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Gene: DNMT3A (DNA methyltransferase 3 alpha) Homo sapiens
Symbol: DNMT3A
Name: DNA methyltransferase 3 alpha
Description: Exhibits several functions, including DNA (cytosine-5-)-methyltransferase activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA methylation and negative regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; euchromatin; and nuclear lumen. Implicated in acute myeloid leukemia; myelodysplastic syndrome; precursor T-lymphoblastic lymphoma/leukemia; precursor lymphoblastic lymphoma/leukemia; and stomach cancer. Biomarker of autoimmune thrombocytopenic purpura; endometriosis (multiple); hepatocellular carcinoma; lung cancer; and myeloid leukemia (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA cytosine methyltransferase 3A2; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNMT3A2; HESJAS; M.HsaIIIA; TBRS
Mus musculus (house mouse) : Dnmt3a (DNA methyltransferase 3A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnmt3a (DNA methyltransferase 3 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3a (DNA methyltransferase 3 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3A (DNA methyltransferase 3 alpha)
Canis lupus familiaris (dog) : DNMT3A (DNA methyltransferase 3 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3a (DNA methyltransferase 3 alpha)
Sus scrofa (pig) : DNMT3A (DNA methyltransferase 3 alpha)
more info ...
Related Pseudogenes: DNMT3AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl225,227,855 - 25,342,590 (-)Ensembl
GRCh38225,227,874 - 25,342,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37225,451,421 - 25,565,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,309,349 - 25,418,963 (-)NCBINCBI36hg18NCBI36
Celera225,296,144 - 25,405,816 (-)NCBI
Cytogenetic Map2p23.3NCBI
HuRef225,193,733 - 25,302,862 (-)NCBIHuRef
CHM1_1225,385,740 - 25,495,369 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNMT3A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606038
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.