
Description:protein kinase AMP-activated catalytic subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7902  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,798,840 - 40,798,900EPDNEW
RGD ID:6803482
Promoter ID:HG_KWN:50024
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000296800,   OTTHUMT00000253832,   OTTHUMT00000253833
Position:
Human AssemblyChrPosition (strand)Source
Build 36540,833,751 - 40,834,372 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5p14.1-q11.1(chr5:26593632-50288555)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|See cases [RCV000051834] Chr5:26593632..50288555 [GRCh38]
Chr5:26593741..49584389 [GRCh37]
Chr5:26629498..49620146 [NCBI36]
Chr5:5p14.1-q11.1
pathogenic
GRCh38/hg38 5p13.2-12(chr5:35700480-45260029)x3 copy number gain See cases [RCV000051835] Chr5:35700480..45260029 [GRCh38]
Chr5:35700582..45260131 [GRCh37]
Chr5:35736339..45295888 [NCBI36]
Chr5:5p13.2-12
pathogenic
GRCh38/hg38 5p13.2-q11.1(chr5:36374107-51103841)x3 copy number gain See cases [RCV000051836] Chr5:36374107..51103841 [GRCh38]
Chr5:36374209..50399675 [GRCh37]
Chr5:36409966..50435432 [NCBI36]
Chr5:5p13.2-q11.1
pathogenic
GRCh38/hg38 5p15.33-12(chr5:54839-45649861)x3 copy number gain See cases [RCV000051810] Chr5:54839..45649861 [GRCh38]
Chr5:54954..45649963 [GRCh37]
Chr5:107954..45685720 [NCBI36]
Chr5:5p15.33-12
pathogenic
GRCh38/hg38 5p15.33-11(chr5:49978-46114984)x3 copy number gain See cases [RCV000135453] Chr5:49978..46114984 [GRCh38]
Chr5:50093..46115086 [GRCh37]
Chr5:103093..46150843 [NCBI36]
Chr5:5p15.33-11
pathogenic
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3 copy number gain See cases [RCV000137302] Chr5:35201559..61903141 [GRCh38]
Chr5:35201661..61198968 [GRCh37]
Chr5:35237418..61234725 [NCBI36]
Chr5:5p13.2-q12.1
pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
GRCh37/hg19 5p15.2-12(chr5:13461664-46098927)x3 copy number gain See cases [RCV000239779] Chr5:13461664..46098927 [GRCh37]
Chr5:5p15.2-12
pathogenic
GRCh37/hg19 5p14.2-11(chr5:24281195-46389339)x3 copy number gain See cases [RCV000512120] Chr5:24281195..46389339 [GRCh37]
Chr5:5p14.2-11
likely pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p14.1-12(chr5:27227243-45685844)x3 copy number gain not provided [RCV000682542] Chr5:27227243..45685844 [GRCh37]
Chr5:5p14.1-12
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p13.3-12(chr5:31351588-43480111)x3 copy number gain not provided [RCV000744593] Chr5:31351588..43480111 [GRCh37]
Chr5:5p13.3-12
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.40779232_40785703del6472 deletion Primary amenorrhea [RCV000754420] Chr5:40779130..40785601 [GRCh38]
Chr5:40779232..40785703 [GRCh37]
Chr5:5p13.1
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_206907.3(PRKAA1):c.597T>C (p.Ser199=) single nucleotide variant not provided [RCV000906719] Chr5:40769460 [GRCh38]
Chr5:40769562 [GRCh37]
Chr5:5p13.1
benign
NM_206907.3(PRKAA1):c.1205A>G (p.His402Arg) single nucleotide variant not provided [RCV000943351] Chr5:40764900 [GRCh38]
Chr5:40765002 [GRCh37]
Chr5:5p13.1
likely benign
NM_206907.3(PRKAA1):c.990A>G (p.Glu330=) single nucleotide variant not provided [RCV000899618] Chr5:40765115 [GRCh38]
Chr5:40765217 [GRCh37]
Chr5:5p13.1
benign
GRCh37/hg19 5p13.2-11(chr5:34453883-46389339)x3 copy number gain not provided [RCV000848003] Chr5:34453883..46389339 [GRCh37]
Chr5:5p13.2-11
pathogenic
NM_206907.3(PRKAA1):c.1331A>G (p.Lys444Arg) single nucleotide variant not provided [RCV000892214] Chr5:40764774 [GRCh38]
Chr5:40764876 [GRCh37]
Chr5:5p13.1
likely benign
GRCh37/hg19 5p13.1-q11.1(chr5:38432180-49441945)x3 copy number gain not provided [RCV001005674] Chr5:38432180..49441945 [GRCh37]
Chr5:5p13.1-q11.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9376 AgrOrtholog
COSMIC PRKAA1 COSMIC
Ensembl Genes ENSG00000132356 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000296800 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000346148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380317 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000296800 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000354209 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000397128 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000132356 GTEx
HGNC ID HGNC:9376 ENTREZGENE
Human Proteome Map PRKAA1 Human Proteome Map
InterPro AMPK_C UniProtKB/Swiss-Prot
  AMPKA1_C UniProtKB/Swiss-Prot
  KA1/Ssp2_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA1_UBA UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5562 UniProtKB/Swiss-Prot
NCBI Gene 5562 ENTREZGENE
OMIM 602739 OMIM
Pfam AdenylateSensor UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33744 PharmGKB, RGD
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AAPK1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q96E92_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8MTQ6 UniProtKB/Swiss-Prot
  B2R7E1 UniProtKB/Swiss-Prot
  O00286 UniProtKB/Swiss-Prot
  Q5D0E1 UniProtKB/Swiss-Prot
  Q86VS1 UniProtKB/Swiss-Prot
  Q9UNQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PRKAA1  protein kinase AMP-activated catalytic subunit alpha 1  PRKAA1  protein kinase, AMP-activated, alpha 1 catalytic subunit  Symbol and/or name change 5135510 APPROVED