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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered hypoxia inducible factor pathway
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Accession:PW:0001102 term browser browse the term
Definition:A hypoxia inducible pathway that deviates from what its normal course should be. Mutations in the von Hippel-Lindau (Vhl), the E3 ubiquitin ligase which targets Hif alpha for degradation under normoxic conditions, lead to a constitutively active pathway regardless the levels of oxygen. Mutations in Vhl and a number of other genes have been implicated in renal cancers.
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altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      transcription factor mediated signaling pathway 445
        altered transcription factor mediated signaling pathway 17
          altered hypoxia inducible factor pathway 1
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          oxygen homeostasis pathway 93
            hypoxia inducible factor pathway 93
              altered hypoxia inducible factor pathway 1
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