tyrphostin AG 1478 - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tyrphostin AG 1478	go back to main search page
Accession:	CHEBI:75404	browse the term
Definition:	A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Synonyms:	exact_synonym:	N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine
	related_synonym:	AG-1478; Formula=C16H14ClN3O2; InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20); InChIKey=GFNNBHLJANVSQV-UHFFFAOYSA-N; SMILES=COC1=C(OC)C=C2C(NC3=CC(Cl)=CC=C3)=NC=NC2=C1
	xref:	CAS:170449-18-0; LINCS:LSM-1224
	xref_mesh:	MESH:C101044
	xref:	PDBeChem:0TO; PMID:11997261; PMID:20008468; PMID:22363408; PMID:22646904; PMID:23758273; PMID:24134630; PMID:8752145; Reaxys:7437034

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Genes (126)

tyrphostin AG 1478

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

angiotensin I converting enzyme

multiple interactions

RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

RTKI cpd results in decreased expression of ACTA2 protein
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

adrenoceptor beta 1

multiple interactions

RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]

NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904

G

angiotensinogen

multiple interactions

RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]; RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of EGFR protein]

PMID:15849355 PMID:25398788

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

AKT serine/threonine kinase 1

multiple interactions

RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of AKT1 protein]]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]

PMID:11309286 PMID:15177934 PMID:15849355 PMID:19233221 PMID:19946718 More...

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

albumin

multiple interactions

RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

arachidonate 5-lipoxygenase

multiple interactions

[RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]
RTKI cpd inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]

PMID:14569062 PMID:20153347

NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119

G

angiopoietin 1

multiple interactions

RTKI cpd inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA]

NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055

G

angiopoietin 2

multiple interactions

RTKI cpd inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA]

NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409

G

androgen receptor

multiple interactions

RTKI cpd inhibits the reaction [EGF protein results in decreased expression of AR protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of AR protein]; RTKI cpd inhibits the reaction [Vehicle Emissions results in increased secretion of AR protein]

PMID:16472761 PMID:24555532

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

amphiregulin

multiple interactions
decreases activity

RTKI cpd inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]
RTKI cpd results in decreased activity of AREG protein

PMID:15706222 PMID:21185374

NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005

G

activating transcription factor 1

multiple interactions

RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]

NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]; RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein]

NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591

G

BCL2 associated X, apoptosis regulator

multiple interactions

RTKI cpd results in increased expression of and results in increased activity of BAX protein
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]]
ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]

PMID:18371937 PMID:34724321 PMID:35716406

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]]

PMID:34724321 PMID:35716406

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

RTKI cpd results in decreased expression of BCL2L1 mRNA; RTKI cpd results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

baculoviral IAP repeat containing 5

multiple interactions
decreases expression

[RTKI cpd results in decreased activity of EGFR protein] which results in decreased expression of BIRC5 protein
RTKI cpd results in decreased expression of BIRC5 protein

PMID:21268125 PMID:29974605

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 4

multiple interactions

RTKI cpd inhibits the reaction [antimonite results in decreased expression of BMP4 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of BMP4 mRNA]

NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761

G

caspase 3

multiple interactions

RTKI cpd promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]]
ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]

PMID:19233221 PMID:34724321 PMID:35716406

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caveolin 1

multiple interactions

RTKI cpd inhibits the reaction [Rosiglitazone results in increased expression of CAV1]

NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179

G

cyclin B1

multiple interactions

RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

multiple interactions
decreases expression

RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]
RTKI cpd results in decreased expression of CCND1 protein

PMID:28446726 PMID:29974605

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E1

multiple interactions
decreases expression

RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]
RTKI cpd results in decreased expression of CCNE1 protein

PMID:15923621 PMID:26385184

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cadherin 1

increases expression

RTKI cpd results in increased expression of CDH1 protein

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cyclin dependent kinase 1

multiple interactions

RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK1 protein]

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 2

multiple interactions

RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK2 protein]

