lead nitrate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lead nitrate	go back to main search page
Accession:	CHEBI:37187	browse the term
Definition:	A lead coordination entity that has formula N2O6Pb.
Synonyms:	exact_synonym:	lead dinitrate; lead(2+) nitrate; lead(II) nitrate
	related_synonym:	Blei(II)-nitrat; Formula=N2O6Pb; InChI=1S/2NO3.Pb/c22-1(3)4;/q2-1;+2; InChIKey=RLJMLMKIBZAXJO-UHFFFAOYSA-N; SMILES=[O-][N+](=O)O[Pb]O[N+]([O-])=O; [Pb(NO3)2]; plumbous nitrate
	xref:	CAS:10099-74-8; Gmelin:7801; KEGG:C15234
	xref_mesh:	MESH:C017461
	xref:	MolBase:1766

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Genes (180)

lead nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of ACO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in decreased expression of ACO1 protein]

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

actin alpha 1, skeletal muscle

increases expression

lead nitrate results in increased expression of ACTA1 protein

NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490

G

aryl-hydrocarbon receptor

increases expression
multiple interactions

lead nitrate results in increased expression of AHR mRNA; lead nitrate results in increased expression of AHR protein
AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

A kinase anchor protein 3

decreases expression

lead nitrate results in decreased expression of AKAP3 mRNA

NCBI chr 6:126,830,061...126,851,271
Ensembl chr 6:126,830,061...126,851,271

G

aminolevulinate, delta-, dehydratase

decreases activity
multiple interactions

lead nitrate results in decreased activity of ALAD protein
lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

apoptotic peptidase activating factor 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of APAF1 protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

Rho, GDP dissociation inhibitor beta

increases expression

lead nitrate results in increased expression of ARHGDIB protein

NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897

G

arrestin domain containing 5

decreases expression

lead nitrate results in decreased expression of ARRDC5 mRNA

NCBI chr17:56,601,111...56,607,262
Ensembl chr17:56,601,111...56,607,286

G

antizyme inhibitor 2

decreases expression

lead nitrate results in decreased expression of AZIN2 mRNA

NCBI chr 4:128,824,026...128,856,250
Ensembl chr 4:128,824,026...128,856,235

G

BCL2-associated X protein

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]
[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA]

PMID:23451106 PMID:30738203

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression
multiple interactions

lead nitrate results in decreased expression of BCL2 protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]
[lead nitrate results in increased abundance of Lead] which results in decreased expression of BCL2 mRNA

PMID:23451106 PMID:30738203

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

increases expression
multiple interactions
increases activity

lead nitrate results in increased expression of CASP3 protein
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]
lead nitrate results in increased activity of CASP3 protein
puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA]

PMID:23451106 PMID:24505050 PMID:30738203

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions
decreases expression

lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of CASP7 mRNA

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 9

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA]

PMID:23451106 PMID:30738203

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

decreases activity
multiple interactions

lead nitrate results in decreased activity of CAT protein
mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein]

PMID:23315276 PMID:23451106 PMID:24987671 PMID:30738203

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cyclin G1

multiple interactions

lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]

NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138

G

CD86 antigen

increases expression

lead nitrate results in increased expression of CD86 protein

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

chromodomain protein, Y chromosome-like

decreases expression

lead nitrate results in decreased expression of CDYL mRNA

NCBI chr13:35,843,801...36,058,047
Ensembl chr13:35,843,816...36,058,046

G

conserved helix-loop-helix ubiquitous kinase

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of CHUK protein
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

cytochrome c oxidase subunit 8C

decreases expression

lead nitrate results in decreased expression of COX8C mRNA

NCBI chr12:102,865,565...102,866,793
Ensembl chr12:102,865,575...102,866,785

G

cysteine-rich secretory protein 2

decreases expression

lead nitrate results in decreased expression of CRISP2 mRNA

NCBI chr17:41,075,625...41,105,037
Ensembl chr17:41,074,911...41,117,894

G

crystallin, alpha A

affects metabolic processing

lead nitrate affects the metabolism of CRYAA protein

NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707

G

crystallin, alpha B

affects metabolic processing

lead nitrate affects the metabolism of CRYAB protein

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

cystatin 8 (cystatin-related epididymal spermatogenic)

decreases expression

lead nitrate results in decreased expression of CST8 mRNA

NCBI chr 2:148,640,759...148,647,516
Ensembl chr 2:148,640,705...148,647,515

G

catenin alpha 1

multiple interactions

lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]

NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832

G

catenin beta 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein; [lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of CTNNB1 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cut-like homeobox 2

multiple interactions

lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]

NCBI chr 5:121,996,025...122,188,522
Ensembl chr 5:121,994,429...122,188,165

G

C-X-C motif chemokine ligand 15

increases expression

lead nitrate results in increased expression of CXCL8 protein

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

lead nitrate inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; lead nitrate promotes the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate results in increased expression of CYP1A1 mRNA; lead nitrate results in increased expression of CYP1A1 protein
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]

PMID:8902619 PMID:11162773 PMID:11408366 PMID:17889500 PMID:23391631 More...

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions

lead nitrate results in decreased activity of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 protein

PMID:8902619 PMID:11162773

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene

increases expression

lead nitrate results in increased expression of CYP2C11 mRNA

NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733

G

cytochrome P450, family 4, subfamily a, polypeptide 12B

increases expression

lead nitrate results in increased expression of CYP4A1 mRNA

NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231

G

cytochrome P450, family 51

increases expression
multiple interactions

lead nitrate results in increased expression of CYP51 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]

PMID:15475176 PMID:22293356

NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746

G

cytochrome P450, family 7, subfamily a, polypeptide 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of CYP7A1 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

DNA-damage inducible transcript 3

increases expression

lead nitrate results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA; [lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein]

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

dentin matrix protein 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DMP1 mRNA]

NCBI chr 5:104,345,441...104,361,968
Ensembl chr 5:104,350,479...104,361,968

G

deoxyribonuclease I

multiple interactions

lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]

NCBI chr16:3,855,007...3,857,888
Ensembl chr16:3,854,806...3,857,888

G

DNA methyltransferase 3A

multiple interactions
decreases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]
lead nitrate results in decreased expression of DNMT3A mRNA; lead nitrate results in decreased expression of DNMT3A protein

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

dentin sialophosphoprotein

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DSPP mRNA]

NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993

G

E2F transcription factor 1

multiple interactions

E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]

NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812

G

EGF-like domain 8

increases expression

lead nitrate results in increased expression of EGFL8 protein

NCBI chr17:34,832,174...34,835,536
Ensembl chr17:34,832,323...34,834,945

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

eukaryotic translation initiation factor 2 alpha kinase 1

increases response to substance
multiple interactions

EIF2AK1 gene mutant form results in increased susceptibility to lead nitrate
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr 5:143,803,586...143,839,535
Ensembl chr 5:143,803,543...143,841,069

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of EIF4EBP1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702

G

excision repair cross-complementing rodent repair deficiency, complementation group 1

multiple interactions

lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]

NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449

G

excision repair cross-complementing rodent repair deficiency, complementation group 3

multiple interactions

lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]

NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204

G

ezrin

multiple interactions

lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]

NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183

G

fatty acid binding protein 9, testis

decreases expression

lead nitrate results in decreased expression of FABP9 mRNA

NCBI chr 3:10,258,683...10,262,343
Ensembl chr 3:10,258,681...10,262,343

G

farnesyl diphosphate farnesyl transferase 1

increases expression

lead nitrate results in increased expression of FDFT1 mRNA

NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027

G

farnesyl diphosphate synthetase

increases expression

lead nitrate results in increased expression of FDPS mRNA

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

four and a half LIM domains 1

decreases expression

lead nitrate results in decreased expression of FHL1 mRNA

NCBI chr X:55,776,569...55,838,704
Ensembl chr X:55,777,147...55,838,706

G

FBJ osteosarcoma oncogene

increases expression

lead nitrate results in increased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

forkhead box A2

multiple interactions

lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]

NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889

G

ferritin light polypeptide 1

increases expression

lead nitrate results in increased expression of FTL protein

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

glucose-6-phosphate dehydrogenase X-linked

decreases activity

lead nitrate results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

growth arrest and DNA-damage-inducible 45 alpha

increases expression

lead nitrate results in increased expression of GADD45A mRNA

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

golgi associated RAB2 interactor 1B

decreases expression

lead nitrate results in decreased expression of GARIN1B mRNA

NCBI chr 6:29,313,468...29,336,021
Ensembl chr 6:29,319,139...29,336,018

G

glial fibrillary acidic protein

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP protein]
lead nitrate results in increased expression of GFAP mRNA; lead nitrate results in increased expression of GFAP protein

