RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Venous Thrombosis
Accession: DOID:9003871
browse the term
Definition: The formation or presence of a blood clot (THROMBUS) within a vein.
Synonyms: exact_synonym: DVT; Deep Vein Thrombosis; Deep Venous Thrombosis; Phlebothromboses; deep vein thromboses; deep venous thromboses; phlebothrombosis; venous thromboses
related_synonym: venous thrombosis, susceptibility to
primary_id: MESH:D020246
xref: EFO:0003907 ; NCI:C49343
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
treatment
IDA
RGD
PMID:21095090
RGD:10449099
NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687
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Apoe
apolipoprotein E
ISO
RGD
PMID:22119245
RGD:6903200
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Arvcf
ARVCF, delta catenin family member
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,588,137...82,645,832
Ensembl chr11:82,587,881...82,645,805
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA, protein:increased expression:vein
RGD
PMID:18167211
RGD:2307053
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Comt
catechol-O-methyltransferase
susceptibility
ISO
DNA:polymorphism: :324G>A ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar RGD
PMID:25741868 PMID:31064749 PMID:18064318
RGD:2289709
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Csf2
colony stimulating factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8120554
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cxcl6
C-X-C motif chemokine ligand 6
IEP
RGD
PMID:7749835
RGD:5135275
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Dgcr8
DGCR8 microprocessor complex subunit
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
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Epo
erythropoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12670338 PMID:17547733
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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F11
coagulation factor XI
susceptibility
ISO
protein:increased activity:blood:
RGD
PMID:10706899
RGD:11041768
NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
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F12
coagulation factor XII
susceptibility
ISO
DNA:polymorphism::46C>T(human) associated with Pregnancy Complications; DNA:polymorphism::46C>T(human)
RGD
PMID:15116249 PMID:20141580
RGD:11041808 , RGD:11041858
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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F13a1
coagulation factor XIII A1 chain
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:cds:p.V34L(human)
CTD RGD
PMID:10365735 PMID:9920839 PMID:12358922
RGD:1581032 , RGD:10450745
NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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F13b
coagulation factor XIII B chain
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Venous thrombosis, susceptibility to
CTD ClinVar
PMID:12456499 PMID:16241947 PMID:25741868
NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381
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F2
coagulation factor II, thrombin
ISO IMP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9869612 PMID:12296757 PMID:19920886 PMID:9409269 PMID:23535565
RGD:1580342 , RGD:10449430
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F3
coagulation factor III, tissue factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14967414
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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F5
coagulation factor V
ISO
DNA:missense mutation:cds:p.R506Q (human) ClinVar Annotator: match by term: Deep venous thrombosis CTD Direct Evidence: marker/mechanism DNA:mutation: :1691G>A (human) associated with Behcet Syndrome;DNA:SNP: :1691G>A (human) associated with lupus erythematosus, systemic; DNA:polymorphism:cds:rs6025(human)
ClinVar CTD RGD
PMID:12296757 PMID:12827938 PMID:12865888 PMID:15033664 PMID:16875063 PMID:19486170 PMID:25741868 PMID:31064749 PMID:9293873 PMID:9836759 PMID:8948311 PMID:22707612 More...
RGD:6893601 , RGD:7394779 , RGD:7394762 , RGD:6893602
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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F7
coagulation factor VII
treatment
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14967414 PMID:16378835
RGD:11041650
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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F8
coagulation factor VIII
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16875063 PMID:15634269
RGD:1582359
NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
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Fga
fibrinogen alpha chain
ISO IEP
DNA:SNP: :rs6050 (human) protein:increased expression:peripheral blood (rat) ClinVar Annotator: match by term: Deep vein thrombosis
ClinVar RGD
PMID:8473507 PMID:8636415 PMID:25741868 PMID:34355501 PMID:22353194 PMID:23199547 More...
