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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:hypoxia inducible factor pathway
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Accession:PW:0000360 term browser browse the term
Definition:The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis.
Synonyms:related_synonym: HIF pathway;   Regulation of gene expression by Hypoxia-inducible Factor
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hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO PID PID:200202 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO PID PID:200036 PID:200202 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Adm adrenomedullin ISO PID PID:200202 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Adora2a adenosine A2a receptor ISO PID PID:200036 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200202 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A ISO PID PID:200202 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Aldoart2 aldolase 1 A retrogene 2 ISO PID PID:200202 NCBI chr 6:78,674,945...78,676,635
Ensembl chr 6:78,673,353...78,680,406 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO PID PID:200036 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO PID
RGD		 PMID:22169972 PID:200036 PID:200202, RGD:6483352 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 ISO RGD PMID:22169972 RGD:6483352 NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:147,599,058...147,801,997 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 ISO PID PID:200036 PID:200202 NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 ISO PID PID:200202 NCBI chr 4:180,565,003...180,569,415
Ensembl chr 4:180,565,003...180,569,355 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200202 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Ca9 carbonic anhydrase 9 ISO PID PID:200202 NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ISO PID PID:200036 PID:200202 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
G Cops5 COP9 signalosome subunit 5 ISO PID PID:200202 NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387 		JBrowse link
G Cp ceruloplasmin ISO PID PID:200202 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO PID PID:200202 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202, RGD:6483358, RGD:6483503 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Cul2 cullin 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO PID PID:200202 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO PID PID:200202 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Edn1 endothelin 1 ISO PID PID:200202 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Efna1 ephrin A1 ISO PID PID:200036 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA
ISO
TAS 		PID
RGD		 PMID:12876291 PMID:20396958 PMID:19364912 PMID:14597660 PID:200036 PID:200202, RGD:727754, RGD:6483503, RGD:6483358, RGD:1334466 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 ISO PID
RGD		 PMID:20396958 PID:200036, RGD:6483503 NCBI chr 1:91,579,205...91,586,985
Ensembl chr 1:91,579,206...91,587,385 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISO PID
RGD		 PMID:20396958 PID:200036 PID:200202, RGD:6483503 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E ISO PID PID:200036 NCBI chr 7:76,224,567...76,257,346
Ensembl chr 7:76,224,568...76,257,785 		JBrowse link
G Elk1 ETS transcription factor ELK1 ISO PID PID:200036 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249 		JBrowse link
G Elob elongin B ISO PID
RGD		 PMID:19364912 PID:200036, RGD:6483358 NCBI chr10:13,353,413...13,358,484
Ensembl chr10:13,353,417...13,358,563 		JBrowse link
G Eloc elongin C ISO PID
RGD		 PMID:19364912 PID:200036, RGD:6483358 NCBI chr 5:7,444,769...7,461,187
Ensembl chr20:25,752,857...25,753,279 		JBrowse link
G Eng endoglin ISO PID PID:200202 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200202 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Ep300 EP300 lysine acetyltransferase ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202, RGD:6483358, RGD:6483503 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO PID
RGD		 PMID:22169972 PMID:20396958 PID:200036, RGD:6483352, RGD:6483503 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Epo erythropoietin ISO PID PID:200036 PID:200202 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO PID PID:200036 PID:200202 NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021 		JBrowse link
G Fech ferrochelatase ISO PID PID:200202 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO PID PID:200036 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200202 NCBI chr 1:143,757,389...143,770,430
Ensembl chr 1:143,757,391...143,773,497 		JBrowse link
G Fxn frataxin ISO PID PID:200036 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:231,300,150...231,323,989 		JBrowse link
G Gata2 GATA binding protein 2 ISO PID PID:200202 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055 		JBrowse link
G Gck glucokinase ISO PID PID:200202 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Hdac7 histone deacetylase 7 ISO PID PID:200202 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:130,803,013...130,841,017 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IDA
ISO 		PID
RGD		 PMID:12388599 PMID:20396958 PMID:22169972 PMID:18614764 PMID:15063765 PID:200202, RGD:628389, RGD:6483503, RGD:6483352, RGD:2301848, RGD:1580561 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor ISO PID
RGD		 PMID:14597660 PMID:19364912 PMID:22169972 PID:200036, RGD:1334466, RGD:6483358, RGD:6483352 NCBI chr 1:253,368,400...253,385,495
Ensembl chr 1:253,367,683...253,385,491 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha TAS
ISO 		RGD PMID:11237857 PMID:22169972 RGD:68201, RGD:6483352 NCBI chr 1:86,846,196...86,878,527
Ensembl chr 1:86,850,554...86,877,838 		JBrowse link
G Hk1 hexokinase 1 ISO PID PID:200202 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hk2 hexokinase 2 ISO PID PID:200202 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmox1 heme oxygenase 1 ISO PID PID:200202 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha ISO PID PID:200202 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO PID PID:200202 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO PID PID:200202 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO PID PID:200202 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kdr kinase insert domain receptor ISO PID PID:200036 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Ldha lactate dehydrogenase A ISO PID PID:200202 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lep leptin ISO PID PID:200202 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200202 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO PID PID:200036 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO PID PID:200202 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO PID PID:200202 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO PID PID:200202 NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO PID PID:200202 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Npm1 nucleophosmin 1 ISO PID PID:200202 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr  X:18,245,740...18,256,024 		JBrowse link
G Nt5e 5' nucleotidase, ecto ISO PID PID:200202 NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin ISO RGD PMID:19364912 RGD:6483358 NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO PID PID:200202 NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052 		JBrowse link
G Pfkl phosphofructokinase, liver type ISO PID PID:200202 NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO PID PID:200036 PID:200202 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959 		JBrowse link
G Pgm1 phosphoglucomutase 1 ISO PID PID:200202 NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:119,710,737...119,770,159 		JBrowse link
G Pkm pyruvate kinase M1/2 ISO PID PID:200202 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Plin2 perilipin 2 ISO PID PID:200202 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO PID PID:200036 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chr  X:44,008,089...44,011,376
Ensembl chr  X:44,006,781...44,011,374 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chr10:54,839,531...54,841,651
Ensembl chr10:54,839,189...54,841,958 		JBrowse link
G Serpine1 serpin family E member 1 ISO PID PID:200036 PID:200202 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sirt1 sirtuin 1 ISO PID PID:200036 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO PID PID:200036 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO PID PID:200036 PID:200202 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Smad3 SMAD family member 3 ISO PID PID:200202 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad4 SMAD family member 4 ISO PID PID:200202 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Sp1 Sp1 transcription factor ISO PID PID:200036 PID:200202 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513 		JBrowse link
G Tert telomerase reverse transcriptase ISO PID PID:200202 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tf transferrin ISO PID PID:200202 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400 		JBrowse link
G Tff3 trefoil factor 3 ISO PID PID:200202 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333 		JBrowse link
G Tfrc transferrin receptor ISO PID PID:200202 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO PID PID:200036 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200036 PID:200202 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO
IDA 		PID
RGD		 PMID:15611513 PMID:15063765 PMID:19364912 PID:200036, RGD:1358257, RGD:1580561, RGD:6483358 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991 		JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      transcription factor mediated signaling pathway 445
        hypoxia inducible factor pathway 93
          altered hypoxia inducible factor pathway 1
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        inorganic chemical homeostasis pathway 430
          oxygen homeostasis pathway 93
            hypoxia inducible factor pathway 93
              altered hypoxia inducible factor pathway 1
paths to the root