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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases expressionISORGD:7338916480464CTDN-acetylsphingosine results in decreased expression of GSK3B protein modified form

PMID:24420784
Gsk3bdecreases phosphorylationISORGD:7338916480464CTDN-acetylsphingosine results in decreased phosphorylation of GSK3B protein

PMID:21821001
Gsk3bmultiple interactionsISORGD:7338916480464CTDGSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]

PMID:21821001
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