RGD:5688756 , RGD:7207783
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Fgb
fibrinogen beta chain
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:12573244 PMID:15795540 PMID:25741868 PMID:28492532 PMID:31064749
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Gnb1l
G protein subunit beta 1 like
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,425,301...82,507,836
Ensembl chr11:82,432,627...82,507,466
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Gp1bb
glycoprotein Ib platelet subunit beta
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
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Gp6
glycoprotein VI
treatment
ISO
protein:increased expression:plasma (human)
RGD
PMID:25253166 PMID:16254207
RGD:401794452 , RGD:401824681
NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326
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Gpx1
glutathione peroxidase 1
ISO
RGD
PMID:23426106
RGD:11352755
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Habp2
hyaluronan binding protein 2
ISO
DNA:SNP: :p.G534E (rs7080536) (human)
RGD
PMID:22421107
RGD:11353820
NCBI chr 1:255,315,870...255,350,161
Ensembl chr 1:255,315,915...255,350,160
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Hif1a
hypoxia inducible factor 1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36162953
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hp
haptoglobin
ISO
associated with Pulmonary Embolism;protein:increased expression:serum
RGD
PMID:17203959
RGD:1626365
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Il10
interleukin 10
susceptibility
ISO
RGD
PMID:16807647
RGD:1598472
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
IEP
protein:increased expression:serum
RGD
PMID:22318348
RGD:8655957
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1a
interleukin 1 alpha
IEP
RGD
PMID:17651586
RGD:2311092
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
IEP
RGD
PMID:17651586
RGD:2311092
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
DNA:haplotype::rs2232354(human)
RGD
PMID:17413037
RGD:11528540
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Itga2
integrin subunit alpha 2
no_association
ISO
RGD
PMID:16380674
RGD:1582295
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Itgb3
integrin subunit beta 3
susceptibility
ISO
associated with Behcet Syndrome; DNA:polymorphism: :
RGD
PMID:21813062
RGD:8693342
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Jak2
Janus kinase 2
no_association
ISO
DNA:SNPs, haplotype: :rs12342421, rs12343867 (human) DNA:SNP: :rs10974944 (human) DNA:mutation: :p.V617F (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20434300 PMID:23845539 PMID:23845539 PMID:17059429
RGD:10449376 , RGD:10449376 , RGD:10449391
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Kdr
kinase insert domain receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26600200
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Klhl22
kelch-like family member 22
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
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Med15
mediator complex subunit 15
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362
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Mmp14
matrix metallopeptidase 14
ISO
RGD
PMID:16171603
RGD:1582570
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Mmp2
matrix metallopeptidase 2
IEP IDA
RGD
PMID:20515599 PMID:16171603
RGD:2325775 , RGD:1582570
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
IEP
RGD
PMID:20515599
RGD:2325775
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
HEP ISO
mRNA:increased expression:femoral vein (rat)
RGD
PMID:20515599 PMID:16920980
RGD:2325775 , RGD:1582648
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mthfr
methylenetetrahydrofolate reductase
no_association susceptibility
ISO
DNA:transition:cds:g.677C>T (human) CTD Direct Evidence: marker/mechanism DNA:transition: :677C>T (human) associated with Lupus Erythematosus, Systemic; DNA:transition, transversion:cds:g.677C>T rs1801133, g.1298A>C rs1801131 (human)
CTD RGD
PMID:19123085 PMID:10929044 PMID:12442281 PMID:10792297 PMID:22707612
RGD:1580590 , RGD:10449394 , RGD:6893655 , RGD:6893602
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Nos3
nitric oxide synthase 3
susceptibility
ISO
associated with orthopedic surgery;DNA:SNP::rs1799983(human)
RGD
PMID:23922896
RGD:11533639
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Pecam1
platelet and endothelial cell adhesion molecule 1
susceptibility
ISO
DNA:missense mutation:cds:p.L125V (human)
RGD
PMID:25846278
RGD:11541089
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pf4
platelet factor 4
ISO
associated with Wounds and Injuries;mRNA:increased expression:blood
RGD
PMID:32347511
RGD:329901817
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Pi4ka
phosphatidylinositol 4-kinase alpha
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080
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Pigm
phosphatidylinositol glycan anchor biosynthesis, class M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16767100
NCBI chr13:84,838,329...84,842,026
Ensembl chr13:84,838,175...84,843,381
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic ClinVar Annotator: match by term: Deep venous thrombosis
CTD ClinVar
PMID:11144008 PMID:15557913 PMID:19415734 PMID:25741868 PMID:31064749
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:3161212 PMID:3488869 PMID:6359570 PMID:15557913
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Plg
plasminogen
ISO
CTD Direct Evidence: therapeutic ClinVar Annotator: match by term: Deep venous thrombosis
CTD ClinVar
PMID:7215189 PMID:10233898 PMID:12850227 PMID:12876630 PMID:15269832 PMID:16849641 PMID:20981092 PMID:22995991 PMID:23629776 PMID:25741868 PMID:26340456 PMID:27976734 PMID:28492532 PMID:30487145 PMID:31064749 PMID:31589614 PMID:31980526 PMID:34355501 More...
