Kcnj10 (potassium inwardly-rectifying channel, subfamily J, member 10) - Rat Genome Database

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Gene: Kcnj10 (potassium inwardly-rectifying channel, subfamily J, member 10) Rattus norvegicus
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Symbol: Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
RGD ID: 61822
Description: Enables identical protein binding activity and signaling receptor binding activity. Involved in several processes, including membrane hyperpolarization; potassium ion import across plasma membrane; and response to corticosteroid. Located in several cellular components, including astrocyte projection; basolateral plasma membrane; and microvillus. Used to study diabetic retinopathy. Biomarker of amyotrophic lateral sclerosis; brain disease (multiple); eye disease (multiple); and sensorineural hearing loss. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; brain-specific inwardly rectifying K(+) channel 1; inward rectifier K(+) channel Kir4.1; kir4.1; potassium channel, inwardly rectifying subfamily J member 10; potassium channel, inwardly rectifying subfamily J, member 10; potassium voltage-gated channel subfamily J member 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnj10em1Mcwi   Kcnj10em3Mcwi  
Genetic Models: SS-Kcnj10em3Mcwi SS-Kcnj10em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,802,026 - 84,835,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,802,009 - 84,835,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,305,458 - 87,334,963 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,705,734 - 88,735,235 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,890,102 - 85,919,618 (+)NCBIRnor_WKY
Rnor_6.01390,722,945 - 90,753,338 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,723,092 - 90,752,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,245,046 - 95,274,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,341,102 - 88,370,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,529,985 - 88,559,475 (+)NCBI
Celera1384,412,223 - 84,441,711 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model. Bataveljic D, etal., Glia. 2012 Dec;60(12):1991-2003. doi: 10.1002/glia.22414. Epub 2012 Sep 14.
2. Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology. Berner AK, etal., Diabetologia. 2012 Mar;55(3):845-54. doi: 10.1007/s00125-011-2393-0. Epub 2011 Dec 6.
3. Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations. Bockenhauer D, etal., N Engl J Med. 2009 May 7;360(19):1960-70. doi: 10.1056/NEJMoa0810276.
4. Cloning and expression of a family of inward rectifier potassium channels. Bond CT, etal., Receptors Channels 1994;2(3):183-91.
5. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Bredt DS, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6753-7.
6. Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. Cha SK, etal., J Biol Chem. 2011 Jan 21;286(3):1828-35. doi: 10.1074/jbc.M110.160390. Epub 2010 Nov 17.
7. Potassium channel Kir4.1 macromolecular complex in retinal glial cells. Connors NC and Kofuji P, Glia. 2006 Jan 15;53(2):124-31.
8. Changes in ocular aquaporin expression following optic nerve crush. Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER). Harada Y, etal., Brain Res. 2013 Jun 23;1517:141-9. doi: 10.1016/j.brainres.2013.04.009. Epub 2013 Apr 17.
12. Alterations in protein expression and membrane properties during Muller cell gliosis in a murine model of transient retinal ischemia. Hirrlinger PG, etal., Neurosci Lett. 2010 Mar 12;472(1):73-8. doi: 10.1016/j.neulet.2010.01.062. Epub 2010 Feb 2.
13. Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Huang C, etal., Am J Physiol Renal Physiol. 2007 Mar;292(3):F1073-81. Epub 2006 Nov 22.
14. Muller cell response to blue light injury of the rat retina. Iandiev I, etal., Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3559-67. Epub 2008 Apr 30.
15. Differential regulation of Kir4.1 and Kir2.1 expression in the ischemic rat retina. Iandiev I, etal., Neurosci Lett. 2006 Mar 27;396(2):97-101. Epub 2005 Dec 5.
16. Kir4.1 expression by astrocytes and oligodendrocytes in CNS white matter: a developmental study in the rat optic nerve. Kalsi AS, etal., J Anat. 2004 Jun;204(6):475-85.
17. Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Kaufhold MA, etal., Gastroenterology. 2008 Apr;134(4):1058-69. Epub 2008 Jan 18.
18. Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. Kinboshi M, etal., Int J Mol Sci. 2019 Feb 26;20(5). pii: ijms20051013. doi: 10.3390/ijms20051013.
19. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Kucheryavykh YV, etal., Glia. 2007 Feb;55(3):274-81.
20. Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. Kurschner C and Yuzaki M, J Neurosci. 1999 Sep 15;19(18):7770-80.
21. MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Lanciotti A, etal., Neurobiol Dis. 2010 Mar;37(3):581-95. Epub 2009 Nov 26.
22. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
23. Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin-induced uveitis rat. Liu XQ, etal., Mol Vis. 2007 Mar 1;13:309-17.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination. Nakajima M, etal., Brain Res. 2013 Nov 6;1537:340-9. doi: 10.1016/j.brainres.2013.09.024. Epub 2013 Sep 23.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy. Obara-Michlewska M, etal., J Neurosci Res. 2011 Dec;89(12):2018-27. doi: 10.1002/jnr.22656. Epub 2011 May 2.
28. Spinal cord injury causes a wide-spread, persistent loss of Kir4.1 and glutamate transporter 1: benefit of 17 beta-oestradiol treatment. Olsen ML, etal., Brain. 2010 Apr;133(Pt 4):1013-25. doi: 10.1093/brain/awq049.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Ocular inflammation alters swelling and membrane characteristics of rat Muller glial cells. Pannicke T, etal., J Neuroimmunol. 2005 Apr;161(1-2):145-54.
31. Impact of global cerebral ischemia on K+ channel expression and membrane properties of glial cells in the rat hippocampus. Pivonkova H, etal., Neurochem Int. 2010 Dec;57(7):783-94. doi: 10.1016/j.neuint.2010.08.016. Epub 2010 Sep 15.
32. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit. Rozengurt N, etal., Hear Res. 2003 Mar;177(1-2):71-80.
37. Chronic dysfunction of astrocytic inwardly rectifying K+ channels specific to the neocortical epileptic focus after fluid percussion injury in the rat. Stewart TH, etal., J Neurophysiol. 2010 Dec;104(6):3345-60. doi: 10.1152/jn.00398.2010. Epub 2010 Sep 22.
38. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
39. A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. Takumi T, etal., J Biol Chem 1995 Jul 7;270(27):16339-46.
40. MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels. Tanemoto M, etal., J Biol Chem. 2008 May 2;283(18):12241-7. Epub 2008 Feb 26.
41. In vivo formation of a proton-sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1. Tanemoto M, etal., J Physiol. 2000 Jun 15;525 Pt 3:587-92.
42. Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury. Vit JP, etal., J Neurosci. 2008 Apr 16;28(16):4161-71.
43. p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage. Yan JH, etal., CNS Neurosci Ther. 2012 Apr;18(4):334-42. doi: 10.1111/j.1755-5949.2012.00299.x. Epub 2012 Mar 15.
44. The disruption of central CO2 chemosensitivity in a mouse model of Rett syndrome. Zhang X, etal., Am J Physiol Cell Physiol. 2011 Sep;301(3):C729-38. doi: 10.1152/ajpcell.00334.2010. Epub 2011 Feb 9.
45. Expression of aquaporin 4 and Kir4.1 in diabetic rat retina: treatment with minocycline. Zhang Y, etal., J Int Med Res. 2011;39(2):464-79.
46. The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Muller glial cells. Zhao M, etal., FASEB J. 2010 May 13.
47. The changes of potassium currents in RCS rat Muller cell during retinal degeneration. Zhao T, etal., Brain Res. 2012 Jan 3;1427:78-87. doi: 10.1016/j.brainres.2011.10.011. Epub 2011 Oct 12.
Additional References at PubMed
PMID:9647694   PMID:10908613   PMID:15292049   PMID:15310750   PMID:15359216   PMID:15775962   PMID:15936844   PMID:16033858   PMID:16306174   PMID:17559083   PMID:17581847   PMID:17869537  
PMID:17942730   PMID:18293411   PMID:19515915   PMID:20074622   PMID:20625331   PMID:20651251   PMID:20678478   PMID:20806048   PMID:20807765   PMID:20926613   PMID:21680091   PMID:22266516  
PMID:22802001   PMID:22871113   PMID:24415225   PMID:25380566   PMID:25451797   PMID:25716834   PMID:26427731   PMID:26768400   PMID:26867573   PMID:26927380   PMID:28395711   PMID:28460049  
PMID:29115470   PMID:29474462   PMID:33161102   PMID:34510584   PMID:35583060  


