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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-acylsphingosine
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Accession:CHEBI:52639 term browser browse the term
Definition:The parent compounds of the ceramide family, composed of sphingosine having an unspecified fatty acyl group attached to the nitrogen.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]alkanamide
 related_synonym: Formula=C19H36NO3R;   N-acylsphingosines;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)NC([*])=O;   an N-acylsphing-4-enine;   ceramide;   ceramide d18:1(4c)
 alt_id: CHEBI:12586;   CHEBI:52573
 xref: KEGG:C00195;   LIPID_MAPS_class:LMSP0201;   PMID:1378088;   PMID:7542630
 cyclic_relationship: is_enantiomer_of CHEBI:83223


show annotations for term's descendants           Sort by:
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
N-acetylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO N-acetylsphingosine results in increased expression of ABCB1 CTD PMID:11573427 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein		 CTD PMID:12640124 PMID:16215670 PMID:21821001 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions		 ISO N-acetylsphingosine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein]		 CTD PMID:24420784 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of BAX mRNA
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]		 CTD PMID:24420784 PMID:33959992 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein		 CTD PMID:9295281 PMID:16215670 PMID:24420784 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] CTD PMID:21821001 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC2 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC3 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein		 CTD PMID:10919278 PMID:16215670 PMID:21259059 PMID:28052715 PMID:33959992 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:12640124 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases localization		 EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] CTD PMID:15319326 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO N-acetylsphingosine results in increased activity of CFTR protein CTD PMID:15474513 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO N-acetylsphingosine results in decreased expression of CLDN4 mRNA; N-acetylsphingosine results in decreased expression of CLDN4 protein CTD PMID:28052715 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO N-acetylsphingosine results in increased expression of CLK1 mRNA CTD PMID:18270325 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Ctsd cathepsin D increases secretion EXP N-acetylsphingosine results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Dapk1 death associated protein kinase 1 increases activity ISO
EXP		 N-acetylsphingosine results in increased activity of DAPK1 protein CTD PMID:17087515 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dffb DNA fragmentation factor subunit beta increases activity EXP N-acetylsphingosine results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dnm1l dynamin 1-like increases expression EXP N-acetylsphingosine results in increased expression of DNM1L protein CTD PMID:18006463 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression		 ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]
N-acetylsphingosine results in increased expression of F3 protein		 CTD PMID:27556861 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP N-acetylsphingosine results in increased expression of FIS1 protein CTD PMID:18006463 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GOT1 protein] CTD PMID:33959992 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:33959992 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of GPX3 protein] CTD PMID:33959992 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO N-acetylsphingosine results in decreased phosphorylation of GSK3A protein CTD PMID:21821001 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions		 ISO N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]		 CTD PMID:21821001 PMID:24420784 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of and results in increased secretion of GSTA1 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 protein] CTD PMID:31385618 PMID:33959992 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
decreases expression		 EXP N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein		 CTD PMID:15155840 PMID:15319326 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA3 protein CTD PMID:15155840 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA5 protein CTD PMID:15155840 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO N-acetylsphingosine results in decreased expression of HMOX1 mRNA CTD PMID:18270325 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases ubiquitination		 EXP
ISO		 N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A protein]
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein		 CTD PMID:15155840 PMID:31385618 PMID:33959992 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]		 CTD PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO N-acetylsphingosine results in decreased expression of ID2 mRNA CTD PMID:18270325 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Il16 interleukin 16 increases expression ISO N-acetylsphingosine results in increased expression of IL16 mRNA CTD PMID:18270325 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] CTD PMID:27556861 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein] CTD PMID:33959992 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]		 CTD PMID:15313899 PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klf6 KLF transcription factor 6 increases expression ISO N-acetylsphingosine results in increased expression of KLF6 mRNA CTD PMID:18270325 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Lgals3 galectin 3 multiple interactions
increases expression
decreases response to substance		 ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine		 CTD PMID:21821001 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] CTD PMID:18270325 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP N-acetylsphingosine results in increased activity of MAPK1 protein CTD PMID:10700234 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP N-acetylsphingosine results in increased activity of MAPK3 protein CTD PMID:10700234 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] CTD PMID:33959992 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:18270325 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] CTD PMID:21821001 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mfn2 mitofusin 2 decreases response to substance EXP MFN2 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:18006463 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir15b microRNA 15b decreases expression ISO N-acetylsphingosine results in decreased expression of MIR15B mRNA CTD PMID:20145152 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir20a microRNA 20a decreases expression ISO N-acetylsphingosine results in decreased expression of MIR20A mRNA CTD PMID:20145152 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir25 microRNA 25 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR25 mRNA CTD PMID:20145152 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015 		JBrowse link
G Mir93 microRNA 93 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR93 mRNA CTD PMID:20145152 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7B mRNA CTD PMID:20145152 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7D mRNA CTD PMID:20145152 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7I mRNA CTD PMID:20145152 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases localization		 EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] CTD PMID:15319326 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] CTD PMID:12381813 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Ocln occludin decreases expression ISO N-acetylsphingosine results in decreased expression of OCLN mRNA; N-acetylsphingosine results in decreased expression of OCLN protein CTD PMID:28052715 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO N-acetylsphingosine results in decreased activity of ODC1 protein CTD PMID:17521618 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases response to substance ISO PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity EXP N-acetylsphingosine results in increased activity of RAF1 protein CTD PMID:10700234 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects activity ISO N-acetylsphingosine affects the activity of RELA protein CTD PMID:12853972 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhob ras homolog family member B increases expression ISO N-acetylsphingosine results in increased expression of RHOB mRNA CTD PMID:18270325 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein CTD PMID:11107162 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:33959992 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO
