|
G |
Crh |
corticotropin releasing hormone |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] |
CTD |
PMID:2153673 |
|
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
Sphingosine results in increased expression of CYP17A1 mRNA |
CTD |
PMID:15666826 |
|
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] |
CTD |
PMID:2153673 |
|
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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|
G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] |
CTD |
PMID:9398635 |
|
NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
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G |
Tert |
telomerase reverse transcriptase |
affects activity |
ISO |
Sphingosine affects the activity of TERT protein |
CTD |
PMID:9434777 |
|
NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
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|
|
G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein |
CTD |
PMID:21195056 |
|
NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
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G |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] |
CTD |
PMID:15498114 |
|
NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] |
CTD |
PMID:15498114 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
C5 |
complement C5 |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] |
CTD |
PMID:19284563 |
|
NCBI chr 3:14,049,993...14,113,931 NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:21195056 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] |
CTD |
PMID:21998146 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein |
CTD |
PMID:21195056 |
|
NCBI chr 2:197,786,212...197,788,992
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein |
CTD |
PMID:21195056 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] |
CTD |
PMID:19284563 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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|
G |
Sphk1 |
sphingosine kinase 1 |
decreases activity decreases expression multiple interactions |
ISO EXP |
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein N,N-dimethylsphingosine results in decreased expression of SPHK1 protein N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] |
CTD |
PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146 |
|
NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine |
CTD |
PMID:21436125 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of ABCB1 |
CTD |
PMID:11573427 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein N-acetylsphingosine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:12640124 PMID:16215670 PMID:21821001 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Bad |
BCL2-associated agonist of cell death |
decreases phosphorylation multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of BAD protein N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein] |
CTD |
PMID:24420784 |
|
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of BAX mRNA |
CTD |
PMID:24420784 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein |
CTD |
PMID:9295281 PMID:16215670 PMID:24420784 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein N-acetylsphingosine results in increased activity of CASP3 protein |
CTD |
PMID:10919278 PMID:16215670 PMID:21259059 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12640124 |
|
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] |
CTD |
PMID:15319326 |
|
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of CFTR protein |
CTD |
PMID:15474513 |
|
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Clk1 |
CDC-like kinase 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of CLK1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
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G |
Ctsd |
cathepsin D |
increases secretion |
EXP |
N-acetylsphingosine results in increased secretion of CTSD protein |
CTD |
PMID:15040013 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Dapk1 |
death associated protein kinase 1 |
increases activity |
ISO EXP |
N-acetylsphingosine results in increased activity of DAPK1 protein |
CTD |
PMID:17087515 |
|
NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of DFFB protein |
CTD |
PMID:15040013 |
|
NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
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G |
Dnm1l |
dynamin 1-like |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of DNM1L protein |
CTD |
PMID:18006463 |
|
NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] |
CTD |
PMID:11082532 |
|
NCBI chr 2:68,820,616...68,895,537
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions increases expression |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] N-acetylsphingosine results in increased expression of F3 protein |
CTD |
PMID:27556861 |
|
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of FIS1 protein |
CTD |
PMID:18006463 |
|
NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
decreases phosphorylation |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:21821001 |
|
NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation decreases expression multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3B protein N-acetylsphingosine results in decreased expression of GSK3B protein modified form GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein] |
CTD |
PMID:21821001 PMID:24420784 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions decreases expression |
EXP |
N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein] N-acetylsphingosine results in decreased expression of GSTA2 protein |
CTD |
PMID:15155840 PMID:15319326 |
|
NCBI chr 8:85,640,081...85,645,621
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|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA3 protein |
CTD |
PMID:15155840 |
|
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA5 protein |
CTD |
PMID:15155840 |
|
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hnf1a |
HNF1 homeobox A |
multiple interactions decreases ubiquitination |
EXP |
N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein N-acetylsphingosine results in decreased ubiquitination of HNF1A protein |
CTD |
PMID:15155840 |
|
NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
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G |
Hrk |
harakiri, BCL2 interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of HRK mRNA N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] |
CTD |
PMID:24420784 |
|
NCBI chr12:44,008,879...44,029,211
|
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of ID2 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
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G |
Il16 |
interleukin 16 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of IL16 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] |
CTD |
PMID:27556861 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA] |
CTD |
PMID:15313899 PMID:15741222 |
|
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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G |
Klf6 |
Kruppel-like factor 6 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of KLF6 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
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G |
Lgals3 |
galectin 3 |
multiple interactions increases expression decreases response to substance |
ISO |
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] LGALS3 results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:21821001 |
|
NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
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|
G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] |
CTD |
