Wnt4 (wingless-type MMTV integration site family, member 4) - Rat Genome Database

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Gene: Wnt4 (wingless-type MMTV integration site family, member 4) Mus musculus
Analyze
Symbol: Wnt4
Name: wingless-type MMTV integration site family, member 4
RGD ID: 733868
MGI Page MGI
Description: Enables frizzled binding activity and transcription corepressor activity. Involved in several processes, including paramesonephric duct development; positive regulation of cellular component biogenesis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including epithelial cell differentiation; morphogenesis of an epithelium; and negative regulation of signal transduction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC123964; signal molecule; wingless-related MMTV integration site 4; Wnt-; Wnt-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)EnsemblGRCm39 Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBIMGSCv36mm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,3-dinitrobenzene  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-nitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calciol  (EXP)
chlordecone  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
Licochalcone B  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
O-methyleugenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
progesterone  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
anatomical structure development  (IGI)
apoptotic signaling pathway  (IGI)
branching involved in ureteric bud morphogenesis  (IMP)
branching morphogenesis of an epithelial tube  (IGI)
canonical Wnt signaling pathway  (IBA,IDA,IGI,ISO)
cell differentiation  (IMP)
cell fate commitment  (IBA,IMP)
cell-cell signaling  (TAS)
cellular response to estradiol stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to starvation  (IEP)
cellular response to transforming growth factor beta stimulus  (ISO)
embryonic epithelial tube formation  (IDA)
epithelial to mesenchymal transition  (ISO)
female gonad development  (IMP)
female sex determination  (ISO,ISS)
fibroblast growth factor receptor signaling pathway  (IGI)
gamete generation  (IGI)
hormone metabolic process  (IMP)
immature T cell proliferation in thymus  (IMP)
kidney development  (ISO)
kidney morphogenesis  (IGI)
liver development  (ISO)
male gonad development  (IMP,ISO,ISS)
mammary gland epithelium development  (ISO)
meiotic nuclear division  (IGI)
mesenchymal to epithelial transition  (IMP)
mesonephric tubule development  (IGI)
mesonephros development  (IMP)
metanephric mesenchymal cell differentiation  (NAS)
metanephric nephron development  (IMP)
metanephric nephron morphogenesis  (IMP)
metanephric tubule formation  (IMP)
metanephros development  (IMP,TAS)
negative regulation of androgen biosynthetic process  (ISO)
negative regulation of apoptotic signaling pathway  (IGI)
negative regulation of cell differentiation  (IMP)
negative regulation of cell migration  (IGI)
negative regulation of DNA-templated transcription  (IDA,IMP,ISO,ISS)
negative regulation of fibroblast growth factor receptor signaling pathway  (IGI)
negative regulation of gene expression  (IMP,ISO)
negative regulation of male gonad development  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of testicular blood vessel morphogenesis  (ISO)
negative regulation of testosterone biosynthetic process  (IMP,ISO)
negative regulation of wound healing  (IGI)
nephron development  (IMP)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (IDA)
non-canonical Wnt signaling pathway via MAPK cascade  (ISO)
oocyte development  (IGI,IMP)
paramesonephric duct development  (IMP,ISO)
pericyte cell differentiation  (IDA,IMP)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cortisol biosynthetic process  (ISO)
positive regulation of dermatome development  (ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO)
positive regulation of focal adhesion assembly  (IGI)
positive regulation of GTPase activity  (IGI)
positive regulation of meiotic nuclear division  (IGI)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stress fiber assembly  (IGI)
regulation of cell-cell adhesion  (IMP)
renal vesicle formation  (IMP)
renal vesicle induction  (IDA)
response to benzoic acid  (ISO)
response to estradiol  (ISO)
response to retinoic acid  (ISO)
Sertoli cell differentiation  (IMP)
sex differentiation  (IMP)
signal transduction  (TAS)
smooth muscle cell differentiation  (IDA,IMP)
somatotropin secreting cell differentiation  (IMP)
T cell differentiation in thymus  (IDA)
tertiary branching involved in mammary gland duct morphogenesis  (IMP)
thyroid-stimulating hormone-secreting cell differentiation  (IMP)
tube morphogenesis  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis morphology  (IAGP)
abnormal adrenal gland physiology  (IAGP)
abnormal female germ cell morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal loop of Henle morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal metanephros morphology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal nephrogenic mesenchyme morphogenesis  (IAGP)
abnormal oogenesis  (IAGP)
abnormal ovary development  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal reproductive system development  (IAGP)
abnormal secondary sex determination  (IAGP)
absent kidney  (IAGP)
absent Mullerian ducts  (IAGP)
absent ovary capsule  (IAGP)
decreased areal bone mineral density  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone trabecula number  (IAGP)
decreased femoral compact bone area  (IAGP)
