TNFAIP6 (TNF alpha induced protein 6) - Rat Genome Database

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Gene: TNFAIP6 (TNF alpha induced protein 6) Homo sapiens
Analyze
Symbol: TNFAIP6
Name: TNF alpha induced protein 6
RGD ID: 1345645
HGNC Page HGNC:11898
Description: Enables several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in several processes, including fibronectin fibril organization; negative regulation of cell differentiation; and negative regulation of neutrophil chemotaxis. Located in extracellular region. Implicated in corneal neovascularization. Biomarker of atopic dermatitis and conjunctival disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hyaluronate-binding protein; TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; TSG-6; TSG6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor, alpha induced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-inducible gene 6 protein; tumor necrosis factor-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382151,357,592 - 151,381,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2151,357,592 - 151,380,046 (+)EnsemblGRCh38hg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
T2T-CHM13v2.02151,809,346 - 151,833,086 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpidem  (EXP)
amodiaquine  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP,ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzyl bromide  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcium atom  (EXP)
calcium dichloride  (EXP)
calcium(0)  (EXP)
carbon nanotube  (EXP,ISO)
chondroitin sulfate  (EXP)
Chorionic gonadotropin  (ISO)
cisplatin  (EXP)
clavulanic acid  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
crocidolite asbestos  (EXP)
D-glucose  (ISO)
daidzein  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diuron  (ISO)
dobutamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
entacapone  (EXP)
epoxiconazole  (ISO)
esmolol  (EXP)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
fludrocortisone  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glycitein  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
irinotecan  (EXP)
isoprenaline  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
nebivolol  (EXP)
nevirapine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
oxaliplatin  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
pepstatin A  (EXP)
peptidoglycan  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pioglitazone  (EXP)
pirprofen  (EXP)
procyclidine  (EXP)
progesterone  (EXP)
propanal  (EXP)
ranitidine  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trazodone  (EXP)
Trihexyphenidyl  (EXP)
troglitazone  (EXP)
Tungsten carbide  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
zafirlukast  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis. Guo P, etal., Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1372-80. doi: 10.1167/iovs.11-8738. Print 2012 Mar.
3. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Oh JY, etal., Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16875-80. doi: 10.1073/pnas.1012451107. Epub 2010 Sep 13.
4. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Park YD, etal., Clin Exp Allergy. 2006 May;36(5):649-57.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6. Roddy GW, etal., Stem Cells. 2011 Oct;29(10):1572-9. doi: 10.1002/stem.708.
7. Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. Wang N, etal., PLoS One. 2012;7(8):e43768. doi: 10.1371/journal.pone.0043768. Epub 2012 Aug 17.
Additional References at PubMed
PMID:1730767   PMID:7516184   PMID:7935377   PMID:8454591   PMID:8568267   PMID:8797823   PMID:9654129   PMID:11278699   PMID:11375929   PMID:11854277   PMID:12401803   PMID:12477932  
PMID:12692188   PMID:14515153   PMID:14718574   PMID:15060082   PMID:15489334   PMID:15653696   PMID:15718240   PMID:15809059   PMID:15840581   PMID:15917224   PMID:16006654   PMID:16453284  
PMID:16467113   PMID:16687630   PMID:16709183   PMID:16771708   PMID:16873769   PMID:17207965   PMID:17585936   PMID:18042364   PMID:18260761   PMID:18448433   PMID:18586671   PMID:18820257  
PMID:19344623   PMID:19383344   PMID:19389798   PMID:20237496   PMID:20463016   PMID:20602615   PMID:20628624   PMID:21239672   PMID:21566135   PMID:21569482   PMID:21596748   PMID:21864707  
