RGD Reference Report - Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion.

Authors: Noma, H  Funatsu, H  Mimura, T  Eguchi, S  Shimada, K  Hori, S 
Citation: Noma H, etal., Curr Eye Res. 2011 Mar;36(3):256-63. doi: 10.3109/02713683.2010.513090. Epub 2011 Jan 28.
RGD ID: 8554901
Pubmed: (View Article at PubMed) PMID:21275514
DOI: Full-text: DOI:10.3109/02713683.2010.513090

PURPOSE: To investigate whether pigment epithelium-derived factor (PEDF) or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO). MATERIALS AND METHODS: In 27 patients who had CRVO with macular edema and 21 patients with nonischemic ocular diseases (control group), retinal ischemia was evaluated by measuring the area of capillary nonperfusion on fluorescein angiography and macular edema was examined by optical coherence tomography. Vitreous fluid samples were obtained during pars plana vitrectomy. RESULTS: The vitreous level of VEGF was significantly higher in the CRVO patients than in the controls (median: 366 vs. 15.6 pg/ml, P < 0.0001), while the vitreous level of PEDF was significantly lower in the patients than in the controls (median: 17.5 vs. 28.4 ng/ml, P = 0.0298). Vitreous levels of VEGF were significantly higher in CRVO patients with retinal ischemia than in those without ischemia (P < 0.0001), while PEDF levels did not show a significant difference. Vitreous levels of VEGF and PEDF were related to the retinal thickness at the central fovea (P = 0.0059 and P = 0.0308, respectively). CONCLUSIONS: VEGF and PEDF may independently influence retinal vascular permeability in CRVO patients with macular edema.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)


Additional Information