PMID:18270325 |
|
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK1 protein |
CTD |
PMID:10700234 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK3 protein |
CTD |
PMID:10700234 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
|
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 2:197,786,212...197,788,992
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein |
CTD |
PMID:18206046 |
|
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
|
|
G |
Mfn2 |
mitofusin 2 |
decreases response to substance |
EXP |
MFN2 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:18006463 |
|
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
|
|
G |
Mir15b |
microRNA 15b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR15B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
|
|
G |
Mir20a |
microRNA 20a |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR20A mRNA |
CTD |
PMID:20145152 |
|
NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
|
|
G |
Mir25 |
microRNA 25 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR25 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:19,307,340...19,307,423
Ensembl chr12:19,307,340...19,307,423
|
|
G |
Mir93 |
microRNA 93 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR93 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
|
|
G |
Mirlet7b |
microRNA let-7b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
|
|
G |
Mirlet7d |
microRNA let-7d |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7D mRNA |
CTD |
PMID:20145152 |
|
NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
|
|
G |
Mirlet7i |
microRNA let-7i |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7I mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] |
CTD |
PMID:15319326 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] |
CTD |
PMID:12381813 |
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NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] |
CTD |
PMID:15741222 |
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NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
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G |
Nrp2 |
neuropilin 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] |
CTD |
PMID:15741222 |
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NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
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G |
Odc1 |
ornithine decarboxylase 1 |
decreases activity |
ISO |
N-acetylsphingosine results in decreased activity of ODC1 protein |
CTD |
PMID:17521618 |
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NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of PARP1 protein |
CTD |
PMID:24420784 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pink1 |
PTEN induced kinase 1 |
decreases response to substance |
ISO |
PINK1 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:24792327 |
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NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein |
CTD |
PMID:11107162 |
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NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions increases degradation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] |
CTD |
PMID:16215670 |
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NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of RAF1 protein |
CTD |
PMID:10700234 |
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NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects activity |
ISO |
N-acetylsphingosine affects the activity of RELA protein |
CTD |
PMID:12853972 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rhob |
ras homolog family member B |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of RHOB mRNA |
CTD |
PMID:18270325 |
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NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein |
CTD |
PMID:11107162 |
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NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO EXP |
N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein] |
CTD |
PMID:9535218 PMID:10428046 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
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NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein |
CTD |
PMID:29945972 |
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NCBI chr X:15,574,579...15,587,826
Ensembl chr X:15,575,934...15,587,419
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G |
Tgif1 |
TGFB-induced factor homeobox 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of TGIF1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein] N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein |
CTD |
PMID:9535218 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Txn1 |
thioredoxin 1 |
decreases activity multiple interactions |
ISO |
N-acetylsphingosine results in decreased activity of TXN protein TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein] |
CTD |
PMID:18270325 |
|
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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G |
Txnip |
thioredoxin interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of TXNIP protein N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
|
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein |
CTD |
PMID:15313899 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
multiple interactions |
ISO |
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
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NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
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G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF4 mRNA ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF6 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA] |
CTD |
PMID:28223344 |
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NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Cs |
citrate synthase |
decreases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in decreased expression of CS mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
Win 55212-2 inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:27556861 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
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G |
Itpr2 |
inositol 1,4,5-trisphosphate receptor, type 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ITPR2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
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G |
Lipc |
lipase C, hepatic type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
|
NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
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G |
Lipg |
lipase G, endothelial type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
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NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
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G |
Mfn2 |
mitofusin 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of MFN2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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G |
Pacs2 |
phosphofurin acidic cluster sorting protein 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of PACS2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 6:137,824,136...137,889,144
Ensembl chr 6:137,824,213...137,887,418
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G |
Pc |
pyruvate carboxylase |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] |
CTD |
PMID:28223344 |
|
NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
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G |
Tnf |
tumor necrosis factor |
