ALOX5 (arachidonate 5-lipoxygenase) - Rat Genome Database

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Gene: ALOX5 (arachidonate 5-lipoxygenase) Homo sapiens
Analyze
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
RGD ID: 732775
HGNC Page HGNC:435
Description: Enables arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including fatty acid derivative biosynthetic process; leukocyte chemotaxis involved in inflammatory response; and regulation of reactive oxygen species biosynthetic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Biomarker of several diseases, including cholangiocarcinoma; common cold; pancreatic cancer; pulmonary fibrosis; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; MGC163204; polyunsaturated fatty acid 5-lipoxygenase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,374,216 - 45,446,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4-hydroxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
baicalin  (ISO)
benoxaprofen  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine 6-sulfate  (EXP)
beta-naphthoflavone  (EXP)
bisphenol A  (ISO)
Bromoenol lactone  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
cetirizine  (EXP)
CGP 52608  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
D-glucitol  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dithiol  (ISO)
docebenone  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ebselen  (EXP)
edaravone  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (EXP)
ethoxyquin  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fructose  (EXP)
furan  (ISO)
glucose  (EXP,ISO)
histamine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxyurea  (EXP)
indometacin  (ISO)
kaempferol  (EXP)
L-methionine  (ISO)
leukotriene A4  (EXP)
leukotriene B4  (EXP,ISO)
leukotriene C4  (EXP,ISO)
leukotriene D4  (EXP,ISO)
leukotriene E4  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lonapalene  (EXP)
loratadine  (EXP)
losartan  (ISO)
luteolin  (EXP)
masoprocol  (EXP,ISO)
meclofenamic acid  (EXP)
melittin  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP)
miquelianin  (EXP)
montelukast  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
niclosamide  (EXP,ISO)
nicotine  (EXP)
nitric oxide  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (EXP)
peroxynitrous acid  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
poly(propylene imine) macromolecule  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
propranolol  (EXP)
quercetin  (EXP)
quercetin 3-sulfate  (EXP)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
steviol  (EXP)
stevioside  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tenidap  (EXP)
tepoxalin  (EXP,ISO)
tert-butanol  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP,ISO)
valproic acid  (EXP)
vitamin E  (EXP,ISO)
zileuton  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
arachidonic acid metabolic process  (IBA)
dendritic cell migration  (IEA,ISS)
glucose homeostasis  (IEA,ISS)
hepoxilin biosynthetic process  (IBA)
humoral immune response  (IEA,ISS)
icosanoid metabolic process  (IEA)
inflammatory response  (IEA,ISO)
leukocyte chemotaxis involved in inflammatory response  (IMP)
leukocyte migration involved in inflammatory response  (IEA,ISS)
leukotriene A4 biosynthetic process  (IDA,IEA,IMP)
leukotriene biosynthetic process  (IDA,IEA,ISO)
leukotriene metabolic process  (IEA,ISO,TAS)
leukotriene production involved in inflammatory response  (IEA,ISO)
linoleic acid metabolic process  (IBA)
lipid metabolic process  (IEA)
lipid oxidation  (IBA)
lipoxin biosynthetic process  (IMP)
lipoxygenase pathway  (IBA,TAS)
long-chain fatty acid biosynthetic process  (TAS)
long-chain fatty acid metabolic process  (IEA)
negative regulation of angiogenesis  (IEA,ISS)
negative regulation of endothelial cell proliferation  (IEA,ISS)
negative regulation of inflammatory response  (IDA)
negative regulation of response to endoplasmic reticulum stress  (IEA,ISS)
negative regulation of sprouting angiogenesis  (IEA,ISS)
negative regulation of vascular wound healing  (IEA,ISS)
negative regulation of wound healing  (IEA,ISS)
oxidative phosphorylation  (IEA)
positive regulation of bone mineralization  (IEA,ISS)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IEA,ISS)
positive regulation of vasoconstriction  (ISO)
regulation of cellular response to oxidative stress  (IEA,ISS)
regulation of cytokine production involved in inflammatory response  (IEA,ISS)
regulation of fat cell differentiation  (IEA,ISS)
regulation of inflammatory response  (IEA,IMP)
regulation of inflammatory response to wounding  (IEA,ISS)
regulation of insulin secretion  (IEA,ISS)
regulation of reactive oxygen species biosynthetic process  (IMP)
response to hyperoxia  (ISO)
response to nutrient  (ISO)
sensory perception of pain  (ISO)
thiamine diphosphate biosynthetic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma. Bai C, etal., Int J Mol Med. 2008 Feb;21(2):139-44.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease. Berger W, etal., Int J Clin Pract. 2007 Apr;61(4):663-76.
4. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. Brock TG, etal., J Biol Chem. 1995 Sep 15;270(37):21652-8. doi: 10.1074/jbc.270.37.21652.
5. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Caironi P, etal., Am J Respir Crit Care Med. 2005 Aug 1;172(3):334-43. Epub 2005 May 13.
6. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. Chen CR, etal., Am J Respir Crit Care Med. 1994 Jan;149(1):34-40.
7. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. Chu SJ, etal., J Immunol. 2000 Oct 15;165(8):4640-8.
8. Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma. Coreno A, etal., J Allergy Clin Immunol. 2000 Sep;106(3):500-6.
9. CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain. Cortes-Burgos LA, etal., Eur J Pharmacol. 2009 Sep 1;617(1-3):59-67. Epub 2009 Jul 4.
10. Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. Cottrell JA and O'Connor JP, J Bone Joint Surg Am. 2009 Nov;91(11):2653-65.
11. 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan. Cuzzocrea S, etal., J Leukoc Biol. 2003 Jun;73(6):739-46.
12. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Drazen JM, etal., Nat Genet 1999 Jun;22(2):168-70.
13. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. Dwyer JH, etal., N Engl J Med 2004 Jan 1;350(1):29-37.
14. Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization. Escoubet-Lozach L, etal., Clin Exp Allergy 2001 Jul;31(7):1094-104.
15. Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury. Failla M, etal., Respir Res. 2006 Nov 21;7:137.
16. Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice? Funk CD, etal., Ann N Y Acad Sci. 2006 Nov;1085:151-60.
17. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
18. 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. Graupera M, etal., Gastroenterology. 2002 Feb;122(2):387-93.
19. Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis. Gross NJ, etal., Radiat Res. 1991 Sep;127(3):317-24.
20. The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson WR Jr, etal., J Exp Med. 1996 Oct 1;184(4):1483-94.
21. 5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue. Hennig R, etal., Am J Pathol. 2002 Aug;161(2):421-8.
22. 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Hennig R, etal., Cancer Res. 2005 Jul 15;65(14):6011-6.
23. ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. Herb F, etal., Hum Mol Genet. 2008 Apr 1;17(7):1052-60. Epub 2008 Jan 3.
24. Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs. Hosford GE, etal., Exp Lung Res. 2002 Dec;28(8):671-84.
25. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
26. Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Jones JE, etal., Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1775-84. Epub 2004 Jan 15.
27. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. Kalayci O, etal., Allergy. 2006 Jan;61(1):97-103.
28. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
29. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Koshino T, etal., Biochem Biophys Res Commun. 1998 Jun 18;247(2):510-3.
30. Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat. Lee DW, etal., J Korean Med Sci. 2009 Jan;24 Suppl:S170-5. Epub 2009 Jan 29.
31. Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. Lee DW, etal., J Korean Med Sci. 2009 Jan;24 Suppl:S183-8. Epub 2009 Jan 29.
32. Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. Lefebvre B, etal., J Hypertens. 2006 Jan;24(1):85-93.
33. Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion. Lisovyy OO, etal., Acta Biochim Pol. 2009;56(4):687-94. Epub 2009 Dec 11.
34. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Mancuso P, etal., Infect Immun. 2010 May;78(5):2264-71. Epub 2010 Mar 15.
35. Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma. Mobius C, etal., Anticancer Res. 2008 Mar-Apr;28(2A):873-8.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats. Peskar BM, etal., Pharmacology. 2009;84(5):294-9. Epub 2009 Oct 8.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. Increased expression of lipoxygenase enzymes during pollen season in nasal biopsies of pollen-allergic patients. Plewako H, etal., Allergy. 2006 Jun;61(6):725-30.