Genomics

Comparative Map Data
Kcnj10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,802,026 - 84,835,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,802,009 - 84,835,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,305,458 - 87,334,963 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,705,734 - 88,735,235 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,890,102 - 85,919,618 (+)NCBIRnor_WKY
Rnor_6.01390,722,945 - 90,753,338 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,723,092 - 90,752,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,245,046 - 95,274,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,341,102 - 88,370,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,529,985 - 88,559,475 (+)NCBI
Celera1384,412,223 - 84,441,711 (+)NCBICelera
Cytogenetic Map13q24NCBI
KCNJ10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,037,467 - 160,070,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1159,998,651 - 160,070,160 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,007,257 - 160,039,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,274,657 - 158,306,585 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,821,107 - 156,853,111NCBI
Celera1133,075,700 - 133,108,518 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,363,984 - 131,396,837 (-)NCBIHuRef
CHM1_11161,402,581 - 161,435,439 (-)NCBICHM1_1
T2T-CHM13v2.01159,174,545 - 159,207,239 (-)NCBIT2T-CHM13v2.0
Kcnj10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,168,777 - 172,201,652 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,168,777 - 172,201,652 (+)EnsemblGRCm39 Ensembl
GRCm381172,341,210 - 172,374,085 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,341,210 - 172,374,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv371174,271,341 - 174,304,216 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,630,700 - 173,663,577 (+)NCBIMGSCv36mm8
MGSCv361174,177,885 - 174,210,760 (+)NCBIMGSCv36mm8
Celera1175,194,717 - 175,227,512 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.69NCBI
Kcnj10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,828,525 - 11,860,365 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,828,525 - 11,860,365 (-)NCBIChiLan1.0ChiLan1.0
KCNJ10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,312,371 - 139,345,145 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01135,391,321 - 135,424,100 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNJ10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,114,718 - 22,143,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,130,508 - 22,140,813 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,189,839 - 22,218,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,234,321 - 22,263,231 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,233,505 - 22,263,228 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,138,483 - 22,167,351 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,534,821 - 22,563,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,944,114 - 22,972,999 (+)NCBIUU_Cfam_GSD_1.0
Kcnj10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,165,284 - 6,198,606 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740555,998 - 586,353 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936740555,948 - 589,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,422,025 - 90,457,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,421,956 - 90,457,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,438,760 - 98,443,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,873,915 - 3,907,587 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,902,513 - 3,903,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,932,155 - 2,964,080 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,180,834 - 1,212,456 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,180,822 - 1,211,781 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj10
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000010146
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat

Markers in Region
G64928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,831,335 - 84,831,473 (+)MAPPERmRatBN7.2
Rnor_6.01390,752,267 - 90,752,404NCBIRnor6.0
Rnor_5.01395,274,221 - 95,274,358UniSTSRnor5.0
RGSC_v3.41388,370,277 - 88,370,414UniSTSRGSC3.4
Celera1384,441,397 - 84,441,534UniSTS
Cytogenetic Map13q24UniSTS


Genetic Models
This gene Kcnj10 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 23
Low 2 1 25 9 19 9 3 3 37 12 17 11 3
Below cutoff 1 32 2 2 2 5 8 2 18 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010146   ⟹   ENSRNOP00000010146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1390,723,092 - 90,752,581 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104019   ⟹   ENSRNOP00000079651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,804,288 - 84,835,387 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119639   ⟹   ENSRNOP00000086322
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,802,009 - 84,835,461 (+)Ensembl
RefSeq Acc Id: NM_031602   ⟹   NP_113790
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,802,146 - 84,831,650 (+)NCBI
Rnor_6.01390,723,077 - 90,752,581 (+)NCBI
Rnor_5.01395,245,046 - 95,274,535 (+)NCBI
RGSC_v3.41388,341,102 - 88,370,591 (+)RGD
Celera1384,412,223 - 84,441,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598774   ⟹   XP_017454263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,802,026 - 84,835,383 (+)NCBI
Rnor_6.01390,722,945 - 90,753,338 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598775   ⟹   XP_017454264
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,804,756 - 84,835,383 (+)NCBI
Rnor_6.01390,724,573 - 90,753,338 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090648   ⟹   XP_038946576
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,821,032 - 84,835,383 (+)NCBI
RefSeq Acc Id: XM_039090649   ⟹   XP_038946577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,808,022 - 84,835,383 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113790   ⟸   NM_031602
- UniProtKB: Q62790 (UniProtKB/Swiss-Prot),   P49655 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454263   ⟸   XM_017598774
- Peptide Label: isoform X1
- UniProtKB: Q62790 (UniProtKB/Swiss-Prot),   P49655 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454264   ⟸   XM_017598775
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G3K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010146   ⟸   ENSRNOT00000010146
RefSeq Acc Id: XP_038946577   ⟸   XM_039090649
- Peptide Label: isoform X1
- UniProtKB: Q62790 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038946576   ⟸   XM_039090648
- Peptide Label: isoform X1
- UniProtKB: Q62790 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000086322   ⟸   ENSRNOT00000119639
RefSeq Acc Id: ENSRNOP00000079651   ⟸   ENSRNOT00000104019
Protein Domains
IRK   IRK_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49655-F1-model_v2 AlphaFold P49655 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61822 AgrOrtholog
BioCyc Gene G2FUF-17323 BioCyc
Ensembl Genes ENSRNOG00000007705 Ensembl
  ENSRNOG00000068444 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000079651 ENTREZGENE
  ENSRNOP00000079651.1 UniProtKB/TrEMBL
  ENSRNOP00000086322 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104019 ENTREZGENE
  ENSRNOT00000104019.1 UniProtKB/TrEMBL
  ENSRNOT00000119639 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir1.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29718 UniProtKB/Swiss-Prot
NCBI Gene 29718 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnj10 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIR12CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G3K4 ENTREZGENE, UniProtKB/TrEMBL
  KCJ10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62790 ENTREZGENE
UniProt Secondary Q62790 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnj10  potassium voltage-gated channel subfamily J member 10  Kcnj10  potassium channel, inwardly rectifying subfamily J, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj10  potassium channel, inwardly rectifying subfamily J, member 10  Kcnj10  potassium inwardly-rectifying channel, subfamily J, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnj10  potassium inwardly-rectifying channel, subfamily J, member 10       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in glial cells of the central nervous system 729280