PMID:21873635   PMID:22267482   PMID:22922154   PMID:23017666   PMID:23129777   PMID:23143601   PMID:23166324   PMID:23314748   PMID:23921952   PMID:24005673   PMID:24162774   PMID:24213015  
PMID:24403066   PMID:24501198   PMID:24667918   PMID:24742347   PMID:25325979   PMID:25329668   PMID:25561734   PMID:25661977   PMID:26468290   PMID:26685054   PMID:26807758   PMID:26823460  
PMID:27044744   PMID:27143355   PMID:27444207   PMID:28005267   PMID:28246883   PMID:28247086   PMID:28701721   PMID:29180197   PMID:29238069   PMID:29301108   PMID:29362135   PMID:29401724  
PMID:30257717   PMID:30507579   PMID:30569148   PMID:30938674   PMID:31310658   PMID:31558705   PMID:31986937   PMID:32317078   PMID:32450526   PMID:32829938   PMID:33221562   PMID:33471224  
PMID:33670243   PMID:33961781   PMID:34382584   PMID:35222359   PMID:35278816   PMID:35353944   PMID:35718975   PMID:35766985   PMID:35773961   PMID:36056472   PMID:36110074   PMID:36379130  
PMID:36578051   PMID:36807440   PMID:37201873   PMID:37948519   PMID:37958918   PMID:38151073   PMID:38376551  


Genomics

Comparative Map Data
TNFAIP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382151,357,592 - 151,381,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2151,357,592 - 151,380,046 (+)EnsemblGRCh38hg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
T2T-CHM13v2.02151,809,346 - 151,833,086 (+)NCBIT2T-CHM13v2.0
Tnfaip6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,928,125 - 51,946,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl251,928,021 - 51,946,698 (+)EnsemblGRCm39 Ensembl
GRCm38252,038,113 - 52,056,681 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl252,038,009 - 52,056,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37251,893,633 - 51,912,201 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36251,860,122 - 51,878,690 (+)NCBIMGSCv36mm8
Celera253,762,777 - 53,783,057 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map229.98NCBI
Tnfaip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8356,911,398 - 56,930,797 (+)NCBIGRCr8
mRatBN7.2336,502,250 - 36,521,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx339,888,035 - 39,907,355 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0348,472,812 - 48,492,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0346,257,353 - 46,276,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
Tnfaip6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544016,916,055 - 16,944,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544016,915,952 - 16,944,375 (+)NCBIChiLan1.0ChiLan1.0
TNFAIP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21354,047,676 - 54,070,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B54,062,655 - 54,085,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B38,669,652 - 38,692,037 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B155,933,842 - 155,956,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B155,933,842 - 155,956,382 (+)Ensemblpanpan1.1panPan2
TNFAIP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11952,607,598 - 52,623,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1952,607,713 - 52,623,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1952,770,629 - 52,786,812 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01954,118,538 - 54,134,777 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1954,118,552 - 54,135,260 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11952,832,140 - 52,848,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01952,902,916 - 52,919,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01954,369,113 - 54,385,510 (+)NCBIUU_Cfam_GSD_1.0
Tnfaip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303115,472,309 - 115,488,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646926,129,331 - 26,145,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646926,129,339 - 26,145,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15862,015 - 881,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115862,013 - 881,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,132,380 - 157,151,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11036,792,505 - 36,814,271 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1036,792,514 - 36,814,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040162,729,309 - 162,750,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248665,706,850 - 5,728,771 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248665,706,483 - 5,758,666 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNFAIP6
