TNFAIP6 (TNF alpha induced protein 6) - Rat Genome Database

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Gene: TNFAIP6 (TNF alpha induced protein 6) Homo sapiens
Analyze
Symbol: TNFAIP6
Name: TNF alpha induced protein 6
RGD ID: 1345645
HGNC Page HGNC
Description: Predicted to have hyaluronic acid binding activity. Involved in negative regulation of inflammatory response. Predicted to localize to extracellular space. Implicated in corneal neovascularization. Biomarker of atopic dermatitis and conjunctival disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hyaluronate-binding protein; TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; TSG-6; TSG6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor, alpha induced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-inducible gene 6 protein; tumor necrosis factor-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2151,357,592 - 151,380,046 (+)EnsemblGRCh38hg38GRCh38
GRCh382151,357,592 - 151,380,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBINCBI36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBI
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpidem  (EXP)
amodiaquine  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzyl bromide  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium dichloride  (EXP)
calcium(0)  (EXP)
carbon nanotube  (EXP,ISO)
chondroitin sulfate  (EXP)
Chorionic gonadotropin  (ISO)
cisplatin  (EXP)
clavulanic acid  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (EXP)
D-glucose  (ISO)
daidzein  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diuron  (ISO)
dobutamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
entacapone  (EXP)
esmolol  (EXP)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
fludrocortisone  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glycitein  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
nebivolol  (EXP)
nevirapine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
oxaliplatin  (ISO)
oxytocin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
pepstatin A  (EXP)
peptidoglycan  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pioglitazone  (EXP)
pirprofen  (EXP)
procyclidine  (EXP)
progesterone  (EXP)
propanal  (EXP)
ranitidine  (ISO)
resveratrol  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trazodone  (EXP)
Trihexyphenidyl  (EXP)
troglitazone  (EXP)
Tungsten carbide  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
zafirlukast  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1730767   PMID:7516184   PMID:7935377   PMID:8454591   PMID:8568267   PMID:8797823   PMID:9654129   PMID:11278699   PMID:11375929   PMID:11854277   PMID:12401803   PMID:12477932  
PMID:12692188   PMID:14515153   PMID:14718574   PMID:15060082   PMID:15489334   PMID:15653696   PMID:15718240   PMID:15809059   PMID:15840581   PMID:15917224   PMID:16006654   PMID:16453284  
PMID:16467113   PMID:16687630   PMID:16709183   PMID:16771708   PMID:16873769   PMID:17207965   PMID:17585936   PMID:18042364   PMID:18260761   PMID:18448433   PMID:18586671   PMID:18820257  
PMID:19344623   PMID:19383344   PMID:19389798   PMID:20237496   PMID:20463016   PMID:20602615   PMID:20628624   PMID:21239672   PMID:21566135   PMID:21569482   PMID:21596748   PMID:21864707  
PMID:21873635   PMID:22267482   PMID:22922154   PMID:23017666   PMID:23129777   PMID:23143601   PMID:23166324   PMID:23314748   PMID:23921952   PMID:24005673   PMID:24162774   PMID:24213015  
PMID:24403066   PMID:24501198   PMID:24667918   PMID:24742347   PMID:25325979   PMID:25329668   PMID:25561734   PMID:25661977   PMID:26468290   PMID:26685054   PMID:26807758   PMID:27044744  
PMID:27143355   PMID:27444207   PMID:28005267   PMID:28246883   PMID:28247086   PMID:28701721   PMID:29180197   PMID:29238069   PMID:29301108   PMID:29362135   PMID:29401724   PMID:30257717  
PMID:30507579   PMID:30569148   PMID:30938674   PMID:31310658   PMID:31558705   PMID:32450526   PMID:33670243  