decreased gonadotroph cell number  (IAGP)
decreased litter size  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased motor neuron number  (IAGP)
decreased oocyte number  (IAGP)
decreased ovary weight  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased somatotroph cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased thyrotroph cell number  (IAGP)
decreased trabecular bone mass  (IAGP)
delayed kidney development  (IAGP)
disheveled coat  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
hydronephrosis  (IAGP)
kidney failure  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oocyte degeneration  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
primary sex reversal  (IAGP)
renal glomerulus cyst  (IAGP)
secondary sex reversal  (IAGP)
small kidney  (IAGP)
small metanephros  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46,XX woman. Biason-Lauber A, etal., N Engl J Med. 2004 Aug 19;351(8):792-8.
2. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
3. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
14. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Tanaka K, etal., Eur J Biochem 2000 Jul;267(13):4300-11.
15. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada Y, etal., J Am Soc Nephrol 2003 May;14(5):1223-33.
16. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
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PMID:8951078   PMID:9165114   PMID:9271117   PMID:9356179   PMID:9435283   PMID:9620855   PMID:9671592   PMID:9716459   PMID:9853965   PMID:9858722   PMID:9889131   PMID:9891778  
PMID:9989404   PMID:10349636   PMID:10415363   PMID:10572052   PMID:10585256   PMID:10654605   PMID:10704890   PMID:10733525   PMID:11042159   PMID:11076861   PMID:11114168   PMID:11171333  
PMID:11265645   PMID:11283799   PMID:11429295   PMID:11507767   PMID:11520664   PMID:11688560   PMID:11832423   PMID:11861511   PMID:11914369   PMID:11920562   PMID:11948913   PMID:11956231  
PMID:12223418   PMID:12379851   PMID:12399432   PMID:12421715   PMID:12466851   PMID:12475749   PMID:12477932   PMID:12482961   PMID:12554773   PMID:12617826   PMID:12619136   PMID:12702652  
PMID:12732619   PMID:12799076   PMID:12815618   PMID:12835383   PMID:12949260   PMID:14628042   PMID:14628051   PMID:14671310   PMID:14681479   PMID:14695376   PMID:15044261   PMID:15149334  
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PMID:18395837   PMID:18403409   PMID:18436715   PMID:18617424   PMID:18617533   PMID:18618131   PMID:18635608   PMID:18682239   PMID:18697834   PMID:18708054   PMID:18729207   PMID:18775421  
PMID:18800919   PMID:18927154   PMID:18981061   PMID:18991257   PMID:19036799   PMID:19060336   PMID:19093031   PMID:19124014   PMID:19129494   PMID:19164599   PMID:19165927   PMID:19185060  
PMID:19268447   PMID:19282366   PMID:19285468   PMID:19301398   PMID:19334288   PMID:19363157   PMID:19369396   PMID:19400999   PMID:19460349   PMID:19501082   PMID:19515997   PMID:19538736  
PMID:19562671   PMID:19591821   PMID:19598129   PMID:19715689   PMID:19740593   PMID:19753101   PMID:19757380   PMID:19806668   PMID:19809516   PMID:19820125   PMID:19830824   PMID:19842175  
PMID:19884258   PMID:19906864   PMID:19961844   PMID:19962424   PMID:20003319   PMID:20005806   PMID:20040496   PMID:20040500   PMID:20106871   PMID:20299358   PMID:20359476   PMID:20371632  
PMID:20454446   PMID:20458143   PMID:20823064   PMID:20843830   PMID:20940229   PMID:20944551   PMID:21041481   PMID:21084449   PMID:21163860   PMID:21185284   PMID:21193738   PMID:21248078  
PMID:21248711   PMID:21255566   PMID:21262216   PMID:21267068   PMID:21293032   PMID:21295565   PMID:21343368   PMID:21350016   PMID:21354128   PMID:21386911   PMID:21430080   PMID:21453014  
PMID:21486947   PMID:21490063   PMID:21491542   PMID:21531785   PMID:21533152   PMID:21541287   PMID:21559298   PMID:21574244   PMID:21592645   PMID:21613322   PMID:21623369   PMID:21654186  
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PMID:25645944   PMID:25651362   PMID:25687138   PMID:25725066   PMID:25758227   PMID:25803581   PMID:25804736   PMID:25805134   PMID:25926361   PMID:26035382   PMID:26047795   PMID:26093309  
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PMID:27624192   PMID:28045957   PMID:28049832   PMID:28118982   PMID:28334964   PMID:28348167   PMID:28575050   PMID:28637242   PMID:28637295   PMID:28659595   PMID:28760814   PMID:28800889  
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PMID:31175162   PMID:31216173   PMID:31226309   PMID:31495781   PMID:31548351   PMID:31604927   PMID:31647919   PMID:31685872   PMID:31689386   PMID:31712577   PMID:31772170   PMID:31910233  
PMID:31923383   PMID:31953387   PMID:32001436   PMID:32141129   PMID:32218432   PMID:32253237   PMID:32324134   PMID:32365547   PMID:32452519   PMID:32493750   PMID:32497039   PMID:32541007  
PMID:32554463   PMID:32586976   PMID:32634398   PMID:32715478   PMID:32855415   PMID:32855417   PMID:32907846   PMID:33103447   PMID:33141892   PMID:33328171   PMID:33441379   PMID:33500353  
PMID:33590845   PMID:33730615   PMID:33846290   PMID:33882146   PMID:34032268   PMID:34108685   PMID:34128985   PMID:34292881   PMID:34321664   PMID:34547456   PMID:34590686   PMID:34815802  
PMID:34850745   PMID:35075134   PMID:35084365   PMID:35105870   PMID:35119382   PMID:35132078   PMID:35137408   PMID:35178390   PMID:35194044   PMID:35337816   PMID:35364055   PMID:35451473  
PMID:35560108   PMID:35613264   PMID:35704566   PMID:35764169   PMID:35874829   PMID:35877077   PMID:35906245  