increases abundance multiple interactions |
ISO |
TNF protein results in increased abundance of N-palmitoylsphingosine ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15946935 PMID:16365044 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
ISO |
sphingosine 1-phosphate results in decreased expression of BAX mRNA sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA] |
CTD |
PMID:24399507 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] |
CTD |
PMID:24399507 PMID:24420784 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of CCN2 mRNA |
CTD |
PMID:25690654 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation multiple interactions |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:18612546 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
decreases expression |
ISO |
sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA |
CTD |
PMID:16224106 |
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NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA |
CTD |
PMID:15666826 |
|
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation multiple interactions |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of EGFR protein JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein] |
CTD |
PMID:26518876 |
|
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Fn1 |
fibronectin 1 |
multiple interactions increases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein] |
CTD |
PMID:21998146 PMID:22406263 |
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NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Gnaq |
G protein subunit alpha q |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] |
CTD |
PMID:25980589 |
|
NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
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G |
Hgf |
hepatocyte growth factor |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of HGF mRNA |
CTD |
PMID:19349368 |
|
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
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G |
Hrk |
harakiri, BCL2 interacting protein |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] |
CTD |
PMID:24399507 PMID:24420784 |
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NCBI chr12:44,008,879...44,029,211
|
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of IGF1 mRNA |
CTD |
PMID:19349368 |
|
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] |
CTD |
PMID:26518876 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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G |
Lama3 |
laminin subunit alpha 3 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMA3 mRNA |
CTD |
PMID:15541073 |
|
NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
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G |
Lamb3 |
laminin subunit beta 3 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMB3 mRNA |
CTD |
PMID:15541073 |
|
NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
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G |
Lamc2 |
laminin subunit gamma 2 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMC2 mRNA |
CTD |
PMID:15541073 |
|
NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form |
CTD |
PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form |
CTD |
PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein] sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein |
CTD |
PMID:26518876 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein |
CTD |
PMID:25980589 PMID:26518876 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] |
CTD |
PMID:15741222 |
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NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
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G |
Nrp2 |
neuropilin 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] |
CTD |
PMID:15741222 |
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NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of PECAM1 protein |
CTD |
PMID:19349368 |
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NCBI chr10:94,850,971...94,913,202
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G |
Plcb4 |
phospholipase C, beta 4 |
increases expression multiple interactions |
ISO |
sphingosine 1-phosphate results in increased expression of PLCB4 protein Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] |
CTD |
PMID:25980589 |
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NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
[Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate |
CTD |
PMID:18024222 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein |
CTD |
PMID:18612546 PMID:26518876 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] |
CTD |
PMID:26518876 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
S1pr1 |
sphingosine-1-phosphate receptor 1 |
increases response to substance increases expression multiple interactions |
EXP ISO |
S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate sphingosine 1-phosphate results in increased expression of S1PR1 mRNA sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein |
CTD |
PMID:20844107 PMID:24399507 |
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NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
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G |
S1pr2 |
sphingosine-1-phosphate receptor 2 |
multiple interactions increases uptake increases activity |
ISO EXP |
S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] sphingosine 1-phosphate results in increased uptake of S1PR2 protein sphingosine 1-phosphate results in increased activity of S1PR2 protein [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1 |
CTD |
PMID:18612546 PMID:22406263 PMID:26518876 |
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NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
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G |
S1pr3 |
sphingosine-1-phosphate receptor 3 |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18612546 PMID:25980589 |
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NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
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G |
S1pr5 |
sphingosine-1-phosphate receptor 5 |
multiple interactions |
ISO |
Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein |
CTD |
PMID:30102254 |
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NCBI chr 8:22,268,635...22,273,708
Ensembl chr 8:22,268,657...22,270,647
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] |
CTD |
PMID:15741222 |
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NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
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G |
Sphk1 |
sphingosine kinase 1 |
increases chemical synthesis multiple interactions |
ISO |
SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein] |
CTD |
PMID:22251058 PMID:24399507 PMID:26045781 |
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NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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G |
Spns2 |
sphingolipid transporter 2 |
increases secretion multiple interactions |
ISO |
SPNS2 protein results in increased secretion of sphingosine 1-phosphate TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] |
CTD |
PMID:29772789 |
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NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] |
CTD |
PMID:29772789 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] |
CTD |
PMID:18981156 PMID:26518876 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] |
CTD |
PMID:18981156 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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