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase inhibitor 1A

multiple interactions

RTKI cpd inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]

PMID:15734884 PMID:16283431

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cAMP responsive element binding protein 1

multiple interactions

RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

PMID:16671086 PMID:17272394 PMID:17322281

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

colony stimulating factor 2

multiple interactions

RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]

PMID:16908450 PMID:19460412 PMID:22581348

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

catenin beta 1

multiple interactions
decreases expression

RTKI cpd inhibits the reaction [arsenite affects the localization of CTNNB1 protein]
RTKI cpd results in decreased expression of CTNNB1 protein

PMID:17400267 PMID:29974605

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

C-X-C motif chemokine ligand 8

multiple interactions
decreases expression

RTKI cpd affects the reaction [Capsaicin results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Diacetyl results in increased expression of and results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [Lead results in increased expression of CXCL8 mRNA]; RTKI cpd inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA]; RTKI cpd inhibits the reaction [NTS protein results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [pentabromodiphenyl ether results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Silicon Dioxide analog results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Vehicle Emissions results in increased secretion of CXCL8 protein]
RTKI cpd results in decreased expression of CXCL8 protein

PMID:15247267 PMID:16908450 PMID:20619260 PMID:20932985 PMID:21762757 More...

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

CYLD lysine 63 deubiquitinase

increases expression

[RTKI cpd results in increased expression of CYLD protein] which results in increased expression of NFKBIA protein; RTKI cpd results in increased expression of CYLD mRNA; RTKI cpd results in increased expression of CYLD protein

NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935

G

DNA methyltransferase 3 alpha

multiple interactions

RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]

NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590

G

endothelin 1

multiple interactions

RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]
RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]

PMID:16261333 PMID:17974986

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

epidermal growth factor

multiple interactions

RTKI cpd inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of AR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased abundance of Calcium]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of STAT3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [EGF protein results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]
RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone]
RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK7 protein]

PMID:10516208 PMID:11309286 PMID:11527950 PMID:11751714 PMID:14737115 More...

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions
decreases expression
decreases phosphorylation
decreases activity

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased chemical synthesis of Oxygen]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to 5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to FSHB protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Topotecan; RTKI cpd inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Capsaicin results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGFR protein binds to GPER1 protein]; RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]
RTKI cpd results in decreased expression of EGFR protein modified form
RTKI cpd results in decreased phosphorylation of EGFR protein
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Genistein results in increased secretion of Testosterone]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased expression of BIRC5 protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased phosphorylation of STAT3 protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to butaprost; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Arsenic affects the localization of EGFR protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of EGFR protein

PMID:9710602 PMID:12794006 PMID:15177934 PMID:15459120 PMID:15504454 More...

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions

RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of EGR1 protein]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

[RTKI cpd co-treated with AG-879] results in decreased phosphorylation of ERBB2 protein
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB2 mRNA]]

PMID:18618485 PMID:35716406

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB4 mRNA]]

NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841

G

ERBB receptor feedback inhibitor 1

decreases expression

RTKI cpd results in decreased expression of ERRFI1 protein

NCBI chr 1:8,011,727...8,026,309
Ensembl chr 1:8,004,404...8,026,309

G

estrogen receptor 1

multiple interactions

RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of ESR1 protein]
ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]

PMID:21813366 PMID:34724321

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

F11 receptor

multiple interactions

RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein]

NCBI chr 1:160,995,211...161,021,152
Ensembl chr 1:160,995,211...161,021,175

G

fibroblast growth factor 2

multiple interactions

RTKI cpd inhibits the reaction [Iloprost results in increased expression of FGF2 mRNA]

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

fms related receptor tyrosine kinase 1

multiple interactions

RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein]

NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Atrazine results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Genistein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Quercetin results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of FOS protein]
RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of FOS mRNA]

PMID:9710602 PMID:10516208 PMID:12154012 PMID:15090535 PMID:18758753 More...

