CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (+)-taxifolin
Accession: CHEBI:17948
browse the term
Definition: A taxifolin that has (2R,3R)-configuration.
Synonyms: exact_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
related_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; (2R,3R)-dihydroquercetin; (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone; Dihydroquercetin; Formula=C15H12O7; InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1; InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N; SMILES=O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)c(O)c1; trans-Dihydroquercetin
alt_id: CHEBI:15206; CHEBI:23764; CHEBI:42225; CHEBI:9415
xref: Beilstein:93548; CAS:480-18-2; DrugBank:DB02224; KEGG:C01617; KNApSAcK:C00000677; LINCS:LSM-5990
xref_mesh: MESH:C003377
xref: PDBeChem:DQH; Wikipedia:Taxifolin
cyclic_relationship: is_conjugate_acid_of CHEBI:58329; is_enantiomer_of CHEBI:41963
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
CTD
PMID:34217736
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions decreases activity
ISO
taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione] taxifolin results in decreased activity of ABCC1 protein
CTD
PMID:15041478
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Afp
alpha-fetoprotein
affects binding
EXP
taxifolin binds to AFP protein
CTD
PMID:23013281 PMID:25349334
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Agt
angiotensinogen
decreases expression
ISO
taxifolin results in decreased expression of AGT protein modified form
CTD
PMID:24269735
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]
CTD
PMID:29584932
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]
CTD
PMID:32828744
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Apoa1
apolipoprotein A1
increases expression
ISO
taxifolin results in increased expression of APOA1 protein
CTD
PMID:11108730
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apob
apolipoprotein B
decreases secretion decreases expression
ISO
taxifolin results in decreased secretion of APOB protein taxifolin results in decreased expression of APOB protein
CTD
PMID:11108730 PMID:15380446
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]
CTD
PMID:32525071
NCBI chr13:22,689,783...22,853,920
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Casp3
caspase 3
decreases activity multiple interactions
EXP
taxifolin results in decreased activity of CASP3 protein taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]
CTD
PMID:24269735 PMID:32828744
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
decreases activity
EXP
taxifolin results in decreased activity of CASP9 protein
CTD
PMID:24269735
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]
CTD
PMID:30372826 PMID:32525071 PMID:33741339
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccna1
cyclin A1
decreases expression
ISO
taxifolin results in decreased expression of CCNA1 mRNA
CTD
PMID:17541156
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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Cdc25a
cell division cycle 25A
decreases expression
ISO
taxifolin results in decreased expression of CDC25A mRNA
CTD
PMID:17541156
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]
CTD
PMID:30372826
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cycs
cytochrome c, somatic
affects localization
EXP
taxifolin affects the localization of CYCS protein
CTD
PMID:24269735
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]
CTD
PMID:32525071
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]
CTD
PMID:22422552 PMID:29584932
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
taxifolin results in decreased expression of CYP2E1 mRNA
CTD
PMID:17541156
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dcc
DCC netrin 1 receptor
increases expression
ISO
taxifolin results in increased expression of DCC mRNA
CTD
PMID:17541156
NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
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Egf
epidermal growth factor
decreases expression
ISO
taxifolin results in decreased expression of EGF mRNA
CTD
PMID:17541156
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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Fgf18
fibroblast growth factor 18
decreases expression
ISO
taxifolin results in decreased expression of FGF18 mRNA
CTD
PMID:17541156
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
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Fgf3
fibroblast growth factor 3
decreases expression
ISO
taxifolin results in decreased expression of FGF3 mRNA
CTD
PMID:17541156
NCBI chr 1:200,001,261...200,005,187
Ensembl chr 1:200,001,261...200,005,187
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]
CTD
PMID:32828744
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gas6
growth arrest specific 6
increases expression
ISO
taxifolin results in increased expression of GAS6 mRNA
CTD
PMID:17541156
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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Gdf15
growth differentiation factor 15
increases expression
ISO
taxifolin results in increased expression of GDF15 mRNA
CTD
PMID:17541156
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]
CTD
PMID:32828744
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein]
CTD
PMID:32525071
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gstm1
glutathione S-transferase mu 1
increases expression
ISO
taxifolin results in increased expression of GSTM1 mRNA
CTD
PMID:17541156
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Hmox1
heme oxygenase 1
increases expression multiple interactions decreases expression
ISO
taxifolin results in increased expression of HMOX1 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]
CTD
PMID:16799064 PMID:31152760
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]
CTD
PMID:32525071
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
CTD
PMID:12044887 PMID:19103272
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]
CTD
PMID:12044887 PMID:19103272 PMID:31152760
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]
CTD
PMID:32828744
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
CTD
PMID:32828744
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Insl3
insulin-like 3
