Gene: Pias2 (protein inhibitor of activated STAT 2) Mus musculus
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Symbol:
Pias2
Name:
protein inhibitor of activated STAT 2
Description:
Exhibits several functions, including SUMO transferase activity; transcription factor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; protein sumoylation; and regulation of osteoblast differentiation. Localizes to the nuclear body. Predicted to colocalize with the PML body. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2); PARTICIPATES IN Jak-Stat signaling pathway; hepatitis C pathway; small cell lung carcinoma pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
6330408K17Rik; AI462206; androgen receptor-interacting protein 3; ARIP3; AU018068; DAB2-interacting protein; Dib; DIP; E3 SUMO-protein ligase PIAS2; Miz1; msx-interacting zinc finger protein; Msx-interacting-zinc finger; PIASxalpha; PIASxalpha6; PIASxb; PIASxbeta; protein inhibitor of activated STAT x; RING-type E3 ubiquitin transferase PIAS2; SIZ2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PIAS2 (protein inhibitor of activated STAT 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Pias2 (protein inhibitor of activated STAT, 2) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pias2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PIAS2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PIAS2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pias2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PIAS2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PIAS2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pias2 (protein inhibitor of activated STAT 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PIAS1 (protein inhibitor of activated STAT 1) HGNC
OrthoMCL
Homo sapiens (human):
PIAS3 (protein inhibitor of activated STAT 3) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Pias2 (protein inhibitor of activated STAT, 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
PIAS2 (protein inhibitor of activated STAT 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
pias2 (protein inhibitor of activated STAT, 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
NFI1
Alliance
DIOPT (Ensembl Compara, Hieranoid, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Su(var)2-10
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
gei-17
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Saccharomyces cerevisiae (baker's yeast):
SIZ1
Alliance
DIOPT (Ensembl Compara, Hieranoid, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
Gm9038
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 18 77,065,208 - 77,153,800 (+) Ensembl GRCm38 18 77,065,176 - 77,155,710 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 18 77,303,947 - 77,394,447 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 18 77,269,658 - 77,358,250 (+) NCBI mm8 Celera 18 78,248,789 - 78,338,301 (+) NCBI Celera Cytogenetic Map 18 E3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of PIAS2 mRNA CTD PMID:24096037 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:71056 6480464 o, p'-DDT results in increased expression of PIAS2 mRNA CTD PMID:24096037 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of PIAS2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIAS2 mRNA CTD PMID:17942748 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:1603704 6480464 [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form] CTD PMID:28751236 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1603704 6480464 2 more ... CTD PMID:19095052 2,3',4,4',5-Pentachlorobiphenyl affects expression EXP 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIAS2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1603704 6480464 Tetrachlorodibenzodioxin results in increased expression of PIAS2 mRNA CTD PMID:21296121 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PIAS2 mRNA CTD PMID:18648102 aflatoxin B1 increases methylation ISO RGD:1603704 6480464 Aflatoxin B1 results in increased methylation of PIAS2 gene CTD PMID:27153756 antirheumatic drug increases expression ISO RGD:1603704 6480464 Antirheumatic Agents results in increased expression of PIAS2 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PIAS2 mRNA CTD PMID:23650126 arsenous acid multiple interactions EXP 6480464 Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] CTD PMID:29095437 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PIAS2 mRNA CTD PMID:29095437 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PIAS2 mRNA CTD PMID:19770486 bisphenol A increases expression ISO RGD:71056 6480464 bisphenol A results in increased expression of PIAS2 mRNA CTD PMID:25181051 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of PIAS2 mRNA, Nanotubes, Carbon results in increased expression of PIAS2 mRNA CTD PMID:25554681 , PMID:25620056 crocidolite asbestos affects expression ISO RGD:1603704 6480464 Asbestos, Crocidolite affects the expression of PIAS2 mRNA CTD PMID:17331233 diarsenic trioxide multiple interactions EXP 6480464 Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] CTD PMID:29095437 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PIAS2 mRNA CTD PMID:29095437 