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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:astilbin
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Accession:CHEBI:38200 term browser browse the term
Definition:A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.
Synonyms:exact_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside
 related_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one;   (2R,3R)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one;   Formula=C21H22O11;   InChI=1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19+,20-,21-/m0/s1;   InChIKey=ZROGCCBNZBKLEL-MPRHSVQHSA-N;   SMILES=C[C@@H]1O[C@@H](O[C@@H]2[C@H](Oc3cc(O)cc(O)c3C2=O)c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O;   dihydroquercetin-3-O-alpha-LRhap
 xref: Beilstein:100564;   CAS:29838-67-3;   HMDB:HMDB0033850
 xref_mesh: MESH:C099069
 xref: PMID:21157633;   PMID:21476602;   PMID:21600261;   PMID:21614752;   Reaxys:100564;   Wikipedia:Astilbin
 cyclic_relationship: is_enantiomer_of CHEBI:27669


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astilbin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions ISO [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:29471006 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29471006 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:29471006 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29471006 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:29471006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:29471006 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] CTD PMID:29471006 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:29471006 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] CTD PMID:29471006 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:29471006 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:29471006 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]		 CTD PMID:29471006 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:29471006 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29471006 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:29471006 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:29471006 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:29471006 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:29471006 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29471006 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        anti-inflammatory agent 16628
          astilbin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic heterocyclic compound 18906
                                  oxacycle 17904
                                    benzopyran 11976
                                      1-benzopyran 11730
                                        flavonoid 7225
                                          anthoxanthin 4580
                                            flavones 4580
                                              hydroxyflavone 4556
                                                flavonols 4428
                                                  7-hydroxyflavonol 4393
                                                    quercetin 4326
                                                      taxifolin 101
                                                        (+)-taxifolin 101
                                                          astilbin 22
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