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Gene: ALOX5 (arachidonate 5-lipoxygenase) Homo sapiens
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
Description: Exhibits arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; regulation of reactive oxygen species biosynthetic process; and unsaturated fatty acid biosynthetic process. Localizes to cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Biomarker of several diseases, including asthma; cholangiocarcinoma; common cold; pulmonary fibrosis; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; MGC163204
Mus musculus (house mouse) : Alox5 (arachidonate 5-lipoxygenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alox5 (arachidonate 5-lipoxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox5 (arachidonate 5-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX5 (arachidonate 5-lipoxygenase)
Canis lupus familiaris (dog) : ALOX5 (arachidonate 5-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox5 (arachidonate 5-lipoxygenase)
Sus scrofa (pig) : ALOX5 (arachidonate 5-lipoxygenase)
Chlorocebus sabaeus (African green monkey) : ALOX5 (arachidonate 5-lipoxygenase)
Heterocephalus glaber (naked mole-rat) : Alox5 (arachidonate 5-lipoxygenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh381045,374,166 - 45,446,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371045,869,624 - 45,941,569 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,833 - 45,980,778 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ALOX5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732775
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.