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Gene: Socs1 (suppressor of cytokine signaling 1) Mus musculus
Symbol: Socs1
Name: suppressor of cytokine signaling 1
Description: Exhibits kinase inhibitor activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of alpha-beta T cell differentiation; and regulation of receptor signaling pathway via JAK-STAT. Predicted to localize to cytoplasmic ribonucleoprotein granule; nucleoplasm; and phosphatidylinositol 3-kinase complex. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; JAB; JAK-binding protein; JAK2-binding protein; SOCS-1; SSI-1; STAT-induced STAT inhibitor 1
Homo sapiens (human) : SOCS1 (suppressor of cytokine signaling 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Socs1 (suppressor of cytokine signaling 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs1 (suppressor of cytokine signaling 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS1 (suppressor of cytokine signaling 1)
Canis lupus familiaris (dog) : SOCS1 (suppressor of cytokine signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs1 (suppressor of cytokine signaling 1)
Sus scrofa (pig) : SOCS1 (suppressor of cytokine signaling 1)
Chlorocebus sabaeus (African green monkey) : SOCS1 (suppressor of cytokine signaling 1)
Heterocephalus glaber (naked mole-rat) : Socs1 (suppressor of cytokine signaling 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)EnsemblGRCm38mm10GRCm38
GRCm381610,783,808 - 10,785,536 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371610,783,901 - 10,785,629 (-)NCBIGRCm37mm9NCBIm37
MGSCv361610,697,386 - 10,699,114 (-)NCBImm8
Celera1611,411,246 - 11,412,974 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Socs1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732457
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.