41. Inhaled carbenoxolone prevents allergic airway inflammation and airway hyperreactivity in a mouse model of asthma. Ram A, etal., Int Arch Allergy Immunol. 2009;149(1):38-46. Epub 2008 Nov 26.
42. Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model. Raychaudhuri A, etal., Naunyn Schmiedebergs Arch Pharmacol. 1997 Apr;355(4):470-4.
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers I, etal., Clin Exp Allergy. 2003 Aug;33(8):1103-10.
46. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. Seymour ML, etal., J Infect Dis. 2002 Feb 15;185(4):540-4. Epub 2002 Jan 31.
47. Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. Smith SR, etal., J Pharmacol Exp Ther. 1992 Aug;262(2):721-8.
48. Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation. Tian W, etal., Circulation. 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629.
49. Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Tong WG, etal., Mol Cancer Ther. 2002 Sep;1(11):929-35.
50. 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
51. Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats. Tu XK, etal., Inflammation. 2010 Mar 5.
52. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Via M, etal., Clin Exp Allergy. 2010 Apr;40(4):582-9. Epub 2010 Jan 11.
53. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. Voelkel NF, etal., J Clin Invest 1996 Jun 1;97(11):2491-8.
54. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. Wilborn J, etal., J Clin Invest. 1996 Apr 15;97(8):1827-36.
55. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Wright L, etal., Am J Respir Crit Care Med. 1998 Jan;157(1):219-29.
56. Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Zhang RL, etal., Exp Neurol. 2003 Dec;184(2):746-52.
57. Lipoxygenase-dependent superoxide release in skeletal muscle. Zuo L, etal., J Appl Physiol. 2004 Aug;97(2):661-8. Epub 2004 Apr 23.
Additional References at PubMed
PMID:1540191   PMID:1939225   PMID:2251250   PMID:2565035   PMID:2829172   PMID:3134355   PMID:3422434   PMID:7556168   PMID:7624354   PMID:7929073   PMID:8066098   PMID:8125298  
PMID:8245774   PMID:8268460   PMID:8585605   PMID:8615788   PMID:8631361   PMID:9079648   PMID:9150468   PMID:9435249   PMID:9639560   PMID:9681993   PMID:10051563   PMID:10514459  
PMID:10673219   PMID:10779545   PMID:11297527   PMID:11462800   PMID:11471199   PMID:11785969   PMID:11796736   PMID:11844797   PMID:12021253   PMID:12107604   PMID:12111389   PMID:12140292  
PMID:12234060   PMID:12354292   PMID:12477932   PMID:12525578   PMID:12629151   PMID:12664574   PMID:12695552   PMID:12730086   PMID:12751728   PMID:12751768   PMID:12751769   PMID:12859962  
PMID:12893830   PMID:12907138   PMID:14532840   PMID:14749922   PMID:14767568   PMID:15010818   PMID:15219851   PMID:15280375   PMID:15301234   PMID:15308583   PMID:15616590   PMID:15661803  
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PMID:16531984   PMID:16537708   PMID:16672272   PMID:16698924   PMID:16733792   PMID:16750418   PMID:16899822   PMID:16919603   PMID:16924104   PMID:17018618   PMID:17072961   PMID:17080223  
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PMID:17825794   PMID:17894944   PMID:17909879   PMID:17924829   PMID:18179798   PMID:18180307   PMID:18218859   PMID:18280718   PMID:18295198   PMID:18339529   PMID:18366797   PMID:18369664  
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PMID:19224689   PMID:19233132   PMID:19247692   PMID:19258923   PMID:19390118   PMID:19423540   PMID:19446447   PMID:19450127   PMID:19473080   PMID:19497113   PMID:19524426   PMID:19578796  
PMID:19579006   PMID:19625176   PMID:19692168   PMID:19717473   PMID:19724895   PMID:19807693   PMID:19851296   PMID:19888660   PMID:19913121   PMID:19919819   PMID:19948975   PMID:20110601  
PMID:20126469   PMID:20139978   PMID:20173757   PMID:20198315   PMID:20372792   PMID:20382140   PMID:20388081   PMID:20406964   PMID:20438785   PMID:20453000   PMID:20503287   PMID:20549218  