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q22.3-24.1(chr2:147251948-157856378)x1 copy number loss See cases [RCV000054090] Chr2:147251948..157856378 [GRCh38]
Chr2:148009516..158712890 [GRCh37]
Chr2:147725986..158421136 [NCBI36]
Chr2:2q22.3-24.1		 pathogenic
GRCh38/hg38 2q22.3-23.3(chr2:147590324-153496674)x1 copy number loss See cases [RCV000054091] Chr2:147590324..153496674 [GRCh38]
Chr2:148347892..154353187 [GRCh37]
Chr2:148064362..154061433 [NCBI36]
Chr2:2q22.3-23.3		 pathogenic
GRCh38/hg38 2q23.1-23.3(chr2:148303135-153274626)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054092]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054092]|See cases [RCV000054092] Chr2:148303135..153274626 [GRCh38]
Chr2:149060704..154131140 [GRCh37]
Chr2:148777174..153839386 [NCBI36]
Chr2:2q23.1-23.3		 pathogenic
GRCh38/hg38 2q23.1-24.3(chr2:148917286-163204623)x1 copy number loss See cases [RCV000054093] Chr2:148917286..163204623 [GRCh38]
Chr2:149674855..164061133 [GRCh37]
Chr2:149391325..163769379 [NCBI36]
Chr2:2q23.1-24.3		 pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:143900149-158321624)x3 copy number gain See cases [RCV000135402] Chr2:143900149..158321624 [GRCh38]
Chr2:144657717..159178136 [GRCh37]
Chr2:144374187..158886382 [NCBI36]
Chr2:2q22.3-24.1		 pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:146324191-156219125)x3 copy number gain See cases [RCV000142582] Chr2:146324191..156219125 [GRCh38]
Chr2:147081759..157075637 [GRCh37]
Chr2:146798229..156783883 [NCBI36]
Chr2:2q22.3-24.1		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q23.3(chr2:150606201-153038451)x1 copy number loss See cases [RCV000447370] Chr2:150606201..153038451 [GRCh37]
Chr2:2q23.3		 likely pathogenic
GRCh37/hg19 2q22.3-23.3(chr2:147063452-154796058)x1 copy number loss See cases [RCV000448667] Chr2:147063452..154796058 [GRCh37]
Chr2:2q22.3-23.3		 pathogenic
GRCh37/hg19 2q23.3(chr2:152061163-152300138)x3 copy number gain See cases [RCV000448597] Chr2:152061163..152300138 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.1-23.3(chr2:148842506-152370040)x1 copy number loss See cases [RCV000448089] Chr2:148842506..152370040 [GRCh37]
Chr2:2q23.1-23.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_007115.4(TNFAIP6):c.739A>G (p.Met247Val) single nucleotide variant not specified [RCV004294084] Chr2:151379438 [GRCh38]
Chr2:152235952 [GRCh37]
Chr2:2q23.3		 likely benign
NM_007115.4(TNFAIP6):c.98G>T (p.Arg33Leu) single nucleotide variant not specified [RCV004310433] Chr2:151363946 [GRCh38]
Chr2:152220460 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3		 drug response
GRCh37/hg19 2q23.2-23.3(chr2:150134077-154848282)x1 copy number loss not provided [RCV000682154] Chr2:150134077..154848282 [GRCh37]
Chr2:2q23.2-23.3		 likely pathogenic
GRCh37/hg19 2q23.3(chr2:152154195-152398045)x3 copy number gain not provided [RCV000849451] Chr2:152154195..152398045 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.3(chr2:152085642-152493987)x3 copy number gain not provided [RCV000848747] Chr2:152085642..152493987 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.3(chr2:152154031-152398045)x3 copy number gain not provided [RCV000846571] Chr2:152154031..152398045 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.3(chr2:152210802-152492520)x3 copy number gain not provided [RCV001005338] Chr2:152210802..152492520 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q22.3-24.1(chr2:147173792-158346266)x1 copy number loss not provided [RCV001005326] Chr2:147173792..158346266 [GRCh37]
Chr2:2q22.3-24.1		 pathogenic
GRCh37/hg19 2q23.3(chr2:152130895-152217331)x1 copy number loss not provided [RCV001259774] Chr2:152130895..152217331 [GRCh37]
Chr2:2q23.3		 likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q21.3-23.3(chr2:136473383-152727396) copy number gain Global developmental delay [RCV001352659] Chr2:136473383..152727396 [GRCh37]
Chr2:2q21.3-23.3		 pathogenic
GRCh37/hg19 2q22.2-23.3(chr2:143258712-152867819) copy number loss not specified [RCV002053238] Chr2:143258712..152867819 [GRCh37]
Chr2:2q22.2-23.3		 pathogenic
GRCh37/hg19 2q22.2-23.3(chr2:142409401-152680804)x3 copy number gain not provided [RCV001834428] Chr2:142409401..152680804 [GRCh37]
Chr2:2q22.2-23.3		 pathogenic
