Aldoart2 (aldolase 1 A retrogene 2) - Rat Genome Database

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Gene: Aldoart2 (aldolase 1 A retrogene 2) Rattus norvegicus
Analyze
Symbol: Aldoart2
Name: aldolase 1 A retrogene 2
RGD ID: 1359133
Description: Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to be located in I band and M band. Predicted to be active in cytosol; PARTICIPATES IN Fanconi syndrome pathway; fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH acrylamide; bisphenol A; furan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aldoal1; Aldoart1; aldolase 1 A retrogene 1; aldolase A-like 1; fructose-bisphosphate aldolase; fructose-bisphosphate aldolase C-B; LOC299052; similar to Fructose-bisphosphate aldolase A (Muscle-type aldolase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,674,945 - 78,676,635 (+)NCBIGRCr8
mRatBN7.2672,939,821 - 72,941,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,939,788 - 72,941,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,361,318 - 73,363,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,667,686 - 73,669,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,095,184 - 73,096,873 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,349,362 - 76,351,052 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,349,362 - 76,351,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,883,180 - 85,884,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,812,016 - 75,813,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,815,141 - 75,816,831 (+)NCBI
Celera671,781,674 - 71,783,364 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
I band  (IEA)
M band  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17659271   PMID:19182904   PMID:22082260  


Genomics

Comparative Map Data
Aldoart2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,674,945 - 78,676,635 (+)NCBIGRCr8
mRatBN7.2672,939,821 - 72,941,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,939,788 - 72,941,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,361,318 - 73,363,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,667,686 - 73,669,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,095,184 - 73,096,873 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,349,362 - 76,351,052 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,349,362 - 76,351,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,883,180 - 85,884,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,812,016 - 75,813,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,815,141 - 75,816,831 (+)NCBI
Celera671,781,674 - 71,783,364 (+)NCBICelera
Cytogenetic Map6q23NCBI
ALDOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,053,151 - 30,070,414 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,064,164 - 30,072,207 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,053,090 - 30,070,420 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,064,164 - 30,070,457 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,064,472 - 30,081,735 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,971,992 - 29,989,236 (+)NCBINCBI36Build 36hg18NCBI36
Build 341629,983,100 - 29,989,235NCBI
Celera1672,713,985 - 72,731,229 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,725,968 - 27,743,009 (+)NCBIHuRef
CHM1_11631,280,168 - 31,297,498 (+)NCBICHM1_1
T2T-CHM13v2.01630,335,801 - 30,353,059 (+)NCBIT2T-CHM13v2.0
Aldoart2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,611,990 - 55,613,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,612,024 - 55,613,681 (+)EnsemblGRCm39 Ensembl
GRCm381255,565,205 - 55,566,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,565,239 - 55,566,896 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,666,122 - 56,667,696 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,483,685 - 56,484,179 (+)NCBIMGSCv36mm8
Celera1256,714,814 - 56,716,388 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.04NCBI
Aldoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,904,091 - 6,908,959 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,904,931 - 6,910,682 (-)NCBIChiLan1.0ChiLan1.0
LOC100995352
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,796,888 - 30,814,367 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,411,499 - 35,428,994 (-)NCBINHGRI_mPanPan1
PanPan1.11630,428,190 - 30,444,910 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC102157295
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,069,839 - 18,077,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,648,461 - 19,655,895 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,205,816 - 18,213,233 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1618,004,777 - 18,012,193 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,920,174 - 17,927,597 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,234,326 - 18,243,209 (+)NCBIUU_Cfam_GSD_1.0
Aldoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,320,230 - 124,326,099 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,418,090 - 12,422,689 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,418,090 - 12,423,959 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103230584
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,588,932 - 26,606,722 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,588,868 - 26,592,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,932,348 - 2,947,575 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,183,924 - 13,189,286 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldoart2
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:193
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000043224
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67222764181132889Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 16 48 46 44 17 22 17 6 106 59 29 14 32 27

Sequence


Ensembl Acc Id: ENSRNOT00000043224   ⟹   ENSRNOP00000041393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,939,788 - 72,941,709 (+)Ensembl
Rnor_6.0 Ensembl676,349,362 - 76,351,051 (+)Ensembl
RefSeq Acc Id: NM_001013943   ⟹   NP_001013965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,674,945 - 78,676,635 (+)NCBI
mRatBN7.2672,939,821 - 72,941,511 (+)NCBI
Rnor_6.0676,349,362 - 76,351,052 (+)NCBI
Rnor_5.0685,883,180 - 85,884,870 (+)NCBI
RGSC_v3.4675,812,016 - 75,813,706 (+)RGD
Celera671,781,674 - 71,783,364 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013965 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79243 (Get FASTA)   NCBI Sequence Viewer  
  EDM03429 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041393.3
  ENSRNOP00000069507.2
RefSeq Acc Id: NP_001013965   ⟸   NM_001013943
- UniProtKB: Q6AY07 (UniProtKB/TrEMBL),   F1LP06 (UniProtKB/TrEMBL),   A0A9K3Y7M7 (UniProtKB/TrEMBL),   A0A8L2R123 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041393   ⟸   ENSRNOT00000043224

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY07-F1-model_v2 AlphaFold Q6AY07 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694607
Promoter ID:EPDNEW_R5132
Type:initiation region
Name:Aldoart2_1
Description:aldolase 1 A retrogene 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,349,361 - 76,349,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359133 AgrOrtholog
BioCyc Gene G2FUF-37485 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000030869 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000052802 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043224.3 UniProtKB/TrEMBL
  ENSRNOT00000087928.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132739 IMAGE-MGC_LOAD
InterPro Aldolase_I UniProtKB/TrEMBL
  Aldolase_I_AS UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/TrEMBL
KEGG Report rno:299052 UniProtKB/TrEMBL
MGC_CLONE MGC:94327 IMAGE-MGC_LOAD
NCBI Gene 299052 ENTREZGENE
PANTHER FRUCTOSE-BISPHOSPHATE ALDOLASE A UniProtKB/TrEMBL
  PTHR11627 UniProtKB/TrEMBL
Pfam Glycolytic UniProtKB/TrEMBL
PhenoGen Aldoart2 PhenoGen
PROSITE ALDOLASE_CLASS_I UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030869 RatGTEx
  ENSRNOG00000052802 RatGTEx
Superfamily-SCOP Aldolase UniProtKB/TrEMBL
UniProt A0A8L2R123 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7M7 ENTREZGENE, UniProtKB/TrEMBL
  F1LP06 ENTREZGENE
  Q6AY07 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LP06 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Aldoart2  aldolase 1 A retrogene 2  Aldoart1  aldolase 1 A retrogene 1  Name and Symbol changed 629549 APPROVED
2012-07-13 Aldoart1  aldolase 1 A retrogene 1  Aldoal1  aldolase A-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Aldoal1  aldolase A-like 1  LOC299052  similar to Fructose-bisphosphate aldolase A (Muscle-type aldolase)  Symbol and Name updated 1299863 PROVISIONAL
2005-07-29 LOC299052  similar to Fructose-bisphosphate aldolase A (Muscle-type aldolase)      Symbol and Name status set to provisional 70820 PROVISIONAL