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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISORGD:7331006480464CTDN-acetylsphingosine results in decreased expression of BCL2 mRNA N-acetylsphingosine results in decreased expression of BCL2 protein

PMID:24420784 PMID:9295281
Bcl2multiple interactionsISORGD:7331006480464CTDBCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein] BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein] BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] N-oxo-5 6-dihydrophenanthridin-2-yl-N N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA] N-oxo-5 6-dihydrophenanthridin-2-yl-N N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA] sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]

PMID:16215670 PMID:24420784
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