PMID:20592751   PMID:20628086   PMID:20677014   PMID:20682687   PMID:21098726   PMID:21200133   PMID:21206090   PMID:21224059   PMID:21233389   PMID:21296957   PMID:21314617   PMID:21403093  
PMID:21482803   PMID:21540635   PMID:21605700   PMID:21723968   PMID:21729626   PMID:21832049   PMID:21873635   PMID:21883892   PMID:22050225   PMID:22199357   PMID:22253131   PMID:22282663  
PMID:22293202   PMID:22363630   PMID:22433003   PMID:22516296   PMID:22616993   PMID:22664934   PMID:22690932   PMID:22739369   PMID:22808264   PMID:22825379   PMID:23067353   PMID:23079278  
PMID:23079635   PMID:23179791   PMID:23246375   PMID:23332172   PMID:23351835   PMID:23448388   PMID:23485709   PMID:23572152   PMID:23600541   PMID:23642263   PMID:23720274   PMID:23727898  
PMID:23746795   PMID:23752617   PMID:23828562   PMID:24005813   PMID:24036216   PMID:24097068   PMID:24130502   PMID:24162774   PMID:24226420   PMID:24282679   PMID:24335295   PMID:24350867  
PMID:24480307   PMID:24662827   PMID:24746852   PMID:24860872   PMID:24893149   PMID:25001243   PMID:25034252   PMID:25193960   PMID:25218842   PMID:25229347   PMID:25309925   PMID:25359714  
PMID:25416956   PMID:25454978   PMID:25483364   PMID:25540201   PMID:25721704   PMID:25910212   PMID:26070487   PMID:26076991   PMID:26173130   PMID:26210919   PMID:26327594   PMID:26329759  
PMID:26334317   PMID:26378572   PMID:26396238   PMID:26427761   PMID:26505400   PMID:26707712   PMID:26842853   PMID:26852002   PMID:26944113   PMID:26959713   PMID:27016075   PMID:27025886  
PMID:27060751   PMID:27411387   PMID:27635633   PMID:27784744   PMID:27855198   PMID:27893808   PMID:28096231   PMID:28257804   PMID:28500307   PMID:28514442   PMID:28566527   PMID:28786533  
PMID:28803964   PMID:28821715   PMID:29041000   PMID:29169426   PMID:29229677   PMID:29392977   PMID:29676528   PMID:30168128   PMID:30291962   PMID:30387822   PMID:30407793   PMID:30521849  
PMID:30678701   PMID:30825235   PMID:30941737   PMID:31203442   PMID:31300449   PMID:31515488   PMID:31664810   PMID:31726220   PMID:31918059   PMID:32027251   PMID:32093765   PMID:32165305  
PMID:32296183   PMID:32313135   PMID:32393899   PMID:32814053   PMID:33174621   PMID:33205517   PMID:33224971   PMID:33561320   PMID:33923148   PMID:33961781   PMID:34121352   PMID:34360703  
PMID:34387870   PMID:34417262   PMID:35251467   PMID:35637792  


Genomics

Comparative Map Data
ALOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,374,216 - 45,446,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBIT2T-CHM13v2.0
Alox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)EnsemblGRCm39 Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBIMGSCv36mm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
Alox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24149,531,329 - 149,578,696 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,531,515 - 149,578,743 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,398,892 - 148,446,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
Alox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555462,494,819 - 2,550,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555462,495,226 - 2,550,909 (+)NCBIChiLan1.0ChiLan1.0
ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11045,639,946 - 45,710,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,639,946 - 45,710,016 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01042,461,398 - 42,531,576 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBIUU_Cfam_GSD_1.0
Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,798,191 - 81,858,352 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365547,807,914 - 7,848,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,859,016 - 90,907,094 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,085,257 - 41,145,760 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,085,361 - 41,145,331 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048764,154 - 824,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