Genomics

Comparative Map Data
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)EnsemblGRCm39 Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBIMGSCv36mm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,117,313 - 22,143,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,117,313 - 22,143,969 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBINCBI36Build 36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
T2T-CHM13v2.0121,941,071 - 21,966,860 (-)NCBIT2T-CHM13v2.0
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,211,413 - 152,230,231 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05153,985,716 - 154,004,530 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05153,967,711 - 153,986,525 (+)NCBIRnor_WKY
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Celera5147,911,190 - 147,930,012 (+)NCBICelera
Cytogenetic Map5q36NCBI
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,252,344 - 22,264,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,659,490 - 77,687,070 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBIUU_Cfam_GSD_1.0
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,921,811 - 6,933,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv374136,851,439 - 136,851,709UniSTSGRCm37
MGSCv374136,851,442 - 136,851,605UniSTSGRCm37
Celera4135,514,068 - 135,514,231UniSTS
Celera4135,514,065 - 135,514,335UniSTS
Cytogenetic Map4D3UniSTS
cM Map4 UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384137,295,527 - 137,295,690UniSTSGRCm38
MGSCv374136,851,442 - 136,851,605UniSTSGRCm37
Celera4135,514,068 - 135,514,231UniSTS
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384137,295,524 - 137,295,794UniSTSGRCm38
MGSCv374136,851,439 - 136,851,709UniSTSGRCm37
Celera4135,514,065 - 135,514,335UniSTS
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
Wnt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
cM Map4 UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
4142082Psds2_mpsoriasis-like skin disease severity 2 (mouse)Not determined4133154678137617995Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
4141779Ssrq8_mstress response QTL 8 (mouse)Not determined136876000137617995Mouse
12050091Shm2_msperm head morphology 2 (mouse)4136876000138342753Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:603
Interacting mature miRNAs:758
Transcripts:ENSMUST00000045747
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045747   ⟹   ENSMUSP00000036580
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)Ensembl
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)Ensembl
RefSeq Acc Id: NM_009523   ⟹   NP_033549
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394137,004,946 - 137,026,812 (+)NCBI
GRCm384137,277,635 - 137,299,501 (+)ENTREZGENE
MGSCv374136,833,550 - 136,852,694 (+)RGD
Celera4135,495,983 - 135,518,012 (+)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033549   ⟸   NM_009523
- Peptide Label: precursor
- UniProtKB: P22724 (UniProtKB/Swiss-Prot),   Q3ZB23 (UniProtKB/TrEMBL),   A0A8C6GGD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036580   ⟸   ENSMUST00000045747

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22724-F1-model_v2 AlphaFold P22724 1-351 view protein structure

Promoters
RGD ID:6836668
Promoter ID:MM_KWN:40243
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:OTTMUST00000022760
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364136,833,266 - 136,833,766 (+)MPROMDB
RGD ID:6885142
Promoter ID:EPDNEW_M6022
Type:multiple initiation site
Name:Wnt4_1
Description:Mus musculus wingless-type MMTV integration site family, member4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384137,277,589 - 137,277,649EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98957 AgrOrtholog
Ensembl Genes ENSMUSG00000036856 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000036580 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045747 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98957 ENTREZGENE
NCBI Gene 22417 ENTREZGENE
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnt4 PhenoGen
PRINTS WNT4PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C6GGD3 ENTREZGENE
  P22724 ENTREZGENE
  Q3ZB23 ENTREZGENE, UniProtKB/TrEMBL
  WNT4_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Wnt4  wingless-type MMTV integration site family, member 4    wingless-related MMTV integration site 4  Symbol and/or name change 5135510 APPROVED