RGD Reference Report - Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study. - Rat Genome Database

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Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study.

Authors: Cochery-Nouvellon, E  Vitry, F  Cornillet-Lefebvre, P  Hezard, N  Gillot, L  Nguyen, P 
Citation: Cochery-Nouvellon E, etal., Thromb Haemost. 2006 Jul;96(1):24-8.
RGD ID: 1598472
Pubmed: (View Article at PubMed) PMID:16807647
DOI: Full-text: DOI:10.1160/TH06-01-0027

The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders. Although IL-10 has been shown to modulate thrombin generation in several experimental models, it is not known whether IL-10 polymorphisms could be a risk factor for venous thrombosis. We therefore conducted a case-control study comparing 74 consecutive patients who experienced at least one episode of documented venous thromboembolic event and 100 healthy controls. All subjects were Caucasians. Five polymorphisms of the IL-10 promoter gene were studied: two highly polymorphic dinucleotide repeats, IL-10 R and IL-10G, and three single nucleotide polymorphisms at position -1082, -819 and -592. Factor VG1691C Leiden mutation was systematically determined. Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis (Odds ratio:OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease.

Annotation

Disease Annotations    
Venous Thrombosis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information