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Term:
Parent Terms Term With Siblings Child Terms
altered androgen signaling pathway   
altered basic helix-loop-helix signaling pathway +  
altered cortisol signaling pathway 
altered estrogen signaling pathway 
altered hypoxia inducible factor pathway   
A hypoxia inducible pathway that deviates from what its normal course should be. Mutations in the von Hippel-Lindau (Vhl), the E3 ubiquitin ligase which targets Hif alpha for degradation under normoxic conditions, lead to a constitutively active pathway regardless the levels of oxygen. Mutations in Vhl and a number of other genes have been implicated in renal cancers.
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altered nuclear factor kappa B signaling pathway 
altered p53 signaling pathway   
altered peroxisome proliferator-activated receptor signaling pathway 

Synonyms
Definition Sources: PMID:22406000

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