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gametogenetin binding protein 1

decreases expression

lead nitrate results in decreased expression of GGNBP1 mRNA

NCBI chr17:27,237,009...27,255,352
Ensembl chr17:27,236,961...27,256,598

G

growth hormone

multiple interactions
decreases secretion

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]
lead nitrate results in decreased secretion of GH1 protein

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

growth hormone releasing hormone

multiple interactions

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]

NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426

G

gap junction protein, alpha 5

multiple interactions
increases expression

lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]
lead nitrate results in increased expression of GJA5 mRNA

NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732

G

gap junction protein, beta 2

multiple interactions

lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]

NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159

G

predicted gene 128

decreases expression

lead nitrate results in decreased expression of C2H1ORF56 mRNA

NCBI chr 3:95,144,230...95,148,946
Ensembl chr 3:95,144,231...95,148,909

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

multiple interactions

lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

increases expression

lead nitrate results in increased expression of GRIN2C mRNA

NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069

G

germ cell associated 1

decreases expression

lead nitrate results in decreased expression of GSG1 mRNA

NCBI chr 6:135,214,327...135,231,334
Ensembl chr 6:135,214,324...135,231,349
Ensembl chr 6:135,214,324...135,231,349

G

glycogen synthase kinase 3 beta

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

multiple interactions
decreases activity

mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, theta 1

multiple interactions

lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]

NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418

G

hepcidin antimicrobial peptide

multiple interactions

[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

high-mobility group box 4

decreases expression

lead nitrate results in decreased expression of HMGB4 mRNA

NCBI chr 4:128,154,005...128,154,688
Ensembl chr 4:128,154,005...128,154,750

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

increases expression
multiple interactions

lead nitrate results in increased expression of HMGCR mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]

PMID:15475176 PMID:16705668 PMID:22293356

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heme oxygenase 1

increases expression

lead nitrate results in increased expression of HMOX1 mRNA

PMID:23391631 PMID:34189835

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hepatic nuclear factor 4, alpha

decreases expression

lead nitrate results in decreased expression of HNF4A mRNA

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

heat shock protein 90 alpha (cytosolic), class B member 1

multiple interactions

lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 2

multiple interactions
increases expression
decreases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA2 mRNA]
lead nitrate results in decreased expression of HSPA2 mRNA

PMID:21628963 PMID:24987671

NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712

G

heat shock protein 5

increases expression

lead nitrate results in increased expression of HSPA5 protein
lead nitrate results in increased expression of HSPA5 mRNA

PMID:14971657 PMID:20435106

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 9

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 protein]
lead nitrate results in increased expression of HSPA9 mRNA; lead nitrate results in increased expression of HSPA9 protein

NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410

G

insulin-like growth factor 2

multiple interactions

lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor binding protein 6

multiple interactions

lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]

NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946

G

interleukin 1 alpha

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1A mRNA

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1B mRNA; lead nitrate results in increased expression of IL1B protein

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

decreases secretion

lead nitrate results in decreased secretion of IL2 protein

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 6 receptor, alpha

multiple interactions

lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]

NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503

G

insulin I

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

IQ motif containing F1

decreases expression

lead nitrate results in decreased expression of IQCF1 mRNA

NCBI chr 9:106,377,166...106,379,449
Ensembl chr 9:106,377,166...106,379,453

G

IQ motif containing F5

decreases expression

lead nitrate results in decreased expression of IQCF5 mRNA

NCBI chr 9:106,391,772...106,393,202
Ensembl chr 9:106,391,772...106,393,209

G

integrin alpha 6

multiple interactions

lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]

NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760

G

integrin alpha M

multiple interactions

lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

keratin 14

increases expression

lead nitrate results in increased expression of KRT14 protein

NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374

G

lysosomal-associated membrane protein 1

increases expression

lead nitrate results in increased expression of LAMP1 protein

NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338

G

lysosomal-associated membrane protein 2

increases expression

lead nitrate results in increased expression of LAMP2 protein

NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331

G

lactate dehydrogenase C

decreases expression

lead nitrate results in decreased expression of LDHC mRNA

NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566

G

leucine rich repeat containing 46

decreases expression

lead nitrate results in decreased expression of LRRC46 mRNA

NCBI chr11:96,925,428...96,932,195
Ensembl chr11:96,925,428...96,932,233

G

lymphotoxin A

multiple interactions

lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]

NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327

G

Ly6/Plaur domain containing 4

decreases expression

lead nitrate results in decreased expression of LYPD4 mRNA

NCBI chr 7:24,564,044...24,569,180
Ensembl chr 7:24,564,045...24,569,366

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

membrane associated ring-CH-type finger 11

decreases expression

lead nitrate results in decreased expression of MARCHF11 mRNA

NCBI chr15:26,309,134...26,409,672
Ensembl chr15:26,309,134...26,409,662

G

myeloid cell leukemia sequence 1

multiple interactions

lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

met proto-oncogene

multiple interactions

lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

microsomal glutathione S-transferase 1

multiple interactions

lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

microRNA 139

increases expression

lead nitrate results in increased expression of MIR139 mRNA

NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650

G

microRNA 142

increases expression

lead nitrate results in increased expression of MIR142 mRNA

NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753

G

maestro heat-like repeat family member 2B

decreases expression

lead nitrate results in decreased expression of MROH2B mRNA

NCBI chr15:4,927,697...4,991,689
Ensembl chr15:4,928,219...4,991,687

G

cytochrome c oxidase I, mitochondrial

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]

NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872

G

cytochrome c oxidase II, mitochondrial

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]

NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696

G

cytochrome c oxidase III, mitochondrial

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA]

NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390

G

metallothionein 1

affects localization
multiple interactions
increases expression
decreases response to substance

lead nitrate affects the localization of MT1 protein
lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]
lead nitrate results in increased expression of MT1 mRNA
MT1 results in decreased susceptibility to lead nitrate

PMID:11891201 PMID:19542206

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

multiple interactions
decreases response to substance

lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]
MT2 results in decreased susceptibility to lead nitrate

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

mechanistic target of rapamycin kinase

multiple interactions
increases phosphorylation

puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myelocytomatosis oncogene

multiple interactions

lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myosin, heavy polypeptide 6, cardiac muscle, alpha

decreases expression

lead nitrate results in decreased expression of MYH6 protein

NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384

G

myosin, heavy polypeptide 7, cardiac muscle, beta

increases expression
multiple interactions

lead nitrate results in increased expression of MYH7 mRNA; lead nitrate results in increased expression of MYH7 protein
resveratrol inhibits the reaction [lead nitrate results in increased expression of MYH7 mRNA]

NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083

G

neural cell adhesion molecule 1

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]
lead nitrate results in decreased expression of NCAM1 mRNA; lead nitrate results in decreased expression of NCAM1 protein

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

decreases expression
multiple interactions

lead nitrate results in decreased expression of NFKBIA protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

multiple interactions

lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]

NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937

G

natriuretic peptide type B

increases expression

lead nitrate results in increased expression of NPPB mRNA

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

NAD(P)H dehydrogenase, quinone 1

increases expression

lead nitrate results in increased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

lead nitrate results in decreased expression of NR0B2 mRNA

PMID:15475176 PMID:16049268

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group H, member 3

decreases expression

lead nitrate results in decreased expression of NR1H3 mRNA

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 5, group A, member 2

increases expression

lead nitrate results in increased expression of NR5A2 mRNA

NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186

G

NUMB endocytic adaptor protein

multiple interactions

lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]

NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708

G

outer dense fiber of sperm tails 1

decreases expression

lead nitrate results in decreased expression of ODF1 mRNA

NCBI chr15:38,219,447...38,226,979
Ensembl chr15:38,219,447...38,226,979

G

3-oxoacid CoA transferase 2A

decreases expression

lead nitrate results in decreased expression of OXCT2A mRNA

NCBI chr 4:123,215,668...123,217,472
Ensembl chr 4:123,215,668...123,217,427

G

progestin and adipoQ receptor family member V

decreases expression

lead nitrate results in decreased expression of PAQR5 mRNA

NCBI chr 9:61,861,020...61,934,085
Ensembl chr 9:61,860,763...61,934,138

G

protein inhibitor of activated STAT 2

multiple interactions

lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]

NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496

G

phospholipase A2, group IVA (cytosolic, calcium-dependent)

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]

NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041

G

polymerase (DNA directed), delta 1, catalytic subunit

multiple interactions

lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]

NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273

G

POU domain, class 3, transcription factor 3

multiple interactions

lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]

NCBI chr 1:42,734,928...42,739,370
Ensembl chr 1:42,734,085...42,742,336

G

protamine 1

decreases expression

lead nitrate results in decreased expression of PRM1 mRNA

NCBI chr16:10,614,196...10,614,687
Ensembl chr16:10,614,190...10,623,703

G

protamine 3

decreases expression

lead nitrate results in decreased expression of PRM3 mRNA

NCBI chr16:10,608,372...10,608,778
Ensembl chr16:10,608,369...10,608,778

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; Decitabine promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]
lead nitrate results in increased expression of PTGS2 mRNA; lead nitrate results in increased expression of PTGS2 protein

PMID:20850495 PMID:21435385 PMID:24639330

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RB transcriptional corepressor 1

multiple interactions
increases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 protein]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

RB transcriptional corepressor like 2

multiple interactions

lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]

NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]
RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of RELA mRNA; lead nitrate results in increased expression of RELA protein

PMID:23451106 PMID:31682781

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

RIB43A domain with coiled-coils 2

decreases expression

lead nitrate results in decreased expression of RIBC2 mRNA

NCBI chr15:85,016,261...85,028,771
Ensembl chr15:85,016,279...85,028,771

G

ribosomal protein S6 kinase, polypeptide 1

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of RPS6KB1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]

NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631

G

runt related transcription factor 1

multiple interactions

lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]

NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037

G

runt related transcription factor 2

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of RUNX2 mRNA]

PMID:30731080 PMID:35738543

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

serine (or cysteine) preptidase inhibitor, clade A, member 1B

multiple interactions

lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]

NCBI chr12:103,694,415...103,704,448
Ensembl chr12:103,694,415...103,796,632

G

sperm mitochondria-associated cysteine-rich protein

decreases expression

lead nitrate results in decreased expression of SMCP mRNA

NCBI chr 3:92,491,173...92,496,380
Ensembl chr 3:92,491,174...92,496,304

G

synuclein, alpha

affects localization
increases expression
multiple interactions

lead nitrate affects the localization of SNCA protein
lead nitrate results in increased expression of SNCA mRNA
MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

suppressor of cytokine signaling 1

multiple interactions

lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]

NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400

G

superoxide dismutase 1, soluble

multiple interactions
decreases activity

Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

trans-acting transcription factor 3

multiple interactions
decreases expression

lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of SP3 mRNA

NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790

G

spermatogenesis associated 18

decreases expression

lead nitrate results in decreased expression of SPATA18 mRNA

NCBI chr 5:73,808,723...73,836,927
Ensembl chr 5:73,808,722...73,836,855

G

spermatogenesis associated 20

decreases expression

lead nitrate results in decreased expression of SPATA20 mRNA

NCBI chr11:94,369,730...94,376,136
Ensembl chr11:94,369,730...94,377,005

G

spermatogenesis associated 21

decreases expression

lead nitrate results in decreased expression of SPATA21 mRNA

NCBI chr 4:140,815,631...140,840,071
Ensembl chr 4:140,815,644...140,840,071

G

spermatogenesis associated 6

decreases expression

lead nitrate results in decreased expression of SPATA6 mRNA

NCBI chr 4:111,577,151...111,686,339
Ensembl chr 4:111,577,181...111,686,381

G

sequestosome 1

multiple interactions
increases expression

lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]
lead nitrate results in increased expression of SQSTM1 protein
puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]

PMID:11891201 PMID:27762461

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

sterol regulatory element binding factor 2

increases expression

lead nitrate results in increased expression of SREBF2 mRNA

PMID:15475176 PMID:16705668

NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580

G

small ubiquitin-like modifier 1

multiple interactions

lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]

NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993

G

T-box 2

multiple interactions

lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]

