Cox8c (cytochrome c oxidase subunit 8C) - Rat Genome Database

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Gene: Cox8c (cytochrome c oxidase subunit 8C) Mus musculus
Analyze
Symbol: Cox8c
Name: cytochrome c oxidase subunit 8C
RGD ID: 1623903
MGI Page MGI
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in several structures, including gonad; liver; lung; muscle tissue; and spleen. Orthologous to human COX8C (cytochrome c oxidase subunit 8C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700007F21Rik; COX VIII-3; COX8-; COX8-3; COXV; COXVIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit 8C, mitochondrial; cytochrome c oxidase subunit VIIIc; cytochrome c oxidase, subunit VIIIc
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,865,565 - 102,866,793 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,865,575 - 102,866,785 (+)EnsemblGRCm39 Ensembl
GRCm3812102,899,306 - 102,900,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,899,316 - 102,900,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712104,137,516 - 104,138,744 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612103,300,356 - 103,301,584 (+)NCBIMGSCv36mm8
Celera12104,116,515 - 104,117,743 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12762575   PMID:12909344   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18614015  
PMID:21873635   PMID:34326397   PMID:37423748  


Genomics

Comparative Map Data
Cox8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,865,565 - 102,866,793 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,865,575 - 102,866,785 (+)EnsemblGRCm39 Ensembl
GRCm3812102,899,306 - 102,900,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,899,316 - 102,900,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712104,137,516 - 104,138,744 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612103,300,356 - 103,301,584 (+)NCBIMGSCv36mm8
Celera12104,116,515 - 104,117,743 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.55NCBI
COX8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381493,347,182 - 93,348,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1493,347,182 - 93,348,356 (+)EnsemblGRCh38hg38GRCh38
GRCh371493,813,528 - 93,814,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,883,290 - 92,884,453 (+)NCBINCBI36Build 36hg18NCBI36
Build 341492,883,289 - 92,884,453NCBI
Celera1473,867,551 - 73,868,714 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,993,564 - 73,994,727 (+)NCBIHuRef
CHM1_11493,751,557 - 93,752,720 (+)NCBICHM1_1
T2T-CHM13v2.01487,579,055 - 87,580,228 (+)NCBIT2T-CHM13v2.0
Cox8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,793,379 - 127,794,702 (+)NCBIGRCr8
mRatBN7.26122,028,566 - 122,029,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,166,956 - 122,168,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,462,221 - 122,463,543 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,798,339 - 121,799,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,766,967 - 126,768,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,972,917 - 135,974,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,161,354 - 127,162,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16127,165,100 - 127,166,424 (+)NCBI
Celera6119,515,028 - 119,516,351 (+)NCBICelera
Cytogenetic Map6q32NCBI
LOC102005637
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543815,480,509 - 15,481,812 (+)NCBIChiLan1.0ChiLan1.0
LOC100984553
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21594,493,815 - 94,571,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,707,703 - 93,772,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,979,629 - 73,984,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11493,316,013 - 93,317,217 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1493,316,013 - 93,317,217 (+)Ensemblpanpan1.1panPan2
LOC100856429
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,401,351 - 25,402,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,051,304 - 25,052,818 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,928,113 - 25,929,627 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11825,496,165 - 25,497,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,140,874 - 25,142,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,753,536 - 25,755,050 (-)NCBIUU_Cfam_GSD_1.0
LOC100157935
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.17114,727,841 - 114,729,102 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27121,313,089 - 121,314,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COX8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12471,098,014 - 71,099,417 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2471,098,346 - 71,099,180 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605358,339,240 - 58,350,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cox8c
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSMUST00000053611
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
Cox8c  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12EUniSTS
cM Map1252.55UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000053611   ⟹   ENSMUSP00000056155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12102,865,575 - 102,866,785 (+)Ensembl
GRCm38.p6 Ensembl12102,899,316 - 102,900,526 (+)Ensembl
RefSeq Acc Id: NM_001039049   ⟹   NP_001034138
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912102,865,565 - 102,866,793 (+)NCBI
GRCm3812102,899,306 - 102,900,534 (+)ENTREZGENE
MGSCv3712104,137,516 - 104,138,744 (+)RGD
Celera12104,116,515 - 104,117,743 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001034138 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6H666 (Get FASTA)   NCBI Sequence Viewer  
  AAI45769 (Get FASTA)   NCBI Sequence Viewer  
  AAI45771 (Get FASTA)   NCBI Sequence Viewer  
  BAC25121 (Get FASTA)   NCBI Sequence Viewer  
  EDL18849 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000056155
  ENSMUSP00000056155.4
RefSeq Acc Id: NP_001034138   ⟸   NM_001039049
- UniProtKB: A6H666 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000056155   ⟸   ENSMUST00000053611

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6H666-F1-model_v2 AlphaFold A6H666 1-72 view protein structure

Promoters
RGD ID:8679066
Promoter ID:EPDNEW_M17564
Type:initiation region
Name:Cox8c_1
Description:Mus musculus cytochrome c oxidase subunit VIIIc , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812102,899,375 - 102,899,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922733 AgrOrtholog
Ensembl Genes ENSMUSG00000043319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053611 ENTREZGENE
  ENSMUST00000053611.5 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.81.10 UniProtKB/Swiss-Prot
InterPro Cyt_c_oxidase_su8 UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su8_sf UniProtKB/Swiss-Prot
KEGG Report mmu:75483 UniProtKB/Swiss-Prot
MGD MGI:1922733 ENTREZGENE
NCBI Gene 75483 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 8C, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR16717 UniProtKB/Swiss-Prot
Pfam COX8 UniProtKB/Swiss-Prot
PhenoGen Cox8c PhenoGen
Superfamily-SCOP SSF81431 UniProtKB/Swiss-Prot
UniProt A6H666 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8CF45_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Cox8c  cytochrome c oxidase subunit 8C    cytochrome c oxidase subunit VIIIc  Symbol and/or name change 5135510 APPROVED
2012-11-27 Cox8c  cytochrome c oxidase subunit VIIIc    cytochrome c oxidase, subunit VIIIc  Symbol and/or name change 5135510 APPROVED