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Gene: MLC1 (modulator of VRAC current 1) Homo sapiens
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Symbol: MLC1
Name: modulator of VRAC current 1
Description: Exhibits identical protein binding activity. Involved in positive regulation of intracellular transport and regulation of response to osmotic stress. Localizes to several cellular components, including basolateral plasma membrane; endosome; and perinuclear region of cytoplasm. Implicated in megalencephalic leukoencephalopathy with subcortical cysts 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KIAA0027; LVM; megalencephalic leukoencephalopathy with subcortical cysts 1; membrane protein MLC1; MLC; VL
Orthologs:
Mus musculus (house mouse) : Mlc1 (megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human))  MGI  Alliance
Rattus norvegicus (Norway rat) : Mlc1 (modulator of VRAC current 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlc1 (modulator of VRAC current 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MLC1 (modulator of VRAC current 1)
Canis lupus familiaris (dog) : MLC1 (modulator of VRAC current 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlc1 (modulator of VRAC current 1)
Sus scrofa (pig) : MLC1 (modulator of VRAC current 1)
Chlorocebus sabaeus (African green monkey) : MLC1 (modulator of VRAC current 1)
Heterocephalus glaber (naked mole-rat) : Mlc1 (modulator of VRAC current 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2250,059,391 - 50,085,902 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2250,059,391 - 50,085,426 (-)EnsemblGRCh38hg38GRCh38
GRCh382250,059,391 - 50,085,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372250,497,820 - 50,524,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362248,839,947 - 48,866,485 (-)NCBINCBI36hg18NCBI36
Build 342248,800,276 - 48,826,195NCBI
Celera2234,372,904 - 34,399,594 (-)NCBI
Cytogenetic Map22q13.33NCBI
HuRef2233,395,631 - 33,422,559 (-)NCBIHuRef
CHM1_12250,456,560 - 50,483,100 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MLC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318392
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.