EXP		 N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]		 CTD PMID:9535218 PMID:10428046 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO N-acetylsphingosine results in increased expression of TGIF1 mRNA CTD PMID:18270325 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO N-acetylsphingosine results in decreased expression of TJP1 mRNA; N-acetylsphingosine results in decreased expression of TJP1 protein CTD PMID:28052715 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein		 CTD PMID:9535218 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 decreases activity
multiple interactions		 ISO N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]		 CTD PMID:18270325 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]		 CTD PMID:18270325 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
N-hexadecanoylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ATF4 mRNA
ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]		 CTD PMID:28223344 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]		 CTD PMID:28223344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Cs citrate synthase decreases expression
multiple interactions		 ISO N-palmitoylsphingosine results in decreased expression of CS mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA]		 CTD PMID:28223344 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] CTD PMID:28223344 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] CTD PMID:28223344 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:27556861 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]		 CTD PMID:28223344 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]		 CTD PMID:28223344 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]		 CTD PMID:28223344 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583 		JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Tnf tumor necrosis factor increases abundance
multiple interactions		 ISO TNF protein results in increased abundance of N-palmitoylsphingosine
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]		 CTD PMID:15946935 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        biochemical role 19566
          metabolite 19533
            eukaryotic metabolite 19358
              animal metabolite 19242
                mammalian metabolite 19241
                  human metabolite 18756
                    N-acylsphingosine 93
                      2-(2-hydroxyacyl)sphingosine + 0
                      Cer(d16:2(4E,6E)/22:0(2OH)) 0
                      N-(17Z-hexacosenoyl)sphingosine 0
                      N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                      N-(hexanoyl)sphing-4-enine 0
                      N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-(omega-hydroxyacyl)-sphingosine + 0
                      N-(omega-hydroxytriacontanoyl)sphingosine 0
                      N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-[(13Z)-docosenoyl]sphingosine 0
                      N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                      N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                      N-acetylsphingosine + 79
                      N-arachidonoylsphingosine 0
                      N-decanoylsphingosine 0
                      N-docosanoylsphingosine 0
                      N-dodecanoylsphingosine 0
                      N-heptadecanoylsphingosine 0
                      N-hexacosahexaenoylsphingosine 0
                      N-hexacosanoylsphingosine 0
                      N-hexacosenoylsphingosine 0
                      N-hexadecanoylsphingosine 16
                      N-icosanoylsphingosine 0
                      N-icosenoylsphingosine + 0
                      N-octacosanoylsphingosine 0
                      N-octadecanoylsphingosine 0
                      N-octanoylsphingosine 0
                      N-oleoylsphingosine + 0
                      N-omega-hydroxyacylsphingosine + 0
                      N-pentacosanoylsphingosine 0
                      N-tetracosadienoylsphingosine 0
                      N-tetracosanoylsphingosine 0
                      N-tetracosenoylsphingosine + 0
                      N-tetradecanoylsphingosine 0
                      N-tricosanoylsphingosine 0
                      xylosyl-beta-D-ceramide(d18:1(4E)) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    main group molecular entity 19806
                      s-block molecular entity 19641
                        hydrogen molecular entity 19622
                          hydrides 19150
                            inorganic hydride 18152
                              pnictogen hydride 18164
                                nitrogen hydride 18055
                                  azane 17882
                                    ammonia 17860
                                      organic amino compound 17860
                                        amino alcohol 1075
                                          aminodiol 190
                                            2-aminooctadecene-1,3-diol 140
                                              2-aminooctadec-4-ene-1,3-diol 140
                                                sphing-4-enine 139
                                                  sphingosine 139
                                                    sphingosine-based sphingolipid 93
                                                      N-acylsphingosine 93
                                                        2-(2-hydroxyacyl)sphingosine + 0
                                                        Cer(d16:2(4E,6E)/22:0(2OH)) 0
                                                        N-(17Z-hexacosenoyl)sphingosine 0
                                                        N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                                                        N-(hexanoyl)sphing-4-enine 0
                                                        N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-(omega-hydroxyacyl)-sphingosine + 0
                                                        N-(omega-hydroxytriacontanoyl)sphingosine 0
                                                        N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-[(13Z)-docosenoyl]sphingosine 0
                                                        N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                                                        N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                                                        N-acetylsphingosine + 79
                                                        N-arachidonoylsphingosine 0
                                                        N-decanoylsphingosine 0
                                                        N-docosanoylsphingosine 0
                                                        N-dodecanoylsphingosine 0
                                                        N-heptadecanoylsphingosine 0
                                                        N-hexacosahexaenoylsphingosine 0
                                                        N-hexacosanoylsphingosine 0
                                                        N-hexacosenoylsphingosine 0
                                                        N-hexadecanoylsphingosine 16
                                                        N-icosanoylsphingosine 0
                                                        N-icosenoylsphingosine + 0
                                                        N-octacosanoylsphingosine 0
                                                        N-octadecanoylsphingosine 0
                                                        N-octanoylsphingosine 0
                                                        N-oleoylsphingosine + 0
                                                        N-omega-hydroxyacylsphingosine + 0
                                                        N-pentacosanoylsphingosine 0
                                                        N-tetracosadienoylsphingosine 0
                                                        N-tetracosanoylsphingosine 0
                                                        N-tetracosenoylsphingosine + 0
                                                        N-tetradecanoylsphingosine 0
                                                        N-tricosanoylsphingosine 0
                                                        xylosyl-beta-D-ceramide(d18:1(4E)) + 0
paths to the root