RGD Reference Report - Association of a common polymorphism in the factor XIII gene with venous thrombosis. - Rat Genome Database

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Association of a common polymorphism in the factor XIII gene with venous thrombosis.

Authors: Catto, AJ  Kohler, HP  Coore, J  Mansfield, MW  Stickland, MH  Grant, PJ 
Citation: Catto AJ, etal., Blood. 1999 Feb 1;93(3):906-8.
RGD ID: 1581032
Pubmed: (View Article at PubMed) PMID:9920839

We have shown an association between a common mutation in the factor XIII a-subunit gene, coding for an amino acid change, 3 amino acids from the thrombin activation site (factor XIII Val34Leu) that may protect against myocardial infarction and predisposes to intracranial hemorrhage. To investigate the possible role of factor XIII Val34Leu in the pathogenesis of venous thromboembolism (VTE) and potential interactions with factor V Leiden (FV:Q506) and prothrombin G --> A 20210, we studied 221 patients with a history of VTE and 254 healthy controls. Patients with VTE showed an increased frequency of the FXIII Val/Val genotype (63% v 49%) and a lower frequency of the Val/Leu genotype (31% v 42%) than controls (P =. 007). FV:Q506 heterozygotes were more frequent in VTE patients (11%) than controls (5%; P =.04). The prothrombin G --> A 20210 mutation was present in only 3 patients and no controls (P =.10). In a logistic regression model for a history of VTE, the odds ratio (95% confidence interval) for FXIII Val/Leu or Leu/Leu genotype was 0.63 (0.38 to 0.82) and for possession of FV:Q506 2.40 (1.17 to 4.90). There was no evidence for an interaction between factor XIII Val34Leu genotype and FV:Q506, prothrombin G --> A 20210, sex, or age. It is concluded that possession of the Leu allele at factor XIII Val34Leu is protective against deep venous thrombosis.


Disease Annotations    
Venous Thrombosis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
F13a1  (coagulation factor XIII A1 chain)

Genes (Mus musculus)
F13a1  (coagulation factor XIII, A1 subunit)

Genes (Homo sapiens)
F13A1  (coagulation factor XIII A chain)

Additional Information