WI-9162  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,941,258 - 45,941,369UniSTSGRCh37
Build 361045,261,264 - 45,261,375RGDNCBI36
Celera1041,939,214 - 41,939,325RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,466,907 - 42,467,018UniSTS
RH40180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,941,109 - 45,941,328UniSTSGRCh37
Build 361045,261,115 - 45,261,334RGDNCBI36
Celera1041,939,065 - 41,939,284RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,466,758 - 42,466,977UniSTS
RH98891  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,927,898 - 45,928,042UniSTSGRCh37
Build 361045,247,904 - 45,248,048RGDNCBI36
Celera1041,925,855 - 41,925,999RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,453,547 - 42,453,691UniSTS
RH102744  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,934,172 - 45,934,326UniSTSGRCh37
Build 361045,254,178 - 45,254,332RGDNCBI36
Celera1041,932,128 - 41,932,282RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,459,821 - 42,459,975UniSTS
GeneMap99-GB4 RH Map10274.75UniSTS
ALOX5_4211  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,940,971 - 45,941,591UniSTSGRCh37
Build 361045,260,977 - 45,261,597RGDNCBI36
Celera1041,938,927 - 41,939,547RGD
HuRef1042,466,620 - 42,467,240UniSTS
SHGC-60141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,922,300 - 45,922,478UniSTSGRCh37
Build 361045,242,306 - 45,242,484RGDNCBI36
Celera1041,920,257 - 41,920,435RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,447,953 - 42,448,131UniSTS
TNG Radiation Hybrid Map1021008.0UniSTS
SHGC-59903  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,923,048 - 45,923,146UniSTSGRCh37
Build 361045,243,054 - 45,243,152RGDNCBI36
Celera1041,921,005 - 41,921,103RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,448,701 - 42,448,799UniSTS
TNG Radiation Hybrid Map557648.0UniSTS
RH79041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,871,765 - 45,871,928UniSTSGRCh37
Build 361045,191,771 - 45,191,934RGDNCBI36
Cytogenetic Map10q11.2UniSTS
HuRef1042,397,036 - 42,397,199UniSTS
GeneMap99-GB4 RH Map10271.88UniSTS
NCBI RH Map10589.1UniSTS
D10S1413  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,880,168 - 45,880,326UniSTSGRCh37
Build 361045,200,174 - 45,200,332RGDNCBI36
Celera1041,879,251 - 41,879,409RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,405,440 - 42,405,598UniSTS
Marshfield Genetic Map1065.97UniSTS
RH17822  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,941,053 - 45,941,195UniSTSGRCh37
Build 361045,261,059 - 45,261,201RGDNCBI36
Celera1041,939,009 - 41,939,151RGD
Cytogenetic Map10q11.2UniSTS
HuRef1042,466,702 - 42,466,844UniSTS
GeneMap99-GB4 RH Map10275.18UniSTS
ALOX5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371045,938,532 - 45,938,635UniSTSGRCh37
Celera1041,936,488 - 41,936,591UniSTS
HuRef1042,464,181 - 42,464,284UniSTS
L18441  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map10q11.2UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map15q24-q25UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map16q24UniSTS
D11S2467  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXq22.3UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map10q11.2UniSTS
D11S3553  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q11.2UniSTS
Cytogenetic Map3p12.1UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map9q33.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2274
Count of miRNA genes:859
Interacting mature miRNAs:1014
Transcripts:ENST00000374391, ENST00000475300, ENST00000481117, ENST00000483623, ENST00000493336, ENST00000498461, ENST00000542434
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 17 19
Medium 1243 1388 361 160 1792 50 1478 488 1205 172 511 868 116 880 844 3
Low 1144 1550 1326 439 72 390 2694 1516 2345 222 883 613 56 1 324 1838 2 2