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
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Ppbp
pro-platelet basic protein
ameliorates
ISO
associated with Wounds and Injuries;mRNA:increased expression:blood
RGD
PMID:32347511 PMID:23550035
RGD:329901817 , RGD:401794958
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
ISO
DNA:missense mutation:cds:p.Q184H (human) DNA:silent mutation, missense mutation:cds:g.66C>T, p.R147W (human) DNA:missense mutations: :p.D297H, p.V420L (human) DNA:missense mutation: :c.565C>T (rs146922325) (human) CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Deep vein thrombosis | ClinVar Annotator: match by term: Deep venous thrombosis
CTD ClinVar RGD
PMID:1868249 PMID:7482420 PMID:8128429 PMID:8499565 PMID:8845458 PMID:12730085 PMID:17152060 PMID:25741868 PMID:25748729 PMID:28492532 PMID:31064749 PMID:31254973 PMID:32717757 PMID:34355501 PMID:35112923 PMID:8400292 PMID:15114590 PMID:23550037 PMID:25748729 PMID:22545135 PMID:10936861 More...
RGD:1578515 , RGD:1578391 , RGD:11035247 , RGD:11099989 , RGD:11099990 , RGD:11100014
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Pros1
protein S
ISO
DNA:missense mutation:cds:p.G295V (human) ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar RGD
PMID:7803790 PMID:12351389 PMID:20880255 PMID:22261441 PMID:25741868 PMID:28492532 PMID:31064749 PMID:32964666 PMID:9424998 More...
RGD:9743896
NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
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Ranbp1
RAN binding protein 1
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
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Rtn4r
reticulon 4 receptor
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,844,309...82,869,251
Ensembl chr11:82,844,309...82,869,466
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Scarf2
scavenger receptor class F, member 2
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:83,175,956...83,187,415
Ensembl chr11:83,175,963...83,187,348
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Septin5
septin 5
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393
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Serpina10
serpin family A member 10
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Venous thrombosis, susceptibility to
CTD ClinVar
PMID:15461625
NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
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Serpina5
serpin family A member 5
susceptibility
ISO
protein:increased expression:plasma (human)
RGD
PMID:12139754
RGD:1580299
NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407
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Serpinc1
serpin family C member 1
ISO
ClinVar Annotator: match by term: Deep venous thrombosis CTD Direct Evidence: marker/mechanism DNA:missense mutations: :multiple
ClinVar CTD RGD
PMID:55783 PMID:1483705 PMID:1555650 PMID:1977621 PMID:2336381 PMID:3472589 PMID:6435583 PMID:8810955 PMID:22498748 PMID:24072242 PMID:24158114 PMID:25741868 PMID:26748602 PMID:28492532 PMID:29215785 PMID:31064749 PMID:23550037 PMID:23932013 More...