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]

NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179

G

forkhead box O3

multiple interactions

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [Estradiol affects the localization of FOXO3 protein]

PMID:23673518 PMID:26470790

NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774

G

follicle stimulating hormone subunit beta

multiple interactions

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to FSHB protein
RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of AKT1 protein]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA]

PMID:21520325 PMID:24071787

NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261

G

gastrin

multiple interactions

RTKI cpd inhibits the reaction [lead acetate results in increased expression of GAST mRNA]

NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969

G

glutamate-cysteine ligase catalytic subunit

multiple interactions
decreases expression

Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein]

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

G protein subunit alpha q

multiple interactions

RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]

NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811

G

G protein-coupled estrogen receptor 1

multiple interactions

RTKI cpd inhibits the reaction [EGF protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [EGFR protein binds to GPER1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of GPER1 protein]
RTKI cpd inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]
RTKI cpd inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]

PMID:19749156 PMID:22645130 PMID:23274518

NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815

G

hyaluronan synthase 2

multiple interactions

RTKI cpd inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]

NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440

G

heparin binding EGF like growth factor

multiple interactions
increases expression
decreases expression

RTKI cpd inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]
RTKI cpd results in increased expression of HBEGF mRNA
RTKI cpd results in decreased expression of HBEGF mRNA; RTKI cpd results in decreased expression of HBEGF protein

PMID:11159045 PMID:22048644 PMID:26800359

NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603

G

hes family bHLH transcription factor 1

multiple interactions

RTKI cpd inhibits the reaction [arsenite results in decreased expression of HES1 mRNA]

NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732

G

heme oxygenase 1

multiple interactions

RTKI cpd inhibits the reaction [arsenite results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

5-hydroxytryptamine receptor 2B

multiple interactions

RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]

NCBI chr 2:231,108,230...231,125,042
Ensembl chr 2:231,108,230...231,125,042

G

interleukin 6

multiple interactions
decreases expression

RTKI cpd affects the reaction [Capsaicin results in increased secretion of IL6 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane results in increased expression of IL6 protein]; RTKI cpd inhibits the reaction [pentabromodiphenyl ether results in increased expression of IL6 protein]; RTKI cpd inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL6 protein]; RTKI cpd inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein]
RTKI cpd results in decreased expression of IL6 protein

PMID:20619260 PMID:24184330 PMID:24844442 PMID:26718265

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

involucrin

multiple interactions
increases expression

RTKI cpd inhibits the reaction [arsenite results in decreased expression of IVL mRNA]
RTKI cpd results in increased expression of IVL protein

NCBI chr 1:152,908,546...152,911,886
Ensembl chr 1:152,908,546...152,911,886

G

jagged canonical Notch ligand 1

multiple interactions

RTKI cpd inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of JAG1 protein]

NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999

G

Janus kinase 3

multiple interactions

RTKI cpd results in decreased phosphorylation of and results in decreased activity of JAK3 protein

NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of JUN mRNA]
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]

PMID:9710602 PMID:11329622 PMID:12154012

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

kallikrein related peptidase 3

multiple interactions

RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]

NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764

G

keratin 1

increases expression

RTKI cpd results in increased expression of KRT1 protein

NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407

G

keratin 10

multiple interactions

RTKI cpd inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of KRT10 protein]

NCBI chr17:40,818,117...40,822,614
Ensembl chr17:40,818,117...40,822,614

G

luteinizing hormone subunit beta

multiple interactions

RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
RTKI cpd inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased expression of TNFAIP6 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of EGFR protein]

PMID:15459120 PMID:21220312

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

RTKI cpd inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]; RTKI cpd promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA]

NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730

G

mitogen-activated protein kinase kinase 1

multiple interactions

RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein]

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 2

multiple interactions

RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K2 protein]

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Atrazine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Calcitriol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Lead results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Thrombin results in increased phosphorylation of MAPK1 protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]
RTKI cpd results in decreased phosphorylation of MAPK1 protein