Below cutoff 28 36 18 13 37 13 119 156 122 20 37 70 3 106

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB208946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW403395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM153780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ003253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM592258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM592259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM592260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM592261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY102907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ728550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000374391   ⟹   ENSP00000363512
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,374,216 - 45,446,117 (+)Ensembl
RefSeq Acc Id: ENST00000475300
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,440,430 - 45,441,585 (+)Ensembl
RefSeq Acc Id: ENST00000481117
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,443,242 - 45,444,232 (+)Ensembl
RefSeq Acc Id: ENST00000483623
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,424,084 - 45,428,486 (+)Ensembl
RefSeq Acc Id: ENST00000493336
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,442,613 - 45,443,447 (+)Ensembl
RefSeq Acc Id: ENST00000498461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,443,421 - 45,444,214 (+)Ensembl
RefSeq Acc Id: ENST00000542434   ⟹   ENSP00000437634
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,374,176 - 45,446,119 (+)Ensembl
RefSeq Acc Id: ENST00000612635   ⟹   ENSP00000483803
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1045,374,280 - 45,445,687 (+)Ensembl
RefSeq Acc Id: NM_000698   ⟹   NP_000689
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
GRCh371045,869,624 - 45,941,569 (+)NCBI
Build 361045,189,635 - 45,261,571 (+)NCBI Archive
HuRef1042,394,884 - 42,467,216 (+)NCBI
CHM1_11045,908,833 - 45,980,778 (+)NCBI
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256153   ⟹   NP_001243082
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
GRCh371045,869,624 - 45,941,569 (+)NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBI
CHM1_11045,908,833 - 45,980,778 (+)NCBI
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256154   ⟹   NP_001243083
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
GRCh371045,869,624 - 45,941,569 (+)NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBI
CHM1_11045,908,833 - 45,980,778 (+)NCBI
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320861   ⟹   NP_001307790
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
CHM1_11045,908,833 - 45,980,778 (+)NCBI
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320862   ⟹   NP_001307791
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
CHM1_11045,908,833 - 45,980,778 (+)NCBI
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047424934   ⟹   XP_047280890
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
RefSeq Acc Id: XM_047424936   ⟹   XP_047280892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,446,117 (+)NCBI
RefSeq Acc Id: XM_047424937   ⟹   XP_047280893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,382,483 - 45,446,117 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_000689   ⟸   NM_000698
- Peptide Label: isoform 1
- UniProtKB: Q5JQ14 (UniProtKB/Swiss-Prot),   P09917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243083   ⟸   NM_001256154
- Peptide Label: isoform 3
- UniProtKB: P09917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243082   ⟸   NM_001256153
- Peptide Label: isoform 2
- UniProtKB: P09917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307791   ⟸   NM_001320862
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001307790   ⟸   NM_001320861
- Peptide Label: isoform 4
- UniProtKB: P09917 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000437634   ⟸   ENST00000542434
RefSeq Acc Id: ENSP00000363512   ⟸   ENST00000374391
