RGD Reference Report - Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis. - Rat Genome Database

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Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis.

Authors: Bank, I  Libourel, EJ  Middeldorp, S  Hamulyak, K  Van Pampus, EC  Koopman, MM  Prins, MH  Van der Meer, J  Buller, HR 
Citation: Bank I, etal., J Thromb Haemost. 2005 Jan;3(1):79-84.
RGD ID: 1582359
Pubmed: PMID:15634269   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1538-7836.2004.01033.x   (Journal Full-text)

Elevated levels of coagulation factor VIII:C (FVIII:C) are associated with an increased risk for venous and arterial thromboembolism. Whether relatives of patients with elevated levels of FVIII:C are also at increased risk for thrombotic disease is unknown. The objective was to determine the annual incidences of both venous and arterial thrombotic events in first-degree relatives of patients with elevated levels of FVIII:C and venous thromboembolism (VTE) or premature atherosclerosis. A retrospective study with 584 first-degree relatives of 177 patients with elevated levels of FVIII:C was performed. The level of FVIII:C was determined and relatives with elevated and normal levels of FVIII:C were compared. Of the participants, 40% had elevated levels of FVIII:C. The annual incidence of a first episode of VTE was 0.34% and 0.13% in relatives with elevated levels of FVIII:C and those with normal levels, respectively [OR 3.7 (95% CI 1.9-7.5)]. The absolute annual incidence in the youngest age group with elevated levels of FVIII:C was 0.16% (0.05-0.37) and gradually increased to 0.99% (0.40-2.04) in those older than 60 years of age, although the odds ratios were not statistically significant. The annual incidences of a first arterial thrombotic event were 0.29% and 0.14% in relatives with and without elevated levels of FVIII:C, respectively [OR 3.1 (1.4-6.6)]. In particular the risks for a first myocardial infarction [OR 4.3 (1.0-18.1); P =0.046] and a first peripheral arterial thrombosis [OR 8.6 (1.6-47.6)] were increased. Within families of patients with elevated levels of FVIII:C and VTE or premature atherosclerosis, 40% of their first-degree relatives has elevated levels of FVIII:C as well, and they are at increased risk for both VTE and arterial thrombosis as compared with their relatives with normal levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F8RatThromboembolism  ISOF8 (Homo sapiens) RGD 
F8HumanThromboembolism  IDA  RGD 
F8MouseThromboembolism  ISOF8 (Homo sapiens) RGD 
F8RatVenous Thrombosis  ISOF8 (Homo sapiens) RGD 
F8HumanVenous Thrombosis  IDA  RGD 
F8MouseVenous Thrombosis  ISOF8 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
F8  (coagulation factor VIII)

Genes (Mus musculus)
F8  (coagulation factor VIII)

Genes (Homo sapiens)
F8  (coagulation factor VIII)


Additional Information