Genomics

Comparative Map Data
TNFAIP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2151,357,592 - 151,380,046 (+)EnsemblGRCh38hg38GRCh38
GRCh382151,357,592 - 151,380,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBINCBI36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBI
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
Tnfaip6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,928,125 - 51,946,693 (+)NCBIGRCm39mm39
GRCm39 Ensembl251,928,021 - 51,946,698 (+)Ensembl
GRCm38252,038,113 - 52,056,681 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl252,038,009 - 52,056,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37251,893,633 - 51,912,201 (+)NCBIGRCm37mm9NCBIm37
MGSCv36251,860,122 - 51,878,690 (+)NCBImm8
Celera253,762,777 - 53,783,057 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
Tnfaip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2336,502,250 - 36,521,652 (+)NCBI
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
Tnfaip6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544016,916,055 - 16,944,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544016,915,952 - 16,944,375 (+)NCBIChiLan1.0ChiLan1.0
TNFAIP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B155,933,842 - 155,956,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B155,933,842 - 155,956,382 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B38,669,652 - 38,692,037 (+)NCBIMhudiblu_PPA_v0panPan3
TNFAIP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11952,607,598 - 52,623,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1952,607,713 - 52,623,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1952,770,629 - 52,786,812 (+)NCBI
ROS_Cfam_1.01954,118,538 - 54,134,777 (+)NCBI
UMICH_Zoey_3.11952,832,140 - 52,848,316 (+)NCBI
UNSW_CanFamBas_1.01952,902,916 - 52,919,491 (+)NCBI
UU_Cfam_GSD_1.01954,369,113 - 54,385,510 (+)NCBI
Tnfaip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303115,472,309 - 115,488,387 (+)NCBI
SpeTri2.0NW_00493646926,129,339 - 26,145,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15862,013 - 881,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115862,013 - 881,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,132,380 - 157,151,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11036,792,505 - 36,814,271 (+)NCBI
ChlSab1.1 Ensembl1036,792,514 - 36,814,494 (+)Ensembl
Vero_WHO_p1.0NW_023666040162,729,309 - 162,750,857 (-)NCBI
Tnfaip6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248665,706,483 - 5,758,666 (-)NCBI

Position Markers
SHGC-85360  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372152,223,073 - 152,223,381UniSTSGRCh37
Build 362151,931,319 - 151,931,627RGDNCBI36
Celera2145,837,344 - 145,837,652RGD
Cytogenetic Map2q23.3UniSTS
HuRef2144,119,423 - 144,119,731UniSTS
TNG Radiation Hybrid Map286698.0UniSTS
TNFAIP6_1246  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372152,235,888 - 152,236,560UniSTSGRCh37
Build 362151,944,134 - 151,944,806RGDNCBI36
Celera2145,850,155 - 145,850,827RGD
HuRef2144,132,427 - 144,133,098UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:166
Interacting mature miRNAs:173
Transcripts:ENST00000243347, ENST00000460812
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1
Medium 477 1208 55 17 646 15 945 342 453 128 426 374 4 376 695 1
Low 1687 1759 835 253 1015 101 3020 1573 2468 158 752 934 157 1 826 1807 3 1
Below cutoff 175 18 728 286 132 279 376 268 722 102 223 164 9 2 284 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000243347   ⟹   ENSP00000243347
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2151,357,592 - 151,380,046 (+)Ensembl
RefSeq Acc Id: ENST00000460812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2151,366,142 - 151,373,744 (+)Ensembl
RefSeq Acc Id: NM_007115   ⟹   NP_009046
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382151,357,592 - 151,380,046 (+)NCBI
GRCh372152,214,106 - 152,236,562 (+)ENTREZGENE
Build 362151,922,351 - 151,944,806 (+)NCBI Archive
HuRef2144,110,453 - 144,133,100 (+)ENTREZGENE
CHM1_12152,219,924 - 152,242,420 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_009046   ⟸   NM_007115
- Peptide Label: precursor
- UniProtKB: P98066 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000243347   ⟸   ENST00000243347
Protein Domains
CUB   Link