RefSeq Acc Id: ENSP00000483803   ⟸   ENST00000612635
RefSeq Acc Id: XP_047280890   ⟸   XM_047424934
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047280892   ⟸   XM_047424936
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047280893   ⟸   XM_047424937
- Peptide Label: isoform X3
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09917-F1-model_v2 AlphaFold P09917 1-674 view protein structure

Promoters
RGD ID:6787673
Promoter ID:HG_KWN:9307
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000399646,   NM_000698,   UC009XMT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361045,188,746 - 45,189,677 (+)MPROMDB
RGD ID:6787332
Promoter ID:HG_KWN:9308
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000047782
Position:
Human AssemblyChrPosition (strand)Source
Build 361045,238,711 - 45,239,522 (+)MPROMDB
RGD ID:6787333
Promoter ID:HG_KWN:9309
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000047783
Position:
Human AssemblyChrPosition (strand)Source
Build 361045,255,031 - 45,255,531 (+)MPROMDB
RGD ID:6787334
Promoter ID:HG_KWN:9310
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000047781,   OTTHUMT00000047784,   OTTHUMT00000047785
Position:
Human AssemblyChrPosition (strand)Source
Build 361045,257,181 - 45,258,787 (+)MPROMDB
RGD ID:7217425
Promoter ID:EPDNEW_H14458
Type:initiation region
Name:ALOX5_1
Description:arachidonate 5-lipoxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381045,374,216 - 45,374,276EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NG_011437.1:g.4922GGGGGC[2] microsatellite Asthma, diminished response to antileukotriene treatment in [RCV000015530]|Atherosclerosis, susceptibility to [RCV000015531] Chr10:45374100..45374123 [GRCh38]
Chr10:45869548..45869571 [GRCh37]
Chr10:10q11.21
risk factor|drug response
GRCh38/hg38 10q11.21-21.2(chr10:42335305-60284876)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052506]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052506]|See cases [RCV000052506] Chr10:42335305..60284876 [GRCh38]
Chr10:42830753..62044634 [GRCh37]
Chr10:42150759..61714640 [NCBI36]
Chr10:10q11.21-21.2
pathogenic
NM_000698.3(ALOX5):c.312C>T (p.Ile104=) single nucleotide variant Malignant melanoma [RCV000068944] Chr10:45382644 [GRCh38]
Chr10:45878092 [GRCh37]
Chr10:45198098 [NCBI36]
Chr10:10q11.21
not provided
NM_000698.5(ALOX5):c.1273-34C>T single nucleotide variant not provided [RCV000106285] Chr10:45443004 [GRCh38]
Chr10:45938452 [GRCh37]
Chr10:10q11.21
not provided
NM_000698.5(ALOX5):c.996G>A (p.Pro332=) single nucleotide variant not provided [RCV000106286] Chr10:45440444 [GRCh38]
Chr10:45935892 [GRCh37]
Chr10:10q11.21
not provided
GRCh38/hg38 10q11.21-21.1(chr10:42884294-52265317)x3 copy number gain See cases [RCV000134381] Chr10:42884294..52265317 [GRCh38]
Chr10:43379742..54025077 [GRCh37]
Chr10:42699748..53695083 [NCBI36]
Chr10:10q11.21-21.1
pathogenic
GRCh38/hg38 10q11.21-11.23(chr10:42395201-50877059)x3 copy number gain See cases [RCV000134846] Chr10:42395201..50877059 [GRCh38]
Chr10:42890649..52636819 [GRCh37]
Chr10:42210655..52306825 [NCBI36]
Chr10:10q11.21-11.23
pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2
pathogenic
GRCh38/hg38 10q11.21-11.22(chr10:45247429-45768908)x3 copy number gain See cases [RCV000141326] Chr10:45247429..45768908 [GRCh38]
Chr10:45742877..46224333 [GRCh37]
Chr10:45062883..45584362 [NCBI36]
Chr10:10q11.21-11.22
likely benign
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22
benign
GRCh38/hg38 10q11.21-21.3(chr10:42112187-67400675)x3 copy number gain See cases [RCV000142967] Chr10:42112187..67400675 [GRCh38]
Chr10:42607635..69160433 [GRCh37]
Chr10:41927641..68830439 [NCBI36]
Chr10:10q11.21-21.3
pathogenic
NM_000698.5(ALOX5):c.490T>G (p.Leu164Val) single nucleotide variant Ductal breast carcinoma [RCV000207073] Chr10:45412249 [GRCh38]
Chr10:45907697 [GRCh37]
Chr10:10q11.21
uncertain significance