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]
CTD
PMID:32525071
NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
taxifolin results in decreased expression of JUN mRNA
CTD
PMID:17541156
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
CTD
PMID:12044887
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mpo
myeloperoxidase
multiple interactions
EXP
taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
CTD
PMID:33741339
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mttp
microsomal triglyceride transfer protein
decreases activity
ISO
taxifolin results in decreased activity of MTTP protein
CTD
PMID:15380446
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression decreases expression multiple interactions
ISO
taxifolin results in increased expression of NFE2L2 protein taxifolin results in decreased expression of NFE2L2 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]
CTD
PMID:16799064 PMID:31152760
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases activity increases expression
ISO
taxifolin results in increased activity of NQO1 protein taxifolin results in increased expression of NQO1 mRNA
CTD
PMID:17541156
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein
CTD
PMID:32828744
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdgfb
platelet derived growth factor subunit B
decreases expression
ISO
taxifolin results in decreased expression of PDGFB mRNA
CTD
PMID:17541156
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
multiple interactions
EXP
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein]
CTD
PMID:32828744
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]
CTD
PMID:32525071
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD
PMID:21341175
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rasa1
RAS p21 protein activator 1
decreases expression
ISO
taxifolin results in decreased expression of RASA1 mRNA
CTD
PMID:17541156
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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Sirt1
sirtuin 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]
CTD
PMID:32525071
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Sod1
superoxide dismutase 1
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein]
CTD
PMID:32525071
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]
CTD
PMID:32525071
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sox9
SRY-box transcription factor 9
multiple interactions
EXP
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA]
CTD
PMID:32525071
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]
CTD
PMID:12044887
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein] taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
CTD
PMID:31152760 PMID:32828744
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Traf3
Tnf receptor-associated factor 3
increases expression
ISO
taxifolin results in increased expression of TRAF3 mRNA
CTD
PMID:17541156
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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Txnrd1
thioredoxin reductase 1
increases expression decreases activity
ISO EXP
taxifolin results in increased expression of TXNRD1 mRNA taxifolin results in decreased activity of TXNRD1 protein modified form
CTD
PMID:16618767 PMID:17541156
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ucp1
uncoupling protein 1
multiple interactions
EXP
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]
CTD
PMID:30372826
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression multiple interactions
ISO
taxifolin results in increased expression of UGT1A1 mRNA AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]
CTD
PMID:29584932
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Xdh
xanthine dehydrogenase
multiple interactions
ISO
taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]
CTD
PMID:19555678
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Xpa
XPA, DNA damage recognition and repair factor
increases expression
ISO
taxifolin results in increased expression of XPA mRNA
CTD
PMID:17541156
NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
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Xrcc4
X-ray repair cross complementing 4
increases expression
ISO
taxifolin results in increased expression of XRCC4 mRNA
CTD
PMID:17541156
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions
ISO
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA
CTD
PMID:29471006
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]
CTD
PMID:29471006
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:29471006
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:29471006
NCBI chr13:22,689,783...22,853,920
G
Casp3
caspase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD
PMID:29471006
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
CTD
PMID:29471006
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:29471006
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]
CTD
PMID:29471006
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]
CTD
PMID:29471006
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Il1b
interleukin 1 beta
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:29471006
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
CTD
PMID:29471006
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29471006
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29471006
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
CTD
PMID:29471006
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29471006
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
CTD
PMID:29471006
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
CTD
PMID:29471006
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD
PMID:29471006
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
CTD
PMID:29471006
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:29471006
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tnf
tumor necrosis factor
multiple interactions
ISO
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD
PMID:29471006
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
multiple interactions
ISO
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29471006
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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