GRCh37/hg19 2q23.3(chr2:150606201-153038451) copy number loss not specified [RCV002053253] Chr2:150606201..153038451 [GRCh37]
Chr2:2q23.3		 likely pathogenic
NM_007115.4(TNFAIP6):c.778A>T (p.Ser260Cys) single nucleotide variant not specified [RCV004145023] Chr2:151379477 [GRCh38]
Chr2:152235991 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.505T>C (p.Tyr169His) single nucleotide variant not specified [RCV004147953] Chr2:151370130 [GRCh38]
Chr2:152226644 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.31C>G (p.Leu11Val) single nucleotide variant not specified [RCV004077576] Chr2:151357697 [GRCh38]
Chr2:152214211 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.128G>T (p.Arg43Leu) single nucleotide variant not specified [RCV004264607] Chr2:151363976 [GRCh38]
Chr2:152220490 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.269G>A (p.Gly90Asp) single nucleotide variant not specified [RCV004366104] Chr2:151366092 [GRCh38]
Chr2:152222606 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.3(chr2:152002316-152547824)x3 copy number gain not provided [RCV003484078] Chr2:152002316..152547824 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q23.3(chr2:152159193-152760566)x1 copy number loss not provided [RCV003485094] Chr2:152159193..152760566 [GRCh37]
Chr2:2q23.3		 uncertain significance
GRCh37/hg19 2q22.3-23.3(chr2:148406827-152954124)x1 copy number loss not provided [RCV003485050] Chr2:148406827..152954124 [GRCh37]
Chr2:2q22.3-23.3		 pathogenic
GRCh37/hg19 2q23.3(chr2:151626277-154149348)x1 copy number loss not specified [RCV003986374] Chr2:151626277..154149348 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.402G>C (p.Glu134Asp) single nucleotide variant not specified [RCV004473082] Chr2:151370027 [GRCh38]
Chr2:152226541 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.515G>A (p.Arg172His) single nucleotide variant not specified [RCV004473084] Chr2:151370140 [GRCh38]
Chr2:152226654 [GRCh37]
Chr2:2q23.3		 likely benign
NM_007115.4(TNFAIP6):c.634G>A (p.Asp212Asn) single nucleotide variant not specified [RCV004473085] Chr2:151373559 [GRCh38]
Chr2:152230073 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.412G>A (p.Val138Ile) single nucleotide variant not specified [RCV004473083] Chr2:151370037 [GRCh38]
Chr2:152226551 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.124G>C (p.Ala42Pro) single nucleotide variant not specified [RCV004473078] Chr2:151363972 [GRCh38]
Chr2:152220486 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.144G>T (p.Lys48Asn) single nucleotide variant not specified [RCV004473079] Chr2:151363992 [GRCh38]
Chr2:152220506 [GRCh37]
Chr2:2q23.3		 uncertain significance
NM_007115.4(TNFAIP6):c.193C>G (p.Leu65Val) single nucleotide variant not specified [RCV004473080] Chr2:151364041 [GRCh38]
Chr2:152220555 [GRCh37]
Chr2:2q23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:166
Interacting mature miRNAs:173
Transcripts:ENST00000243347, ENST00000460812
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407197271GWAS846247_Htumor necrosis factor-inducible gene 6 protein measurement QTL GWAS846247 (human)2e-11tumor necrosis factor-inducible gene 6 protein measurement2151370056151370057Human
407048886GWAS697862_Hsphingomyelin 16:0 measurement QTL GWAS697862 (human)0.000006blood phospholipid amount (VT:0006084)2151368574151368575Human
407256784GWAS905760_Hglomerular filtration rate QTL GWAS905760 (human)6e-18glomerular filtration rateglomerular filtration rate (CMO:0000490)2151369205151369206Human
406959721GWAS608697_Htumor necrosis factor-inducible gene 6 protein measurement QTL GWAS608697 (human)3e-110tumor necrosis factor-inducible gene 6 protein measurement2151369205151369206Human
407177673GWAS826649_Hdiabetic maculopathy QTL GWAS826649 (human)0.0000009diabetic maculopathy2151369363151369364Human
407175720GWAS824696_Hblood protein measurement QTL GWAS824696 (human)6e-27blood protein measurementblood protein measurement (CMO:0000028)2151361717151361718Human

Markers in Region
SHGC-85360  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372152,223,073 - 152,223,381UniSTSGRCh37
Build 362151,931,319 - 151,931,627RGDNCBI36
Celera2145,837,344 - 145,837,652RGD
Cytogenetic Map2q23.3UniSTS
HuRef2144,119,423 - 144,119,731UniSTS
TNG Radiation Hybrid Map286698.0UniSTS
TNFAIP6_1246  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372152,235,888 - 152,236,560UniSTSGRCh37
