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Gene: DNMT3L (DNA methyltransferase 3 like) Homo sapiens
Symbol: DNMT3L
Name: DNA methyltransferase 3 like
RGD ID: 1343645
Description: Exhibits enzyme activator activity and enzyme binding activity. Involved in negative regulation of transcription, DNA-templated. Localizes to cytosol and nucleus. Predicted to colocalize with ESC/E(Z) complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; human cytosine-5-methyltransferase 3-like protein; MGC1090
Mus musculus (house mouse) : Dnmt3l (DNA (cytosine-5-)-methyltransferase 3-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnmt3l (DNA methyltransferase 3 like)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3l (DNA methyltransferase 3 like)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3L (DNA methyltransferase 3 like)
Canis lupus familiaris (dog) : DNMT3L (DNA methyltransferase 3 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3l (DNA methyltransferase 3 like)
Sus scrofa (pig) : DNMT3L (DNA methyltransferase 3 like)
Chlorocebus sabaeus (African green monkey) : DNMT3L (DNA methyltransferase 3 like)
Heterocephalus glaber (naked mole-rat) : Dnmt3l (DNA methyltransferase 3 like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2144,246,339 - 44,262,216 (-)EnsemblGRCh38hg38GRCh38
GRCh382144,246,339 - 44,261,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372145,666,222 - 45,682,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,490,651 - 44,506,527 (-)NCBINCBI36hg18NCBI36
Build 342144,490,650 - 44,506,527NCBI
Celera2130,771,480 - 30,787,356 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2131,036,675 - 31,052,591 (-)NCBIHuRef
CHM1_12145,226,863 - 45,242,733 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNMT3L
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343645
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.