Iqcf1 (IQ motif containing F1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Iqcf1 (IQ motif containing F1) Mus musculus
Analyze
Symbol: Iqcf1
Name: IQ motif containing F1
RGD ID: 1558133
MGI Page MGI
Description: Exhibits calmodulin binding activity. Involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Localizes to acrosomal vesicle. Orthologous to human IQCF1 (IQ motif containing F1); INTERACTS WITH 1,2-dimethylhydrazine; folic acid; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700055J15Rik; IQ domain-containing protein F1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,377,166 - 106,379,449 (+)NCBIGRCm39mm39
GRCm389106,499,967 - 106,502,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,499,967 - 106,502,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,402,298 - 106,404,581 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,358,083 - 106,360,352 (+)NCBImm8
Celera9106,118,274 - 106,120,561 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:25380116  


Genomics

Comparative Map Data
Iqcf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,377,166 - 106,379,449 (+)NCBIGRCm39mm39
GRCm389106,499,967 - 106,502,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,499,967 - 106,502,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,402,298 - 106,404,581 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,358,083 - 106,360,352 (+)NCBImm8
Celera9106,118,274 - 106,120,561 (+)NCBICelera
Cytogenetic Map9F1NCBI
IQCF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl351,894,876 - 51,903,353 (-)EnsemblGRCh38hg38GRCh38
GRCh38351,894,876 - 51,903,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37351,928,892 - 51,937,386 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,903,932 - 51,912,391 (-)NCBINCBI36hg18NCBI36
Build 34351,903,932 - 51,912,391NCBI
Celera351,907,728 - 51,916,218 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef351,992,583 - 52,001,072 (-)NCBIHuRef
CHM1_1351,881,593 - 51,890,082 (-)NCBICHM1_1
Iqcf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08115,191,919 - 115,195,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,193,146 - 115,195,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,556,972 - 114,559,887 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,635,585 - 111,638,080 (+)NCBIRGSC3.4rn4RGSC3.4
Celera8106,442,644 - 106,445,131 (+)NCBICelera
Cytogenetic Map8q32NCBI
IQCF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1353,068,288 - 53,076,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,068,302 - 53,076,490 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0351,836,683 - 51,847,503 (-)NCBIMhudiblu_PPA_v0panPan3
IQCF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2037,797,325 - 37,799,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12037,797,253 - 37,799,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC100620649
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,057,694 - 34,059,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,057,694 - 34,059,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,254,232 - 37,255,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQCF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,264,183 - 13,271,409 (-)NCBI
ChlSab1.1 Ensembl2213,264,197 - 13,270,856 (-)Ensembl


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:114
Interacting mature miRNAs:118
Transcripts:ENSMUST00000085114, ENSMUST00000164965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000085114   ⟹   ENSMUSP00000082195
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,499,992 - 106,502,254 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164965   ⟹   ENSMUSP00000126039
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,499,967 - 106,502,244 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215037   ⟹   ENSMUSP00000149801
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,500,001 - 106,502,248 (+)Ensembl
RefSeq Acc Id: NM_001146701   ⟹   NP_001140173
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,377,166 - 106,379,449 (+)NCBI
GRCm389106,499,967 - 106,502,250 (+)ENTREZGENE
MGSCv379106,402,298 - 106,404,581 (+)RGD
Celera9106,118,274 - 106,120,561 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028843   ⟹   NP_083119
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,377,166 - 106,379,448 (+)NCBI
GRCm389106,499,967 - 106,502,249 (+)NCBI
MGSCv379106,402,298 - 106,404,581 (+)RGD
Celera9106,118,274 - 106,120,561 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001140173 (Get FASTA)   NCBI Sequence Viewer  
  NP_083119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH49769 (Get FASTA)   NCBI Sequence Viewer  
  BAB24744 (Get FASTA)   NCBI Sequence Viewer  
  EDL21152 (Get FASTA)   NCBI Sequence Viewer  
  Q9D9K8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001140173   ⟸   NM_001146701
- Peptide Label: isoform 2
- UniProtKB: Q9D9K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_083119   ⟸   NM_028843
- Peptide Label: isoform 1
- UniProtKB: Q9D9K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126039   ⟸   ENSMUST00000164965
RefSeq Acc Id: ENSMUSP00000082195   ⟸   ENSMUST00000085114
RefSeq Acc Id: ENSMUSP00000149801   ⟸   ENSMUST00000215037
Protein Domains
IQ

Promoters
RGD ID:8670742
Promoter ID:EPDNEW_M13402
Type:initiation region
Name:Iqcf1_1
Description:Mus musculus IQ motif containing F1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,499,990 - 106,500,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921517 AgrOrtholog
Ensembl Genes ENSMUSG00000066383 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000082195 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126039 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149801 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085114 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000164965 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000215037 UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  IQCF UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:74267 UniProtKB/Swiss-Prot
MGD MGI:1921517 ENTREZGENE
NCBI Gene 74267 ENTREZGENE
PANTHER PTHR21633 UniProtKB/Swiss-Prot
Pfam PF00612 UniProtKB/Swiss-Prot
PhenoGen Iqcf1 PhenoGen
PROSITE PS50096 UniProtKB/Swiss-Prot
SMART SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniGene Mm.116682 ENTREZGENE
UniProt A0A1L1SS97_MOUSE UniProtKB/TrEMBL
  IQCF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q810M2 UniProtKB/Swiss-Prot