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Gene: Pias2 (protein inhibitor of activated STAT 2) Mus musculus
Symbol: Pias2
Name: protein inhibitor of activated STAT 2
Description: Exhibits several functions, including SUMO transferase activity; transcription factor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; protein sumoylation; and regulation of osteoblast differentiation. Localizes to the nuclear body. Predicted to colocalize with the PML body. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2); PARTICIPATES IN Jak-Stat signaling pathway; hepatitis C pathway; small cell lung carcinoma pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330408K17Rik; AI462206; androgen receptor-interacting protein 3; ARIP3; AU018068; DAB2-interacting protein; Dib; DIP; E3 SUMO-protein ligase PIAS2; Miz1; msx-interacting zinc finger protein; Msx-interacting-zinc finger; PIASxalpha; PIASxalpha6; PIASxb; PIASxbeta; protein inhibitor of activated STAT x; RING-type E3 ubiquitin transferase PIAS2; SIZ2
Homo sapiens (human) : PIAS2 (protein inhibitor of activated STAT 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pias2 (protein inhibitor of activated STAT, 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pias2 (protein inhibitor of activated STAT 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PIAS2 (protein inhibitor of activated STAT 2)
Canis lupus familiaris (dog) : PIAS2 (protein inhibitor of activated STAT 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pias2 (protein inhibitor of activated STAT 2)
Sus scrofa (pig) : PIAS2 (protein inhibitor of activated STAT 2)
Chlorocebus sabaeus (African green monkey) : PIAS2 (protein inhibitor of activated STAT 2)
Heterocephalus glaber (naked mole-rat) : Pias2 (protein inhibitor of activated STAT 2)
more info ...
Related Pseudogenes: Gm9038  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1877,065,208 - 77,153,800 (+)Ensembl
GRCm381877,065,176 - 77,155,710 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371877,303,947 - 77,394,447 (+)NCBIGRCm37mm9NCBIm37
MGSCv361877,269,658 - 77,358,250 (+)NCBImm8
Celera1878,248,789 - 78,338,301 (+)NCBICelera
Cytogenetic Map18 E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pias2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735930
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.