Build 362151,944,134 - 151,944,806RGDNCBI36
Celera2145,850,155 - 145,850,827RGD
HuRef2144,132,427 - 144,133,098UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2339 2786 2239 4866 1618 2131 6 556 1793 395 2255 6972 6300 43 3644 1 812 1659 1475 170 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047445635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054343598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ413948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ413949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ419936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ421518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU102580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA307541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA415298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS722271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000243347   ⟹   ENSP00000243347
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2151,357,592 - 151,380,046 (+)Ensembl
Ensembl Acc Id: ENST00000460812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2151,366,142 - 151,373,744 (+)Ensembl
RefSeq Acc Id: NM_007115   ⟹   NP_009046
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382151,357,592 - 151,380,046 (+)NCBI
GRCh372152,214,106 - 152,236,562 (+)ENTREZGENE
Build 362151,922,351 - 151,944,806 (+)NCBI Archive
HuRef2144,110,453 - 144,133,100 (+)ENTREZGENE
CHM1_12152,219,924 - 152,242,420 (+)NCBI
T2T-CHM13v2.02151,809,346 - 151,831,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047445635   ⟹   XP_047301591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382151,357,592 - 151,381,340 (+)NCBI
RefSeq Acc Id: XM_054343598   ⟹   XP_054199573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02151,809,346 - 151,833,086 (+)NCBI
RefSeq Acc Id: NP_009046   ⟸   NM_007115
- Peptide Label: precursor
- UniProtKB: Q53TI7 (UniProtKB/Swiss-Prot),   Q8WWI9 (UniProtKB/Swiss-Prot),   P98066 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000243347   ⟸   ENST00000243347
RefSeq Acc Id: XP_047301591   ⟸   XM_047445635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054199573   ⟸   XM_054343598
- Peptide Label: isoform X1
Protein Domains
CUB   Link

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98066-F1-model_v2 AlphaFold P98066 1-277 view protein structure

Promoters
RGD ID:6861728
Promoter ID:EPDNEW_H4029
Type:multiple initiation site
Name:TNFAIP6_1
Description:TNF alpha induced protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382151,357,592 - 151,357,652EPDNEW
RGD ID:6798349
Promoter ID:HG_KWN:35394
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_007115
Position:
Human AssemblyChrPosition (strand)Source
Build 362151,922,016 - 151,922,516 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11898 AgrOrtholog
COSMIC TNFAIP6 COSMIC
Ensembl Genes ENSG00000123610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000243347 ENTREZGENE
  ENST00000243347.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot
  3.10.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000123610 GTEx
HGNC ID HGNC:11898 ENTREZGENE
Human Proteome Map TNFAIP6 Human Proteome Map
InterPro C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  CUB_dom UniProtKB/Swiss-Prot
  Link_dom UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  Spermadhesin-Link_domain UniProtKB/Swiss-Prot
KEGG Report hsa:7130 UniProtKB/Swiss-Prot
NCBI Gene 7130 ENTREZGENE
OMIM 600410 OMIM
PANTHER CUBILIN-LIKE PROTEIN UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  Xlink UniProtKB/Swiss-Prot
PharmGKB PA36595 PharmGKB
PRINTS LINKMODULE UniProtKB/Swiss-Prot
PROSITE CUB UniProtKB/Swiss-Prot
  LINK_1 UniProtKB/Swiss-Prot
  LINK_2 UniProtKB/Swiss-Prot
SMART CUB UniProtKB/Swiss-Prot
  LINK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
  SSF56436 UniProtKB/Swiss-Prot
UniProt P98066 ENTREZGENE
  Q53TI7 ENTREZGENE
  Q8WWI9 ENTREZGENE
  TSG6_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q53TI7 UniProtKB/Swiss-Prot
  Q8WWI9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 TNFAIP6  TNF alpha induced protein 6    tumor necrosis factor, alpha induced protein 6  Symbol and/or name change 5135510 APPROVED
2015-11-24 TNFAIP6  tumor necrosis factor, alpha induced protein 6    tumor necrosis factor, alpha-induced protein 6  Symbol and/or name change 5135510 APPROVED