PMID:9710602 PMID:10516208 PMID:11309286 PMID:11329622 PMID:12761878 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

multiple interactions

RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK14 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Atrazine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Calcitriol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Lead results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Thrombin results in increased phosphorylation of MAPK3 protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]
RTKI cpd results in decreased phosphorylation of MAPK3 protein

PMID:9710602 PMID:10516208 PMID:11309286 PMID:11329622 PMID:12761878 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 7

multiple interactions

RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK7 protein]

NCBI chr17:19,377,750...19,383,544
Ensembl chr17:19,377,721...19,383,544

G

mitogen-activated protein kinase 8

multiple interactions

RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]
RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK8 protein]

PMID:11329622 PMID:15574683 PMID:26514923

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

RTKI cpd results in decreased expression of MCL1 mRNA; RTKI cpd results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

microRNA 126

multiple interactions

RTKI cpd promotes the reaction [Asbestos, Crocidolite results in increased expression of MIR126 mRNA]

NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686

G

microRNA 21

multiple interactions

RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]

NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337

G

microRNA 222

multiple interactions

RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of MIR222 mRNA]

NCBI chr X:45,747,015...45,747,124
Ensembl chr X:45,747,015...45,747,124

G

matrix metallopeptidase 1

multiple interactions

RTKI cpd inhibits the reaction [EGF protein results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; RTKI cpd inhibits the reaction [Histamine results in increased secretion of MMP1 protein]

NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160

G

matrix metallopeptidase 13

multiple interactions

RTKI cpd inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

matrix metallopeptidase 14

multiple interactions

RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

G

matrix metallopeptidase 2

multiple interactions

RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]

PMID:23462309 PMID:25312822

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 7

multiple interactions

RTKI cpd inhibits the reaction [antimonite results in increased expression of MMP7 mRNA]; RTKI cpd inhibits the reaction [arsenite results in increased expression of MMP7 mRNA]

NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750

G

matrix metallopeptidase 9

multiple interactions

RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP9 mRNA]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased secretion of MMP9 protein]

PMID:15504454 PMID:18006877 PMID:23462309 PMID:25312822 PMID:26514923

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

metallothionein 2A

multiple interactions

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

mechanistic target of rapamycin kinase

multiple interactions

RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MTOR protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

RTKI cpd inhibits the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]

PMID:10640773 PMID:20971882 PMID:22820758 PMID:31944254

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases phosphorylation

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]
RTKI cpd results in decreased phosphorylation of NFE2L2 protein

PMID:24015256 PMID:33148531

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

increases expression

[RTKI cpd results in increased expression of CYLD protein] which results in increased expression of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 3

multiple interactions

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

notch receptor 1

multiple interactions
increases expression

RTKI cpd inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]
RTKI cpd results in increased expression of NOTCH1 protein modified form

PMID:18633435 PMID:25118938

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

NADPH oxidase 4

multiple interactions
increases expression

Doxorubicin promotes the reaction [RTKI cpd results in increased expression of NOX4 mRNA]

NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187

G

natriuretic peptide A

multiple interactions

RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

neuregulin 1

multiple interactions

RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB4 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PIK3R1 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]]

NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666

G

neurotensin

multiple interactions

RTKI cpd inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased secretion of CXCL8 protein]

PMID:15177934 PMID:15247267

NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992

G

proliferating cell nuclear antigen

decreases expression

RTKI cpd results in decreased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PIK3R1 mRNA]]

NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821

G

phospholipase A2 group IVA

multiple interactions

RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]
RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]

PMID:19662385 PMID:20850495

NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981

G

peroxisome proliferator activated receptor delta

multiple interactions

RTKI cpd inhibits the reaction [antimonite results in increased expression of PPARD mRNA]; RTKI cpd inhibits the reaction [arsenite results in increased expression of PPARD mRNA]

NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191

G

peroxisome proliferator activated receptor gamma

multiple interactions

RTKI cpd inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein kinase C alpha

multiple interactions

RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C delta

multiple interactions

RTKI cpd inhibits the reaction [sodium arsenite affects the expression of PRKCD protein]; RTKI cpd inhibits the reaction [sodium arsenite results in decreased phosphorylation of PRKCD protein]

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

prostaglandin-endoperoxide synthase 2

multiple interactions

RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]
RTKI cpd inhibits the reaction [LHB protein results in increased expression of PTGS2 mRNA]
RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]

PMID:15459120 PMID:20660715 PMID:20850495 PMID:24639330

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

multiple interactions

[RTKI cpd co-treated with bisphenol A] results in increased phosphorylation of PTK2 protein

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

RB transcriptional corepressor 1

multiple interactions

RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RUNX family transcription factor 2

decreases expression

RTKI cpd results in decreased expression of RUNX2 mRNA

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

SHC adaptor protein 1

multiple interactions

RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]

PMID:9710602 PMID:19168439

NCBI chr 1:154,962,298...154,974,376
Ensembl chr 1:154,962,298...154,974,395

G

solute carrier family 1 member 2

multiple interactions

RTKI cpd inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]

PMID:22645130 PMID:24782323

NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063

G

Sp1 transcription factor

multiple interactions

RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]; RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA]

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]

PMID:14569062 PMID:23376140 PMID:25813982 PMID:25856345

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

sterol regulatory element binding transcription factor 1

multiple interactions

RTKI cpd inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein]

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

steroidogenic acute regulatory protein

multiple interactions

RTKI cpd inhibits the reaction [bisphenol A results in increased expression of STAR mRNA]

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

signal transducer and activator of transcription 3

multiple interactions
decreases expression

RTKI cpd inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of STAT3 protein]
RTKI cpd results in decreased expression of STAT3 protein modified form
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased phosphorylation of STAT3 protein

PMID:21268125 PMID:21909620 PMID:23376140 PMID:25841994 PMID:29974605

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

signal transducer and activator of transcription 5B

multiple interactions

[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]

NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633

G

tachykinin precursor 1

multiple interactions

RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472

G

transcription factor AP-2 alpha

multiple interactions

RTKI cpd inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]; RTKI cpd inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein]

NCBI chr 6:10,396,677...10,419,659
Ensembl chr 6:10,393,186...10,419,659

G

transforming growth factor alpha

multiple interactions

RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein]

PMID:11309286 PMID:19749156 PMID:24555532

NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193

G

transforming growth factor beta 1

multiple interactions
decreases expression

RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]
RTKI cpd results in decreased expression of TGFB1 protein
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]

PMID:25398788 PMID:35850069

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions

RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF alpha induced protein 6

multiple interactions

RTKI cpd inhibits the reaction [LHB protein results in increased expression of TNFAIP6 mRNA]

NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046

G

tumor protein p53

multiple interactions

RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

transient receptor potential cation channel subfamily V member 1

multiple interactions

RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]

NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411

G

vascular endothelial growth factor A

multiple interactions

RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of VEGFA protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of VEGFA protein]

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

vimentin

decreases expression
multiple interactions

RTKI cpd results in decreased expression of VIM protein
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of VIM protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VIM protein]

PMID:25856345 PMID:26971374 PMID:35850069

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26034
role	25961
biological role	25929
antimicrobial agent	21890
antiviral agent	11721
tyrphostin AG 1478	126
Path 2
Term	Annotations
CHEBI ontology	26034
subatomic particle	26009
composite particle	26009
hadron	26020
baryon	26009
nucleon	26009
atomic nucleus	26009
atom	26009
main group element atom	25834
p-block element atom	25834
carbon group element atom	25434
carbon atom	25403
organic molecular entity	25392
organic molecule	25222
organic cyclic compound	24274
carbocyclic compound	22040
benzenoid aromatic compound	20099
benzenes	19797
chlorobenzenes	15570
monochlorobenzenes	12175
tyrphostin AG 1478	126

paths to the root