NC_000010.10:g.43611191_61663279inv inversion Pediatric metastatic thyroid tumour [RCV000585841] Chr10:43611191..61663279 [GRCh37]
Chr10:10q11.21-21.2
likely pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q11.21-11.22(chr10:45618211-46293591)x3 copy number gain See cases [RCV000511453] Chr10:45618211..46293591 [GRCh37]
Chr10:10q11.21-11.22
uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q11.23(chr10:100026-50961640)x3 copy number gain See cases [RCV000510893] Chr10:100026..50961640 [GRCh37]
Chr10:10p15.3-q11.23
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q11.21-11.22(chr10:45844836-46215431)x3 copy number gain not provided [RCV000683228] Chr10:45844836..46215431 [GRCh37]
Chr10:10q11.21-11.22
uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p11.21-q11.22(chr10:37149872-46169876)x3 copy number gain not provided [RCV000762700] Chr10:37149872..46169876 [GRCh37]
Chr10:10p11.21-q11.22
likely pathogenic
NM_000698.5(ALOX5):c.855G>A (p.Val285=) single nucleotide variant not provided [RCV000949964] Chr10:45428638 [GRCh38]
Chr10:45924086 [GRCh37]
Chr10:10q11.21
likely benign
NM_000698.5(ALOX5):c.981+9C>T single nucleotide variant not provided [RCV000971016] Chr10:45428773 [GRCh38]
Chr10:45924221 [GRCh37]
Chr10:10q11.21
likely benign
NM_000698.5(ALOX5):c.237C>T (p.Asp79=) single nucleotide variant not provided [RCV000914721] Chr10:45382569 [GRCh38]
Chr10:45878017 [GRCh37]
Chr10:10q11.21
likely benign
NM_000698.5(ALOX5):c.397C>T (p.Arg133Cys) single nucleotide variant not provided [RCV000918208] Chr10:45395902 [GRCh38]
Chr10:45891350 [GRCh37]
Chr10:10q11.21
likely benign
NM_000698.5(ALOX5):c.210C>T (p.Ile70=) single nucleotide variant not provided [RCV000938537] Chr10:45382542 [GRCh38]
Chr10:45877990 [GRCh37]
Chr10:10q11.21
likely benign
NM_000698.5(ALOX5):c.318C>T (p.Gly106=) single nucleotide variant not provided [RCV000886177] Chr10:45382650 [GRCh38]
Chr10:45878098 [GRCh37]
Chr10:10q11.21
benign
GRCh37/hg19 10q11.21(chr10:45822136-46004831)x3 copy number gain See cases [RCV001270256] Chr10:45822136..46004831 [GRCh37]
Chr10:10q11.21
uncertain significance
GRCh37/hg19 10p15.3-q11.22(chr10:135655-47688677)x4 copy number gain Mosaic supernumerary isodicentric chromosome 10 [RCV001825164] Chr10:135655..47688677 [GRCh37]
Chr10:10p15.3-q11.22
not provided

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:435 AgrOrtholog
COSMIC ALOX5 COSMIC
Ensembl Genes ENSG00000012779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000275565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000363512 ENTREZGENE
  ENSP00000363512.2 UniProtKB/Swiss-Prot
  ENSP00000437634 ENTREZGENE
  ENSP00000437634.1 UniProtKB/Swiss-Prot
  ENSP00000479452.1 UniProtKB/TrEMBL
  ENSP00000479958.1 UniProtKB/Swiss-Prot
  ENSP00000484468.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000374391 ENTREZGENE
  ENST00000374391.7 UniProtKB/Swiss-Prot
  ENST00000542434 ENTREZGENE
  ENST00000542434.5 UniProtKB/Swiss-Prot
  ENST00000610656.4 UniProtKB/Swiss-Prot
  ENST00000622021.4 UniProtKB/Swiss-Prot
  ENST00000622238.1 UniProtKB/TrEMBL
GTEx ENSG00000012779 GTEx
  ENSG00000275565 GTEx
HGNC ID HGNC:435 ENTREZGENE
Human Proteome Map ALOX5 Human Proteome Map
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot
  LipOase_C_sf UniProtKB/Swiss-Prot
  LipOase_CS UniProtKB/Swiss-Prot
  LipOase_Fe_BS UniProtKB/Swiss-Prot
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:240 UniProtKB/Swiss-Prot
NCBI Gene 240 ENTREZGENE
OMIM 152390 OMIM
  600807 OMIM
PANTHER PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALOX5 RGD, PharmGKB
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087X109_HUMAN UniProtKB/TrEMBL
  I0CLG0_HUMAN UniProtKB/TrEMBL
  LOX5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5JQ14 ENTREZGENE
UniProt Secondary B7ZLS0 UniProtKB/Swiss-Prot
  E5FPY5 UniProtKB/Swiss-Prot
  E5FPY7 UniProtKB/Swiss-Prot
  E5FPY8 UniProtKB/Swiss-Prot
  Q5JQ14 UniProtKB/Swiss-Prot