dorsomorphin multiple interactions ISO RGD:1603704 6480464 [NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1603704 6480464 Doxorubicin results in decreased expression of PIAS2 mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:1603704 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PIAS2 protein CTD PMID:23301498 finasteride increases expression ISO RGD:71056 6480464 Finasteride results in increased expression of PIAS2 mRNA CTD PMID:24136188 flutamide increases expression ISO RGD:71056 6480464 Flutamide results in increased expression of PIAS2 mRNA CTD PMID:24136188 furan increases methylation ISO RGD:71056 6480464 furan results in increased methylation of PIAS2 gene CTD PMID:22079235 hydrogen peroxide multiple interactions ISO RGD:1603704 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS2 protein CTD PMID:18951874 lead nitrate multiple interactions EXP 6480464 lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA], lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA] CTD PMID:11891201 mercury atom affects expression ISO RGD:1603704 6480464 Mercury affects the expression of PIAS2 mRNA CTD PMID:23920476 mercury dichloride multiple interactions ISO RGD:1603704 6480464 [NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIAS2 mRNA CTD PMID:27188386 mercury(0) affects expression ISO RGD:1603704 6480464 Mercury affects the expression of PIAS2 mRNA CTD PMID:23920476 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] CTD PMID:29095437 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of PIAS2 mRNA CTD PMID:25270620 N-nitrosodiethylamine multiple interactions ISO RGD:71056 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PIAS2 mRNA CTD PMID:20360939 okadaic acid increases expression EXP 6480464 Okadaic Acid results in increased expression of PIAS2 mRNA CTD PMID:25270620 perfluorooctanoic acid increases expression ISO RGD:71056 6480464 perfluorooctanoic acid results in increased expression of PIAS2 mRNA CTD PMID:19162173 phenethyl caffeate multiple interactions ISO RGD:71056 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PIAS2 mRNA CTD PMID:20360939 pirinixic acid increases expression ISO RGD:71056 6480464 pirinixic acid results in increased expression of PIAS2 mRNA CTD PMID:19162173 pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of PIAS2 mRNA] CTD PMID:21318169 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PIAS2 mRNA CTD PMID:21318169 SB 431542 multiple interactions ISO RGD:1603704 6480464 [NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom decreases expression EXP 6480464 Silver results in decreased expression of PIAS2 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of PIAS2 mRNA CTD PMID:27131904 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIAS2 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PIAS2 mRNA CTD PMID:21641980 , PMID:26378955 sunitinib increases expression ISO RGD:1603704 6480464 Sunitinib results in increased expression of PIAS2 mRNA CTD PMID:31533062 theophylline multiple interactions ISO RGD:1603704 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS2 protein CTD PMID:18951874 thimerosal multiple interactions ISO RGD:1603704 6480464 [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIAS2 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1603704 6480464 Valproic Acid results in increased expression of PIAS2 mRNA CTD PMID:23179753
Gene Ontology Annotations
Biological Process androgen receptor signaling pathway ISO RGD:71056 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of androgen receptor signaling pathway ISO UniProtKB:O75928 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of DNA-binding transcription factor activity ISO UniProtKB:O75928 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of dendrite morphogenesis ISO RGD:71056 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:1929027, PMID:11104669) MGI MGI:MGI:1929027 , PMID:11104669 positive regulation of transcription, DNA-templated IDA 2290270 (MGI:MGI:3723333, PMID:17623776) MGI MGI:MGI:3723333 , PMID:17623776 positive regulation of transcription, DNA-templated ISO RGD:71056 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein sumoylation IDA 2290270 (MGI:MGI:3575864, PMID:15767674) MGI MGI:MGI:3575864 , PMID:15767674 protein sumoylation IBA MGI:MGI:1096566 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein sumoylation ISO UniProtKB:O75928 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of androgen receptor signaling pathway ISO UniProtKB:Q6AZ28 2290270 (MGI:MGI:1329791, PMID:9920921) MGI MGI:MGI:1329791 , PMID:9920921 regulation of osteoblast differentiation IMP 2290270 (MGI:MGI:3723333, PMID:17623776) MGI MGI:MGI:3723333 , PMID:17623776 regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:894957, PMID:9256341) MGI MGI:MGI:894957 , PMID:9256341 regulation of transcription by RNA polymerase II IBA MGI:MGI:1096566 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of transcription, DNA-templated ISO RGD:71056 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 transcription, DNA-templated IDA 2290270 (MGI:MGI:894957, PMID:9256341) MGI MGI:MGI:894957 , PMID:9256341 
Gene Ontology Annotations
