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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnip
Name: thioredoxin interacting protein
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnipincreases expressionISORGD:13435746480464CTDN-acetylsphingosine results in increased expression of TXNIP protein

PMID:18270325
Txnipincreases expressionISORGD:7321416480464CTDN-acetylsphingosine results in increased expression of TXNIP mRNA N-acetylsphingosine results in increased expression of TXNIP protein

PMID:18270325
Txnipmultiple interactionsISORGD:13435746480464CTDTXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein] TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]

PMID:18270325
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