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Gene: KCNB2 (potassium voltage-gated channel subfamily B member 2) Homo sapiens
Symbol: KCNB2
Name: potassium voltage-gated channel subfamily B member 2
Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: delayed rectifier potassium channel protein; KV2.2; potassium channel Kv2.2; potassium channel, voltage gated Shab related subfamily B, member 2; potassium voltage gated channel, shab-related subfamily, member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38872,537,391 - 72,945,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37873,449,626 - 73,850,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36873,612,180 - 74,013,138 (+)NCBINCBI36hg18NCBI36
Build 34873,612,179 - 74,013,136NCBI
Celera869,452,496 - 69,847,725 (+)NCBI
Cytogenetic Map8q21.11NCBI
HuRef868,946,299 - 69,341,459 (+)NCBIHuRef
CHM1_1873,502,691 - 73,903,408 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732631
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.