NCBI chr11:85,723,441...85,732,774
Ensembl chr11:85,723,377...85,732,774

G

tektin 2

decreases expression

lead nitrate results in decreased expression of TEKT2 mRNA

NCBI chr 4:126,215,914...126,219,481
Ensembl chr 4:126,215,914...126,219,481

G

tektin 4

decreases expression

lead nitrate results in decreased expression of TEKT4 mRNA

NCBI chr17:25,673,511...25,695,576
Ensembl chr17:25,673,515...25,695,576

G

tropomodulin 1

decreases expression

lead nitrate results in decreased expression of TMOD1 mRNA

NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032

G

tumor necrosis factor

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]
Lead nitrate increases expression of Tnf mRNA in liver

CTD
RGD

PMID:15475176 PMID:16049268 PMID:22293356 PMID:7943184 PMID:9049203

RGD:14995476, RGD:14995487

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 1a

multiple interactions

lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

multiple interactions

lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

transition protein 1

decreases expression

lead nitrate results in decreased expression of TNP1 mRNA

NCBI chr 1:73,054,233...73,055,058
Ensembl chr 1:73,054,233...73,055,068

G

transition protein 2

decreases expression

lead nitrate results in decreased expression of TNP2 mRNA

NCBI chr16:10,605,799...10,606,519
Ensembl chr16:10,605,800...10,606,524

G

tubulin polymerization-promoting protein family member 2

decreases expression

lead nitrate results in decreased expression of TPPP2 mRNA

NCBI chr14:52,155,887...52,158,161
Ensembl chr14:52,155,882...52,158,157

G

tripartite motif-containing 27

multiple interactions

lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]

NCBI chr13:21,363,570...21,378,893
Ensembl chr13:21,363,615...21,378,894

G

transformation related protein 53

multiple interactions
increases expression

[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA]

PMID:30738203 PMID:31682781

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397

G

TSC22 domain family, member 3

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408

G

tumor susceptibility gene 101

multiple interactions

lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]

NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717

G

testis-specific serine kinase 2

decreases expression

lead nitrate results in decreased expression of TSSK2 mRNA

NCBI chr16:17,716,501...17,717,888
Ensembl chr16:17,716,501...17,717,888

G

testis-specific serine kinase 3

decreases expression

lead nitrate results in decreased expression of TSSK3 mRNA

NCBI chr 4:129,382,801...129,385,523
Ensembl chr 4:129,382,807...129,384,815

G

transcription termination factor, RNA polymerase I

multiple interactions

lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]

NCBI chr 2:28,950,211...28,977,668
Ensembl chr 2:28,950,274...28,977,668

G

tubulin, alpha 8

decreases expression

lead nitrate results in decreased expression of TUBA8 mRNA

NCBI chr 6:121,187,666...121,209,304
Ensembl chr 6:121,187,655...121,203,813

G

TUB like protein 2

decreases expression

lead nitrate results in decreased expression of TULP2 mRNA

NCBI chr 7:45,131,450...45,173,070
Ensembl chr 7:45,131,301...45,173,056

G

wingless-type MMTV integration site family, member 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]

NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718

G

wingless-type MMTV integration site family, member 3A

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]

NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578

G

wingless-type MMTV integration site family, member 4

multiple interactions

lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]

NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037

G

zinc finger homeobox 3

multiple interactions

lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]

NCBI chr 8:109,005,975...109,688,272
Ensembl chr 8:108,669,276...109,688,262

G

zinc and ring finger 4

decreases expression

lead nitrate results in decreased expression of ZNRF4 mRNA

NCBI chr17:56,818,248...56,819,483
Ensembl chr17:56,818,248...56,819,431

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22210
chemical entity	22209
molecular entity	22201
main group molecular entity	22136
main-group coordination entity	2452
lead coordination entity	2344
lead nitrate	180
Path 2
Term	Annotations
CHEBI ontology	22210
subatomic particle	22202
composite particle	22202
hadron	22202
baryon	22202
nucleon	22202
atomic nucleus	22202
atom	22202
main group element atom	22136
p-block element atom	22136
chalcogen	21465
oxygen atom	21443
oxygen molecular entity	21443
oxide	13384
oxoanion	10751
pnictogen oxoanion	6383
nitrogen oxoanion	355
nitrate	341
nitrate salt	341
inorganic nitrate salt	341
lead nitrate	180

paths to the root