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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-taxifolin
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Accession:CHEBI:17948 term browser browse the term
Definition:A taxifolin that has (2R,3R)-configuration.
Synonyms:exact_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;   (2R,3R)-dihydroquercetin;   (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone;   Dihydroquercetin;   Formula=C15H12O7;   InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1;   InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N;   SMILES=O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)c(O)c1;   trans-Dihydroquercetin
 alt_id: CHEBI:15206;   CHEBI:23764;   CHEBI:42225;   CHEBI:9415
 xref: Beilstein:93548;   CAS:480-18-2;   DrugBank:DB02224;   KEGG:C01617;   KNApSAcK:C00000677;   LINCS:LSM-5990
 xref_mesh: MESH:C003377
 xref: PDBeChem:DQH;   Wikipedia:Taxifolin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58329;   is_enantiomer_of CHEBI:41963

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(+)-taxifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
taxifolin results in decreased activity of ABCC1 protein		 CTD PMID:15041478 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP taxifolin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agt angiotensinogen decreases expression ISO taxifolin results in decreased expression of AGT protein modified form CTD PMID:24269735 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:32828744 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO taxifolin results in increased expression of APOA1 protein CTD PMID:11108730 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression		 ISO taxifolin results in decreased secretion of APOB protein
taxifolin results in decreased expression of APOB protein		 CTD PMID:11108730 PMID:15380446 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein] CTD PMID:32525071 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions		 EXP taxifolin results in decreased activity of CASP3 protein
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]		 CTD PMID:24269735 PMID:32828744 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases activity EXP taxifolin results in decreased activity of CASP9 protein CTD PMID:24269735 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA] CTD PMID:30372826 PMID:32525071 PMID:33741339 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO taxifolin results in decreased expression of CCNA1 mRNA CTD PMID:17541156 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO taxifolin results in decreased expression of CDC25A mRNA CTD PMID:17541156 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cycs cytochrome c, somatic affects localization EXP taxifolin affects the localization of CYCS protein CTD PMID:24269735 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein] CTD PMID:32525071 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]		 CTD PMID:22422552 PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO taxifolin results in decreased expression of CYP2E1 mRNA CTD PMID:17541156 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dcc DCC netrin 1 receptor increases expression ISO taxifolin results in increased expression of DCC mRNA CTD PMID:17541156 NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740 		JBrowse link
G Egf epidermal growth factor decreases expression ISO taxifolin results in decreased expression of EGF mRNA CTD PMID:17541156 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fgf18 fibroblast growth factor 18 decreases expression ISO taxifolin results in decreased expression of FGF18 mRNA CTD PMID:17541156 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf3 fibroblast growth factor 3 decreases expression ISO taxifolin results in decreased expression of FGF3 mRNA CTD PMID:17541156 NCBI chr 1:200,001,261...200,005,187
Ensembl chr 1:200,001,261...200,005,187 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:32828744 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO taxifolin results in increased expression of GAS6 mRNA CTD PMID:17541156 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO taxifolin results in increased expression of GDF15 mRNA CTD PMID:17541156 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:32828744 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein] CTD PMID:32525071 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO taxifolin results in increased expression of GSTM1 mRNA CTD PMID:17541156 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
decreases expression		 ISO taxifolin results in increased expression of HMOX1 protein
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:31152760 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein] CTD PMID:32525071 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] CTD PMID:12044887 PMID:19103272 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]		 CTD PMID:12044887 PMID:19103272 PMID:31152760 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein] CTD PMID:32828744 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] CTD PMID:32828744 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insl3 insulin-like 3 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein] CTD PMID:32525071 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO taxifolin results in decreased expression of JUN mRNA CTD PMID:17541156 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] CTD PMID:12044887 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:33741339 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases activity ISO taxifolin results in decreased activity of MTTP protein CTD PMID:15380446 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
decreases expression
multiple interactions		 ISO taxifolin results in increased expression of NFE2L2 protein
taxifolin results in decreased expression of NFE2L2 protein
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]		 CTD PMID:16799064 PMID:31152760 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO taxifolin results in increased activity of NQO1 protein
taxifolin results in increased expression of NQO1 mRNA		 CTD PMID:17541156 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein CTD PMID:32828744 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO taxifolin results in decreased expression of PDGFB mRNA CTD PMID:17541156 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] CTD PMID:32828744 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein] CTD PMID:32525071 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21341175 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression ISO taxifolin results in decreased expression of RASA1 mRNA CTD PMID:17541156 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein] CTD PMID:32525071 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA] CTD PMID:32525071 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions EXP taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA] CTD PMID:32525071 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein] CTD PMID:12044887 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]		 CTD PMID:31152760 PMID:32828744 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 increases expression ISO taxifolin results in increased expression of TRAF3 mRNA CTD PMID:17541156 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases activity		 ISO
EXP		 taxifolin results in increased expression of TXNRD1 mRNA
taxifolin results in decreased activity of TXNRD1 protein modified form		 CTD PMID:16618767 PMID:17541156 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO taxifolin results in increased expression of UGT1A1 mRNA
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]		 CTD PMID:29584932 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] CTD PMID:19555678 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression ISO taxifolin results in increased expression of XPA mRNA CTD PMID:17541156 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 increases expression ISO taxifolin results in increased expression of XRCC4 mRNA CTD PMID:17541156 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
astilbin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:29471006 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29471006 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:29471006 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29471006 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:29471006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:29471006 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] CTD PMID:29471006 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:29471006 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] CTD PMID:29471006 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:29471006 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:29471006 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]		 CTD PMID:29471006 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:29471006 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29471006 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:29471006 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:29471006 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:29471006 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase multiple interactions ISO [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:29471006 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29471006 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            (+)-taxifolin 71
              (+)-taxifolin 3-O-acetate 0
              (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
              (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
              (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
              (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
              (+)-taxifolin 3-O-beta-D-xylopyranoside 0
              6-methoxytaxifolin 0
              astilbin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  oxacycle 17586
                                    benzopyran 10410
                                      1-benzopyran 10136
                                        flavonoid 6516
                                          flavones 4204
                                            hydroxyflavone 4192
                                              flavonols 4103
                                                7-hydroxyflavonol 4081
                                                  quercetin 4029
                                                    taxifolin 71
                                                      (+)-taxifolin 71
                                                        (+)-taxifolin 3-O-acetate 0
                                                        (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
                                                        (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
                                                        (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
                                                        (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
                                                        (+)-taxifolin 3-O-beta-D-xylopyranoside 0
                                                        6-methoxytaxifolin 0
                                                        astilbin 22
paths to the root