Iqcf1 (IQ motif containing F1) - Rat Genome Database

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Gene: Iqcf1 (IQ motif containing F1) Mus musculus
Analyze
Symbol: Iqcf1
Name: IQ motif containing F1
RGD ID: 1558133
MGI Page MGI
Description: Enables calmodulin binding activity. Involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. Orthologous to human IQCF1 (IQ motif containing F1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700055J15Rik; IQ domain-containing protein F1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,377,166 - 106,379,449 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,377,166 - 106,379,453 (+)EnsemblGRCm39 Ensembl
GRCm389106,499,967 - 106,502,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,499,967 - 106,502,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,402,298 - 106,404,581 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,358,083 - 106,360,352 (+)NCBIMGSCv36mm8
Celera9106,118,274 - 106,120,561 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:25380116   PMID:38355793  


Genomics

Comparative Map Data
Iqcf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,377,166 - 106,379,449 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,377,166 - 106,379,453 (+)EnsemblGRCm39 Ensembl
GRCm389106,499,967 - 106,502,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,499,967 - 106,502,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,402,298 - 106,404,581 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,358,083 - 106,360,352 (+)NCBIMGSCv36mm8
Celera9106,118,274 - 106,120,561 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.65NCBI
IQCF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38351,894,876 - 51,903,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl351,894,876 - 51,903,353 (-)EnsemblGRCh38hg38GRCh38
GRCh37351,928,892 - 51,937,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,903,932 - 51,912,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 34351,903,932 - 51,912,391NCBI
Celera351,907,728 - 51,916,218 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef351,992,583 - 52,001,072 (-)NCBIHuRef
CHM1_1351,881,593 - 51,890,082 (-)NCBICHM1_1
T2T-CHM13v2.0351,927,807 - 51,936,279 (-)NCBIT2T-CHM13v2.0
Iqcf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,008,081 - 116,011,950 (+)NCBIGRCr8
mRatBN7.28107,129,462 - 107,133,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,130,704 - 107,133,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,753,894 - 112,756,362 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,953,070 - 110,955,538 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,795,852 - 108,798,320 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,191,919 - 115,195,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,193,146 - 115,195,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,556,972 - 114,559,887 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,635,585 - 111,638,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8106,442,644 - 106,445,131 (+)NCBICelera
Cytogenetic Map8q32NCBI
LOC102021703
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,559,990 - 3,561,238 (-)NCBIChiLan1.0ChiLan1.0
IQCF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2251,890,290 - 51,927,780 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1351,882,930 - 51,905,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,836,683 - 51,847,503 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,068,288 - 53,076,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,068,302 - 53,076,490 (-)Ensemblpanpan1.1panPan2
IQCF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,797,253 - 37,799,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,797,325 - 37,799,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,777,288 - 37,779,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02038,146,404 - 38,148,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,146,476 - 38,148,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,510,001 - 37,511,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,918,928 - 37,920,765 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,203,853 - 38,205,711 (+)NCBIUU_Cfam_GSD_1.0
LOC101959243
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,502,800 - 66,504,791 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365293,263,311 - 3,266,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQCF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,057,164 - 34,060,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,057,694 - 34,059,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,254,232 - 37,255,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQCF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,264,183 - 13,271,409 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,264,197 - 13,270,856 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,634,100 - 153,670,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714413
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247305,706,146 - 5,706,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqcf1
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:114
Interacting mature miRNAs:118
Transcripts:ENSMUST00000085114, ENSMUST00000164965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985779563108518385Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972859058106859205Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972859058106859205Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse


Sequence


Ensembl Acc Id: ENSMUST00000085114   ⟹   ENSMUSP00000082195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9106,377,191 - 106,379,453 (+)Ensembl
GRCm38.p6 Ensembl9106,499,992 - 106,502,254 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164965   ⟹   ENSMUSP00000126039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9106,377,166 - 106,379,443 (+)Ensembl
GRCm38.p6 Ensembl9106,499,967 - 106,502,244 (+)Ensembl
Ensembl Acc Id: ENSMUST00000215037   ⟹   ENSMUSP00000149801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9106,377,200 - 106,379,447 (+)Ensembl
GRCm38.p6 Ensembl9106,500,001 - 106,502,248 (+)Ensembl
RefSeq Acc Id: NM_001146701   ⟹   NP_001140173
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,377,166 - 106,379,449 (+)NCBI
GRCm389106,499,967 - 106,502,250 (+)ENTREZGENE
MGSCv379106,402,298 - 106,404,581 (+)RGD
Celera9106,118,274 - 106,120,561 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028843   ⟹   NP_083119
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,377,166 - 106,379,448 (+)NCBI
GRCm389106,499,967 - 106,502,249 (+)NCBI
MGSCv379106,402,298 - 106,404,581 (+)RGD
Celera9106,118,274 - 106,120,561 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001140173   ⟸   NM_001146701
- Peptide Label: isoform 2
- UniProtKB: Q9D9K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_083119   ⟸   NM_028843
- Peptide Label: isoform 1
- UniProtKB: Q810M2 (UniProtKB/Swiss-Prot),   Q9D9K8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000126039   ⟸   ENSMUST00000164965
Ensembl Acc Id: ENSMUSP00000082195   ⟸   ENSMUST00000085114
Ensembl Acc Id: ENSMUSP00000149801   ⟸   ENSMUST00000215037
Protein Domains
IQ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D9K8-F1-model_v2 AlphaFold Q9D9K8 1-182 view protein structure

Promoters
RGD ID:8670742
Promoter ID:EPDNEW_M13402
Type:initiation region
Name:Iqcf1_1
Description:Mus musculus IQ motif containing F1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,499,990 - 106,500,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921517 AgrOrtholog
Ensembl Genes ENSMUSG00000066383 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085114 ENTREZGENE
  ENSMUST00000085114.8 UniProtKB/Swiss-Prot
  ENSMUST00000164965 ENTREZGENE
  ENSMUST00000164965.3 UniProtKB/Swiss-Prot
  ENSMUST00000215037.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.190 UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  IQCF UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:74267 UniProtKB/Swiss-Prot
MGD MGI:1921517 ENTREZGENE
NCBI Gene 74267 ENTREZGENE
PANTHER IQ DOMAIN-CONTAINING PROTEIN F1 UniProtKB/Swiss-Prot
  PTHR21633 UniProtKB/Swiss-Prot
Pfam PF00612 UniProtKB/Swiss-Prot
PhenoGen Iqcf1 PhenoGen
PROSITE PS50096 UniProtKB/Swiss-Prot
SMART SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A1L1SS97_MOUSE UniProtKB/TrEMBL
  IQCF1_MOUSE UniProtKB/Swiss-Prot
  Q810M2 ENTREZGENE
  Q9D9K8 ENTREZGENE
UniProt Secondary Q810M2 UniProtKB/Swiss-Prot