Promoters
RGD ID:6861728
Promoter ID:EPDNEW_H4029
Type:multiple initiation site
Name:TNFAIP6_1
Description:TNF alpha induced protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382151,357,592 - 151,357,652EPDNEW
RGD ID:6798349
Promoter ID:HG_KWN:35394
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_007115
Position:
Human AssemblyChrPosition (strand)Source
Build 362151,922,016 - 151,922,516 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q22.3-24.1(chr2:147251948-157856378)x1 copy number loss See cases [RCV000054090] Chr2:147251948..157856378 [GRCh38]
Chr2:148009516..158712890 [GRCh37]
Chr2:147725986..158421136 [NCBI36]
Chr2:2q22.3-24.1
pathogenic
GRCh38/hg38 2q22.3-23.3(chr2:147590324-153496674)x1 copy number loss See cases [RCV000054091] Chr2:147590324..153496674 [GRCh38]
Chr2:148347892..154353187 [GRCh37]
Chr2:148064362..154061433 [NCBI36]
Chr2:2q22.3-23.3
pathogenic
GRCh38/hg38 2q23.1-23.3(chr2:148303135-153274626)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054092]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054092]|See cases [RCV000054092] Chr2:148303135..153274626 [GRCh38]
Chr2:149060704..154131140 [GRCh37]
Chr2:148777174..153839386 [NCBI36]
Chr2:2q23.1-23.3
pathogenic
GRCh38/hg38 2q23.1-24.3(chr2:148917286-163204623)x1 copy number loss See cases [RCV000054093] Chr2:148917286..163204623 [GRCh38]
Chr2:149674855..164061133 [GRCh37]
Chr2:149391325..163769379 [NCBI36]
Chr2:2q23.1-24.3
pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:143900149-158321624)x3 copy number gain See cases [RCV000135402] Chr2:143900149..158321624 [GRCh38]
Chr2:144657717..159178136 [GRCh37]
Chr2:144374187..158886382 [NCBI36]
Chr2:2q22.3-24.1
pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:146324191-156219125)x3 copy number gain See cases [RCV000142582] Chr2:146324191..156219125 [GRCh38]
Chr2:147081759..157075637 [GRCh37]
Chr2:146798229..156783883 [NCBI36]
Chr2:2q22.3-24.1
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q23.3(chr2:150606201-153038451)x1 copy number loss See cases [RCV000447370] Chr2:150606201..153038451 [GRCh37]
Chr2:2q23.3
likely pathogenic
GRCh37/hg19 2q22.3-23.3(chr2:147063452-154796058)x1 copy number loss See cases [RCV000448667] Chr2:147063452..154796058 [GRCh37]
Chr2:2q22.3-23.3
pathogenic
GRCh37/hg19 2q23.3(chr2:152061163-152300138)x3 copy number gain See cases [RCV000448597] Chr2:152061163..152300138 [GRCh37]
Chr2:2q23.3
uncertain significance
GRCh37/hg19 2q23.1-23.3(chr2:148842506-152370040)x1 copy number loss See cases [RCV000448089] Chr2:148842506..152370040 [GRCh37]
Chr2:2q23.1-23.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2q23.2-23.3(chr2:150134077-154848282)x1 copy number loss not provided [RCV000682154] Chr2:150134077..154848282 [GRCh37]
Chr2:2q23.2-23.3
likely pathogenic
GRCh37/hg19 2q23.3(chr2:152154195-152398045)x3 copy number gain not provided [RCV000849451] Chr2:152154195..152398045 [GRCh37]
Chr2:2q23.3
uncertain significance
GRCh37/hg19 2q23.3(chr2:152085642-152493987)x3 copy number gain not provided [RCV000848747] Chr2:152085642..152493987 [GRCh37]
Chr2:2q23.3
uncertain significance
GRCh37/hg19 2q23.3(chr2:152154031-152398045)x3 copy number gain not provided [RCV000846571] Chr2:152154031..152398045 [GRCh37]
Chr2:2q23.3
uncertain significance
GRCh37/hg19 2q23.3(chr2:152210802-152492520)x3 copy number gain not provided [RCV001005338] Chr2:152210802..152492520 [GRCh37]
Chr2:2q23.3
uncertain significance
GRCh37/hg19 2q22.3-24.1(chr2:147173792-158346266)x1 copy number loss not provided [RCV001005326] Chr2:147173792..158346266 [GRCh37]
Chr2:2q22.3-24.1
pathogenic
GRCh37/hg19 2q23.3(chr2:152130895-152217331)x1 copy number loss not provided [RCV001259774] Chr2:152130895..152217331 [GRCh37]
Chr2:2q23.3
likely benign
GRCh37/hg19 2q21.3-23.3(chr2:136473383-152727396) copy number gain Global developmental delay [RCV001352659] Chr2:136473383..152727396 [GRCh37]
Chr2:2q21.3-23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11898 AgrOrtholog
COSMIC TNFAIP6 COSMIC
Ensembl Genes ENSG00000123610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000243347 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000243347 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot
  3.10.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000123610 GTEx
HGNC ID HGNC:11898 ENTREZGENE
Human Proteome Map TNFAIP6 Human Proteome Map
InterPro C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  CUB_dom UniProtKB/Swiss-Prot
  Link_dom UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:7130 UniProtKB/Swiss-Prot
NCBI Gene 7130 ENTREZGENE
OMIM 600410 OMIM
Pfam CUB UniProtKB/Swiss-Prot
  Xlink UniProtKB/Swiss-Prot
PharmGKB PA36595 PharmGKB
PRINTS LINKMODULE UniProtKB/Swiss-Prot
PROSITE CUB UniProtKB/Swiss-Prot
  LINK_1 UniProtKB/Swiss-Prot
  LINK_2 UniProtKB/Swiss-Prot
SMART CUB UniProtKB/Swiss-Prot
  LINK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
  SSF56436 UniProtKB/Swiss-Prot
UniProt P98066 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q53TI7 UniProtKB/Swiss-Prot
  Q8WWI9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 TNFAIP6  TNF alpha induced protein 6    tumor necrosis factor, alpha induced protein 6  Symbol and/or name change 5135510 APPROVED
2015-11-24 TNFAIP6  tumor necrosis factor, alpha induced protein 6    tumor necrosis factor, alpha-induced protein 6  Symbol and/or name change 5135510 APPROVED