RGD Reference Report - Coagulation factor V gene mutation increases the risk of venous thrombosis in behcet's disease. - Rat Genome Database

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Coagulation factor V gene mutation increases the risk of venous thrombosis in behcet's disease.

Authors: Gul, A  Ozbek, U  Ozturk, C  Inanc, M  Konice, M  Ozcelik, T 
Citation: Gul A, etal., Br J Rheumatol. 1996 Nov;35(11):1178-80.
RGD ID: 7394762
Pubmed: (View Article at PubMed) PMID:8948311

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.

Annotation

Disease Annotations    
Venous Thrombosis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
F5  (coagulation factor V)

Genes (Mus musculus)
F5  (coagulation factor V)

Genes (Homo sapiens)
F5  (coagulation factor V)


Additional Information