RGD:11035247 , RGD:11035248
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpind1
serpin family D member 1
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
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Serpine1
serpin family E member 1
ISO IMP IEP
DNA:deletion:promoter:g.-676_-674delG (human) mRNA:increased expression:femoral vein (rat)
RGD
PMID:14653439 PMID:9535178 PMID:26535698
RGD:1580132 , RGD:8547875 , RGD:11060966
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Tango2
transport and golgi organization 2 homolog
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,645,978...82,692,574
Ensembl chr11:82,645,974...82,692,574
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Tbx1
T-box transcription factor 1
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
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Tbxa2r
thromboxane A2 receptor
treatment
IMP
RGD
PMID:7848332
RGD:11059887
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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Tfpi
tissue factor pathway inhibitor
ISO
protein:increased expression:plasma: CTD Direct Evidence: therapeutic
CTD RGD
PMID:18480984 PMID:18600090 PMID:17973652 PMID:12560220
RGD:11060130 , RGD:11060257 , RGD:11060137
NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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Trmt2a
tRNA methyltransferase 2 homolog A
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,737,689...82,742,423
Ensembl chr11:82,737,689...82,742,336
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Txnrd2
thioredoxin reductase 2
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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Vcam1
vascular cell adhesion molecule 1
IEP
protein:increased expression:thrombus, vein
RGD
PMID:23199547
RGD:7207783
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Zdhhc8
zinc finger DHHC-type palmitoyltransferase 8
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr11:82,755,110...82,769,280
Ensembl chr11:82,755,143...82,767,734
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Zim1
zinc finger, imprinted 1
ISO
ClinVar Annotator: match by term: Deep venous thrombosis
ClinVar
PMID:25741868 PMID:31064749
NCBI chr 1:67,132,076...67,157,843
Ensembl chr 1:67,132,147...67,153,761
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Apoa1
apolipoprotein A1
ISO
protein: decreased expression: plasma (human)
RGD
PMID:21145806
RGD:25671435
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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F5
coagulation factor V
severity susceptibility disease_progression
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Budd-Chiari syndrome DNA:missense mutation:cds:R506Q (human) associated with hyperhomocysteinemia:DNA:missense mutation:cds: (R506Q) (human)
OMIM CTD ClinVar RGD
PMID:11950065 PMID:16246256 PMID:19486170 PMID:24033266 PMID:25741868 PMID:28492532 PMID:31064749 PMID:34355501 PMID:29771426 PMID:26238013 PMID:9245936 PMID:16825912 More...
RGD:14700660 , RGD:11537993 , RGD:15036813 , RGD:14700661
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Insl6
insulin-like 6
ISO
ClinVar Annotator: match by term: Budd-Chiari syndrome
ClinVar
PMID:15781101 PMID:15793561 PMID:15837627 PMID:15858187 PMID:15920007 PMID:16081687 PMID:16247455 PMID:16293597 PMID:16325696 PMID:16603627 PMID:16707754 PMID:16709929 PMID:16762626 PMID:17989398 PMID:18256599 PMID:18394554 PMID:19036091 PMID:19074595 PMID:19287384 PMID:19293426 PMID:20339092 PMID:20631743 PMID:20703299 PMID:21120162 PMID:21689158 PMID:22041374 PMID:22397670 PMID:22422826 PMID:22571758 PMID:22818858 PMID:22829971 PMID:23115274 PMID:23535062 PMID:24404189 PMID:24728327 PMID:24986690 PMID:25043017 PMID:25157968 PMID:25671252 PMID:25741868 PMID:28492532 PMID:32581362 More...
NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493
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Jak2
Janus kinase 2
ISO
ClinVar Annotator: match by term: Budd-Chiari syndrome CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
PMID:15781101 PMID:15793561 PMID:15837627 PMID:15858187 PMID:15920007 PMID:16081687 PMID:16247455 PMID:16293597 PMID:16325696 PMID:16603627 PMID:16707754 PMID:16709929 PMID:16762626 PMID:17989398 PMID:18256599 PMID:18394554 PMID:19036091 PMID:19074595 PMID:19287384 PMID:19293426 PMID:20339092 PMID:20631743 PMID:20703299 PMID:21120162 PMID:21689158 PMID:22041374 PMID:22397670 PMID:22422826 PMID:22571758 PMID:22818858 PMID:22829971 PMID:23115274 PMID:23535062 PMID:24404189 PMID:24728327 PMID:24986690 PMID:25043017 PMID:25157968 PMID:25671252 PMID:25741868 PMID:28492532 PMID:32581362 More...
