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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61822
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj10increases expressionISOKcnj10 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of KCNJ10 proteinPMID:34474083
Kcnj10multiple interactionsISOKcnj10 (Mus musculus)6480464CTDKCNJ10 protein promotes the reaction [Lipopolysaccharides results in increased expression of CAPN1 protein]; KCNJ10 protein promotes the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]; KCNJ10 protein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]; KCNJ10 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of GRIN2B protein]PMID:34474083
Kcnj10multiple interactionsISOKCNJ10 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of KCNJ10 mRNAPMID:35811015
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