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:transition: :677C>T (human) DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD
PMID:12221667 PMID:26238013
RGD:10449395 , RGD:11537993
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:20688738
RGD:11100028
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Serpinf1
serpin family F member 1
IEP
protein:increased expression:neuroretina (rat)
RGD
PMID:21487926
RGD:5490120
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
ISO
ClinVar Annotator: match by term: Cerebral venous thrombosis
ClinVar
PMID:25741868 PMID:26467025 PMID:28492532
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Gpx3
glutathione peroxidase 3
no_association
ISO
DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human)
RGD
PMID:18096833 PMID:19095977
RGD:401827161 , RGD:401827164
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Ccl2
C-C motif chemokine ligand 2
ISO
associated with Behcet Syndrome;protein:increased expression:serum (human)
RGD
PMID:16273763
RGD:8548850
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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F2
coagulation factor II, thrombin
severity
ISO
associated with liver cirrhosis;protein:increased expression:plasma (human)
RGD
PMID:28465646
RGD:14985237
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Igf1r
insulin-like growth factor 1 receptor
susceptibility
ISO
associated with hepatocellular carcinoma;DNA:SNP:3'UTR:rs3743251(human)
RGD
PMID:24758241
RGD:14985227
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNP: :677C>T(human)
RGD
PMID:27221722 PMID:25987440
RGD:14696705 , RGD:14696749
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:
RGD
PMID:25987440
RGD:14696749
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Aqp1
aquaporin 1
IEP
RGD
PMID:21487926
RGD:5490120
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Aqp4
aquaporin 4
IEP
mRNA:decreased expression:retina
RGD
PMID:21487926
RGD:5490120
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Crp
C-reactive protein
ISO
protein:increased expression:serum:
RGD
PMID:6720266
RGD:9491754
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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F2
coagulation factor II, thrombin
no_association
ISO
DNA:SNP: :20210G>A (human)
RGD
PMID:22800650 PMID:14994919
RGD:7387258 , RGD:7394774
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F5
coagulation factor V
onset no_association
ISO
associated with Behcet Syndrome;DNA:missense mutation:cds:p.R506Q (human) CTD Direct Evidence: marker/mechanism DNA:missense mutation:cds:1691G>A (human) DNA:SNP:cds:1691G>A (human)
CTD RGD
PMID:12022286 PMID:10511031 PMID:16113792 PMID:10634550
RGD:7394767 , RGD:7394778 , RGD:7394773
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Fgf2
fibroblast growth factor 2
IEP
RGD
PMID:10342378
RGD:8655593
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Il1b
interleukin 1 beta
IEP
mRNA:increased expression:neuroretina, retinal pigment epithelium (rat)
RGD
PMID:21487926
RGD:5490120
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
IEP
RGD
PMID:21487926
RGD:5490120
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itga2
integrin subunit alpha 2
susceptibility
ISO
DNA:snp, haplotype:cds:g.807C>T (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12928694 PMID:12928694
RGD:8686430
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
IEP
RGD
PMID:21487926
RGD:5490120
NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461
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Mmp2
matrix metallopeptidase 2
ISO
DNA:SNP:promoter:-1306C>T (rs243865) (human)
RGD
PMID:23791966
RGD:8657048
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mthfr
methylenetetrahydrofolate reductase
susceptibility no_association
ISO
DNA:SNP: :677C>T(human) DNA:missense mutation:cds:677C>T (human) DNA:SNP: :1298A>C(human)
RGD
PMID:10485556 PMID:24250697 PMID:23289804
RGD:7387256 , RGD:10449421 , RGD:10449405
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Nrp1
neuropilin 1
ISS
MouseDO
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Pon1
paraoxonase 1
susceptibility
ISO
DNA:missense mutation:cds:p.L55M (human) protein:decreased activity:serum (human)
RGD
PMID:23441121 PMID:18084236
RGD:8547547 , RGD:8547555
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:deletion:promoter:g.-676_-674delG (human) protein:increased activity:plasma (human)
RGD
PMID:16244763 PMID:15213845
RGD:8547742 , RGD:8547805
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinf1
serpin family F member 1
ISO
protein:decreased expression:vitreous humor (human)
RGD
PMID:21275514
RGD:8554901
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Vegfa
vascular endothelial growth factor A
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16680105 PMID:21487926
RGD:5490120
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb
vascular endothelial growth factor B
IEP
RGD
PMID:21487926
RGD:5490120
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Mir223
microRNA 223
IMP
RGD
PMID:32141571
RGD:26884338
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Pros1
protein S
ISO
RGD
PMID:12907438
RGD:1578677
NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
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RT1-CE13
RT1 class I, locus CE13
ISO
associated with Behcet Syndrome; DNA:polymorphisms:cds:HLA-B35, HLA-B51 (human, Turkish)
RGD
PMID:12372094
RGD:7364924
NCBI chr20:3,314,830...3,318,106
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Itga2
integrin subunit alpha 2
no_association
ISO
DNA:snp:cds:g.807C>T (human)
RGD
PMID:16157382
RGD:1582301
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
G
Serpinf1
serpin family F member 1
ISO
protein:decreased expression:vitreous humor (human)
RGD
PMID:20714746
RGD:8554903
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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